Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	63893
Gene name	Ubiquitin conjugating enzyme E2 O
Gene symbol	UBE2O
Synonyms (NCBI Gene)	E2-230K
Chromosome	17
Chromosome location	17q25.1

215

Show/Hide all (215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017347	hsa-miR-335-5p	Microarray	18185580
MIRT048803	hsa-miR-93-5p	CLASH	23622248
MIRT043811	hsa-miR-328-3p	CLASH	23622248
MIRT041058	hsa-miR-505-3p	CLASH	23622248
MIRT038542	hsa-miR-30c-1-3p	CLASH	23622248
MIRT037423	hsa-miR-744-5p	CLASH	23622248
MIRT037063	hsa-miR-877-3p	CLASH	23622248
MIRT439359	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT439358	hsa-miR-432-3p	HITS-CLIP	24374217
MIRT439359	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT439358	hsa-miR-432-3p	HITS-CLIP	24374217
MIRT1468492	hsa-miR-1245b-5p	CLIP-seq
MIRT1468493	hsa-miR-1253	CLIP-seq
MIRT1468494	hsa-miR-219-1-3p	CLIP-seq
MIRT1468495	hsa-miR-22	CLIP-seq
MIRT1468496	hsa-miR-23a	CLIP-seq
MIRT1468497	hsa-miR-23b	CLIP-seq
MIRT1468498	hsa-miR-23c	CLIP-seq
MIRT1468499	hsa-miR-3140-3p	CLIP-seq
MIRT1468500	hsa-miR-3142	CLIP-seq
MIRT1468501	hsa-miR-3188	CLIP-seq
MIRT1468502	hsa-miR-34a	CLIP-seq
MIRT1468503	hsa-miR-34c-5p	CLIP-seq
MIRT1468504	hsa-miR-3545-3p	CLIP-seq
MIRT1468505	hsa-miR-3616-3p	CLIP-seq
MIRT1468506	hsa-miR-376c	CLIP-seq
MIRT1468507	hsa-miR-377	CLIP-seq
MIRT1468508	hsa-miR-421	CLIP-seq
MIRT1468509	hsa-miR-4436b-3p	CLIP-seq
MIRT1468510	hsa-miR-4446-3p	CLIP-seq
MIRT1468511	hsa-miR-4492	CLIP-seq
MIRT1468512	hsa-miR-4498	CLIP-seq
MIRT1468513	hsa-miR-449a	CLIP-seq
MIRT1468514	hsa-miR-449b	CLIP-seq
MIRT1468515	hsa-miR-4645-3p	CLIP-seq
MIRT1468516	hsa-miR-4709-5p	CLIP-seq
MIRT1468517	hsa-miR-4721	CLIP-seq
MIRT1468518	hsa-miR-4789-5p	CLIP-seq
MIRT1468519	hsa-miR-487b	CLIP-seq
MIRT1468520	hsa-miR-554	CLIP-seq
MIRT1468521	hsa-miR-571	CLIP-seq
MIRT1468522	hsa-miR-629	CLIP-seq
MIRT1468523	hsa-miR-762	CLIP-seq
MIRT2140724	hsa-miR-1184	CLIP-seq
MIRT2140725	hsa-miR-1205	CLIP-seq
MIRT2140726	hsa-miR-1225-3p	CLIP-seq
MIRT1468493	hsa-miR-1253	CLIP-seq
MIRT2140727	hsa-miR-149	CLIP-seq
MIRT2140728	hsa-miR-1909	CLIP-seq
MIRT2140729	hsa-miR-2110	CLIP-seq
MIRT1468496	hsa-miR-23a	CLIP-seq
MIRT1468497	hsa-miR-23b	CLIP-seq
MIRT1468498	hsa-miR-23c	CLIP-seq
MIRT2140730	hsa-miR-3127-3p	CLIP-seq
MIRT2140731	hsa-miR-3144-5p	CLIP-seq
MIRT2140732	hsa-miR-3150a-3p	CLIP-seq
MIRT2140733	hsa-miR-3175	CLIP-seq
MIRT2140734	hsa-miR-3189-3p	CLIP-seq
MIRT2140735	hsa-miR-3191	CLIP-seq
MIRT2140736	hsa-miR-326	CLIP-seq
MIRT2140737	hsa-miR-330-5p	CLIP-seq
MIRT1468502	hsa-miR-34a	CLIP-seq
MIRT2140738	hsa-miR-34b	CLIP-seq
MIRT1468503	hsa-miR-34c-5p	CLIP-seq
MIRT2140739	hsa-miR-3611	CLIP-seq
MIRT1468505	hsa-miR-3616-3p	CLIP-seq
MIRT1468507	hsa-miR-377	CLIP-seq
MIRT2140740	hsa-miR-3943	CLIP-seq
MIRT2140741	hsa-miR-4291	CLIP-seq
MIRT2140742	hsa-miR-4310	CLIP-seq
MIRT2140743	hsa-miR-4325	CLIP-seq
MIRT2140744	hsa-miR-4434	CLIP-seq
