Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64344
Gene name	Hypoxia inducible factor 3 subunit alpha
Gene symbol	HIF3A
Synonyms (NCBI Gene)	HIF-3AHIF3-alpha-1IPASMOP7PASD7bHLHe17
Chromosome	19
Chromosome location	19q13.32
Summary	The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain fo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023941	hsa-miR-1-3p	Microarray	18668037
MIRT054793	hsa-miR-485-5p	Luciferase reporter assayWestern blotqRT-PCR	24927770
MIRT054794	hsa-miR-210-3p	Luciferase reporter assayWestern blotqRT-PCR	24927770
MIRT475655	hsa-miR-3125	PAR-CLIP	20371350
MIRT475654	hsa-miR-3916	PAR-CLIP	20371350
MIRT475653	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT475652	hsa-miR-6165	PAR-CLIP	20371350
MIRT475651	hsa-miR-4459	PAR-CLIP	20371350
MIRT560228	hsa-miR-3185	PAR-CLIP	20371350
MIRT560229	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT475650	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT475649	hsa-miR-6077	PAR-CLIP	20371350
MIRT475648	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT475645	hsa-miR-6880-5p	PAR-CLIP	20371350
MIRT475655	hsa-miR-3125	PAR-CLIP	23592263
MIRT475654	hsa-miR-3916	PAR-CLIP	23592263
MIRT475653	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT475652	hsa-miR-6165	PAR-CLIP	23592263
MIRT475651	hsa-miR-4459	PAR-CLIP	23592263
MIRT475650	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT475649	hsa-miR-6077	PAR-CLIP	23592263
MIRT475647	hsa-miR-6081	PAR-CLIP	23592263
MIRT475648	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT475646	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT475645	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT735537	hsa-miR-29b-3p	Flow cytometryImmunohistochemistry (IHC)In situ hybridizationLuciferase reporter assayqRT-PCRWestern blotting	32296392
MIRT475655	hsa-miR-3125	PAR-CLIP	20371350
MIRT475654	hsa-miR-3916	PAR-CLIP	20371350
MIRT475653	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT475652	hsa-miR-6165	PAR-CLIP	20371350
MIRT475651	hsa-miR-4459	PAR-CLIP	20371350
MIRT560228	hsa-miR-3185	PAR-CLIP	20371350
MIRT560229	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT475650	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT475649	hsa-miR-6077	PAR-CLIP	20371350
MIRT475648	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT475645	hsa-miR-6880-5p	PAR-CLIP	20371350
MIRT475655	hsa-miR-3125	PAR-CLIP	23592263
MIRT475654	hsa-miR-3916	PAR-CLIP	23592263
MIRT475653	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT475652	hsa-miR-6165	PAR-CLIP	23592263
MIRT475651	hsa-miR-4459	PAR-CLIP	23592263
MIRT475650	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT475649	hsa-miR-6077	PAR-CLIP	23592263
MIRT475647	hsa-miR-6081	PAR-CLIP	23592263
MIRT475648	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT475646	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT475645	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT1045895	hsa-miR-1200	CLIP-seq
MIRT1045896	hsa-miR-1224-3p	CLIP-seq
MIRT1045897	hsa-miR-1260	CLIP-seq
MIRT1045898	hsa-miR-1260b	CLIP-seq
MIRT1045899	hsa-miR-1268	CLIP-seq
MIRT1045900	hsa-miR-1268b	CLIP-seq
MIRT1045901	hsa-miR-1270	CLIP-seq
MIRT1045902	hsa-miR-1280	CLIP-seq
MIRT1045903	hsa-miR-1304	CLIP-seq
MIRT1045904	hsa-miR-1827	CLIP-seq
MIRT1045905	hsa-miR-2114	CLIP-seq
MIRT1045906	hsa-miR-24	CLIP-seq
MIRT1045907	hsa-miR-3122	CLIP-seq
