FBRS (fibrosin)

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Gene SNPs miRNA Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64319
• Gene name: Fibrosin
• Gene symbol: FBRS
• Synonyms (NCBI Gene): FBS, FBS1
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1259852690	C>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1567547614	G>A	Likely-pathogenic	Coding sequence variant, missense variant

miRNA Show/Hide all (127)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041717	hsa-miR-484	CLASH	23622248
MIRT039273	hsa-miR-671-5p	CLASH	23622248
MIRT037203	hsa-miR-877-3p	CLASH	23622248
MIRT703642	hsa-miR-29a-3p	HITS-CLIP	23313552
MIRT703641	hsa-miR-29c-3p	HITS-CLIP	23313552
MIRT703640	hsa-miR-29b-3p	HITS-CLIP	23313552
MIRT703639	hsa-miR-3914	HITS-CLIP	23313552
MIRT703638	hsa-miR-3065-3p	HITS-CLIP	23313552
MIRT703637	hsa-miR-622	HITS-CLIP	23313552
MIRT703635	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT703636	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT703634	hsa-miR-6804-5p	HITS-CLIP	23313552
MIRT703642	hsa-miR-29a-3p	HITS-CLIP	23313552
MIRT703641	hsa-miR-29c-3p	HITS-CLIP	23313552
MIRT703640	hsa-miR-29b-3p	HITS-CLIP	23313552
MIRT703639	hsa-miR-3914	HITS-CLIP	23313552
MIRT703638	hsa-miR-3065-3p	HITS-CLIP	23313552
MIRT703637	hsa-miR-622	HITS-CLIP	23313552
MIRT703635	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT703636	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT703634	hsa-miR-6804-5p	HITS-CLIP	23313552
MIRT990164	hsa-miR-1303	CLIP-seq
MIRT990165	hsa-miR-1304	CLIP-seq
MIRT990166	hsa-miR-1915	CLIP-seq
MIRT990167	hsa-miR-2467-5p	CLIP-seq
MIRT990168	hsa-miR-29a	CLIP-seq
MIRT990169	hsa-miR-29b	CLIP-seq
MIRT990170	hsa-miR-29c	CLIP-seq
MIRT990171	hsa-miR-3148	CLIP-seq
MIRT990172	hsa-miR-3151	CLIP-seq
MIRT990173	hsa-miR-3165	CLIP-seq
MIRT990174	hsa-miR-3182	CLIP-seq
MIRT990175	hsa-miR-3185	CLIP-seq
MIRT990176	hsa-miR-3188	CLIP-seq
MIRT990177	hsa-miR-3607-5p	CLIP-seq
MIRT990178	hsa-miR-3929	CLIP-seq
MIRT990179	hsa-miR-3975	CLIP-seq
MIRT990180	hsa-miR-4251	CLIP-seq
MIRT990181	hsa-miR-4260	CLIP-seq
MIRT990182	hsa-miR-4265	CLIP-seq
MIRT990183	hsa-miR-4294	CLIP-seq
MIRT990184	hsa-miR-4296	CLIP-seq
MIRT990185	hsa-miR-4309	CLIP-seq
MIRT990186	hsa-miR-4322	CLIP-seq
MIRT990187	hsa-miR-4323	CLIP-seq
MIRT990188	hsa-miR-4329	CLIP-seq
MIRT990189	hsa-miR-4419b	CLIP-seq
MIRT990190	hsa-miR-4447	CLIP-seq
MIRT990191	hsa-miR-4472	CLIP-seq
MIRT990192	hsa-miR-4478	CLIP-seq
MIRT990193	hsa-miR-4652-3p	CLIP-seq
MIRT990194	hsa-miR-4663	CLIP-seq
MIRT990195	hsa-miR-4668-5p	CLIP-seq
