Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	644
Gene name	Biliverdin reductase A
Gene symbol	BLVRA
Synonyms (NCBI Gene)	BLVRBVRBVRABVRalpha
Chromosome	7
Chromosome location	7p13
Summary	The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternativel

Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050960	hsa-miR-17-5p	CLASH	23622248
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT735775	hsa-miR-139-5p	Western blottingqRT-PCR	31758243
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT822177	hsa-miR-221	CLIP-seq
MIRT822178	hsa-miR-222	CLIP-seq
MIRT822179	hsa-miR-302a	CLIP-seq
MIRT822180	hsa-miR-302b	CLIP-seq
MIRT822181	hsa-miR-302c	CLIP-seq
MIRT822182	hsa-miR-302d	CLIP-seq
MIRT822183	hsa-miR-302e	CLIP-seq
MIRT822184	hsa-miR-372	CLIP-seq
MIRT822185	hsa-miR-373	CLIP-seq
MIRT822186	hsa-miR-499-3p	CLIP-seq
MIRT822187	hsa-miR-499a-3p	CLIP-seq
MIRT822188	hsa-miR-520a-3p	CLIP-seq
MIRT822189	hsa-miR-520b	CLIP-seq
MIRT822190	hsa-miR-520c-3p	CLIP-seq
MIRT822191	hsa-miR-520d-3p	CLIP-seq
MIRT822192	hsa-miR-520e	CLIP-seq
MIRT822193	hsa-miR-548v	CLIP-seq
MIRT2181753	hsa-miR-105	CLIP-seq
MIRT2181754	hsa-miR-1253	CLIP-seq
MIRT2181755	hsa-miR-138	CLIP-seq
MIRT2181756	hsa-miR-548b-3p	CLIP-seq
MIRT2181757	hsa-miR-548q	CLIP-seq
MIRT2181753	hsa-miR-105	CLIP-seq
MIRT2181755	hsa-miR-138	CLIP-seq
MIRT2181756	hsa-miR-548b-3p	CLIP-seq
MIRT2181757	hsa-miR-548q	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IBA
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IDA	7929092, 8424666, 8631357, 10858451
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IEA
GO:0005515	Function	Protein binding	IPI	18463290, 25416956, 29892012, 31515488
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	7929092, 8424666
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006641	Process	Triglyceride metabolic process	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0032094	Process	Response to food	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034440	Process	Lipid oxidation	IEA
GO:0038178	Process	Complement component C5a signaling pathway	IEA
GO:0042167	Process	Heme catabolic process	IDA	10858451
GO:0042167	Process	Heme catabolic process	IEA
GO:0042440	Process	Pigment metabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:0106276	Function	Biliberdin reductase (NADH) activity	IDA	7929092, 8424666, 8631357
GO:0106276	Function	Biliberdin reductase (NADH) activity	IEA
GO:0106277	Function	Biliverdin reductase (NADPH) activity	IEA
GO:0160025	Process	Sensory perception of itch	IEA
GO:1905237	Process	Response to cyclosporin A	IEA

MIM	HGNC	e!Ensembl
109750	1062	ENSG00000106605

P53004

Protein name

Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase)

Protein function

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin I

PDB

2H63

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01408	GFO_IDH_MocA	9 → 125	Oxidoreductase family, NAD-binding Rossmann fold	Family
PF09166	Biliv-reduc_cat	133 → 245	Biliverdin reductase, catalytic	Domain

Tissue specificity

TISSUE SPECIFICITY: Liver. {ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666}.

Sequence

MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE
DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV
LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF
GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN
VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK

Sequence length

296

Interactions

View interactions

	KEGG		Reactome
	Porphyrin metabolism Metabolic pathways		Heme degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hyperbiliverdinemia	Likely pathogenic; Pathogenic	rs747902950, rs387906595, rs387906596	RCV001331360 RCV000022451 RCV000022452	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BLVRA-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATARACT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLESTASIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (52)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adult Hepatocellular Carcinoma	Liver carcinoma	BEFREE	27740521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	21241799	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	22549002, 34367470	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm, Abdominal	Aortic Aneurysm	BEFREE	31704097		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	27740521	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	35910837	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Childhood Hepatocellular Carcinoma	Liver carcinoma	BEFREE	27740521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangitis Sclerosing	Sclerosing cholangitis	Pubtator	39683940	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholelithiasis	Cholelithiasis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholestasis	Cholestasis	CTD_human_DG	18706437		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholestasis	Cholestasis	HPO_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cirrhosis	Cirrhosis	BEFREE	31758243		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	21241799	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	22549002	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	39596612	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	19238116		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	25239864		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	31065010	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28198575		★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	25391381		★★★★★ ★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	BEFREE	21721974		★★★★★ ★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	Pubtator	21721974	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	29494209		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty liver	Pubtator	30826467, 33260451	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	30826467, 31422074		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gilbert Disease	Gilbert syndrome	Pubtator	28389660	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	33260451	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperbilirubinemia	Hyperbilirubinemia	BEFREE	27943244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperbilirubinemia Neonatal	Hyperbilirubinemia	Pubtator	38279097	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperbilirubinemia, Neonatal	Hyperbilirubinemia	BEFREE	30636082		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperbiliverdinemia	Hyperbiliverdinemia	BEFREE	19580635		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hyperbiliverdinemia	Hyperbiliverdinemia	ORPHANET_DG	21278388		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hyperbiliverdinemia	Hyperbiliverdinemia	Orphanet			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hyperbiliverdinemia	Hyperbiliverdinemia	CTD_human_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hyperbiliverdinemia	Hyperbiliverdinemia	CLINVAR_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	21721974, 30826467	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	26393580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27740521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	19580635, 31758243		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	39683940	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	27740521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	30826467	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	21241799, 21483094, 22549002, 30738142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	35910837	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	21483094		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	31422074		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30826467		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	30826467	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	33260451	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Emphysema	Pulmonary Emphysema	BEFREE	29051040		★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	23042203		★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	29494209		★★★★★ ★☆☆☆☆ Found in Text Mining only

BLVRA (biliverdin reductase A)