MIRT1045908	hsa-miR-3150a-3p	CLIP-seq
MIRT1045909	hsa-miR-3156-5p	CLIP-seq
MIRT1045910	hsa-miR-3165	CLIP-seq
MIRT1045911	hsa-miR-3168	CLIP-seq
MIRT1045912	hsa-miR-3173-3p	CLIP-seq
MIRT1045913	hsa-miR-3174	CLIP-seq
MIRT1045914	hsa-miR-3175	CLIP-seq
MIRT1045915	hsa-miR-3197	CLIP-seq
MIRT1045916	hsa-miR-3200-5p	CLIP-seq
MIRT1045917	hsa-miR-3202	CLIP-seq
MIRT1045918	hsa-miR-3609	CLIP-seq
MIRT1045919	hsa-miR-3612	CLIP-seq
MIRT1045920	hsa-miR-3656	CLIP-seq
MIRT1045921	hsa-miR-3688-5p	CLIP-seq
MIRT1045922	hsa-miR-3689a-3p	CLIP-seq
MIRT1045923	hsa-miR-3689c	CLIP-seq
MIRT1045924	hsa-miR-3689d	CLIP-seq
MIRT1045925	hsa-miR-3714	CLIP-seq
MIRT1045926	hsa-miR-3913-5p	CLIP-seq
MIRT1045927	hsa-miR-3929	CLIP-seq
MIRT1045928	hsa-miR-4266	CLIP-seq
MIRT1045929	hsa-miR-4284	CLIP-seq
MIRT1045930	hsa-miR-4324	CLIP-seq
MIRT1045931	hsa-miR-4419b	CLIP-seq
MIRT1045932	hsa-miR-4434	CLIP-seq
MIRT1045933	hsa-miR-4443	CLIP-seq
MIRT1045934	hsa-miR-4478	CLIP-seq
MIRT1045935	hsa-miR-4486	CLIP-seq
MIRT1045936	hsa-miR-4516	CLIP-seq
MIRT1045937	hsa-miR-4531	CLIP-seq
MIRT1045938	hsa-miR-4533	CLIP-seq
MIRT1045939	hsa-miR-4649-3p	CLIP-seq
MIRT1045940	hsa-miR-4680-3p	CLIP-seq
MIRT1045941	hsa-miR-4728-5p	CLIP-seq
MIRT1045942	hsa-miR-4747-5p	CLIP-seq
MIRT1045943	hsa-miR-4768-3p	CLIP-seq
MIRT1045944	hsa-miR-486-5p	CLIP-seq
MIRT1045945	hsa-miR-539	CLIP-seq
MIRT1045946	hsa-miR-544b	CLIP-seq
MIRT1045947	hsa-miR-548ah	CLIP-seq
MIRT1045948	hsa-miR-585	CLIP-seq
MIRT1045949	hsa-miR-620	CLIP-seq
MIRT1045950	hsa-miR-650	CLIP-seq
MIRT1045951	hsa-miR-651	CLIP-seq
MIRT1045952	hsa-miR-665	CLIP-seq
MIRT1045953	hsa-miR-671-5p	CLIP-seq
MIRT1045954	hsa-miR-765	CLIP-seq
MIRT1045955	hsa-miR-9	CLIP-seq
MIRT1045956	hsa-miR-939	CLIP-seq
MIRT1045957	hsa-miR-940	CLIP-seq
MIRT1045896	hsa-miR-1224-3p	CLIP-seq
MIRT1045958	hsa-miR-141	CLIP-seq
MIRT1045904	hsa-miR-1827	CLIP-seq
MIRT1045959	hsa-miR-200a	CLIP-seq
MIRT1045906	hsa-miR-24	CLIP-seq
MIRT1045907	hsa-miR-3122	CLIP-seq
MIRT1045960	hsa-miR-3128	CLIP-seq
MIRT1045917	hsa-miR-3202	CLIP-seq
MIRT1045919	hsa-miR-3612	CLIP-seq
MIRT1045961	hsa-miR-3665	CLIP-seq
MIRT1045922	hsa-miR-3689a-3p	CLIP-seq
MIRT1045923	hsa-miR-3689c	CLIP-seq
MIRT1045924	hsa-miR-3689d	CLIP-seq
MIRT1045926	hsa-miR-3913-5p	CLIP-seq
MIRT1045962	hsa-miR-3926	CLIP-seq
MIRT1045927	hsa-miR-3929	CLIP-seq
MIRT1045929	hsa-miR-4284	CLIP-seq
MIRT1045963	hsa-miR-4286	CLIP-seq
MIRT1045931	hsa-miR-4419b	CLIP-seq
MIRT1045933	hsa-miR-4443	CLIP-seq
MIRT1045934	hsa-miR-4478	CLIP-seq
MIRT1045938	hsa-miR-4533	CLIP-seq
MIRT1045964	hsa-miR-4537	CLIP-seq
MIRT1045939	hsa-miR-4649-3p	CLIP-seq
MIRT1045965	hsa-miR-4684-5p	CLIP-seq
MIRT1045941	hsa-miR-4728-5p	CLIP-seq
MIRT1045966	hsa-miR-4736	CLIP-seq
MIRT1045967	hsa-miR-4768-5p	CLIP-seq
MIRT1045968	hsa-miR-494	CLIP-seq
MIRT1045969	hsa-miR-548s	CLIP-seq
MIRT1045970	hsa-miR-593	CLIP-seq
MIRT1045950	hsa-miR-650	CLIP-seq
MIRT1045952	hsa-miR-665	CLIP-seq
MIRT1045957	hsa-miR-940	CLIP-seq
MIRT1045971	hsa-miR-942	CLIP-seq
MIRT1045972	hsa-miR-1283	CLIP-seq
MIRT1045973	hsa-miR-3150a-5p	CLIP-seq
MIRT1045974	hsa-miR-3150b-5p	CLIP-seq
MIRT1045965	hsa-miR-4684-5p	CLIP-seq
MIRT2010219	hsa-miR-4257	CLIP-seq
MIRT2010220	hsa-miR-4487	CLIP-seq
MIRT2242524	hsa-miR-1262	CLIP-seq
MIRT1045904	hsa-miR-1827	CLIP-seq
MIRT1045905	hsa-miR-2114	CLIP-seq
MIRT1045906	hsa-miR-24	CLIP-seq
MIRT2242525	hsa-miR-3120-5p	CLIP-seq
