Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	63917
Gene name	Polypeptide N-acetylgalactosaminyltransferase 11
Gene symbol	GALNT11
Synonyms (NCBI Gene)	GALNAC-T11GALNACT11
Chromosome	7
Chromosome location	7q36.1\|7q36.1

Show/Hide all (87)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029838	hsa-miR-26b-5p	Microarray	19088304
MIRT052104	hsa-let-7b-5p	CLASH	23622248
MIRT046225	hsa-miR-27b-3p	CLASH	23622248
MIRT526847	hsa-miR-4323	PAR-CLIP	22012620
MIRT526848	hsa-miR-5009-3p	PAR-CLIP	22012620
MIRT526846	hsa-miR-5699-5p	PAR-CLIP	22012620
MIRT526845	hsa-miR-3612	PAR-CLIP	22012620
MIRT526844	hsa-miR-650	PAR-CLIP	22012620
MIRT526847	hsa-miR-4323	PAR-CLIP	22012620
MIRT526848	hsa-miR-5009-3p	PAR-CLIP	22012620
MIRT526846	hsa-miR-5699-5p	PAR-CLIP	22012620
MIRT526845	hsa-miR-3612	PAR-CLIP	22012620
MIRT526844	hsa-miR-650	PAR-CLIP	22012620
MIRT1010796	hsa-miR-1237	CLIP-seq
MIRT1010797	hsa-miR-1322	CLIP-seq
MIRT1010798	hsa-miR-340	CLIP-seq
MIRT1010799	hsa-miR-3646	CLIP-seq
MIRT1010800	hsa-miR-4297	CLIP-seq
MIRT1010801	hsa-miR-4471	CLIP-seq
MIRT1010802	hsa-miR-4497	CLIP-seq
MIRT1010803	hsa-miR-4645-5p	CLIP-seq
MIRT1010804	hsa-miR-4670-3p	CLIP-seq
MIRT1010805	hsa-miR-4673	CLIP-seq
MIRT1010806	hsa-miR-4803	CLIP-seq
MIRT1010807	hsa-miR-532-5p	CLIP-seq
MIRT1999356	hsa-miR-1247	CLIP-seq
MIRT1999357	hsa-miR-1324	CLIP-seq
MIRT1999358	hsa-miR-4426	CLIP-seq
MIRT1010801	hsa-miR-4471	CLIP-seq
MIRT1010802	hsa-miR-4497	CLIP-seq
MIRT1999359	hsa-miR-4647	CLIP-seq
MIRT1999360	hsa-miR-4662b	CLIP-seq
MIRT1999361	hsa-miR-515-5p	CLIP-seq
MIRT1999362	hsa-miR-593	CLIP-seq
MIRT1999363	hsa-miR-942	CLIP-seq
MIRT2233018	hsa-miR-329	CLIP-seq
MIRT2233019	hsa-miR-362-3p	CLIP-seq
MIRT2233020	hsa-miR-371-5p	CLIP-seq
MIRT1010801	hsa-miR-4471	CLIP-seq
MIRT1010802	hsa-miR-4497	CLIP-seq
MIRT2233021	hsa-miR-4660	CLIP-seq
MIRT2233022	hsa-miR-646	CLIP-seq
MIRT1010801	hsa-miR-4471	CLIP-seq
MIRT2536829	hsa-miR-1200	CLIP-seq
MIRT2536830	hsa-miR-1273g	CLIP-seq
MIRT2536831	hsa-miR-217	CLIP-seq
MIRT2536832	hsa-miR-3152-5p	CLIP-seq
MIRT2536833	hsa-miR-383	CLIP-seq
MIRT2536834	hsa-miR-4318	CLIP-seq
MIRT2536835	hsa-miR-4450	CLIP-seq
MIRT2536836	hsa-miR-451b	CLIP-seq
MIRT2536837	hsa-miR-4693-5p	CLIP-seq
MIRT2536838	hsa-miR-4711-5p	CLIP-seq
MIRT2536839	hsa-miR-4772-5p	CLIP-seq
MIRT2536840	hsa-miR-4774-3p	CLIP-seq
MIRT2536841	hsa-miR-548aa	CLIP-seq
MIRT2536842	hsa-miR-548ac	CLIP-seq
MIRT2536843	hsa-miR-548ae	CLIP-seq
MIRT2536844	hsa-miR-548aj	CLIP-seq
MIRT2536845	hsa-miR-548am	CLIP-seq
MIRT2536846	hsa-miR-548d-3p	CLIP-seq
MIRT2536847	hsa-miR-548x	CLIP-seq
MIRT2536848	hsa-miR-548z	CLIP-seq
MIRT2536849	hsa-miR-577	CLIP-seq
MIRT2536850	hsa-miR-583	CLIP-seq
MIRT2536851	hsa-miR-892a	CLIP-seq
MIRT2536829	hsa-miR-1200	CLIP-seq
MIRT2536830	hsa-miR-1273g	CLIP-seq
MIRT2536831	hsa-miR-217	CLIP-seq
MIRT2536832	hsa-miR-3152-5p	CLIP-seq
MIRT2536833	hsa-miR-383	CLIP-seq
MIRT2536834	hsa-miR-4318	CLIP-seq
MIRT2536836	hsa-miR-451b	CLIP-seq
MIRT2536837	hsa-miR-4693-5p	CLIP-seq
MIRT2536838	hsa-miR-4711-5p	CLIP-seq
MIRT2536839	hsa-miR-4772-5p	CLIP-seq
MIRT2536840	hsa-miR-4774-3p	CLIP-seq
