Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64087
Gene name	Methylcrotonyl-CoA carboxylase subunit 2
Gene symbol	MCCC2
Synonyms (NCBI Gene)	MCCBMCCCbeta
Chromosome	5
Chromosome location	5q13.2
Summary	This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrot

Show/Hide all (37)

SNP ID	Visualize variation	Clinical significance	Consequence
rs35068278	C>G	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Non coding transcript variant, coding sequence variant, genic downstream transcript variant, missense variant
rs119103219	G>A,C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant
rs119103220	G>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs119103221	C>G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs119103223	G>C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant
rs119103225	A>G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs119103226	G>T	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs140806722	T>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant
rs141030969	C>T	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs147903984	C>G,T	Pathogenic	Coding sequence variant, stop gained, missense variant, non coding transcript variant
rs148773718	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant, genic downstream transcript variant
rs150591260	G>A,C	Conflicting-interpretations-of-pathogenicity, pathogenic-likely-pathogenic	Non coding transcript variant, genic downstream transcript variant, coding sequence variant, missense variant, intron variant
rs398124372	C>G	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs587776533	->T	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs727504010	C>T	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs730880265	G>A	Pathogenic	Splice donor variant, genic downstream transcript variant
rs748028684	C>A,T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs757052602	A>T	Pathogenic-likely-pathogenic, pathogenic	Missense variant, non coding transcript variant, coding sequence variant, intron variant, genic downstream transcript variant
rs763293192	C>T	Pathogenic	Coding sequence variant, stop gained, 3 prime UTR variant, non coding transcript variant, genic downstream transcript variant
rs766753795	A>G	Pathogenic	Intron variant, coding sequence variant, missense variant, non coding transcript variant
rs770769655	->C	Pathogenic	Intron variant, coding sequence variant, frameshift variant, non coding transcript variant
rs770917710	A>G	Likely-pathogenic	Intron variant
rs773774134	C>T	Pathogenic, conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant
rs776559643	A>G	Conflicting-interpretations-of-pathogenicity	Intron variant
rs780011606	C>T	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs780304038	CA>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant, genic downstream transcript variant
rs797044772	CAGA>TTGTCGAGGTAAGTGT	Likely-pathogenic	Coding sequence variant, inframe indel, non coding transcript variant
rs886043524	G>A	Likely-pathogenic	Coding sequence variant, intron variant, non coding transcript variant, missense variant
rs886060738	A>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, genic downstream transcript variant, non coding transcript variant, synonymous variant
rs1184301452	C>T	Pathogenic	Stop gained, coding sequence variant, non coding transcript variant
rs1190325113	C>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant
rs1554134061	TG>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs1554137532	->T	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs1554138265	T>C	Likely-pathogenic	Splice donor variant, genic downstream transcript variant
rs1580273474	G>T	Likely-pathogenic	Splice donor variant
rs1580280976	->A	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1580319814	GA>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant

