PRDM15 (PR/SET domain 15)

Gene

• Entrez ID: 63977
• Gene name: PR/SET domain 15
• Gene symbol: PRDM15
• Synonyms (NCBI Gene): C21orf83, PFM15, ZNF298
• Chromosome: 21
• Chromosome location: 21q22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT497153	hsa-miR-132-3p	PAR-CLIP	22291592
MIRT497152	hsa-miR-212-3p	PAR-CLIP	22291592
MIRT497151	hsa-miR-4635	PAR-CLIP	22291592
MIRT497150	hsa-miR-4529-5p	PAR-CLIP	22291592
MIRT497149	hsa-miR-548s	PAR-CLIP	22291592
MIRT497148	hsa-miR-4701-5p	PAR-CLIP	22291592
MIRT497147	hsa-miR-588	PAR-CLIP	22291592
MIRT497146	hsa-miR-4435	PAR-CLIP	22291592
MIRT497145	hsa-miR-3187-3p	PAR-CLIP	22291592
MIRT441549	hsa-miR-4311	PAR-CLIP	22100165
MIRT441548	hsa-miR-1276	PAR-CLIP	22100165
MIRT441547	hsa-miR-583	PAR-CLIP	22100165
MIRT441546	hsa-miR-587	PAR-CLIP	22100165
MIRT441549	hsa-miR-4311	PAR-CLIP	22100165
MIRT441548	hsa-miR-1276	PAR-CLIP	22100165
MIRT441547	hsa-miR-583	PAR-CLIP	22100165
MIRT441546	hsa-miR-587	PAR-CLIP	22100165
MIRT497153	hsa-miR-132-3p	PAR-CLIP	22291592
MIRT497152	hsa-miR-212-3p	PAR-CLIP	22291592
MIRT497151	hsa-miR-4635	PAR-CLIP	22291592
MIRT497150	hsa-miR-4529-5p	PAR-CLIP	22291592
MIRT497149	hsa-miR-548s	PAR-CLIP	22291592
MIRT497148	hsa-miR-4701-5p	PAR-CLIP	22291592
MIRT497147	hsa-miR-588	PAR-CLIP	22291592
MIRT497146	hsa-miR-4435	PAR-CLIP	22291592
MIRT497145	hsa-miR-3187-3p	PAR-CLIP	22291592
MIRT441549	hsa-miR-4311	PAR-CLIP	22100165
MIRT441548	hsa-miR-1276	PAR-CLIP	22100165
MIRT441547	hsa-miR-583	PAR-CLIP	22100165
MIRT441546	hsa-miR-587	PAR-CLIP	22100165
MIRT441549	hsa-miR-4311	PAR-CLIP	22100165
MIRT441548	hsa-miR-1276	PAR-CLIP	22100165
MIRT441547	hsa-miR-583	PAR-CLIP	22100165
MIRT441546	hsa-miR-587	PAR-CLIP	22100165
MIRT1259999	hsa-miR-105	CLIP-seq
MIRT1260000	hsa-miR-1233	CLIP-seq
MIRT1260001	hsa-miR-1252	CLIP-seq
MIRT1260002	hsa-miR-1257	CLIP-seq
MIRT1260003	hsa-miR-1272	CLIP-seq
MIRT1260004	hsa-miR-1288	CLIP-seq
MIRT1260005	hsa-miR-1298	CLIP-seq
MIRT1260006	hsa-miR-150	CLIP-seq
MIRT1260007	hsa-miR-181a	CLIP-seq
MIRT1260008	hsa-miR-181b	CLIP-seq
MIRT1260009	hsa-miR-181c	CLIP-seq
MIRT1260010	hsa-miR-181d	CLIP-seq
MIRT1260011	hsa-miR-200b	CLIP-seq
