Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64284
Gene name	RAB17, member RAS oncogene family
Gene symbol	RAB17
Synonyms (NCBI Gene)	-
Chromosome	2
Chromosome location	2q37.3
Summary	The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

209

Show/Hide all (209)

miRTarBase ID	miRNA	Experiments	Reference
MIRT639730	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639729	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT649513	hsa-miR-3183	HITS-CLIP	23824327
MIRT649512	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT649511	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT639728	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT639727	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT649510	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT639726	hsa-miR-4706	HITS-CLIP	23824327
MIRT639725	hsa-miR-4749-5p	HITS-CLIP	23824327
MIRT649509	hsa-miR-744-5p	HITS-CLIP	23824327
MIRT639724	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT639723	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT639722	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT649508	hsa-miR-198	HITS-CLIP	23824327
MIRT649507	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT649506	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT649505	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT639721	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT639730	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639729	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT639728	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT639727	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT639726	hsa-miR-4706	HITS-CLIP	23824327
MIRT639725	hsa-miR-4749-5p	HITS-CLIP	23824327
MIRT639724	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT639723	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT639722	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT639721	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT733893	hsa-miR-370-3p	Luciferase reporter assayqRT-PCRWestern blotting	33380810
MIRT733893	hsa-miR-370-3p	Flow cytometryLuciferase reporter assayqRT-PCRWestern blotting	33380810
MIRT639730	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639729	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT649513	hsa-miR-3183	HITS-CLIP	23824327
MIRT649512	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT649511	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT639728	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT639727	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT649510	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT639726	hsa-miR-4706	HITS-CLIP	23824327
MIRT639725	hsa-miR-4749-5p	HITS-CLIP	23824327
MIRT649509	hsa-miR-744-5p	HITS-CLIP	23824327
MIRT639724	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT639723	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT639722	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT649508	hsa-miR-198	HITS-CLIP	23824327
MIRT649507	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT649506	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT649505	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT639721	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT639730	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639729	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT639728	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT639727	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT639726	hsa-miR-4706	HITS-CLIP	23824327
MIRT639725	hsa-miR-4749-5p	HITS-CLIP	23824327
MIRT639724	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT639723	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT639722	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT639721	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT1282032	hsa-miR-1245b-3p	CLIP-seq
MIRT1282033	hsa-miR-1913	CLIP-seq
MIRT1282034	hsa-miR-217	CLIP-seq
MIRT1282035	hsa-miR-219-5p	CLIP-seq
MIRT1282036	hsa-miR-3148	CLIP-seq
MIRT1282037	hsa-miR-3176	CLIP-seq
MIRT1282038	hsa-miR-3184	CLIP-seq
MIRT1282039	hsa-miR-324-3p	CLIP-seq
MIRT1282040	hsa-miR-361-3p	CLIP-seq
MIRT1282041	hsa-miR-3922-3p	CLIP-seq
MIRT1282042	hsa-miR-3929	CLIP-seq
MIRT1282043	hsa-miR-423-5p	CLIP-seq
MIRT1282044	hsa-miR-4252	CLIP-seq
MIRT1282045	hsa-miR-4269	CLIP-seq
MIRT1282046	hsa-miR-4313	CLIP-seq
MIRT1282047	hsa-miR-4419b	CLIP-seq
MIRT1282048	hsa-miR-4443	CLIP-seq
MIRT1282049	hsa-miR-4450	CLIP-seq
MIRT1282050	hsa-miR-4471	CLIP-seq
MIRT1282051	hsa-miR-4478	CLIP-seq
