FAM110C (family with sequence similarity 110 member C)

Gene

• Entrez ID: 642273
• Gene name: Family with sequence similarity 110 member C
• Gene symbol: FAM110C
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016776	hsa-miR-335-5p	Microarray	18185580
MIRT026135	hsa-miR-192-5p	Microarray	19074876
MIRT537507	hsa-miR-1273d	PAR-CLIP	22012620
MIRT026135	hsa-miR-192-5p	PAR-CLIP	22012620
MIRT537506	hsa-miR-215-5p	PAR-CLIP	22012620
MIRT537507	hsa-miR-1273d	PAR-CLIP	22012620
MIRT026135	hsa-miR-192-5p	PAR-CLIP	22012620
MIRT537506	hsa-miR-215-5p	PAR-CLIP	22012620
MIRT977098	hsa-miR-122	CLIP-seq
MIRT977099	hsa-miR-1252	CLIP-seq
MIRT977100	hsa-miR-1264	CLIP-seq
MIRT977101	hsa-miR-128	CLIP-seq
MIRT977102	hsa-miR-1299	CLIP-seq
MIRT977103	hsa-miR-130a	CLIP-seq
MIRT977104	hsa-miR-130b	CLIP-seq
MIRT977105	hsa-miR-140-3p	CLIP-seq
MIRT977106	hsa-miR-155	CLIP-seq
MIRT977107	hsa-miR-199a-3p	CLIP-seq
MIRT977108	hsa-miR-199b-3p	CLIP-seq
MIRT977109	hsa-miR-2110	CLIP-seq
MIRT977110	hsa-miR-22	CLIP-seq
MIRT977111	hsa-miR-2278	CLIP-seq
MIRT977112	hsa-miR-23a	CLIP-seq
MIRT977113	hsa-miR-23b	CLIP-seq
MIRT977114	hsa-miR-23c	CLIP-seq
MIRT977115	hsa-miR-2681	CLIP-seq
MIRT977116	hsa-miR-301a	CLIP-seq
MIRT977117	hsa-miR-301b	CLIP-seq
MIRT977118	hsa-miR-302a	CLIP-seq
MIRT977119	hsa-miR-302b	CLIP-seq
MIRT977120	hsa-miR-302c	CLIP-seq
MIRT977121	hsa-miR-302d	CLIP-seq
MIRT977122	hsa-miR-302e	CLIP-seq
MIRT977123	hsa-miR-3120-3p	CLIP-seq
MIRT977124	hsa-miR-3122	CLIP-seq
MIRT977125	hsa-miR-3128	CLIP-seq
MIRT977126	hsa-miR-3129-3p	CLIP-seq
MIRT977127	hsa-miR-3129-5p	CLIP-seq
MIRT977128	hsa-miR-3135b	CLIP-seq
MIRT977129	hsa-miR-3150a-3p	CLIP-seq
MIRT977130	hsa-miR-3155	CLIP-seq
MIRT977131	hsa-miR-3155b	CLIP-seq
MIRT977132	hsa-miR-3170	CLIP-seq
MIRT977133	hsa-miR-3180-5p	CLIP-seq
MIRT977134	hsa-miR-3194-3p	CLIP-seq
MIRT977135	hsa-miR-3202	CLIP-seq
MIRT977136	hsa-miR-324-5p	CLIP-seq
MIRT977137	hsa-miR-3613-3p	CLIP-seq
MIRT977138	hsa-miR-3647-3p	CLIP-seq
MIRT977139	hsa-miR-3652	CLIP-seq
MIRT977140	hsa-miR-3666	CLIP-seq
MIRT977141	hsa-miR-3689d	CLIP-seq
MIRT977142	hsa-miR-372	CLIP-seq
MIRT977143	hsa-miR-373	CLIP-seq
MIRT977144	hsa-miR-3908	CLIP-seq
MIRT977145	hsa-miR-3913-5p	CLIP-seq
MIRT977146	hsa-miR-3940-5p	CLIP-seq
MIRT977147	hsa-miR-3942-5p	CLIP-seq
MIRT977148	hsa-miR-409-3p	CLIP-seq
MIRT977149	hsa-miR-4256	CLIP-seq
MIRT977150	hsa-miR-4267	CLIP-seq
MIRT977151	hsa-miR-4271	CLIP-seq
MIRT977152	hsa-miR-4290	CLIP-seq
MIRT977153	hsa-miR-4295	CLIP-seq
MIRT977154	hsa-miR-4307	CLIP-seq
MIRT977155	hsa-miR-4427	CLIP-seq
MIRT977156	hsa-miR-4430	CLIP-seq
MIRT977157	hsa-miR-4507	CLIP-seq
MIRT977158	hsa-miR-4533	CLIP-seq
MIRT977159	hsa-miR-4539	CLIP-seq
MIRT977160	hsa-miR-454	CLIP-seq
MIRT977161	hsa-miR-4668-5p	CLIP-seq
MIRT977162	hsa-miR-4671-3p	CLIP-seq