MIRT1260012	hsa-miR-200c	CLIP-seq
MIRT1260013	hsa-miR-2052	CLIP-seq
MIRT1260014	hsa-miR-2117	CLIP-seq
MIRT1260015	hsa-miR-2276	CLIP-seq
MIRT1260016	hsa-miR-28-5p	CLIP-seq
MIRT1260017	hsa-miR-2909	CLIP-seq
MIRT1260018	hsa-miR-3064-5p	CLIP-seq
MIRT1260019	hsa-miR-3065-3p	CLIP-seq
MIRT1260020	hsa-miR-3120-5p	CLIP-seq
MIRT1260021	hsa-miR-3121-5p	CLIP-seq
MIRT1260022	hsa-miR-3127-3p	CLIP-seq
MIRT1260023	hsa-miR-3128	CLIP-seq
MIRT1260024	hsa-miR-3139	CLIP-seq
MIRT1260025	hsa-miR-3150a-5p	CLIP-seq
MIRT1260026	hsa-miR-3150b-5p	CLIP-seq
MIRT1260027	hsa-miR-3156-3p	CLIP-seq
MIRT1260028	hsa-miR-3157-5p	CLIP-seq
MIRT1260029	hsa-miR-3160-5p	CLIP-seq
MIRT1260030	hsa-miR-3169	CLIP-seq
MIRT1260031	hsa-miR-3183	CLIP-seq
MIRT1260032	hsa-miR-3616-5p	CLIP-seq
MIRT1260033	hsa-miR-3647-5p	CLIP-seq
MIRT1260034	hsa-miR-3661	CLIP-seq
MIRT1260035	hsa-miR-3663-5p	CLIP-seq
MIRT1260036	hsa-miR-3673	CLIP-seq
MIRT1260037	hsa-miR-370	CLIP-seq
MIRT1260038	hsa-miR-375	CLIP-seq
MIRT1260039	hsa-miR-4262	CLIP-seq
MIRT1260040	hsa-miR-4266	CLIP-seq
MIRT1260041	hsa-miR-4268	CLIP-seq
MIRT1260042	hsa-miR-4272	CLIP-seq
MIRT1260043	hsa-miR-4273	CLIP-seq
MIRT1260044	hsa-miR-4278	CLIP-seq
MIRT1260045	hsa-miR-429	CLIP-seq
MIRT1260046	hsa-miR-4301	CLIP-seq
MIRT1260047	hsa-miR-4328	CLIP-seq
MIRT1260048	hsa-miR-4436a	CLIP-seq
MIRT1260049	hsa-miR-4448	CLIP-seq
MIRT1260050	hsa-miR-4501	CLIP-seq
MIRT1260051	hsa-miR-4504	CLIP-seq
MIRT1260052	hsa-miR-4634	CLIP-seq
MIRT1260053	hsa-miR-4670-3p	CLIP-seq
MIRT1260054	hsa-miR-4677-5p	CLIP-seq
MIRT1260055	hsa-miR-4687-3p	CLIP-seq
MIRT1260056	hsa-miR-4688	CLIP-seq
MIRT1260057	hsa-miR-4691-3p	CLIP-seq
MIRT1260058	hsa-miR-4695-3p	CLIP-seq
MIRT1260059	hsa-miR-4713-5p	CLIP-seq
MIRT1260060	hsa-miR-4715-3p	CLIP-seq
MIRT1260061	hsa-miR-4723-3p	CLIP-seq
MIRT1260062	hsa-miR-4760-5p	CLIP-seq
MIRT1260063	hsa-miR-4763-5p	CLIP-seq
MIRT1260064	hsa-miR-4765	CLIP-seq
MIRT1260065	hsa-miR-4772-3p	CLIP-seq
MIRT1260066	hsa-miR-4793-5p	CLIP-seq
MIRT1260067	hsa-miR-485-3p	CLIP-seq
MIRT1260068	hsa-miR-487a	CLIP-seq
MIRT1260069	hsa-miR-501-5p	CLIP-seq
MIRT1260070	hsa-miR-513c	CLIP-seq
MIRT1260071	hsa-miR-514b-5p	CLIP-seq