MIRT1468509	hsa-miR-4436b-3p	CLIP-seq
MIRT1468511	hsa-miR-4492	CLIP-seq
MIRT1468512	hsa-miR-4498	CLIP-seq
MIRT1468513	hsa-miR-449a	CLIP-seq
MIRT1468514	hsa-miR-449b	CLIP-seq
MIRT2140745	hsa-miR-4516	CLIP-seq
MIRT2140746	hsa-miR-4652-5p	CLIP-seq
MIRT2140747	hsa-miR-4716-5p	CLIP-seq
MIRT1468518	hsa-miR-4789-5p	CLIP-seq
MIRT1468519	hsa-miR-487b	CLIP-seq
MIRT2140748	hsa-miR-491-5p	CLIP-seq
MIRT2140749	hsa-miR-561	CLIP-seq
MIRT2140750	hsa-miR-603	CLIP-seq
MIRT1468522	hsa-miR-629	CLIP-seq
MIRT1468523	hsa-miR-762	CLIP-seq
MIRT2140751	hsa-miR-939	CLIP-seq
MIRT2361719	hsa-miR-105	CLIP-seq
MIRT2361720	hsa-miR-124	CLIP-seq
MIRT2361721	hsa-miR-150	CLIP-seq
MIRT2361722	hsa-miR-2277-3p	CLIP-seq
MIRT1468496	hsa-miR-23a	CLIP-seq
MIRT1468497	hsa-miR-23b	CLIP-seq
MIRT1468498	hsa-miR-23c	CLIP-seq
MIRT2140731	hsa-miR-3144-5p	CLIP-seq
MIRT2140735	hsa-miR-3191	CLIP-seq
MIRT2140738	hsa-miR-34b	CLIP-seq
MIRT2361723	hsa-miR-371-5p	CLIP-seq
MIRT2361724	hsa-miR-371b-5p	CLIP-seq
MIRT1468507	hsa-miR-377	CLIP-seq
MIRT2361725	hsa-miR-3911	CLIP-seq
MIRT1468508	hsa-miR-421	CLIP-seq
MIRT2361726	hsa-miR-4276	CLIP-seq
MIRT2361727	hsa-miR-4323	CLIP-seq
MIRT2361728	hsa-miR-4646-5p	CLIP-seq
MIRT2140746	hsa-miR-4652-5p	CLIP-seq
MIRT2361729	hsa-miR-4697-3p	CLIP-seq
MIRT2361730	hsa-miR-4704-3p	CLIP-seq
MIRT2361731	hsa-miR-4708-3p	CLIP-seq
MIRT2361732	hsa-miR-4747-5p	CLIP-seq
MIRT2361733	hsa-miR-4758-3p	CLIP-seq
MIRT1468518	hsa-miR-4789-5p	CLIP-seq
MIRT2361734	hsa-miR-483-3p	CLIP-seq
MIRT1468519	hsa-miR-487b	CLIP-seq
MIRT2140748	hsa-miR-491-5p	CLIP-seq
MIRT2361735	hsa-miR-506	CLIP-seq
MIRT2361736	hsa-miR-513c	CLIP-seq
MIRT2361737	hsa-miR-514b-5p	CLIP-seq
MIRT2361738	hsa-miR-542-3p	CLIP-seq
MIRT2140749	hsa-miR-561	CLIP-seq
MIRT2361739	hsa-miR-609	CLIP-seq
MIRT1468522	hsa-miR-629	CLIP-seq
MIRT2361740	hsa-miR-646	CLIP-seq
MIRT2361741	hsa-miR-668	CLIP-seq
MIRT2361723	hsa-miR-371-5p	CLIP-seq
MIRT2361724	hsa-miR-371b-5p	CLIP-seq
MIRT1468507	hsa-miR-377	CLIP-seq
MIRT2361727	hsa-miR-4323	CLIP-seq
MIRT2361730	hsa-miR-4704-3p	CLIP-seq
MIRT2361733	hsa-miR-4758-3p	CLIP-seq
MIRT1468518	hsa-miR-4789-5p	CLIP-seq
MIRT2361734	hsa-miR-483-3p	CLIP-seq
MIRT1468519	hsa-miR-487b	CLIP-seq
MIRT2361736	hsa-miR-513c	CLIP-seq
MIRT2361737	hsa-miR-514b-5p	CLIP-seq
MIRT2361739	hsa-miR-609	CLIP-seq
MIRT2361741	hsa-miR-668	CLIP-seq
MIRT1468492	hsa-miR-1245b-5p	CLIP-seq
MIRT2441585	hsa-miR-1301	CLIP-seq
MIRT2140727	hsa-miR-149	CLIP-seq
MIRT1468500	hsa-miR-3142	CLIP-seq
MIRT2441586	hsa-miR-3944-5p	CLIP-seq
MIRT2441587	hsa-miR-4312	CLIP-seq
MIRT2441588	hsa-miR-4313	CLIP-seq
MIRT1468510	hsa-miR-4446-3p	CLIP-seq
MIRT1468511	hsa-miR-4492	CLIP-seq
MIRT1468512	hsa-miR-4498	CLIP-seq
MIRT1468515	hsa-miR-4645-3p	CLIP-seq
MIRT2441589	hsa-miR-4660	CLIP-seq
MIRT1468517	hsa-miR-4721	CLIP-seq
MIRT2441590	hsa-miR-5047	CLIP-seq
MIRT1468520	hsa-miR-554	CLIP-seq
MIRT1468523	hsa-miR-762	CLIP-seq
MIRT2442813	hsa-miR-129-5p	CLIP-seq