MIRT990196	hsa-miR-4716-5p	CLIP-seq
MIRT990197	hsa-miR-4726-3p	CLIP-seq
MIRT990198	hsa-miR-4733-3p	CLIP-seq
MIRT990199	hsa-miR-4758-3p	CLIP-seq
MIRT990200	hsa-miR-485-5p	CLIP-seq
MIRT990201	hsa-miR-491-5p	CLIP-seq
MIRT990202	hsa-miR-581	CLIP-seq
MIRT990203	hsa-miR-877	CLIP-seq
MIRT1993418	hsa-miR-1254	CLIP-seq
MIRT1993419	hsa-miR-2355-5p	CLIP-seq
MIRT1993420	hsa-miR-296-3p	CLIP-seq
MIRT1993421	hsa-miR-296-5p	CLIP-seq
MIRT990168	hsa-miR-29a	CLIP-seq
MIRT990169	hsa-miR-29b	CLIP-seq
MIRT990170	hsa-miR-29c	CLIP-seq
MIRT1993422	hsa-miR-3116	CLIP-seq
MIRT1993423	hsa-miR-3122	CLIP-seq
MIRT990171	hsa-miR-3148	CLIP-seq
MIRT990173	hsa-miR-3165	CLIP-seq
MIRT990175	hsa-miR-3185	CLIP-seq
MIRT1993424	hsa-miR-3197	CLIP-seq
MIRT1993425	hsa-miR-3202	CLIP-seq
MIRT1993426	hsa-miR-3612	CLIP-seq
MIRT1993427	hsa-miR-370	CLIP-seq
MIRT1993428	hsa-miR-3913-5p	CLIP-seq
MIRT990179	hsa-miR-3975	CLIP-seq
MIRT990180	hsa-miR-4251	CLIP-seq
MIRT1993429	hsa-miR-4254	CLIP-seq
MIRT1993430	hsa-miR-4270	CLIP-seq
MIRT990183	hsa-miR-4294	CLIP-seq
MIRT990185	hsa-miR-4309	CLIP-seq
MIRT990187	hsa-miR-4323	CLIP-seq
MIRT990188	hsa-miR-4329	CLIP-seq
MIRT1993431	hsa-miR-4434	CLIP-seq
MIRT1993432	hsa-miR-4441	CLIP-seq
MIRT1993433	hsa-miR-4443	CLIP-seq
MIRT1993434	hsa-miR-4516	CLIP-seq
MIRT990195	hsa-miR-4668-5p	CLIP-seq
MIRT1993435	hsa-miR-4690-3p	CLIP-seq
MIRT990197	hsa-miR-4726-3p	CLIP-seq
MIRT990198	hsa-miR-4733-3p	CLIP-seq
MIRT1993436	hsa-miR-4747-5p	CLIP-seq
MIRT990199	hsa-miR-4758-3p	CLIP-seq
MIRT1993437	hsa-miR-566	CLIP-seq
MIRT1993438	hsa-miR-629	CLIP-seq
MIRT1993439	hsa-miR-650	CLIP-seq
MIRT1993440	hsa-miR-766	CLIP-seq
MIRT1993441	hsa-miR-887	CLIP-seq
MIRT1993442	hsa-miR-943	CLIP-seq
MIRT2227320	hsa-miR-1270	CLIP-seq
MIRT1993420	hsa-miR-296-3p	CLIP-seq
MIRT2227321	hsa-miR-3127-3p	CLIP-seq
MIRT990171	hsa-miR-3148	CLIP-seq
MIRT990175	hsa-miR-3185	CLIP-seq
MIRT990181	hsa-miR-4260	CLIP-seq
MIRT1993430	hsa-miR-4270	CLIP-seq
MIRT990187	hsa-miR-4323	CLIP-seq
MIRT1993431	hsa-miR-4434	CLIP-seq
MIRT1993432	hsa-miR-4441	CLIP-seq
MIRT1993434	hsa-miR-4516	CLIP-seq
MIRT2227322	hsa-miR-4531	CLIP-seq
MIRT990195	hsa-miR-4668-5p	CLIP-seq
MIRT990197	hsa-miR-4726-3p	CLIP-seq
MIRT990198	hsa-miR-4733-3p	CLIP-seq
MIRT2227323	hsa-miR-4749-3p	CLIP-seq
MIRT990199	hsa-miR-4758-3p	CLIP-seq
MIRT2227324	hsa-miR-486-3p	CLIP-seq
MIRT2227325	hsa-miR-620	CLIP-seq
MIRT2387901	hsa-miR-1225-3p	CLIP-seq
MIRT2387902	hsa-miR-1233	CLIP-seq
MIRT2387903	hsa-miR-361-3p	CLIP-seq
MIRT2387904	hsa-miR-3667-3p	CLIP-seq
MIRT2227323	hsa-miR-4749-3p	CLIP-seq
MIRT2387905	hsa-miR-502-5p	CLIP-seq