640

Show/Hide all (640)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016273	hsa-miR-193b-3p	Proteomics	21512034
MIRT039205	hsa-miR-769-5p	CLASH	23622248
MIRT646936	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT646935	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT646934	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT646933	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT646932	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT646931	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT646930	hsa-miR-612	HITS-CLIP	23824327
MIRT646929	hsa-miR-6860	HITS-CLIP	23824327
MIRT646928	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT039205	hsa-miR-769-5p	HITS-CLIP	23824327
MIRT646927	hsa-miR-661	HITS-CLIP	23824327
MIRT646925	hsa-miR-3606-5p	HITS-CLIP	23824327
MIRT646926	hsa-miR-3672	HITS-CLIP	23824327
MIRT646924	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT646933	hsa-miR-1285-3p	PAR-CLIP	27292025
MIRT646932	hsa-miR-3187-5p	PAR-CLIP	27292025
MIRT646926	hsa-miR-3672	PAR-CLIP	27292025
MIRT646936	hsa-miR-4714-3p	PAR-CLIP	27292025
MIRT646928	hsa-miR-4786-5p	PAR-CLIP	27292025
MIRT646931	hsa-miR-5189-5p	PAR-CLIP	27292025
MIRT646930	hsa-miR-612	PAR-CLIP	27292025
MIRT646927	hsa-miR-661	PAR-CLIP	27292025
MIRT646935	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT646929	hsa-miR-6860	PAR-CLIP	27292025
MIRT646924	hsa-miR-6864-3p	PAR-CLIP	27292025
MIRT039205	hsa-miR-769-5p	PAR-CLIP	27292025
MIRT646934	hsa-miR-939-3p	PAR-CLIP	27292025
MIRT646936	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT646935	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT646934	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT646933	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT646932	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT646931	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT646930	hsa-miR-612	HITS-CLIP	23824327
MIRT646929	hsa-miR-6860	HITS-CLIP	23824327
MIRT646928	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT039205	hsa-miR-769-5p	HITS-CLIP	23824327
MIRT646927	hsa-miR-661	HITS-CLIP	23824327
MIRT646925	hsa-miR-3606-5p	HITS-CLIP	23824327
MIRT646926	hsa-miR-3672	HITS-CLIP	23824327
MIRT646924	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT1136561	hsa-miR-1183	CLIP-seq
MIRT1136562	hsa-miR-1207-3p	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136564	hsa-miR-1246	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT1136566	hsa-miR-1252	CLIP-seq
MIRT1136567	hsa-miR-1265	CLIP-seq
MIRT1136568	hsa-miR-1270	CLIP-seq
MIRT1136569	hsa-miR-1272	CLIP-seq
MIRT1136570	hsa-miR-1276	CLIP-seq
MIRT1136571	hsa-miR-128	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136573	hsa-miR-1290	CLIP-seq
MIRT1136574	hsa-miR-1294	CLIP-seq
MIRT1136575	hsa-miR-1298	CLIP-seq
MIRT1136576	hsa-miR-1299	CLIP-seq
MIRT1136577	hsa-miR-1321	CLIP-seq
MIRT1136578	hsa-miR-143	CLIP-seq
MIRT1136579	hsa-miR-146a	CLIP-seq
MIRT1136580	hsa-miR-146b-5p	CLIP-seq
MIRT1136581	hsa-miR-151-3p	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT1136586	hsa-miR-1827	CLIP-seq
MIRT1136587	hsa-miR-194	CLIP-seq
MIRT1136588	hsa-miR-2053	CLIP-seq
MIRT1136589	hsa-miR-2114	CLIP-seq
MIRT1136590	hsa-miR-24	CLIP-seq
MIRT1136591	hsa-miR-2682	CLIP-seq
MIRT1136592	hsa-miR-2964a-5p	CLIP-seq
MIRT1136593	hsa-miR-299-3p	CLIP-seq
MIRT1136594	hsa-miR-302a	CLIP-seq
MIRT1136595	hsa-miR-302b	CLIP-seq
MIRT1136596	hsa-miR-302c	CLIP-seq
MIRT1136597	hsa-miR-302d	CLIP-seq
MIRT1136598	hsa-miR-302e	CLIP-seq
MIRT1136599	hsa-miR-30a	CLIP-seq
MIRT1136600	hsa-miR-30b	CLIP-seq
MIRT1136601	hsa-miR-30c	CLIP-seq
MIRT1136602	hsa-miR-30d	CLIP-seq
MIRT1136603	hsa-miR-30e	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT1136605	hsa-miR-3135b	CLIP-seq
MIRT1136606	hsa-miR-3150a-3p	CLIP-seq