MIRT2442814	hsa-miR-3119	CLIP-seq
MIRT2442815	hsa-miR-511	CLIP-seq
MIRT1468492	hsa-miR-1245b-5p	CLIP-seq
MIRT2655613	hsa-miR-1275	CLIP-seq
MIRT2442813	hsa-miR-129-5p	CLIP-seq
MIRT2140727	hsa-miR-149	CLIP-seq
MIRT2655614	hsa-miR-199a-5p	CLIP-seq
MIRT2655615	hsa-miR-199b-5p	CLIP-seq
MIRT2442814	hsa-miR-3119	CLIP-seq
MIRT1468500	hsa-miR-3142	CLIP-seq
MIRT2140731	hsa-miR-3144-5p	CLIP-seq
MIRT2655616	hsa-miR-3160-3p	CLIP-seq
MIRT2140735	hsa-miR-3191	CLIP-seq
MIRT2655617	hsa-miR-3198	CLIP-seq
MIRT2655618	hsa-miR-3607-5p	CLIP-seq
MIRT2655619	hsa-miR-4263	CLIP-seq
MIRT2361726	hsa-miR-4276	CLIP-seq
MIRT2655620	hsa-miR-4302	CLIP-seq
MIRT2655621	hsa-miR-4309	CLIP-seq
MIRT2655622	hsa-miR-432	CLIP-seq
MIRT2655623	hsa-miR-4424	CLIP-seq
MIRT1468510	hsa-miR-4446-3p	CLIP-seq
MIRT2655624	hsa-miR-4487	CLIP-seq
MIRT1468511	hsa-miR-4492	CLIP-seq
MIRT1468512	hsa-miR-4498	CLIP-seq
MIRT2655625	hsa-miR-4525	CLIP-seq
MIRT1468515	hsa-miR-4645-3p	CLIP-seq
MIRT2140746	hsa-miR-4652-5p	CLIP-seq
MIRT2655626	hsa-miR-4653-3p	CLIP-seq
MIRT2655627	hsa-miR-4665-5p	CLIP-seq
MIRT1468517	hsa-miR-4721	CLIP-seq
MIRT2655628	hsa-miR-4723-5p	CLIP-seq
MIRT2655629	hsa-miR-4728-5p	CLIP-seq
MIRT2140748	hsa-miR-491-5p	CLIP-seq
MIRT2442815	hsa-miR-511	CLIP-seq
MIRT1468520	hsa-miR-554	CLIP-seq
MIRT2655630	hsa-miR-558	CLIP-seq
MIRT2655631	hsa-miR-576-5p	CLIP-seq
MIRT2655632	hsa-miR-591	CLIP-seq
MIRT2655633	hsa-miR-625	CLIP-seq
MIRT1468522	hsa-miR-629	CLIP-seq
MIRT1468523	hsa-miR-762	CLIP-seq
MIRT2655634	hsa-miR-889	CLIP-seq
MIRT1468492	hsa-miR-1245b-5p	CLIP-seq
MIRT2442813	hsa-miR-129-5p	CLIP-seq
MIRT2442814	hsa-miR-3119	CLIP-seq
MIRT1468500	hsa-miR-3142	CLIP-seq
MIRT2140731	hsa-miR-3144-5p	CLIP-seq
MIRT2140735	hsa-miR-3191	CLIP-seq
MIRT1468510	hsa-miR-4446-3p	CLIP-seq
MIRT1468511	hsa-miR-4492	CLIP-seq
MIRT1468512	hsa-miR-4498	CLIP-seq
MIRT1468515	hsa-miR-4645-3p	CLIP-seq
MIRT2140746	hsa-miR-4652-5p	CLIP-seq
MIRT1468517	hsa-miR-4721	CLIP-seq
MIRT2140748	hsa-miR-491-5p	CLIP-seq
MIRT2442815	hsa-miR-511	CLIP-seq
MIRT1468520	hsa-miR-554	CLIP-seq
MIRT1468522	hsa-miR-629	CLIP-seq
MIRT1468523	hsa-miR-762	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	23455153, 24703950
GO:0005515	Function	Protein binding	IPI	19549727, 23455153, 25416956, 28514442, 32296183, 32814053, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	24703950
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	24703950
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006513	Process	Protein monoubiquitination	IDA	23455153, 24703950
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0030513	Process	Positive regulation of BMP signaling pathway	IDA	23455153
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IMP	23452853
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	23455153
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IDA	23455153
GO:0070534	Process	Protein K63-linked ubiquitination	IMP	23452853

