Gene Gene information from NCBI Gene database.
Entrez ID 64328
Gene name Exportin 4
Gene symbol XPO4
Synonyms (NCBI Gene)
exp4
Chromosome 13
Chromosome location 13q12.11
Summary XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
miRNA miRNA information provided by mirtarbase database.
609
miRTarBase ID miRNA Experiments Reference
MIRT027480 hsa-miR-98-5p Microarray 19088304
MIRT051210 hsa-miR-16-5p CLASH 23622248
MIRT041613 hsa-miR-146b-5p CLASH 23622248
MIRT040935 hsa-miR-18a-3p CLASH 23622248
MIRT037079 hsa-miR-877-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0005049 Function Nuclear export signal receptor activity IBA
GO:0005049 Function Nuclear export signal receptor activity IDA 10944119, 26787900
GO:0005049 Function Nuclear export signal receptor activity IEA
GO:0005515 Function Protein binding IPI 10944119, 15282309
GO:0005634 Component Nucleus IDA 10944119
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611449 17796 ENSG00000132953
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9C0E2
Protein name Exportin-4 (Exp4)
Protein function Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (PubMed:10944119, PubMed:16449645, PubMed:26787900). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-boun
Family and domains
Sequence
MMAAALGPPEVIAQLENAAKVLMAPPSMVNNEQRQHAEHIFLSFRKSKSPFAVCKHILET
SKVDYVLFQAATAIMEAVVREWILLEKGSIESLRTFLLTYVLQRPNLQKYVREQILLAVA
VIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSSSSKTSNIGLSM
EFHGNCKRVFQEEDLRQIFMLTVEVLQEFSRRENLNAQMSSVFQRYLALANQVLSWNFLP
PNLGRHYIAMFESSQNVLLKPTESWRETLLDSRVMELFFTVHRKIREDSDMAQDSLQCLA
QLASLHGPIFPDEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVL
TAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVQDDKHF
HKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDRDQFSDQLAS
VGMLGRIAAEHCIPLLTSLLEERVTRLHGQLQRHQQQLLASPGSSTVDNKMLDDLYEDIH
WLILVTGYLLADDTQGETPLIPPEIMEYSIKHSSEVDINTTLQILGSPGEKASSIPGYNR
TDSVIRLLSAILRVSEVESRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQI
SLPFSTAFGADTEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLV
IQCENWWNLAKQFASRSPPLNFLSSPVQRTLMKALVLGGFAHMDTETKQQYWTEVLQPLQ
QRFLRVINQENFQQMCQQEEVKQEITATLEALCGIAEATQIDNVAILFNFLMDFLTNCIG
LMEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMNLYEACLTLLQVYSKNNLGRQRID
VTAEEEQYQDLLLIMELLTNLLSKEFIDFSDTDEVFRGHEPGQAANRSVSAADVVLYGVN
LILPLMSQDLLKFPTLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMTSMSSE
VCQLCLEALTPLAEQCAKAQETDSPLFLATRHFLKLVFDMLVLQKHNTEMTTAAGEAFYT
LVCLHQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASSTPPTLDRKQKMAFLKSLEEF
MANVGGLLCVK
Sequence length 1151
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Nucleocytoplasmic transport  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CUTANEOUS MELANOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anterior segment mesenchymal dysgenesis Anterior segment mesenchymal dysgenesis Pubtator 37239394 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 24743702, 31371628 Associate
★☆☆☆☆
Found in Text Mining only
Complete atrioventricular block Complete Atrioventricular Block BEFREE 24597692
★☆☆☆☆
Found in Text Mining only
Fatty Liver Fatty liver Pubtator 26293807 Inhibit
★☆☆☆☆
Found in Text Mining only
Fatty Liver Alcoholic Fatty liver, alcoholic Pubtator 26293807 Associate
★☆☆☆☆
Found in Text Mining only
Fatty Liver Disease Fatty Liver BEFREE 26293807
★☆☆☆☆
Found in Text Mining only
Hearing Loss Sensorineural Hearing loss Pubtator 37239394 Associate
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 19012953, 21332550, 24597692, 24743702
★☆☆☆☆
Found in Text Mining only
Liver Cirrhosis Liver Cirrhosis BEFREE 24597692, 24743702
★☆☆☆☆
Found in Text Mining only
Liver Cirrhosis Liver cirrhosis Pubtator 24743702 Associate
★☆☆☆☆
Found in Text Mining only