MIRT2242526	hsa-miR-3145-5p	CLIP-seq
MIRT1045911	hsa-miR-3168	CLIP-seq
MIRT2242527	hsa-miR-3199	CLIP-seq
MIRT1045919	hsa-miR-3612	CLIP-seq
MIRT2242528	hsa-miR-3613-3p	CLIP-seq
MIRT2242529	hsa-miR-3664-5p	CLIP-seq
MIRT1045922	hsa-miR-3689a-3p	CLIP-seq
MIRT1045923	hsa-miR-3689c	CLIP-seq
MIRT1045924	hsa-miR-3689d	CLIP-seq
MIRT2242530	hsa-miR-371-5p	CLIP-seq
MIRT2242531	hsa-miR-371b-5p	CLIP-seq
MIRT2242532	hsa-miR-4252	CLIP-seq
MIRT1045929	hsa-miR-4284	CLIP-seq
MIRT1045933	hsa-miR-4443	CLIP-seq
MIRT2242533	hsa-miR-4481	CLIP-seq
MIRT2242534	hsa-miR-4522	CLIP-seq
MIRT1045964	hsa-miR-4537	CLIP-seq
MIRT2242535	hsa-miR-4648	CLIP-seq
MIRT2242536	hsa-miR-4701-3p	CLIP-seq
MIRT1045941	hsa-miR-4728-5p	CLIP-seq
MIRT2242537	hsa-miR-4745-5p	CLIP-seq
MIRT1045943	hsa-miR-4768-3p	CLIP-seq
MIRT2242538	hsa-miR-4777-5p	CLIP-seq
MIRT2242539	hsa-miR-4797-5p	CLIP-seq
MIRT2242540	hsa-miR-508-5p	CLIP-seq
MIRT2242541	hsa-miR-518d-5p	CLIP-seq
MIRT2242542	hsa-miR-519b-5p	CLIP-seq
MIRT2242543	hsa-miR-519c-5p	CLIP-seq
MIRT2242544	hsa-miR-520c-5p	CLIP-seq
MIRT2242545	hsa-miR-526a	CLIP-seq
MIRT2242546	hsa-miR-542-3p	CLIP-seq
MIRT1045950	hsa-miR-650	CLIP-seq
MIRT2242547	hsa-miR-661	CLIP-seq
MIRT1045952	hsa-miR-665	CLIP-seq
MIRT2242548	hsa-miR-759	CLIP-seq
MIRT2242549	hsa-miR-766	CLIP-seq
MIRT2388980	hsa-miR-1264	CLIP-seq
MIRT1045908	hsa-miR-3150a-3p	CLIP-seq
MIRT1045914	hsa-miR-3175	CLIP-seq
MIRT1045919	hsa-miR-3612	CLIP-seq
MIRT1045925	hsa-miR-3714	CLIP-seq
MIRT1045962	hsa-miR-3926	CLIP-seq
MIRT1045927	hsa-miR-3929	CLIP-seq
MIRT2388981	hsa-miR-3942-3p	CLIP-seq
MIRT1045931	hsa-miR-4419b	CLIP-seq
MIRT1045933	hsa-miR-4443	CLIP-seq
MIRT1045934	hsa-miR-4478	CLIP-seq
MIRT1045940	hsa-miR-4680-3p	CLIP-seq
MIRT2388982	hsa-miR-518a-5p	CLIP-seq
MIRT2388983	hsa-miR-527	CLIP-seq
MIRT1045969	hsa-miR-548s	CLIP-seq
MIRT1045950	hsa-miR-650	CLIP-seq
MIRT2388984	hsa-miR-658	CLIP-seq
MIRT2242548	hsa-miR-759	CLIP-seq
MIRT1045956	hsa-miR-939	CLIP-seq
MIRT1045907	hsa-miR-3122	CLIP-seq
MIRT1045973	hsa-miR-3150a-5p	CLIP-seq
MIRT1045974	hsa-miR-3150b-5p	CLIP-seq
MIRT1045961	hsa-miR-3665	CLIP-seq
MIRT1045922	hsa-miR-3689a-3p	CLIP-seq
MIRT1045923	hsa-miR-3689c	CLIP-seq
MIRT1045925	hsa-miR-3714	CLIP-seq
MIRT1045926	hsa-miR-3913-5p	CLIP-seq
MIRT1045965	hsa-miR-4684-5p	CLIP-seq
MIRT1045941	hsa-miR-4728-5p	CLIP-seq
MIRT1045966	hsa-miR-4736	CLIP-seq
MIRT1045957	hsa-miR-940	CLIP-seq
MIRT1045907	hsa-miR-3122	CLIP-seq
MIRT1045961	hsa-miR-3665	CLIP-seq
MIRT1045922	hsa-miR-3689a-3p	CLIP-seq
MIRT1045923	hsa-miR-3689c	CLIP-seq
MIRT1045925	hsa-miR-3714	CLIP-seq
MIRT1045926	hsa-miR-3913-5p	CLIP-seq
MIRT1045941	hsa-miR-4728-5p	CLIP-seq
MIRT1045966	hsa-miR-4736	CLIP-seq
MIRT1045957	hsa-miR-940	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	31768607
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	31768607
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	11573933, 31768607
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001525	Process	Angiogenesis	IEA
GO:0001666	Process	Response to hypoxia	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	16126907
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	11573933
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0032364	Process	Intracellular oxygen homeostasis	IBA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0071456	Process	Cellular response to hypoxia	IDA	11573933