MIM	HGNC	e!Ensembl
617649	29554	ENSG00000175931

Q9C0C9

Protein name

(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-23

Protein function

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently o

PDB

7UN3 , 7UN6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00179	UQ_con	957 → 1107	Ubiquitin-conjugating enzyme	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11311559}.

Sequence

MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLL
FSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRG
YVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGT
NCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKL
YDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQ
VVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAK
VEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCSPDTQCSRDHSMEDPDKKGE
SKTKSEAESASPEETPDGSASPVEMQDEGAEEPHEAGEQLPPFLLKEGRDDRLHSAEQDA
DDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKP
GDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPD
PAVYGVVQSGDHIGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVI
RIGNTEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYD
SVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPPLEQPVAPEDKGVVISEEA
ATAAVQGAVAMAAPMAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSP
TVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIVEEEKMEAVPDVERKEDKPEGQSPVKA
EWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRK
EMALLATSLPEGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFC
YLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYN
EAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVN
RIESWLETHALLEKAQALPNGVPKASSSPEPPAVAELSDSGQQEPEDGGPAPGEASQGSD
SEGGAQGLASASRDHTDQTSETAPDASVPPSVKPKKRRKSYRSFLPEKSGYPDIGFPLFP
LSKGFIKSIRGVLTQFRAALLEAGMPECTEDK

Sequence length

1292

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis		Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	31907353	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34790050, 38129382	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36385010	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	31292296		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	31292296		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31292296		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemochromatosis	Hemochromatosis	Pubtator	35668470	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Iron Overload	Iron overload	Pubtator	35668470	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	29476712		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29562734		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	31292296		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	31292296		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	28673317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	37373211	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30856283		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	31292296		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29871923		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	37992172	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

UBE2O (ubiquitin conjugating enzyme E2 O)