Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64106
Gene name	Neuropeptide FF receptor 1
Gene symbol	NPFFR1
Synonyms (NCBI Gene)	GPR147NPFF1NPFF1R1OT7T022
Chromosome	10
Chromosome location	10q22.1

Show/Hide all (78)

miRTarBase ID	miRNA	Experiments	Reference
MIRT490444	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT490443	hsa-miR-885-3p	PAR-CLIP	20371350
MIRT490444	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT490443	hsa-miR-885-3p	PAR-CLIP	20371350
MIRT522248	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT522236	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT522247	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT522246	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT522245	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT522244	hsa-miR-4794	PAR-CLIP	23446348
MIRT522243	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT522242	hsa-miR-1273f	PAR-CLIP	23446348
MIRT522241	hsa-miR-1254	PAR-CLIP	23446348
MIRT522240	hsa-miR-3116	PAR-CLIP	23446348
MIRT522239	hsa-miR-661	PAR-CLIP	23446348
MIRT522238	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT522237	hsa-miR-4775	PAR-CLIP	23446348
MIRT522236	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT522235	hsa-miR-2113	PAR-CLIP	23446348
MIRT522234	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT522233	hsa-miR-4438	PAR-CLIP	23446348
MIRT522232	hsa-miR-3943	PAR-CLIP	23446348
MIRT522231	hsa-miR-532-5p	PAR-CLIP	23446348
MIRT522230	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT522229	hsa-miR-3176	PAR-CLIP	23446348
MIRT522227	hsa-miR-3922-3p	PAR-CLIP	23446348
MIRT522228	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT522226	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT522225	hsa-miR-5095	PAR-CLIP	23446348
MIRT522224	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT522223	hsa-miR-4633-5p	PAR-CLIP	23446348
MIRT522222	hsa-miR-3976	PAR-CLIP	23446348
MIRT522221	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT522220	hsa-miR-633	PAR-CLIP	23446348
MIRT522219	hsa-miR-3170	PAR-CLIP	23446348
MIRT522218	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT522217	hsa-miR-5096	PAR-CLIP	23446348
MIRT490444	hsa-miR-4781-5p	PAR-CLIP	23592263
MIRT490443	hsa-miR-885-3p	PAR-CLIP	23592263
MIRT490444	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT490443	hsa-miR-885-3p	PAR-CLIP	20371350
MIRT490444	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT490443	hsa-miR-885-3p	PAR-CLIP	20371350
MIRT522248	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT522236	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT522247	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT522246	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT522245	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT522244	hsa-miR-4794	PAR-CLIP	23446348
MIRT522243	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT522242	hsa-miR-1273f	PAR-CLIP	23446348
MIRT522241	hsa-miR-1254	PAR-CLIP	23446348
MIRT522240	hsa-miR-3116	PAR-CLIP	23446348
MIRT522239	hsa-miR-661	PAR-CLIP	23446348
MIRT522238	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT522237	hsa-miR-4775	PAR-CLIP	23446348
MIRT522236	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT522235	hsa-miR-2113	PAR-CLIP	23446348
MIRT522234	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT522233	hsa-miR-4438	PAR-CLIP	23446348
MIRT522232	hsa-miR-3943	PAR-CLIP	23446348
MIRT522231	hsa-miR-532-5p	PAR-CLIP	23446348
MIRT522230	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT522229	hsa-miR-3176	PAR-CLIP	23446348
MIRT522227	hsa-miR-3922-3p	PAR-CLIP	23446348
MIRT522228	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT522226	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT522225	hsa-miR-5095	PAR-CLIP	23446348
MIRT522224	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT522223	hsa-miR-4633-5p	PAR-CLIP	23446348
MIRT522222	hsa-miR-3976	PAR-CLIP	23446348
MIRT522221	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT522220	hsa-miR-633	PAR-CLIP	23446348
MIRT522219	hsa-miR-3170	PAR-CLIP	23446348
MIRT522218	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT522217	hsa-miR-5096	PAR-CLIP	23446348
MIRT490444	hsa-miR-4781-5p	PAR-CLIP	23592263
MIRT490443	hsa-miR-885-3p	PAR-CLIP	23592263

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	NAS	11024015
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11024015
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IDA	28154160
GO:0005929	Component	Cilium	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IDA	11024015
GO:0007218	Process	Neuropeptide signaling pathway	IDA	11024015
GO:0007218	Process	Neuropeptide signaling pathway	ISS
GO:0008188	Function	Neuropeptide receptor activity	IDA	11024015, 11025660
GO:0008188	Function	Neuropeptide receptor activity	IEA
GO:0008188	Function	Neuropeptide receptor activity	ISS
GO:0008188	Function	Neuropeptide receptor activity	NAS	11024015
GO:0016020	Component	Membrane	IEA
GO:0032870	Process	Cellular response to hormone stimulus	IBA

MIM	HGNC	e!Ensembl
607448	17425	ENSG00000148734

Q9GZQ6

Protein name

Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022)

Protein function

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	60 → 329	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVG
NTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSG
LVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTL
TVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIA
RKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSA
PQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAY
SERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSH
LPLTIPAWDI

Sequence length

430

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

NPFFR1 (neuropeptide FF receptor 1)