MIRT1136607	hsa-miR-3152-3p	CLIP-seq
MIRT1136608	hsa-miR-3154	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT1136610	hsa-miR-3167	CLIP-seq
MIRT1136611	hsa-miR-3173-3p	CLIP-seq
MIRT1136612	hsa-miR-3175	CLIP-seq
MIRT1136613	hsa-miR-3185	CLIP-seq
MIRT1136614	hsa-miR-323-5p	CLIP-seq
MIRT1136615	hsa-miR-335	CLIP-seq
MIRT1136616	hsa-miR-338-3p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT1136618	hsa-miR-342-3p	CLIP-seq
MIRT1136619	hsa-miR-3529	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT1136621	hsa-miR-3612	CLIP-seq
MIRT1136622	hsa-miR-3613-3p	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136624	hsa-miR-3647-3p	CLIP-seq
MIRT1136625	hsa-miR-3653	CLIP-seq
MIRT1136626	hsa-miR-3654	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT1136628	hsa-miR-3658	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136630	hsa-miR-3663-3p	CLIP-seq
MIRT1136631	hsa-miR-3684	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT1136635	hsa-miR-3714	CLIP-seq
MIRT1136636	hsa-miR-372	CLIP-seq
MIRT1136637	hsa-miR-373	CLIP-seq
MIRT1136638	hsa-miR-378	CLIP-seq
MIRT1136639	hsa-miR-378b	CLIP-seq
MIRT1136640	hsa-miR-378c	CLIP-seq
MIRT1136641	hsa-miR-378d	CLIP-seq
MIRT1136642	hsa-miR-378e	CLIP-seq
MIRT1136643	hsa-miR-378f	CLIP-seq
MIRT1136644	hsa-miR-378h	CLIP-seq
MIRT1136645	hsa-miR-378i	CLIP-seq
MIRT1136646	hsa-miR-379	CLIP-seq
MIRT1136647	hsa-miR-3913-3p	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136649	hsa-miR-3919	CLIP-seq
MIRT1136650	hsa-miR-3922-5p	CLIP-seq
MIRT1136651	hsa-miR-3927	CLIP-seq
MIRT1136652	hsa-miR-3929	CLIP-seq
MIRT1136653	hsa-miR-3935	CLIP-seq
MIRT1136654	hsa-miR-3937	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT1136656	hsa-miR-422a	CLIP-seq
MIRT1136657	hsa-miR-425	CLIP-seq
MIRT1136658	hsa-miR-4251	CLIP-seq
MIRT1136659	hsa-miR-4255	CLIP-seq
MIRT1136660	hsa-miR-4257	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT1136662	hsa-miR-4263	CLIP-seq
MIRT1136663	hsa-miR-4265	CLIP-seq
MIRT1136664	hsa-miR-4270	CLIP-seq
MIRT1136665	hsa-miR-4272	CLIP-seq
MIRT1136666	hsa-miR-4275	CLIP-seq
MIRT1136667	hsa-miR-4282	CLIP-seq
MIRT1136668	hsa-miR-4284	CLIP-seq
MIRT1136669	hsa-miR-4296	CLIP-seq
MIRT1136670	hsa-miR-4302	CLIP-seq
MIRT1136671	hsa-miR-4311	CLIP-seq
MIRT1136672	hsa-miR-4316	CLIP-seq
MIRT1136673	hsa-miR-4322	CLIP-seq
MIRT1136674	hsa-miR-4326	CLIP-seq
MIRT1136675	hsa-miR-4419b	CLIP-seq
MIRT1136676	hsa-miR-4420	CLIP-seq
MIRT1136677	hsa-miR-4428	CLIP-seq
MIRT1136678	hsa-miR-4432	CLIP-seq
MIRT1136679	hsa-miR-4435	CLIP-seq
MIRT1136680	hsa-miR-4437	CLIP-seq
MIRT1136681	hsa-miR-4441	CLIP-seq
MIRT1136682	hsa-miR-4443	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT1136684	hsa-miR-4463	CLIP-seq
MIRT1136685	hsa-miR-4477b	CLIP-seq
MIRT1136686	hsa-miR-4478	CLIP-seq
MIRT1136687	hsa-miR-4491	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT1136689	hsa-miR-4499	CLIP-seq
MIRT1136690	hsa-miR-449c	CLIP-seq
MIRT1136691	hsa-miR-4511	CLIP-seq
MIRT1136692	hsa-miR-4519	CLIP-seq
MIRT1136693	hsa-miR-4521	CLIP-seq
MIRT1136694	hsa-miR-4530	CLIP-seq
MIRT1136695	hsa-miR-4649-3p	CLIP-seq
MIRT1136696	hsa-miR-4650-3p	CLIP-seq
MIRT1136697	hsa-miR-4653-3p	CLIP-seq
MIRT1136698	hsa-miR-4657	CLIP-seq
MIRT1136699	hsa-miR-4661-3p	CLIP-seq
MIRT1136700	hsa-miR-4666-5p	CLIP-seq
MIRT1136701	hsa-miR-4674	CLIP-seq
MIRT1136702	hsa-miR-4683	CLIP-seq
MIRT1136703	hsa-miR-4684-5p	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136705	hsa-miR-4691-5p	CLIP-seq
MIRT1136706	hsa-miR-4693-5p	CLIP-seq
MIRT1136707	hsa-miR-4705	CLIP-seq
MIRT1136708	hsa-miR-4709-3p	CLIP-seq
MIRT1136709	hsa-miR-4712-5p	CLIP-seq
MIRT1136710	hsa-miR-4716-3p	CLIP-seq
MIRT1136711	hsa-miR-4720-3p	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT1136713	hsa-miR-4723-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136715	hsa-miR-4735-5p	CLIP-seq