MIRT977163	hsa-miR-4680-3p	CLIP-seq
MIRT977164	hsa-miR-4703-5p	CLIP-seq
MIRT977165	hsa-miR-4720-5p	CLIP-seq
MIRT977166	hsa-miR-4725-3p	CLIP-seq
MIRT977167	hsa-miR-4738-3p	CLIP-seq
MIRT977168	hsa-miR-4747-5p	CLIP-seq
MIRT977169	hsa-miR-4766-3p	CLIP-seq
MIRT977170	hsa-miR-4769-3p	CLIP-seq
MIRT977171	hsa-miR-4778-3p	CLIP-seq
MIRT977172	hsa-miR-4790-3p	CLIP-seq
MIRT977173	hsa-miR-4793-5p	CLIP-seq
MIRT977174	hsa-miR-4799-3p	CLIP-seq
MIRT977175	hsa-miR-484	CLIP-seq
MIRT977176	hsa-miR-510	CLIP-seq
MIRT977177	hsa-miR-512-3p	CLIP-seq
MIRT977178	hsa-miR-519a	CLIP-seq
MIRT977179	hsa-miR-519b-3p	CLIP-seq
MIRT977180	hsa-miR-519c-3p	CLIP-seq
MIRT977181	hsa-miR-520a-3p	CLIP-seq
MIRT977182	hsa-miR-520b	CLIP-seq
MIRT977183	hsa-miR-520c-3p	CLIP-seq
MIRT977184	hsa-miR-520d-3p	CLIP-seq
MIRT977185	hsa-miR-520e	CLIP-seq
MIRT977186	hsa-miR-545	CLIP-seq
MIRT977187	hsa-miR-548p	CLIP-seq
MIRT977188	hsa-miR-598	CLIP-seq
MIRT977189	hsa-miR-615-5p	CLIP-seq
MIRT977190	hsa-miR-668	CLIP-seq
MIRT977191	hsa-miR-671-5p	CLIP-seq
MIRT977192	hsa-miR-875-3p	CLIP-seq
MIRT977193	hsa-miR-934	CLIP-seq
MIRT1989579	hsa-miR-1207-5p	CLIP-seq
MIRT977098	hsa-miR-122	CLIP-seq
MIRT1989580	hsa-miR-1225-5p	CLIP-seq
MIRT977100	hsa-miR-1264	CLIP-seq
MIRT977101	hsa-miR-128	CLIP-seq
MIRT977103	hsa-miR-130a	CLIP-seq
MIRT977104	hsa-miR-130b	CLIP-seq
MIRT1989581	hsa-miR-132	CLIP-seq
MIRT1989582	hsa-miR-1343	CLIP-seq
MIRT977105	hsa-miR-140-3p	CLIP-seq
MIRT1989583	hsa-miR-145	CLIP-seq
MIRT1989584	hsa-miR-150	CLIP-seq
MIRT977107	hsa-miR-199a-3p	CLIP-seq
MIRT977108	hsa-miR-199b-3p	CLIP-seq
MIRT1989585	hsa-miR-205	CLIP-seq
MIRT1989586	hsa-miR-212	CLIP-seq
MIRT1989587	hsa-miR-224	CLIP-seq
MIRT1989588	hsa-miR-25	CLIP-seq
MIRT977115	hsa-miR-2681	CLIP-seq
MIRT1989589	hsa-miR-300	CLIP-seq
MIRT977116	hsa-miR-301a	CLIP-seq
MIRT977117	hsa-miR-301b	CLIP-seq
MIRT977124	hsa-miR-3122	CLIP-seq
MIRT977125	hsa-miR-3128	CLIP-seq
MIRT977127	hsa-miR-3129-5p	CLIP-seq
MIRT977128	hsa-miR-3135b	CLIP-seq
MIRT977130	hsa-miR-3155	CLIP-seq
MIRT977131	hsa-miR-3155b	CLIP-seq
MIRT977134	hsa-miR-3194-3p	CLIP-seq
MIRT1989590	hsa-miR-32	CLIP-seq
MIRT1989591	hsa-miR-330-3p	CLIP-seq
MIRT1989592	hsa-miR-338-5p	CLIP-seq
MIRT1989593	hsa-miR-363	CLIP-seq
MIRT977139	hsa-miR-3652	CLIP-seq
MIRT977140	hsa-miR-3666	CLIP-seq
MIRT1989594	hsa-miR-367	CLIP-seq
MIRT1989595	hsa-miR-371-5p	CLIP-seq
MIRT1989596	hsa-miR-371b-5p	CLIP-seq
MIRT1989597	hsa-miR-381	CLIP-seq
MIRT1989598	hsa-miR-3910	CLIP-seq
MIRT977145	hsa-miR-3913-5p	CLIP-seq
MIRT1989599	hsa-miR-3920	CLIP-seq
MIRT1989600	hsa-miR-3925-3p	CLIP-seq
MIRT1989601	hsa-miR-3973	CLIP-seq
MIRT977153	hsa-miR-4295	CLIP-seq
MIRT1989602	hsa-miR-4310	CLIP-seq
MIRT1989603	hsa-miR-4325	CLIP-seq
MIRT1989604	hsa-miR-4422	CLIP-seq
MIRT1989605	hsa-miR-4423-3p	CLIP-seq
MIRT977156	hsa-miR-4430	CLIP-seq