Other IDs

• MIM: 608601
• HGNC: 20442
• e!Ensembl: ENSG00000156860

Protein

• UniProt ID: Q9HAH7
• Protein name: Probable fibrosin-1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15336	Auts2	82 → 282	Autism susceptibility gene 2 protein	Family

• Sequence:

  MFEKYPGKMEGLFRHNPYTAFPPAVPGLPPGLPPAVSFGSLQGAFQPKSTNPELPPRLGP
  VPSGLSQKGTQIPDHFRPPLRKPGKWCAMHVRVAYMILRHQEKMKGDSHKLDFRNDLLPC
  LPGPYGALPPGQELSHPASLFTATGAVHAAANPFTAAPGAHGPFLSPSTHIDPFGRPTSF
  ASLAALSNGAFGGLGSPTFNSGAVFAQKESPGAPPAFASPPDPWGRLHRSPLTFPAWVRP
  PEAARTPGSDKERPVERREPSITKEEKDRDLPFSRPQLRVSPATPKARAGEEGPRPTKES
  VRVKEERKEEAAAAAAAAAAAAAAAAAAATGPQGLHLLFERPRPPPFLGPSPPDRCAGFL
  EPTWLAAPPRLARPPRFYEAGEELTGPGAVAAARLYGLEPAHPLLYSRLAPPPPPAAAPG
  TPHLLSKTPPGALLGAPPPLVPAPRPSSPPRGPGPARADR

• Sequence length: 460

Pathways

KEGG Pathway:

Polycomb repressive complex

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Short stature	Likely pathogenic	rs1567547614, rs1259852690	RCV000736120 RCV000736121	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Associations from Text Mining Show/Hide Text Mining Associations (36)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	30891164		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	31726193		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	18338817		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	31726193		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	25435410, 27268613		★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	21372829		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	21372829		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	30324578		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	28151034, 31486697		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29742131		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	29340105, 29365333, 29491638		★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	30572719		★☆☆☆☆ Found in Text Mining only
Fanconi-Bickel Syndrome	Fanconi-Bickel Syndrome	BEFREE	27527641, 28523479		★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	10493891		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28592121		★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	30809043	Associate	★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	31708005		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	29340105, 31708005		★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	26276873		★☆☆☆☆ Found in Text Mining only
Isolated somatotropin deficiency	Isolated Somatotropin Deficiency	BEFREE	23436191		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29491644, 31724462		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25435410, 27268613		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	21372829		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	17418805, 21557276		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29455394, 31724462, 31830181		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	30309709		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	1384657, 29048614, 30465280		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	21372829		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	21118808	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29200724, 31060423		★☆☆☆☆ Found in Text Mining only
Pituitary dwarfism	Pituitary dwarfism	BEFREE	23436191		★☆☆☆☆ Found in Text Mining only
Polycystic Kidney Autosomal Dominant	Polycystic kidney disease	Pubtator	38404150	Associate	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	26625974		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	17418805, 21557276		★☆☆☆☆ Found in Text Mining only
Scleroderma	Scleroderma	BEFREE	8957104		★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	8957104		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for FBRS.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FBRS.