MIRT1136716	hsa-miR-4736	CLIP-seq
MIRT1136717	hsa-miR-4739	CLIP-seq
MIRT1136718	hsa-miR-4740-5p	CLIP-seq
MIRT1136719	hsa-miR-4753-5p	CLIP-seq
MIRT1136720	hsa-miR-4756-5p	CLIP-seq
MIRT1136721	hsa-miR-4764-5p	CLIP-seq
MIRT1136722	hsa-miR-4768-5p	CLIP-seq
MIRT1136723	hsa-miR-4770	CLIP-seq
MIRT1136724	hsa-miR-4773	CLIP-seq
MIRT1136725	hsa-miR-4775	CLIP-seq
MIRT1136726	hsa-miR-4782-5p	CLIP-seq
MIRT1136727	hsa-miR-4787-5p	CLIP-seq
MIRT1136728	hsa-miR-4790-3p	CLIP-seq
MIRT1136729	hsa-miR-4795-5p	CLIP-seq
MIRT1136730	hsa-miR-4804-3p	CLIP-seq
MIRT1136731	hsa-miR-485-3p	CLIP-seq
MIRT1136732	hsa-miR-485-5p	CLIP-seq
MIRT1136733	hsa-miR-499-5p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT1136736	hsa-miR-513a-3p	CLIP-seq
MIRT1136737	hsa-miR-516b	CLIP-seq
MIRT1136738	hsa-miR-520a-3p	CLIP-seq
MIRT1136739	hsa-miR-520b	CLIP-seq
MIRT1136740	hsa-miR-520c-3p	CLIP-seq
MIRT1136741	hsa-miR-520d-3p	CLIP-seq
MIRT1136742	hsa-miR-520e	CLIP-seq
MIRT1136743	hsa-miR-520f	CLIP-seq
MIRT1136744	hsa-miR-539	CLIP-seq
MIRT1136745	hsa-miR-545	CLIP-seq
MIRT1136746	hsa-miR-548a-3p	CLIP-seq
MIRT1136747	hsa-miR-548ag	CLIP-seq
MIRT1136748	hsa-miR-548ai	CLIP-seq
MIRT1136749	hsa-miR-548b-3p	CLIP-seq
MIRT1136750	hsa-miR-548c-3p	CLIP-seq
MIRT1136751	hsa-miR-548e	CLIP-seq
MIRT1136752	hsa-miR-548f	CLIP-seq
MIRT1136753	hsa-miR-548g	CLIP-seq
MIRT1136754	hsa-miR-548k	CLIP-seq
MIRT1136755	hsa-miR-548n	CLIP-seq
MIRT1136756	hsa-miR-548p	CLIP-seq
MIRT1136757	hsa-miR-569	CLIP-seq
MIRT1136758	hsa-miR-576-3p	CLIP-seq
MIRT1136759	hsa-miR-583	CLIP-seq
MIRT1136760	hsa-miR-589	CLIP-seq
MIRT1136761	hsa-miR-590-3p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136763	hsa-miR-604	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT1136765	hsa-miR-607	CLIP-seq
MIRT1136766	hsa-miR-620	CLIP-seq
MIRT1136767	hsa-miR-625	CLIP-seq
MIRT1136768	hsa-miR-634	CLIP-seq
MIRT1136769	hsa-miR-647	CLIP-seq
MIRT1136770	hsa-miR-650	CLIP-seq
MIRT1136771	hsa-miR-653	CLIP-seq
MIRT1136772	hsa-miR-663b	CLIP-seq
MIRT1136773	hsa-miR-664	CLIP-seq
MIRT1136774	hsa-miR-770-5p	CLIP-seq
MIRT1136775	hsa-miR-876-3p	CLIP-seq
MIRT1136776	hsa-miR-876-5p	CLIP-seq
MIRT1136777	hsa-miR-939	CLIP-seq
MIRT1136778	hsa-miR-940	CLIP-seq
MIRT1136779	hsa-miR-95	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136564	hsa-miR-1246	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT2038883	hsa-miR-1256	CLIP-seq
MIRT1136567	hsa-miR-1265	CLIP-seq
MIRT2038884	hsa-miR-1271	CLIP-seq
MIRT1136569	hsa-miR-1272	CLIP-seq
MIRT2038885	hsa-miR-1283	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136573	hsa-miR-1290	CLIP-seq
MIRT1136574	hsa-miR-1294	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT1136586	hsa-miR-1827	CLIP-seq
MIRT1136589	hsa-miR-2114	CLIP-seq
MIRT1136593	hsa-miR-299-3p	CLIP-seq
MIRT2038886	hsa-miR-3117-3p	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT2038887	hsa-miR-3127-5p	CLIP-seq
MIRT1136608	hsa-miR-3154	CLIP-seq
MIRT2038888	hsa-miR-3156-5p	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT1136610	hsa-miR-3167	CLIP-seq
MIRT2038889	hsa-miR-3169	CLIP-seq
MIRT1136613	hsa-miR-3185	CLIP-seq
MIRT2038890	hsa-miR-3190	CLIP-seq
MIRT1136614	hsa-miR-323-5p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT2038891	hsa-miR-3616-3p	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136624	hsa-miR-3647-3p	CLIP-seq
MIRT1136628	hsa-miR-3658	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136630	hsa-miR-3663-3p	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT1136647	hsa-miR-3913-3p	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136651	hsa-miR-3927	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT2038892	hsa-miR-411	CLIP-seq
MIRT2038893	hsa-miR-4252	CLIP-seq