MIRT1260072	hsa-miR-518a-5p	CLIP-seq
MIRT1260073	hsa-miR-527	CLIP-seq
MIRT1260074	hsa-miR-532-3p	CLIP-seq
MIRT1260075	hsa-miR-542-3p	CLIP-seq
MIRT1260076	hsa-miR-544	CLIP-seq
MIRT1260077	hsa-miR-548an	CLIP-seq
MIRT1260078	hsa-miR-548n	CLIP-seq
MIRT1260079	hsa-miR-548t	CLIP-seq
MIRT1260080	hsa-miR-570	CLIP-seq
MIRT1260081	hsa-miR-573	CLIP-seq
MIRT1260082	hsa-miR-582-3p	CLIP-seq
MIRT1260083	hsa-miR-602	CLIP-seq
MIRT1260084	hsa-miR-631	CLIP-seq
MIRT1260085	hsa-miR-664	CLIP-seq
MIRT1260086	hsa-miR-670	CLIP-seq
MIRT1260087	hsa-miR-708	CLIP-seq
MIRT2076580	hsa-miR-149	CLIP-seq
MIRT1260007	hsa-miR-181a	CLIP-seq
MIRT1260008	hsa-miR-181b	CLIP-seq
MIRT1260009	hsa-miR-181c	CLIP-seq
MIRT1260010	hsa-miR-181d	CLIP-seq
MIRT1260018	hsa-miR-3064-5p	CLIP-seq
MIRT1260039	hsa-miR-4262	CLIP-seq
MIRT2076581	hsa-miR-4320	CLIP-seq
MIRT2076582	hsa-miR-4436b-5p	CLIP-seq
MIRT2076583	hsa-miR-4659a-3p	CLIP-seq
MIRT2076584	hsa-miR-4659b-3p	CLIP-seq
MIRT2076585	hsa-miR-4794	CLIP-seq
MIRT1260067	hsa-miR-485-3p	CLIP-seq
MIRT1260068	hsa-miR-487a	CLIP-seq
MIRT2303209	hsa-miR-122	CLIP-seq
MIRT2303210	hsa-miR-1273f	CLIP-seq
MIRT2303211	hsa-miR-143	CLIP-seq
MIRT2303212	hsa-miR-155	CLIP-seq
MIRT1260011	hsa-miR-200b	CLIP-seq
MIRT1260012	hsa-miR-200c	CLIP-seq
MIRT1260014	hsa-miR-2117	CLIP-seq
MIRT2303213	hsa-miR-302a	CLIP-seq
MIRT2303214	hsa-miR-302b	CLIP-seq
MIRT2303215	hsa-miR-302c	CLIP-seq
MIRT2303216	hsa-miR-302d	CLIP-seq
MIRT2303217	hsa-miR-302e	CLIP-seq
MIRT1260019	hsa-miR-3065-3p	CLIP-seq
MIRT1260020	hsa-miR-3120-5p	CLIP-seq
MIRT2303218	hsa-miR-3126-3p	CLIP-seq
MIRT2303219	hsa-miR-3153	CLIP-seq
MIRT2303220	hsa-miR-3198	CLIP-seq
MIRT2303221	hsa-miR-338-5p	CLIP-seq
MIRT1260032	hsa-miR-3616-5p	CLIP-seq
MIRT1260033	hsa-miR-3647-5p	CLIP-seq
MIRT2303222	hsa-miR-365	CLIP-seq
MIRT2303223	hsa-miR-372	CLIP-seq
MIRT2303224	hsa-miR-373	CLIP-seq
MIRT2303225	hsa-miR-4251	CLIP-seq
MIRT1260043	hsa-miR-4273	CLIP-seq
MIRT1260045	hsa-miR-429	CLIP-seq
MIRT2303226	hsa-miR-4309	CLIP-seq
MIRT2303227	hsa-miR-4434	CLIP-seq
MIRT2303228	hsa-miR-450b-3p	CLIP-seq
MIRT2303229	hsa-miR-4516	CLIP-seq
MIRT2303230	hsa-miR-4531	CLIP-seq
