Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64105
Gene name	Centromere protein K
Gene symbol	CENPK
Synonyms (NCBI Gene)	AF5alphaCENP-KFKSG14P33Solt
Chromosome	5
Chromosome location	5q12.3
Summary	CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[sup

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024346	hsa-miR-215-5p	Microarray	19074876
MIRT026538	hsa-miR-192-5p	Microarray	19074876
MIRT690237	hsa-miR-3662	HITS-CLIP	23313552
MIRT526198	hsa-miR-3646	HITS-CLIP	23313552
MIRT690236	hsa-miR-95-5p	HITS-CLIP	23313552
MIRT690235	hsa-miR-5589-3p	HITS-CLIP	23313552
MIRT690234	hsa-miR-885-3p	HITS-CLIP	23313552
MIRT690233	hsa-miR-106a-3p	HITS-CLIP	23313552
MIRT371526	hsa-miR-450b-5p	HITS-CLIP	23313552
MIRT690232	hsa-miR-507	HITS-CLIP	23313552
MIRT690231	hsa-miR-557	HITS-CLIP	23313552
MIRT690230	hsa-miR-3680-3p	HITS-CLIP	23313552
MIRT526198	hsa-miR-3646	PAR-CLIP	22012620
MIRT526199	hsa-miR-1252-3p	PAR-CLIP	22012620
MIRT371527	hsa-miR-4528	PAR-CLIP	22012620
MIRT526197	hsa-miR-6734-3p	PAR-CLIP	22012620
MIRT526196	hsa-miR-6759-3p	PAR-CLIP	22012620
MIRT526195	hsa-miR-374a-5p	PAR-CLIP	22012620
MIRT526194	hsa-miR-374b-5p	PAR-CLIP	22012620
MIRT690237	hsa-miR-3662	HITS-CLIP	23313552
MIRT526198	hsa-miR-3646	HITS-CLIP	23313552
MIRT690236	hsa-miR-95-5p	HITS-CLIP	23313552
MIRT690235	hsa-miR-5589-3p	HITS-CLIP	23313552
MIRT690234	hsa-miR-885-3p	HITS-CLIP	23313552
MIRT690233	hsa-miR-106a-3p	HITS-CLIP	23313552
MIRT371526	hsa-miR-450b-5p	HITS-CLIP	23313552
MIRT690232	hsa-miR-507	HITS-CLIP	23313552
MIRT690231	hsa-miR-557	HITS-CLIP	23313552
MIRT690230	hsa-miR-3680-3p	HITS-CLIP	23313552
MIRT526198	hsa-miR-3646	PAR-CLIP	22012620
MIRT526199	hsa-miR-1252-3p	PAR-CLIP	22012620
MIRT371527	hsa-miR-4528	PAR-CLIP	22012620
MIRT526197	hsa-miR-6734-3p	PAR-CLIP	22012620
MIRT526196	hsa-miR-6759-3p	PAR-CLIP	22012620
MIRT526195	hsa-miR-374a-5p	PAR-CLIP	22012620
MIRT526194	hsa-miR-374b-5p	PAR-CLIP	22012620
MIRT884955	hsa-let-7a	CLIP-seq
MIRT884956	hsa-let-7b	CLIP-seq
MIRT884957	hsa-let-7c	CLIP-seq
MIRT884958	hsa-let-7d	CLIP-seq
MIRT884959	hsa-let-7e	CLIP-seq
MIRT884960	hsa-let-7f	CLIP-seq
MIRT884961	hsa-let-7g	CLIP-seq
MIRT884962	hsa-let-7i	CLIP-seq
MIRT884963	hsa-miR-1273g	CLIP-seq
MIRT884964	hsa-miR-186	CLIP-seq
MIRT884965	hsa-miR-1914	CLIP-seq
MIRT884966	hsa-miR-202	CLIP-seq
MIRT884967	hsa-miR-25	CLIP-seq
MIRT884968	hsa-miR-3065-5p	CLIP-seq
MIRT884969	hsa-miR-3161	CLIP-seq
MIRT884970	hsa-miR-32	CLIP-seq
MIRT884971	hsa-miR-323-3p	CLIP-seq
MIRT884972	hsa-miR-323b-3p	CLIP-seq
MIRT884973	hsa-miR-362-5p	CLIP-seq
MIRT884974	hsa-miR-363	CLIP-seq
MIRT884975	hsa-miR-367	CLIP-seq
MIRT884976	hsa-miR-4307	CLIP-seq
MIRT884977	hsa-miR-4458	CLIP-seq
MIRT884978	hsa-miR-4500	CLIP-seq
MIRT884979	hsa-miR-4540	CLIP-seq
MIRT884980	hsa-miR-487a	CLIP-seq
MIRT884981	hsa-miR-500b	CLIP-seq
MIRT884982	hsa-miR-501-5p	CLIP-seq
MIRT884983	hsa-miR-548ag	CLIP-seq
MIRT884984	hsa-miR-548ai	CLIP-seq
MIRT884985	hsa-miR-92a	CLIP-seq
MIRT884986	hsa-miR-92b	CLIP-seq
MIRT884987	hsa-miR-98	CLIP-seq
MIRT884964	hsa-miR-186	CLIP-seq
MIRT2198851	hsa-miR-3680	CLIP-seq
MIRT2198852	hsa-miR-4420	CLIP-seq
MIRT2198853	hsa-miR-4422	CLIP-seq
MIRT2198854	hsa-miR-4427	CLIP-seq
MIRT2501645	hsa-miR-3607-3p	CLIP-seq
MIRT2501646	hsa-miR-3686	CLIP-seq
MIRT2501647	hsa-miR-374a	CLIP-seq
MIRT2501648	hsa-miR-374b	CLIP-seq
MIRT2501649	hsa-miR-4330	CLIP-seq
MIRT2501650	hsa-miR-4715-3p	CLIP-seq
MIRT2501651	hsa-miR-4777-3p	CLIP-seq
MIRT2501652	hsa-miR-548aa	CLIP-seq
MIRT2501653	hsa-miR-556-3p	CLIP-seq
MIRT2501654	hsa-miR-590-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000070	Process	Mitotic sister chromatid segregation	IBA
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IEA
GO:0000939	Component	Inner kinetochore	IPI	36085283
GO:0005515	Function	Protein binding	IPI	24981860, 25416956, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	36085283
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007059	Process	Chromosome segregation	NAS	36085283
GO:0051382	Process	Kinetochore assembly	IEA

