EDDM3B (epididymal protein 3B)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 64184
Gene name Epididymal protein 3B
Gene symbol EDDM3B
Synonyms (NCBI Gene)
EP3BFAM12BHE3-BETAHE3BRAM2
Chromosome 14
Chromosome location 14q11.2
Summary Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive c
miRNA miRNA information provided by mirtarbase database.
5
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (5)
miRTarBase ID miRNA Experiments Reference
MIRT016833 hsa-miR-335-5p Microarray 18185580
MIRT952307 hsa-miR-4742-5p CLIP-seq
MIRT952308 hsa-miR-584 CLIP-seq
MIRT952307 hsa-miR-4742-5p CLIP-seq
MIRT952308 hsa-miR-584 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
2
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (2)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
611582 19223 ENSG00000181552
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P56851
Protein name Epididymal secretory protein E3-beta (Human epididymis-specific protein 3-beta) (HE3-beta)
Protein function Possible function in sperm maturation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00074 RnaseA 28 → 143 Pancreatic ribonuclease Domain
Tissue specificity TISSUE SPECIFICITY: Epididymis.
Sequence
Sequence length 147
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TREATMENT-RESISTANT HYPERTENSION — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (2)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthma Asthma Pubtator 30367910 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cyclocephaly Cyclocephaly BEFREE 28789611
★★★★★
★☆☆☆☆
Found in Text Mining only