MIRT2303231	hsa-miR-4663	CLIP-seq
MIRT2303232	hsa-miR-4668-5p	CLIP-seq
MIRT2303233	hsa-miR-4708-5p	CLIP-seq
MIRT2303234	hsa-miR-4713-3p	CLIP-seq
MIRT2303235	hsa-miR-4727-3p	CLIP-seq
MIRT2303236	hsa-miR-4770	CLIP-seq
MIRT2303237	hsa-miR-4795-5p	CLIP-seq
MIRT1260067	hsa-miR-485-3p	CLIP-seq
MIRT1260068	hsa-miR-487a	CLIP-seq
MIRT2303238	hsa-miR-512-3p	CLIP-seq
MIRT2303239	hsa-miR-513b	CLIP-seq
MIRT2303240	hsa-miR-515-5p	CLIP-seq
MIRT2303241	hsa-miR-516b	CLIP-seq
MIRT2303242	hsa-miR-520a-3p	CLIP-seq
MIRT2303243	hsa-miR-520b	CLIP-seq
MIRT2303244	hsa-miR-520c-3p	CLIP-seq
MIRT2303245	hsa-miR-520d-3p	CLIP-seq
MIRT2303246	hsa-miR-520e	CLIP-seq
MIRT2303247	hsa-miR-532-5p	CLIP-seq
MIRT2303248	hsa-miR-539	CLIP-seq
MIRT1260080	hsa-miR-570	CLIP-seq
MIRT1260081	hsa-miR-573	CLIP-seq
MIRT1260083	hsa-miR-602	CLIP-seq
MIRT2303249	hsa-miR-638	CLIP-seq
MIRT2303250	hsa-miR-769-3p	CLIP-seq
MIRT2303251	hsa-miR-935	CLIP-seq
MIRT2457109	hsa-miR-142-5p	CLIP-seq
MIRT2457110	hsa-miR-203	CLIP-seq
MIRT2457111	hsa-miR-297	CLIP-seq
MIRT2457112	hsa-miR-4307	CLIP-seq
MIRT2457113	hsa-miR-561	CLIP-seq
MIRT2457114	hsa-miR-567	CLIP-seq
MIRT2599926	hsa-miR-1193	CLIP-seq
MIRT2599927	hsa-miR-1228	CLIP-seq
MIRT2303210	hsa-miR-1273f	CLIP-seq
MIRT2599928	hsa-miR-1287	CLIP-seq
MIRT2303211	hsa-miR-143	CLIP-seq
MIRT2599929	hsa-miR-183	CLIP-seq
MIRT2599930	hsa-miR-3177-3p	CLIP-seq
MIRT2599931	hsa-miR-3652	CLIP-seq
MIRT2599932	hsa-miR-3681	CLIP-seq
MIRT2599933	hsa-miR-3691-5p	CLIP-seq
MIRT2599934	hsa-miR-4430	CLIP-seq
MIRT2599935	hsa-miR-4456	CLIP-seq
MIRT2599936	hsa-miR-4505	CLIP-seq
MIRT2303233	hsa-miR-4708-5p	CLIP-seq
MIRT2303236	hsa-miR-4770	CLIP-seq
MIRT2303240	hsa-miR-515-5p	CLIP-seq
MIRT2599937	hsa-miR-548ad	CLIP-seq
MIRT2688544	hsa-miR-1271	CLIP-seq
MIRT2688545	hsa-miR-3614-5p	CLIP-seq
MIRT2688546	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	15904895
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	ISS
GO:1990841	Function	Promoter-specific chromatin binding	IEA
GO:1990841	Function	Promoter-specific chromatin binding	ISS
GO:2000035	Process	Regulation of stem cell division	IEA
GO:2000035	Process	Regulation of stem cell division	ISS