MIRT1136660	hsa-miR-4257	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT1136664	hsa-miR-4270	CLIP-seq
MIRT1136666	hsa-miR-4275	CLIP-seq
MIRT1136670	hsa-miR-4302	CLIP-seq
MIRT1136672	hsa-miR-4316	CLIP-seq
MIRT1136674	hsa-miR-4326	CLIP-seq
MIRT1136679	hsa-miR-4435	CLIP-seq
MIRT1136681	hsa-miR-4441	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT1136687	hsa-miR-4491	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT1136692	hsa-miR-4519	CLIP-seq
MIRT2038894	hsa-miR-4633-5p	CLIP-seq
MIRT1136696	hsa-miR-4650-3p	CLIP-seq
MIRT1136698	hsa-miR-4657	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136705	hsa-miR-4691-5p	CLIP-seq
MIRT1136707	hsa-miR-4705	CLIP-seq
MIRT1136708	hsa-miR-4709-3p	CLIP-seq
MIRT2038895	hsa-miR-4721	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136715	hsa-miR-4735-5p	CLIP-seq
MIRT2038896	hsa-miR-4759	CLIP-seq
MIRT1136721	hsa-miR-4764-5p	CLIP-seq
MIRT1136724	hsa-miR-4773	CLIP-seq
MIRT1136725	hsa-miR-4775	CLIP-seq
MIRT1136728	hsa-miR-4790-3p	CLIP-seq
MIRT1136731	hsa-miR-485-3p	CLIP-seq
MIRT2038897	hsa-miR-491-3p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT2038898	hsa-miR-532-5p	CLIP-seq
MIRT1136745	hsa-miR-545	CLIP-seq
MIRT1136746	hsa-miR-548a-3p	CLIP-seq
MIRT1136751	hsa-miR-548e	CLIP-seq
MIRT1136752	hsa-miR-548f	CLIP-seq
MIRT1136753	hsa-miR-548g	CLIP-seq
MIRT1136754	hsa-miR-548k	CLIP-seq
MIRT1136755	hsa-miR-548n	CLIP-seq
MIRT1136756	hsa-miR-548p	CLIP-seq
MIRT1136761	hsa-miR-590-3p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136763	hsa-miR-604	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT1136768	hsa-miR-634	CLIP-seq
MIRT1136769	hsa-miR-647	CLIP-seq
MIRT1136771	hsa-miR-653	CLIP-seq
MIRT1136772	hsa-miR-663b	CLIP-seq
MIRT2038899	hsa-miR-671-5p	CLIP-seq
MIRT2038900	hsa-miR-802	CLIP-seq
MIRT1136775	hsa-miR-876-3p	CLIP-seq
MIRT1136776	hsa-miR-876-5p	CLIP-seq
MIRT2038901	hsa-miR-96	CLIP-seq
MIRT1136561	hsa-miR-1183	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136564	hsa-miR-1246	CLIP-seq
MIRT1136568	hsa-miR-1270	CLIP-seq
MIRT1136569	hsa-miR-1272	CLIP-seq
MIRT1136571	hsa-miR-128	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136573	hsa-miR-1290	CLIP-seq
MIRT1136575	hsa-miR-1298	CLIP-seq
MIRT1136577	hsa-miR-1321	CLIP-seq
MIRT1136578	hsa-miR-143	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT1136586	hsa-miR-1827	CLIP-seq
MIRT1136587	hsa-miR-194	CLIP-seq
MIRT2268861	hsa-miR-203	CLIP-seq
MIRT1136588	hsa-miR-2053	CLIP-seq
MIRT1136589	hsa-miR-2114	CLIP-seq
MIRT1136590	hsa-miR-24	CLIP-seq
MIRT1136593	hsa-miR-299-3p	CLIP-seq
MIRT1136599	hsa-miR-30a	CLIP-seq
MIRT1136600	hsa-miR-30b	CLIP-seq
MIRT1136601	hsa-miR-30c	CLIP-seq
MIRT1136602	hsa-miR-30d	CLIP-seq
MIRT1136603	hsa-miR-30e	CLIP-seq
MIRT2038886	hsa-miR-3117-3p	CLIP-seq
MIRT2038887	hsa-miR-3127-5p	CLIP-seq
MIRT2268862	hsa-miR-3136-3p	CLIP-seq
MIRT1136607	hsa-miR-3152-3p	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT1136610	hsa-miR-3167	CLIP-seq
MIRT2038889	hsa-miR-3169	CLIP-seq
MIRT1136612	hsa-miR-3175	CLIP-seq
MIRT1136613	hsa-miR-3185	CLIP-seq
MIRT2038890	hsa-miR-3190	CLIP-seq
MIRT1136614	hsa-miR-323-5p	CLIP-seq
MIRT1136616	hsa-miR-338-3p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT1136618	hsa-miR-342-3p	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136624	hsa-miR-3647-3p	CLIP-seq
MIRT1136625	hsa-miR-3653	CLIP-seq
MIRT1136626	hsa-miR-3654	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT1136628	hsa-miR-3658	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136630	hsa-miR-3663-3p	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT2268863	hsa-miR-369-3p	CLIP-seq
MIRT2268864	hsa-miR-374c	CLIP-seq
MIRT1136647	hsa-miR-3913-3p	CLIP-seq
MIRT1136649	hsa-miR-3919	CLIP-seq
MIRT1136650	hsa-miR-3922-5p	CLIP-seq
MIRT1136651	hsa-miR-3927	CLIP-seq
MIRT1136652	hsa-miR-3929	CLIP-seq
