Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64111
Gene name	Neuropeptide VF precursor
Gene symbol	NPVF
Synonyms (NCBI Gene)	C7orf9RFRP
Chromosome	7
Chromosome location	7p15.3

Show/Hide all (57)

miRTarBase ID	miRNA	Experiments	Reference
MIRT715230	hsa-miR-4779	HITS-CLIP	19536157
MIRT715229	hsa-miR-3174	HITS-CLIP	19536157
MIRT715228	hsa-miR-885-5p	HITS-CLIP	19536157
MIRT715227	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT715226	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT715225	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT715224	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT715223	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT715222	hsa-miR-3150b-3p	HITS-CLIP	19536157
MIRT715221	hsa-miR-4784	HITS-CLIP	19536157
MIRT715220	hsa-miR-3909	HITS-CLIP	19536157
MIRT715219	hsa-miR-6852-3p	HITS-CLIP	19536157
MIRT715218	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT715217	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT715216	hsa-miR-921	HITS-CLIP	19536157
MIRT715215	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT715214	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT715213	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT715212	hsa-miR-4689	HITS-CLIP	19536157
MIRT715211	hsa-miR-6858-5p	HITS-CLIP	19536157
MIRT715210	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT715209	hsa-miR-4326	HITS-CLIP	19536157
MIRT715230	hsa-miR-4779	HITS-CLIP	19536157
MIRT715229	hsa-miR-3174	HITS-CLIP	19536157
MIRT715228	hsa-miR-885-5p	HITS-CLIP	19536157
MIRT715227	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT715226	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT715225	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT715224	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT715223	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT715222	hsa-miR-3150b-3p	HITS-CLIP	19536157
MIRT715221	hsa-miR-4784	HITS-CLIP	19536157
MIRT715220	hsa-miR-3909	HITS-CLIP	19536157
MIRT715219	hsa-miR-6852-3p	HITS-CLIP	19536157
MIRT715218	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT715217	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT715216	hsa-miR-921	HITS-CLIP	19536157
MIRT715215	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT715214	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT715213	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT715212	hsa-miR-4689	HITS-CLIP	19536157
MIRT715211	hsa-miR-6858-5p	HITS-CLIP	19536157
MIRT715210	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT715209	hsa-miR-4326	HITS-CLIP	19536157
MIRT1191683	hsa-miR-593	CLIP-seq
MIRT2055564	hsa-miR-3140-3p	CLIP-seq
MIRT2055565	hsa-miR-450b-5p	CLIP-seq
MIRT2055566	hsa-miR-4672	CLIP-seq
MIRT2055567	hsa-miR-4775	CLIP-seq
MIRT2055568	hsa-miR-590-3p	CLIP-seq
MIRT2284502	hsa-miR-3941	CLIP-seq
MIRT2284503	hsa-miR-466	CLIP-seq
MIRT2055566	hsa-miR-4672	CLIP-seq
MIRT2439064	hsa-miR-409-3p	CLIP-seq
MIRT2439065	hsa-miR-4307	CLIP-seq
MIRT2055567	hsa-miR-4775	CLIP-seq
MIRT2439066	hsa-miR-587	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IDA	11025660
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IDA	11024015
GO:0007218	Process	Neuropeptide signaling pathway	IDA	11025660, 18752651
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007218	Process	Neuropeptide signaling pathway	NAS	11025660
GO:0032277	Process	Negative regulation of gonadotropin secretion	IBA
GO:0032277	Process	Negative regulation of gonadotropin secretion	IDA	20027225
GO:0160041	Function	Neuropeptide activity	IDA	18752651
GO:0160041	Function	Neuropeptide activity	IDA	11025660, 18752651

MIM	HGNC	e!Ensembl
616984	13782	ENSG00000105954

Q9HCQ7

Protein name

Pro-FMRFamide-related neuropeptide VF [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVF (Neuropeptide RFRP-3)]

Protein function

[Neuropeptide RFRP-1]: Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion (PubMed:11025660, PubMed:20027225). Induces secretion of prolactin (By similarity). {EC

Family and domains

Tissue specificity

TISSUE SPECIFICITY: [Isoform 1]: Specifically expressed in the retina. {ECO:0000269|PubMed:11951088}.; TISSUE SPECIFICITY: [Neuropeptide RFRP-1]: Detected in the hypothalamus. {ECO:0000269|PubMed:20027225}.; TISSUE SPECIFICITY: [Neuropeptide NPVF]: Detect

Sequence

MEIISSKLFILLTLATSSLLTSNIFCADELVISNLHSKENYDKYSEPRGYPKGERSLNFE
ELKDWGPKNVIKMSTPAVNKMPHSFANLPLRFGRNVQEERSAGATANLPLRSGRNMEVSL
VRRVPNLPQRFGRTTTAKSVCRMLSDLCQGSMHSPCANDLFYSMTCQHQEIQNPDQKQSR
RLLFKKIDDAELKQEK

Sequence length

196

Interactions

View interactions

	KEGG
	Neuroactive ligand-receptor interaction

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Choroid Plexus Papilloma	Choroid Plexus Papilloma	BEFREE	25180599	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	30081043	★★★★★ ★☆☆☆☆ Found in Text Mining only
Macular Edema, Cystoid	Cystoid macular edema	BEFREE	11951088	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30075164	★★★★★ ★☆☆☆☆ Found in Text Mining only

NPVF (neuropeptide VF precursor)