Other IDs

• MIM: 617692
• HGNC: 13999
• e!Ensembl: ENSG00000141956

Protein

• UniProt ID: P57071
• Protein name: PR domain zinc finger protein 15 (EC 2.1.1.-) (PR domain-containing protein 15) (Zinc finger protein 298)
• Protein function: Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	738 → 760	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	826 → 848	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	1056 → 1078	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	1084 → 1106	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	1196 → 1219	Zinc finger, C2H2 type	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in all tissues examined. {ECO:0000269|PubMed:15904895}.
• Sequence:

  MPRRRPPASGAAQFPERIATRSPDPIPLCTFQRQPRAAPVQPPCRLFFVTFAGCGHRWRS
  ESKPGWISRSRSGIALRAARPPGSSPPRPAAPRPPPPGGVVAEAPGDVVIPRPRVQPMRV
  ARGGPWTPNPAFREAESWSQIGNQRVSEQLLETSLGNEVSDTEPLSPASAGLRRNPALPP
  GPFAQNFSWGNQENLPPALGKIANGGGTGAGKAECGYETESHLLEPHEIPLNVNTHKFSD
  CEFPYEFCTVCFSPFKLLGMSGVEGVWNQHSRSASMHTFLNHSATGIREAGCRKDMPVSE
  MAEDGSEEIMFIWCEDCSQYHDSECPELGPVVMVKDSFVLSRARSWPASGHVHTQAGQGM
  RGYEDRDRADPQQLPEAVPAGLVRRLSGQQLPCRSTLTWGRLCHLVAQGRSSLPPNLEIR
  RLEDGAEGVFAITQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDC
  NWMMLVRPAAEAEHQNLTAYQHGSDVYFTTSRDIPPGTELRVWYAAFYAKKMDKPMLKQA
  GSGVHAAGTPENSAPVESEPSQWACKVCSATFLELQLLNEHLLGHLEQAKSLPPGSQSEA
  AAPEKEQDTPRGEPPAVPESENVATKEQKKKPRRGRKPKVSKAEQPLVIVEDKEPTEQVA
  EIITEVPPDEPVSATPDERIMELVLGKLATTTTDTSSVPKFTHHQNNTITLKRSLILSSR
  HGIRRKLIKQLGEHKRVYQCNICSKIFQNSSNLSRHVRSHGDKLFKCEECAKLFSRKESL
  KQHVSYKHSRNEVDGEYRYRCGTCEKTFRIESALEFHNCRTDDKTFQCEMCFRFFSTNSN
  LSKHKKKHGDKKFACEVCSKMFYRKDVMLDHQRRHLEGVRRVKREDLEAGGENLVRYKKE
  PSGCPVCGKVFSCRSNMNKHLLTHGDKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDD
  HQREEFIGKIGISSEENDDNSDESADSEPHKYSCKRCQLTFGRGKEYLKHIMEVHKEKGY
  GCSICNRRFALKATYHAHMVIHRENLPDPNVQKYIHPCEICGRIFNSIGNLERHKLIHTG
  VKSHACEQCGKSFARKDMLKEHMRVHDNVREYLCAECGKGMKTKHALRHHMKLHKGIKEY
  ECKECHRRFAQKVNMLKHCKRHTGIKDFMCELCGKTFSERNTMETHKLIHTVGKQWTCSV
  CDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLD
  HLPETTTIDASSIGIVQPELTLEQEDLAEGKHGKAAKRSHKRKQKPEEEAGAPVPEDATF
  SEYSEKETEFTGSVGDETNSAVQSIQQVVVTLGDPNVTTPSSSVGLTNITVTPITTAAAT
  QFTNLQPVAVGHLTTPERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIHPQPEASNPQS
  VAHFINLTTLVNSITPLGSQLSDQHPLTWRAVPQTDVLPPSQPQAPPQQAAQPQVQAEQQ
  QQQMYSY

• Sequence length: 1507

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Pervasive developmental disorder	Likely pathogenic	rs2061840290	RCV004577954	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	37817227	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36402747	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	23616578		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	16036106	Associate	★☆☆☆☆ Found in Text Mining only