MIM	HGNC	e!Ensembl
611502	29479	ENSG00000123219

Q9BS16

Protein name

Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33)

Protein function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesiz

PDB

7PB4 , 7PKN , 7QOO , 7R5S , 7R5V , 7XHN , 7XHO , 7YWX , 7YYH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11802	CENP-K	10 → 269	Centromere-associated protein K	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta. {ECO:0000269|PubMed:8950979}.

Sequence

MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLL
IMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKE
DLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTL
GEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWP
PYVELLLRNGIALRHPEDPTRIRLEAFHQ

Sequence length

269

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS, CASTRATION-RESISTANT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyloidosis	Amyloidosis	BEFREE	31234498		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	15365563		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	15365563		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	37370088	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36312839	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	10463820		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diverticular Diseases	Diverticular Diseases	GWASCAT_DG	30177863		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibroadenoma	Fibroadenoma	BEFREE	15365563		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29088763, 30774374		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	15365563		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	33046735	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12835293, 2555151, 29088763, 30774374, 31027511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oligodendroglioma	Oligodendroglioma	Pubtator	26468983	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Cancer, Castration-Resistant	Prostatic Cancer, Castration-Resistant	CTD_human_DG	29581250		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms, Castration-Resistant	Prostatic Neoplasms, Castration-Resistant	CTD_human_DG	29581250		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Retinal Diseases	Retinal Diseases	BEFREE	18997086		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis Pigmentosa	BEFREE	31648555		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	34719665	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	23254957		★★★★★ ★☆☆☆☆ Found in Text Mining only

CENPK (centromere protein K)