Gene Gene information from NCBI Gene database.
Entrez ID 6422
Gene name Secreted frizzled related protein 1
Gene symbol SFRP1
Synonyms (NCBI Gene)
FRPFRP-1FRP1FrzASARP2
Chromosome 8
Chromosome location 8p11.21
Summary This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes lead
miRNA miRNA information provided by mirtarbase database.
449
miRTarBase ID miRNA Experiments Reference
MIRT017159 hsa-miR-335-5p Microarray 18185580
MIRT052899 hsa-miR-1260b Luciferase reporter assayqRT-PCRWestern blot 23591200
MIRT052899 hsa-miR-1260b Luciferase reporter assayqRT-PCRWestern blot 23591200
MIRT438354 hsa-miR-206 FlowqRT-PCR 24855559
MIRT438280 hsa-miR-127-3p Luciferase reporter assayqRT-PCRWestern blot 24517116
Transcription factors Transcription factors information provided by TRRUST V2 database.
6
Transcription factor Regulation Reference
DNMT1 Unknown 23770846;24374650
DNMT3A Unknown 24374650
EZH2 Unknown 21515604
GLI1 Activation 19930158
HDAC1 Unknown 23770846
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
131
GO ID Ontology Definition Evidence Reference
GO:0001649 Process Osteoblast differentiation IEP 16149051
GO:0001657 Process Ureteric bud development IEA
GO:0001756 Process Somitogenesis IEA
GO:0001843 Process Neural tube closure IEA
GO:0001954 Process Positive regulation of cell-matrix adhesion ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604156 10776 ENSG00000104332
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N474
Protein name Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)
Protein function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-cat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01392 Fz 58 165 Fz domain Domain
PF01759 NTR 200 296 UNC-6/NTR/C345C module Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle c
Sequence
Sequence length 314
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Wnt signaling pathway  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BILIARY TRACT DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 22031861
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 16407829
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 16991125
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 15825175, 21567192
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 23802127, 24643460
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 16523202, 17131472, 17762966, 25432628, 26482433, 28058013, 30578081
★☆☆☆☆
Found in Text Mining only
Adenoma of large intestine Colorectal adenoma BEFREE 26482433
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 20486992, 20628379, 20856206, 28708837
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 20208569, 21107850
★☆☆☆☆
Found in Text Mining only
Aphasia Aphasia Pubtator 27251476 Associate
★☆☆☆☆
Found in Text Mining only