MIRT1136654	hsa-miR-3937	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT1136660	hsa-miR-4257	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT1136663	hsa-miR-4265	CLIP-seq
MIRT1136664	hsa-miR-4270	CLIP-seq
MIRT1136665	hsa-miR-4272	CLIP-seq
MIRT1136666	hsa-miR-4275	CLIP-seq
MIRT2268865	hsa-miR-4276	CLIP-seq
MIRT1136668	hsa-miR-4284	CLIP-seq
MIRT1136669	hsa-miR-4296	CLIP-seq
MIRT1136673	hsa-miR-4322	CLIP-seq
MIRT1136674	hsa-miR-4326	CLIP-seq
MIRT1136675	hsa-miR-4419b	CLIP-seq
MIRT1136679	hsa-miR-4435	CLIP-seq
MIRT1136681	hsa-miR-4441	CLIP-seq
MIRT1136682	hsa-miR-4443	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT1136685	hsa-miR-4477b	CLIP-seq
MIRT1136686	hsa-miR-4478	CLIP-seq
MIRT2268866	hsa-miR-4487	CLIP-seq
MIRT1136687	hsa-miR-4491	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT2268867	hsa-miR-451	CLIP-seq
MIRT1136691	hsa-miR-4511	CLIP-seq
MIRT2268868	hsa-miR-451b	CLIP-seq
MIRT1136693	hsa-miR-4521	CLIP-seq
MIRT1136694	hsa-miR-4530	CLIP-seq
MIRT2268869	hsa-miR-4537	CLIP-seq
MIRT1136695	hsa-miR-4649-3p	CLIP-seq
MIRT1136696	hsa-miR-4650-3p	CLIP-seq
MIRT2268870	hsa-miR-4656	CLIP-seq
MIRT1136698	hsa-miR-4657	CLIP-seq
MIRT1136699	hsa-miR-4661-3p	CLIP-seq
MIRT1136700	hsa-miR-4666-5p	CLIP-seq
MIRT2268871	hsa-miR-4682	CLIP-seq
MIRT1136702	hsa-miR-4683	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136705	hsa-miR-4691-5p	CLIP-seq
MIRT1136706	hsa-miR-4693-5p	CLIP-seq
MIRT1136707	hsa-miR-4705	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136715	hsa-miR-4735-5p	CLIP-seq
MIRT1136717	hsa-miR-4739	CLIP-seq
MIRT1136720	hsa-miR-4756-5p	CLIP-seq
MIRT2038896	hsa-miR-4759	CLIP-seq
MIRT2268872	hsa-miR-4760-5p	CLIP-seq
MIRT1136723	hsa-miR-4770	CLIP-seq
MIRT1136725	hsa-miR-4775	CLIP-seq
MIRT2268873	hsa-miR-4786-3p	CLIP-seq
MIRT1136728	hsa-miR-4790-3p	CLIP-seq
MIRT1136729	hsa-miR-4795-5p	CLIP-seq
MIRT1136731	hsa-miR-485-3p	CLIP-seq
MIRT1136732	hsa-miR-485-5p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT2268874	hsa-miR-501-5p	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT2268875	hsa-miR-508-5p	CLIP-seq
MIRT1136737	hsa-miR-516b	CLIP-seq
MIRT1136745	hsa-miR-545	CLIP-seq
MIRT1136746	hsa-miR-548a-3p	CLIP-seq
MIRT1136747	hsa-miR-548ag	CLIP-seq
MIRT1136748	hsa-miR-548ai	CLIP-seq
MIRT1136749	hsa-miR-548b-3p	CLIP-seq
MIRT1136751	hsa-miR-548e	CLIP-seq
MIRT1136752	hsa-miR-548f	CLIP-seq
MIRT1136753	hsa-miR-548g	CLIP-seq
MIRT1136754	hsa-miR-548k	CLIP-seq
MIRT1136755	hsa-miR-548n	CLIP-seq
MIRT1136756	hsa-miR-548p	CLIP-seq
MIRT1136757	hsa-miR-569	CLIP-seq
MIRT2268876	hsa-miR-570	CLIP-seq
MIRT1136761	hsa-miR-590-3p	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT1136766	hsa-miR-620	CLIP-seq
MIRT1136768	hsa-miR-634	CLIP-seq
MIRT2268877	hsa-miR-655	CLIP-seq
MIRT2268878	hsa-miR-656	CLIP-seq
MIRT1136772	hsa-miR-663b	CLIP-seq
MIRT1136773	hsa-miR-664	CLIP-seq
MIRT2038899	hsa-miR-671-5p	CLIP-seq
MIRT2268879	hsa-miR-766	CLIP-seq
MIRT1136775	hsa-miR-876-3p	CLIP-seq
MIRT1136776	hsa-miR-876-5p	CLIP-seq
MIRT1136779	hsa-miR-95	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT2568311	hsa-miR-10a	CLIP-seq
MIRT2568312	hsa-miR-10b	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT1136569	hsa-miR-1272	CLIP-seq
MIRT2038885	hsa-miR-1283	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT1136589	hsa-miR-2114	CLIP-seq
MIRT2568313	hsa-miR-2392	CLIP-seq
MIRT1136599	hsa-miR-30a	CLIP-seq
MIRT1136600	hsa-miR-30b	CLIP-seq
MIRT1136601	hsa-miR-30c	CLIP-seq
MIRT1136602	hsa-miR-30d	CLIP-seq
MIRT1136603	hsa-miR-30e	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT2568314	hsa-miR-3179	CLIP-seq
MIRT2568315	hsa-miR-3187-3p	CLIP-seq
MIRT2568316	hsa-miR-323-3p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT2568317	hsa-miR-339-5p	CLIP-seq