MIRT1989606	hsa-miR-4434	CLIP-seq
MIRT1989607	hsa-miR-4436b-3p	CLIP-seq
MIRT1989608	hsa-miR-4484	CLIP-seq
MIRT1989609	hsa-miR-450b-3p	CLIP-seq
MIRT1989610	hsa-miR-451	CLIP-seq
MIRT1989611	hsa-miR-4516	CLIP-seq
MIRT1989612	hsa-miR-4531	CLIP-seq
MIRT977159	hsa-miR-4539	CLIP-seq
MIRT977160	hsa-miR-454	CLIP-seq
MIRT1989613	hsa-miR-4642	CLIP-seq
MIRT1989614	hsa-miR-4666-3p	CLIP-seq
MIRT977165	hsa-miR-4720-5p	CLIP-seq
MIRT1989615	hsa-miR-4724-5p	CLIP-seq
MIRT1989616	hsa-miR-4760-3p	CLIP-seq
MIRT1989617	hsa-miR-4763-3p	CLIP-seq
MIRT1989618	hsa-miR-4772-5p	CLIP-seq
MIRT977174	hsa-miR-4799-3p	CLIP-seq
MIRT977175	hsa-miR-484	CLIP-seq
MIRT1989619	hsa-miR-500a	CLIP-seq
MIRT1989620	hsa-miR-508-5p	CLIP-seq
MIRT1989621	hsa-miR-5096	CLIP-seq
MIRT977176	hsa-miR-510	CLIP-seq
MIRT1989622	hsa-miR-512-5p	CLIP-seq
MIRT1989623	hsa-miR-513c	CLIP-seq
MIRT1989624	hsa-miR-514b-5p	CLIP-seq
MIRT1989625	hsa-miR-520g	CLIP-seq
MIRT1989626	hsa-miR-520h	CLIP-seq
MIRT977186	hsa-miR-545	CLIP-seq
MIRT1989627	hsa-miR-548an	CLIP-seq
MIRT1989628	hsa-miR-622	CLIP-seq
MIRT977190	hsa-miR-668	CLIP-seq
MIRT1989629	hsa-miR-7	CLIP-seq
MIRT1989630	hsa-miR-769-3p	CLIP-seq
MIRT1989631	hsa-miR-92a	CLIP-seq
MIRT1989632	hsa-miR-92b	CLIP-seq
MIRT2223912	hsa-miR-103a	CLIP-seq
MIRT2223913	hsa-miR-106a	CLIP-seq
MIRT2223914	hsa-miR-106b	CLIP-seq
MIRT2223915	hsa-miR-107	CLIP-seq
MIRT2223916	hsa-miR-1182	CLIP-seq
MIRT977098	hsa-miR-122	CLIP-seq
MIRT2223917	hsa-miR-1301	CLIP-seq
MIRT2223918	hsa-miR-1303	CLIP-seq
MIRT1989582	hsa-miR-1343	CLIP-seq
MIRT2223919	hsa-miR-15a	CLIP-seq
MIRT2223920	hsa-miR-15b	CLIP-seq
MIRT2223921	hsa-miR-16	CLIP-seq
MIRT2223922	hsa-miR-17	CLIP-seq
MIRT2223923	hsa-miR-193a-5p	CLIP-seq
MIRT2223924	hsa-miR-195	CLIP-seq
MIRT2223925	hsa-miR-20a	CLIP-seq
MIRT2223926	hsa-miR-20b	CLIP-seq
MIRT977109	hsa-miR-2110	CLIP-seq
MIRT977111	hsa-miR-2278	CLIP-seq
MIRT977115	hsa-miR-2681	CLIP-seq
MIRT977118	hsa-miR-302a	CLIP-seq
MIRT977119	hsa-miR-302b	CLIP-seq
MIRT977120	hsa-miR-302c	CLIP-seq
MIRT977121	hsa-miR-302d	CLIP-seq
MIRT977122	hsa-miR-302e	CLIP-seq
MIRT977123	hsa-miR-3120-3p	CLIP-seq
MIRT977128	hsa-miR-3135b	CLIP-seq
MIRT977129	hsa-miR-3150a-3p	CLIP-seq
MIRT977130	hsa-miR-3155	CLIP-seq
MIRT977131	hsa-miR-3155b	CLIP-seq
MIRT2223927	hsa-miR-3160-5p	CLIP-seq
MIRT977134	hsa-miR-3194-3p	CLIP-seq
MIRT2223928	hsa-miR-3200-3p	CLIP-seq
MIRT2223929	hsa-miR-345	CLIP-seq
MIRT2223930	hsa-miR-3646	CLIP-seq
MIRT977138	hsa-miR-3647-3p	CLIP-seq
MIRT977139	hsa-miR-3652	CLIP-seq
MIRT977142	hsa-miR-372	CLIP-seq
MIRT977143	hsa-miR-373	CLIP-seq
MIRT2223931	hsa-miR-424	CLIP-seq
MIRT977149	hsa-miR-4256	CLIP-seq
MIRT977151	hsa-miR-4271	CLIP-seq
MIRT2223932	hsa-miR-431	CLIP-seq
MIRT1989602	hsa-miR-4310	CLIP-seq
MIRT2223933	hsa-miR-4420	CLIP-seq
MIRT977156	hsa-miR-4430	CLIP-seq