MIRT1282052	hsa-miR-4755-3p	CLIP-seq
MIRT1282053	hsa-miR-4775	CLIP-seq
MIRT1282054	hsa-miR-4782-3p	CLIP-seq
MIRT1282055	hsa-miR-485-5p	CLIP-seq
MIRT1282056	hsa-miR-491-5p	CLIP-seq
MIRT1282057	hsa-miR-520a-5p	CLIP-seq
MIRT1282058	hsa-miR-525-5p	CLIP-seq
MIRT1282059	hsa-miR-548a-3p	CLIP-seq
MIRT1282060	hsa-miR-548ae	CLIP-seq
MIRT1282061	hsa-miR-548aj	CLIP-seq
MIRT1282062	hsa-miR-548am	CLIP-seq
MIRT1282063	hsa-miR-548e	CLIP-seq
MIRT1282064	hsa-miR-548f	CLIP-seq
MIRT1282065	hsa-miR-548x	CLIP-seq
MIRT1282066	hsa-miR-566	CLIP-seq
MIRT1282067	hsa-miR-590-3p	CLIP-seq
MIRT1282068	hsa-miR-765	CLIP-seq
MIRT2083412	hsa-miR-1202	CLIP-seq
MIRT2083413	hsa-miR-1224-3p	CLIP-seq
MIRT2083414	hsa-miR-124	CLIP-seq
MIRT1282032	hsa-miR-1245b-3p	CLIP-seq
MIRT2083415	hsa-miR-1260	CLIP-seq
MIRT2083416	hsa-miR-1260b	CLIP-seq
MIRT2083417	hsa-miR-1266	CLIP-seq
MIRT2083418	hsa-miR-1280	CLIP-seq
MIRT2083419	hsa-miR-1343	CLIP-seq
MIRT2083420	hsa-miR-1825	CLIP-seq
MIRT2083421	hsa-miR-1915	CLIP-seq
MIRT2083422	hsa-miR-197	CLIP-seq
MIRT2083423	hsa-miR-1972	CLIP-seq
MIRT1282034	hsa-miR-217	CLIP-seq
MIRT2083424	hsa-miR-296-5p	CLIP-seq
MIRT2083425	hsa-miR-3074-5p	CLIP-seq
MIRT2083426	hsa-miR-3124-3p	CLIP-seq
MIRT2083427	hsa-miR-3126-3p	CLIP-seq
MIRT1282036	hsa-miR-3148	CLIP-seq
MIRT2083428	hsa-miR-3155	CLIP-seq
MIRT2083429	hsa-miR-3155b	CLIP-seq
MIRT1282037	hsa-miR-3176	CLIP-seq
MIRT2083430	hsa-miR-3190	CLIP-seq
MIRT2083431	hsa-miR-3192	CLIP-seq
MIRT2083432	hsa-miR-3194-5p	CLIP-seq
MIRT2083433	hsa-miR-3202	CLIP-seq
MIRT2083434	hsa-miR-3607-5p	CLIP-seq
MIRT1282040	hsa-miR-361-3p	CLIP-seq
MIRT2083435	hsa-miR-3664-3p	CLIP-seq
MIRT2083436	hsa-miR-3665	CLIP-seq
MIRT2083437	hsa-miR-370	CLIP-seq
MIRT2083438	hsa-miR-3714	CLIP-seq
MIRT2083439	hsa-miR-371b-3p	CLIP-seq
MIRT2083440	hsa-miR-383	CLIP-seq
MIRT2083441	hsa-miR-3910	CLIP-seq
MIRT1282041	hsa-miR-3922-3p	CLIP-seq
MIRT2083442	hsa-miR-3937	CLIP-seq
MIRT2083443	hsa-miR-3972	CLIP-seq
MIRT2083444	hsa-miR-412	CLIP-seq
MIRT2083445	hsa-miR-4300	CLIP-seq
MIRT1282046	hsa-miR-4313	CLIP-seq
MIRT2083446	hsa-miR-4317	CLIP-seq
MIRT2083447	hsa-miR-4330	CLIP-seq
MIRT2083448	hsa-miR-4436b-3p	CLIP-seq
MIRT1282048	hsa-miR-4443	CLIP-seq
MIRT1282049	hsa-miR-4450	CLIP-seq
MIRT2083449	hsa-miR-4491	CLIP-seq
MIRT2083450	hsa-miR-4501	CLIP-seq
MIRT2083451	hsa-miR-4518	CLIP-seq
MIRT2083452	hsa-miR-4533	CLIP-seq
MIRT2083453	hsa-miR-4645-5p	CLIP-seq
MIRT2083454	hsa-miR-4657	CLIP-seq
MIRT2083455	hsa-miR-4673	CLIP-seq
MIRT2083456	hsa-miR-4688	CLIP-seq
MIRT2083457	hsa-miR-4726-3p	CLIP-seq
MIRT2083458	hsa-miR-4734	CLIP-seq
MIRT2083459	hsa-miR-4761-3p	CLIP-seq
MIRT1282053	hsa-miR-4775	CLIP-seq
MIRT2083460	hsa-miR-4786-5p	CLIP-seq
MIRT2083461	hsa-miR-484	CLIP-seq
MIRT1282056	hsa-miR-491-5p	CLIP-seq
MIRT2083462	hsa-miR-500a	CLIP-seq
MIRT2083463	hsa-miR-506	CLIP-seq
MIRT2083464	hsa-miR-512-5p	CLIP-seq
MIRT1282057	hsa-miR-520a-5p	CLIP-seq
MIRT1282058	hsa-miR-525-5p	CLIP-seq
MIRT2083465	hsa-miR-541	CLIP-seq
MIRT2083466	hsa-miR-542-5p	CLIP-seq
MIRT1282059	hsa-miR-548a-3p	CLIP-seq
MIRT1282060	hsa-miR-548ae	CLIP-seq
MIRT1282061	hsa-miR-548aj	CLIP-seq
MIRT1282062	hsa-miR-548am	CLIP-seq
MIRT1282063	hsa-miR-548e	CLIP-seq
MIRT1282064	hsa-miR-548f	CLIP-seq
MIRT1282065	hsa-miR-548x	CLIP-seq
MIRT2083467	hsa-miR-576-3p	CLIP-seq
MIRT1282067	hsa-miR-590-3p	CLIP-seq
MIRT2083468	hsa-miR-591	CLIP-seq
MIRT2083469	hsa-miR-654-5p	CLIP-seq
MIRT2083470	hsa-miR-744	CLIP-seq
MIRT1282068	hsa-miR-765	CLIP-seq
MIRT2083471	hsa-miR-767-3p	CLIP-seq
MIRT2083472	hsa-miR-891b	CLIP-seq
MIRT2083473	hsa-miR-920	CLIP-seq
MIRT2083474	hsa-miR-938	CLIP-seq
MIRT2083412	hsa-miR-1202	CLIP-seq
MIRT2083419	hsa-miR-1343	CLIP-seq
MIRT2083421	hsa-miR-1915	CLIP-seq
MIRT2083422	hsa-miR-197	CLIP-seq
MIRT2083424	hsa-miR-296-5p	CLIP-seq
MIRT2308701	hsa-miR-3128	CLIP-seq
MIRT2083431	hsa-miR-3192	CLIP-seq
MIRT2083432	hsa-miR-3194-5p	CLIP-seq
MIRT2308702	hsa-miR-34a	CLIP-seq
MIRT2308703	hsa-miR-34c-5p	CLIP-seq
MIRT2083434	hsa-miR-3607-5p	CLIP-seq
MIRT2083443	hsa-miR-3972	CLIP-seq
MIRT2083444	hsa-miR-412	CLIP-seq
MIRT1282045	hsa-miR-4269	CLIP-seq
MIRT2083445	hsa-miR-4300	CLIP-seq
MIRT2083446	hsa-miR-4317	CLIP-seq
MIRT2308704	hsa-miR-449a	CLIP-seq
MIRT2308705	hsa-miR-449b	CLIP-seq
MIRT2083450	hsa-miR-4501	CLIP-seq
MIRT2083456	hsa-miR-4688	CLIP-seq
MIRT2308706	hsa-miR-4720-5p	CLIP-seq
MIRT2083457	hsa-miR-4726-3p	CLIP-seq
MIRT2308707	hsa-miR-4799-3p	CLIP-seq
MIRT2083464	hsa-miR-512-5p	CLIP-seq
MIRT2083466	hsa-miR-542-5p	CLIP-seq
MIRT2083472	hsa-miR-891b	CLIP-seq
MIRT2083473	hsa-miR-920	CLIP-seq