MIRT2568318	hsa-miR-34b	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT1136622	hsa-miR-3613-3p	CLIP-seq
MIRT2568319	hsa-miR-3620	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT2568320	hsa-miR-3660	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT2568321	hsa-miR-371-5p	CLIP-seq
MIRT2568322	hsa-miR-371b-5p	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT1136657	hsa-miR-425	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT1136676	hsa-miR-4420	CLIP-seq
MIRT2568323	hsa-miR-4421	CLIP-seq
MIRT1136682	hsa-miR-4443	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT2568324	hsa-miR-4466	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT2568325	hsa-miR-4526	CLIP-seq
MIRT2568326	hsa-miR-4529-5p	CLIP-seq
MIRT1136699	hsa-miR-4661-3p	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT2268875	hsa-miR-508-5p	CLIP-seq
MIRT2568327	hsa-miR-5096	CLIP-seq
MIRT1136750	hsa-miR-548c-3p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT2568328	hsa-miR-675	CLIP-seq
MIRT2568311	hsa-miR-10a	CLIP-seq
MIRT2568312	hsa-miR-10b	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT2038885	hsa-miR-1283	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT2684731	hsa-miR-2110	CLIP-seq
MIRT1136599	hsa-miR-30a	CLIP-seq
MIRT1136600	hsa-miR-30b	CLIP-seq
MIRT1136601	hsa-miR-30c	CLIP-seq
MIRT1136602	hsa-miR-30d	CLIP-seq
MIRT1136603	hsa-miR-30e	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT2038887	hsa-miR-3127-5p	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT2568314	hsa-miR-3179	CLIP-seq
MIRT2568316	hsa-miR-323-3p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT2568317	hsa-miR-339-5p	CLIP-seq
MIRT2568318	hsa-miR-34b	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT1136622	hsa-miR-3613-3p	CLIP-seq
MIRT2568319	hsa-miR-3620	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT2568320	hsa-miR-3660	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT2568321	hsa-miR-371-5p	CLIP-seq
MIRT2568322	hsa-miR-371b-5p	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT2684732	hsa-miR-4271	CLIP-seq
MIRT1136676	hsa-miR-4420	CLIP-seq
MIRT2568323	hsa-miR-4421	CLIP-seq
MIRT1136682	hsa-miR-4443	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT2568325	hsa-miR-4526	CLIP-seq
MIRT1136699	hsa-miR-4661-3p	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT2684733	hsa-miR-4725-3p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT2684734	hsa-miR-491-5p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT1136750	hsa-miR-548c-3p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	IBA
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	IDA	17360195
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	IEA
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	IEA
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	NAS	11170888, 11181649
GO:0005515	Function	Protein binding	IPI	17360195, 27499296, 33961781, 35156780, 36012204
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	11170888
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	11181649
GO:0005759	Component	Mitochondrial matrix	IDA	16023992, 17360195
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006552	Process	L-leucine catabolic process	IBA
GO:0006552	Process	L-leucine catabolic process	IEA
GO:0006552	Process	L-leucine catabolic process	TAS	11170888
GO:0009083	Process	Branched-chain amino acid catabolic process	NAS	17360195
GO:0015936	Process	Coenzyme A metabolic process	IEA
GO:0016874	Function	Ligase activity	IEA
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	IBA
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	IDA	17360195
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	IPI	17360195
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	NAS	11170888, 11181649
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	TAS	22869039