MIRT2223934	hsa-miR-4490	CLIP-seq
MIRT2223935	hsa-miR-4524	CLIP-seq
MIRT977161	hsa-miR-4668-5p	CLIP-seq
MIRT2223936	hsa-miR-4698	CLIP-seq
MIRT2223937	hsa-miR-4704-5p	CLIP-seq
MIRT977166	hsa-miR-4725-3p	CLIP-seq
MIRT2223938	hsa-miR-4762-3p	CLIP-seq
MIRT2223939	hsa-miR-4772-3p	CLIP-seq
MIRT977171	hsa-miR-4778-3p	CLIP-seq
MIRT977175	hsa-miR-484	CLIP-seq
MIRT2223940	hsa-miR-497	CLIP-seq
MIRT2223941	hsa-miR-503	CLIP-seq
MIRT2223942	hsa-miR-5047	CLIP-seq
MIRT977176	hsa-miR-510	CLIP-seq
MIRT2223943	hsa-miR-519d	CLIP-seq
MIRT977181	hsa-miR-520a-3p	CLIP-seq
MIRT977182	hsa-miR-520b	CLIP-seq
MIRT977183	hsa-miR-520c-3p	CLIP-seq
MIRT977184	hsa-miR-520d-3p	CLIP-seq
MIRT977185	hsa-miR-520e	CLIP-seq
MIRT2223944	hsa-miR-520f	CLIP-seq
MIRT977186	hsa-miR-545	CLIP-seq
MIRT2223945	hsa-miR-548k	CLIP-seq
MIRT2223946	hsa-miR-548n	CLIP-seq
MIRT977187	hsa-miR-548p	CLIP-seq
MIRT2223947	hsa-miR-548t	CLIP-seq
MIRT2223948	hsa-miR-646	CLIP-seq
MIRT977190	hsa-miR-668	CLIP-seq
MIRT2223949	hsa-miR-93	CLIP-seq
MIRT1989579	hsa-miR-1207-5p	CLIP-seq
MIRT977098	hsa-miR-122	CLIP-seq
MIRT977128	hsa-miR-3135b	CLIP-seq
MIRT977130	hsa-miR-3155	CLIP-seq
MIRT977131	hsa-miR-3155b	CLIP-seq
MIRT977139	hsa-miR-3652	CLIP-seq
MIRT977156	hsa-miR-4430	CLIP-seq
MIRT1989607	hsa-miR-4436b-3p	CLIP-seq
MIRT2387679	hsa-miR-4722-3p	CLIP-seq
MIRT1989617	hsa-miR-4763-3p	CLIP-seq
MIRT977175	hsa-miR-484	CLIP-seq
MIRT977176	hsa-miR-510	CLIP-seq
MIRT977190	hsa-miR-668	CLIP-seq
MIRT977098	hsa-miR-122	CLIP-seq
MIRT977115	hsa-miR-2681	CLIP-seq
MIRT977128	hsa-miR-3135b	CLIP-seq
MIRT977130	hsa-miR-3155	CLIP-seq
MIRT977131	hsa-miR-3155b	CLIP-seq
MIRT977139	hsa-miR-3652	CLIP-seq
MIRT2223933	hsa-miR-4420	CLIP-seq
MIRT977156	hsa-miR-4430	CLIP-seq
MIRT2223939	hsa-miR-4772-3p	CLIP-seq
MIRT977175	hsa-miR-484	CLIP-seq
MIRT977176	hsa-miR-510	CLIP-seq
MIRT977190	hsa-miR-668	CLIP-seq
MIRT977098	hsa-miR-122	CLIP-seq
MIRT977128	hsa-miR-3135b	CLIP-seq
MIRT977130	hsa-miR-3155	CLIP-seq
MIRT977131	hsa-miR-3155b	CLIP-seq
MIRT977139	hsa-miR-3652	CLIP-seq
MIRT977156	hsa-miR-4430	CLIP-seq
MIRT977175	hsa-miR-484	CLIP-seq
MIRT977176	hsa-miR-510	CLIP-seq
MIRT977190	hsa-miR-668	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	19698782, 21988832, 23455922, 32707033, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005938	Component	Cell cortex	IBA
GO:0005938	Component	Cell cortex	IDA	19698782
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030335	Process	Positive regulation of cell migration	IMP	19698782
GO:0043014	Function	Alpha-tubulin binding	IBA
GO:0043014	Function	Alpha-tubulin binding	IDA	19698782
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	19698782
GO:0060491	Process	Regulation of cell projection assembly	IBA
GO:0060491	Process	Regulation of cell projection assembly	IMP	19698782