Show/Hide all (60)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002415	Process	Immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IEA
GO:0002415	Process	Immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	ISS
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	17646400
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	17646400, 25416956, 32296183
GO:0005525	Function	GTP binding	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0012505	Component	Endomembrane system	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0019003	Function	GDP binding	IDA	20937701
GO:0030139	Component	Endocytic vesicle	IDA	17646400
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032401	Process	Establishment of melanosome localization	IEA
GO:0032401	Process	Establishment of melanosome localization	ISS
GO:0032402	Process	Melanosome transport	IEA
GO:0032402	Process	Melanosome transport	ISS
GO:0032456	Process	Endocytic recycling	IBA
GO:0032456	Process	Endocytic recycling	IEA
GO:0032456	Process	Endocytic recycling	ISS
GO:0032839	Component	Dendrite cytoplasm	IEA
GO:0042470	Component	Melanosome	IEA
GO:0042470	Component	Melanosome	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043025	Component	Neuronal cell body	ISS
GO:0045056	Process	Transcytosis	IEA
GO:0045056	Process	Transcytosis	ISS
GO:0046847	Process	Filopodium assembly	IEA
GO:0046847	Process	Filopodium assembly	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050773	Process	Regulation of dendrite development	IEA
GO:0050773	Process	Regulation of dendrite development	ISS
GO:0051489	Process	Regulation of filopodium assembly	IEA
GO:0051489	Process	Regulation of filopodium assembly	ISS
GO:0051963	Process	Regulation of synapse assembly	IEA
GO:0051963	Process	Regulation of synapse assembly	ISS
GO:0055037	Component	Recycling endosome	IEA
GO:0055037	Component	Recycling endosome	ISS
GO:0055038	Component	Recycling endosome membrane	IBA
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0055038	Component	Recycling endosome membrane	ISS
GO:0060271	Process	Cilium assembly	IMP	17646400
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0098794	Component	Postsynapse	IEA
GO:0098937	Process	Anterograde dendritic transport	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0120031	Process	Plasma membrane bounded cell projection assembly	IEA

MIM	HGNC	e!Ensembl
602206	16523	ENSG00000124839

Q9H0T7

Protein name

Ras-related protein Rab-17 (EC 3.6.5.2)

Protein function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	21 → 182	Ras family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in melanocytes (at protein level). {ECO:0000269|PubMed:21291502}.

Sequence

MAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVV
DVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEEL
HPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQEL
LQRSDEEGQALRGDAAVALNKGPARQAKCCAH

Sequence length

212

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis		RAB geranylgeranylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	25707355	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25707355, 26191189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26191189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22328529, 25707355, 26191189, 31841274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31841274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	24716914	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RAB17 (RAB17, member RAS oncogene family)