MIRT2536841	hsa-miR-548aa	CLIP-seq
MIRT2536842	hsa-miR-548ac	CLIP-seq
MIRT2536843	hsa-miR-548ae	CLIP-seq
MIRT2536844	hsa-miR-548aj	CLIP-seq
MIRT2536845	hsa-miR-548am	CLIP-seq
MIRT2536846	hsa-miR-548d-3p	CLIP-seq
MIRT2536847	hsa-miR-548x	CLIP-seq
MIRT2536848	hsa-miR-548z	CLIP-seq
MIRT2536849	hsa-miR-577	CLIP-seq
MIRT2536851	hsa-miR-892a	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0004653	Function	Polypeptide N-acetylgalactosaminyltransferase activity	IBA
GO:0004653	Function	Polypeptide N-acetylgalactosaminyltransferase activity	IDA	24226769
GO:0004653	Function	Polypeptide N-acetylgalactosaminyltransferase activity	IEA
GO:0004653	Function	Polypeptide N-acetylgalactosaminyltransferase activity	TAS
GO:0005112	Function	Notch binding	IBA
GO:0005112	Function	Notch binding	IDA	24226769
GO:0005112	Function	Notch binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006493	Process	Protein O-linked glycosylation	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007220	Process	Notch receptor processing	ISS
GO:0007368	Process	Determination of left/right symmetry	ISS
GO:0008593	Process	Regulation of Notch signaling pathway	IBA
GO:0008593	Process	Regulation of Notch signaling pathway	ISS
GO:0016020	Component	Membrane	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060271	Process	Cilium assembly	ISS
GO:0061314	Process	Notch signaling involved in heart development	ISS

MIM	HGNC	e!Ensembl
615130	19875	ENSG00000178234

Q8NCW6

Protein name

Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11)

Protein function

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00535	Glycos_transf_2	154 → 339	Glycosyl transferase family 2	Family
PF00652	Ricin_B_lectin	481 → 604	Ricin-type beta-trefoil lectin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli. {ECO:0000269|PubMed:1192545

Sequence

MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFT
RGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFN
MLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEV
LVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHF
KWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPD
LKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVL
QRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMS
ETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSS
SQQWHLEG

Sequence length

608

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Other types of O-glycan biosynthesis Metabolic pathways		O-linked glycosylation of mucins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GALNT11-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	24076351		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26620301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Abnormalities	Congenital abnormalities	Pubtator	29061174	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	29061174	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30758710		★★★★★ ★☆☆☆☆ Found in Text Mining only
Situs ambiguus	Situs ambiguus	BEFREE	24226769		★★★★★ ★☆☆☆☆ Found in Text Mining only

GALNT11 (polypeptide N-acetylgalactosaminyltransferase 11)