Other IDs

• MIM: 611395
• HGNC: 33340
• e!Ensembl: ENSG00000184731

Protein

• UniProt ID: Q1W6H9
• Protein name: Protein FAM110C
• Protein function: May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14161	FAM110_N	2 → 105	Centrosome-associated N terminus	Family
  PF14160	FAM110_C	194 → 303	Centrosome-associated C terminus	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in stomach, thyroid, trachea, adrenal gland and testis, and at low levels in prostate, ovary, intestine, colon, spinal cord and lymph node. {ECO:0000269|PubMed:17499476}.
• Sequence:

  MRALAALSAPPNERLLPRDPAATRDPDAARPARRSAVERLAADRAKYVRGRPGTGRGVAS
  EGSGPGAIKCPGNDPGPPARAPAPVARRAIARKPLRPDSLIIYRQKCEFVRGSGADGPRA
  SLVKKLFQGPGKDKAPVPRTGDEGKAGNPETVPTTPGPAADPAIPETPAPAARSAAPSSV
  PAAPPGPEPRVVRRRGLQRSQSDLSSRYSAALAESDTFFQYCGLDPEVVEALGRENFTAG
  SDCVTLKVRSVSVATSGSGFSRHSGGDDEGLQEEELIEQVPSTTSVIERNARIIKWLYTC
  KKAKETPSQEQSRTRGSKPSR

• Sequence length: 321

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Aplasia/Hypoplasia of the phalanges of the 4th toe	Pathogenic	rs2464926753, rs1430363516	RCV002292653 RCV002292654	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Streaky metaphyseal sclerosis	Pathogenic	rs2464926753, rs1430363516	RCV002292653 RCV002292654	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34414947	Associate	★☆☆☆☆ Found in Text Mining only
Hepatitis B Chronic	Hepatitis b	Pubtator	34414947	Associate	★☆☆☆☆ Found in Text Mining only