MIM	HGNC	e!Ensembl
609976	15825	ENSG00000124440

Q9Y2N7

Protein name

Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-contain

Protein function

Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhib

PDB

4WN5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00989	PAS	89 → 176	PAS fold	Domain
PF08447	PAS_3	251 → 338	PAS fold	Domain
PF11413	HIF-1	478 → 509	Hypoxia-inducible factor-1	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in vascular cells (at protein level) (PubMed:21069422). Expressed in kidney (PubMed:11573933, PubMed:19694616). Expressed in lung epithelial cells (PubMed:16775626). Expressed in endothelial cells (venous and arterial cells f

Sequence

MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLT
ISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLS
QLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLN
LKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA
FLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAV
TGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHS
RRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGP
ILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQ
DADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLL
PRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH
ENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQ
PRAGSAQAD

Sequence length

669

Interactions

View interactions

	Reactome
			Regulation of gene expression by Hypoxia-inducible Factor Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (46)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
ARTHROGRYPOSIS, DISTAL, TYPE 2B	Sheldon-Hall syndrome	BEFREE	25340332		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	25935004	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	34245041	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	31595977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Hypertrophic	Hypertrophic cardiomyopathy	Pubtator	26174816	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	33226577	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	29953500	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Periodontitis	Periodontitis	Pubtator	33604388	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	29953500		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	17998805		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	26861791		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	32296392	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	34680921	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Eclampsia	Eclampsia	BEFREE	31262346		★★★★★ ★☆☆☆☆ Found in Text Mining only
Erythrocytosis familial, 1	Erythrocytosis	BEFREE	31376207		★★★★★ ★☆☆☆☆ Found in Text Mining only
Familial erythrocytosis	Erythrocytosis	BEFREE	31376207		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hashimoto Disease	Hashimoto disease	Pubtator	37545519	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	20653473, 21389259, 25405996, 28686797, 34680921, 39456823	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	36277475	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ichthyosis, X-Linked	Ichthyosis	BEFREE	24927770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	31234835	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	27594926	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	21558328		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	21558328		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	31595977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	28928287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic syndrome	Pubtator	29084231	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myasthenia Gravis	Myasthenia Gravis	BEFREE	31809976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28485161		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	26717317, 27346320, 28754107		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26717317, 27346320, 28754107, 35534502	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	31595977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	28928287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29054108		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pediatric Obesity	Childhood obesity	BEFREE	26717317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	31852255	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
PNEUMOTHORAX, PRIMARY SPONTANEOUS	Pneumothorax	BEFREE	20653473		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	37545519	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycythemia	Polycythemia	Pubtator	27651169, 34680921	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26383847, 30866497	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	17998805		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	24927770	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe Combined Immunodeficiency	Severe combined immunodeficiency disease	LHGDN	17998805		★★★★★ ★☆☆☆☆ Found in Text Mining only
Steroid Sulfatase Deficiency Disease	Steroid Sulfatase Deficiency Disease	BEFREE	24927770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thymoma	Thymoma	BEFREE	31809976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	36277475	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HIF3A (hypoxia inducible factor 3 subunit alpha)