MIM	HGNC	e!Ensembl
609014	6937	ENSG00000131844

Q9HCC0

Protein name

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)

Protein function

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360

PDB

8J4Z , 8J73 , 8J78 , 8J7D , 8J99 , 8JAK , 8JAW , 8JXL , 8JXM , 8JXN , 8K2V , 8XL6 , 8XL7 , 8XL8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01039	Carboxyl_trans	74 → 558	Carboxyl transferase domain	Family

Sequence

MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERV
EHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGII
TGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPR
QADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIF
LAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKL
DVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFA
RIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAK
DGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAAN
VLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLV
LGLSFSAALNAPIEKTDFGIFRM

Sequence length

563

Interactions

View interactions

	KEGG		Reactome
	Valine, leucine and isoleucine degradation Metabolic pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Branched-chain amino acid catabolism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
3-methylcrotonyl-CoA carboxylase 2 deficiency	Likely pathogenic; Pathogenic	rs1352606118, rs398124372, rs2112308599, rs2112460011, rs730880265, rs2112251301, rs2112308910, rs2112437401, rs2112438432, rs764286389, rs2112251855, rs758794885, rs2112427637, rs2112468012, rs2112437820 View all (128 more)	RCV001312292 RCV003764769 RCV001378821 RCV001379035 RCV001379033 View all (148 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Autism spectrum disorder	Likely pathogenic; Pathogenic	rs119103221	RCV003313912	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
MCCC2-related disorder	Likely pathogenic; Pathogenic	rs150591260, rs757052602, rs2530858195, rs148773718, rs760881963, rs751970792, rs277995	RCV003407683 RCV004751353 RCV003412441 RCV003915571 RCV004751926 RCV004751665 RCV003928278 View all (2 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Methylcrotonyl-CoA carboxylase deficiency	Likely pathogenic; Pathogenic	rs142887940, rs2112463755, rs765438239, rs769558016, rs119103219, rs119103221, rs119103222, rs119103224, rs2530723770, rs774241918, rs2530733439, rs547662164, rs150591260, rs757052602, rs781013376 View all (10 more)	RCV005419298 RCV004017888 RCV003403657 RCV004782864 RCV005406719 View all (20 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Nonpapillary renal cell carcinoma	Likely pathogenic; Pathogenic	rs142887940	RCV005925485	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY	—	Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANNABIS DEPENDENCE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	-	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign; Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL DISEASES	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (39)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
3-methylcrotonyl CoA carboxylase 1 deficiency	3-methylcrotonyl CoA carboxylase deficiency	CLINGEN_DG	11170888, 11181649, 17968484, 22642865, 27601257		★★★★★ ★☆☆☆☆ Found in Text Mining only
3-methylcrotonyl CoA carboxylase 1 deficiency	3-methylcrotonyl CoA carboxylase deficiency	BEFREE	16835865, 22264772		★★★★★ ★☆☆☆☆ Found in Text Mining only
3-methylcrotonyl CoA carboxylase 1 deficiency	3-methylcrotonyl CoA carboxylase deficiency	ORPHANET_DG	22264772, 22642865		★★★★★ ★☆☆☆☆ Found in Text Mining only
3-methylcrotonyl CoA carboxylase 2 deficiency	3-methylcrotonyl CoA carboxylase deficiency	UNIPROT_DG	11170888, 11181649, 11406611, 16010683, 17968484, 21071250, 22150417, 22264772, 22642865, 25382614, 27601257		★★★★★ ★☆☆☆☆ Found in Text Mining only
3-methylcrotonyl CoA carboxylase 2 deficiency	3-methylcrotonyl CoA carboxylase deficiency	CLINVAR_DG	11170888, 11181649, 16010683, 17908719, 17968484, 21071250, 22030835, 22150417, 22264772, 22642865, 25087612, 25356967, 27601257, 28018443		★★★★★ ★☆☆☆☆ Found in Text Mining only
3-methylcrotonyl CoA carboxylase 2 deficiency	3-methylcrotonyl CoA carboxylase deficiency	GENOMICS_ENGLAND_DG	27604308		★★★★★ ★☆☆☆☆ Found in Text Mining only
3-methylcrotonyl CoA carboxylase 2 deficiency	3-methylcrotonyl CoA carboxylase deficiency	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
3-methylcrotonyl-CoA carboxylase deficiency	3-methylcrotonyl CoA carboxylase deficiency	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alopecia	Alopecia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	38287090	Associate	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Autistic Disorder	Autism	Pubtator	38287090	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30895811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28401470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic schizophrenia	Schizophrenia	BEFREE	30029051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37828426	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	38287090	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
HYPERGLYCINURIA (disorder)	Hyperglycinuria	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ketonuria	Ketonuria	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ketosis	Ketosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30895811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28401470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	21829708		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	14960587	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Methylcrotonyl-CoA carboxylase deficiency	Methylcrotonyl-CoA Carboxylase Deficiency	BEFREE	16835865, 22264772		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Movement Disorders	Movement Disorders	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Atrophy Spinal	Spinal muscular atrophy	Pubtator	33148303	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	GWASDB_DG	21211798		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30895811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peroxisome Biogenesis Disorder, Complementation Group 7	Zellweger Syndrome	BEFREE	11170888		★★★★★ ★☆☆☆☆ Found in Text Mining only
Propionic acidemia	Propionic acidemia	BEFREE	14960587		★★★★★ ★☆☆☆☆ Found in Text Mining only
Propionic acidemia	Propionic acidemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	21829708		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21829708	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizoaffective Disorder	Schizoaffective Disorder	BEFREE	29486955		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	29243531		★★★★★ ★☆☆☆☆ Found in Text Mining only
Seborrheic dermatitis	Seborrheic dermatitis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only

MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)