Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	63876
Gene name	PBX/knotted 1 homeobox 2
Gene symbol	PKNOX2
Synonyms (NCBI Gene)	PREP2
Chromosome	11
Chromosome location	11q24.2
Summary	Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class

Show/Hide all (97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT655040	hsa-miR-665	HITS-CLIP	23824327
MIRT655039	hsa-miR-5193	HITS-CLIP	23824327
MIRT655038	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT655037	hsa-miR-2114-3p	HITS-CLIP	23824327
MIRT655035	hsa-miR-6823-3p	HITS-CLIP	23824327
MIRT655036	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT655034	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT655033	hsa-miR-185-5p	HITS-CLIP	23824327
MIRT655032	hsa-miR-4306	HITS-CLIP	23824327
MIRT655031	hsa-miR-4644	HITS-CLIP	23824327
MIRT655030	hsa-miR-5192	HITS-CLIP	23824327
MIRT490209	hsa-miR-4323	PAR-CLIP	23592263
MIRT490208	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT490207	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT490206	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT490204	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT490205	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT490203	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT490202	hsa-miR-4271	PAR-CLIP	23592263
MIRT490201	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT490200	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT490199	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT490198	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT490197	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT490196	hsa-miR-5698	PAR-CLIP	23592263
MIRT490195	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT490194	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT490193	hsa-miR-4525	PAR-CLIP	23592263
MIRT490192	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT490191	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT490190	hsa-miR-4447	PAR-CLIP	23592263
MIRT490188	hsa-miR-4472	PAR-CLIP	23592263
MIRT490189	hsa-miR-1275	PAR-CLIP	23592263
MIRT490187	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT439957	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439957	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT655040	hsa-miR-665	HITS-CLIP	23824327
MIRT655039	hsa-miR-5193	HITS-CLIP	23824327
MIRT655038	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT655037	hsa-miR-2114-3p	HITS-CLIP	23824327
MIRT655035	hsa-miR-6823-3p	HITS-CLIP	23824327
MIRT655036	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT655034	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT655033	hsa-miR-185-5p	HITS-CLIP	23824327
MIRT655032	hsa-miR-4306	HITS-CLIP	23824327
MIRT655031	hsa-miR-4644	HITS-CLIP	23824327
MIRT655030	hsa-miR-5192	HITS-CLIP	23824327
MIRT490209	hsa-miR-4323	PAR-CLIP	23592263
MIRT490208	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT490207	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT490206	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT490204	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT490205	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT490203	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT490202	hsa-miR-4271	PAR-CLIP	23592263
MIRT490201	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT490200	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT490199	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT490198	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT490197	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT490196	hsa-miR-5698	PAR-CLIP	23592263
MIRT490195	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT490194	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT490193	hsa-miR-4525	PAR-CLIP	23592263
MIRT490192	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT490191	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT490190	hsa-miR-4447	PAR-CLIP	23592263
MIRT490188	hsa-miR-4472	PAR-CLIP	23592263
MIRT490189	hsa-miR-1275	PAR-CLIP	23592263
MIRT490187	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT1238007	hsa-miR-2682	CLIP-seq
MIRT1238008	hsa-miR-27a	CLIP-seq
MIRT1238009	hsa-miR-27b	CLIP-seq
MIRT1238010	hsa-miR-3184	CLIP-seq
MIRT1238011	hsa-miR-3665	CLIP-seq
MIRT1238012	hsa-miR-423-5p	CLIP-seq
MIRT1238013	hsa-miR-4421	CLIP-seq
MIRT1238014	hsa-miR-4423-3p	CLIP-seq
MIRT1238015	hsa-miR-449c	CLIP-seq
MIRT1238016	hsa-miR-4656	CLIP-seq
MIRT1238017	hsa-miR-4736	CLIP-seq
MIRT1238018	hsa-miR-490-3p	CLIP-seq
MIRT1238019	hsa-miR-5096	CLIP-seq
MIRT1238020	hsa-miR-513a-5p	CLIP-seq
MIRT1238021	hsa-miR-616	CLIP-seq
MIRT1238022	hsa-miR-649	CLIP-seq
MIRT1238023	hsa-miR-940	CLIP-seq
MIRT2069995	hsa-miR-4757-5p	CLIP-seq
MIRT2069996	hsa-miR-663b	CLIP-seq
MIRT2297284	hsa-miR-1238	CLIP-seq
MIRT2297285	hsa-miR-183	CLIP-seq
MIRT2297286	hsa-miR-2276	CLIP-seq
MIRT2297287	hsa-miR-3924	CLIP-seq
MIRT2297288	hsa-miR-4642	CLIP-seq
MIRT2297289	hsa-miR-4696	CLIP-seq
MIRT2297290	hsa-miR-4762-3p	CLIP-seq
MIRT2297291	hsa-miR-4772-3p	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003785	Function	Actin monomer binding	IEA
GO:0005515	Function	Protein binding	IPI	20211142, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015630	Component	Microtubule cytoskeleton	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045171	Component	Intercellular bridge	IDA
GO:0051015	Function	Actin filament binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
613066	16714	ENSG00000165495

Q96KN3

Protein name

Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16493	Meis_PKNOX_N	96 → 181	N-terminal of Homeobox Meis and PKNOX1	Family
PF05920	Homeobox_KN	306 → 345	Homeobox KN domain	Family

Sequence

MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP
IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH
KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL
GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG
GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHAT
NIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAP
KAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQA
MMAAHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEHSDSLE

Sequence length

472

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CREUTZFELDT JACOB DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR POSITIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, FAMILIAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TESTICULAR CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TESTICULAR GERM CELL TUMOR	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autosomal dominant compelling helio ophthalmic outburst syndrome	Achoo syndrome	GWASCAT_DG	27182965	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	29159193, 31268414	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi Anemia	BEFREE	30515693	★★★★★ ★☆☆☆☆ Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	Anemia	BEFREE	30515693	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydrolethalus syndrome	Hydrolethalus Syndrome	BEFREE	15843405	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30745575	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30745575	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate cancer, familial	Prostate cancer	CTD_human_DG	29892016	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, HEREDITARY, 1	Prostate Cancer, Hereditary	CTD_human_DG	29892016	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	GWASCAT_DG	29892016	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	22648509	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	22648509	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30745575	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular Germ Cell Tumor	GWASCAT_DG	28604728	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

PKNOX2 (PBX/knotted 1 homeobox 2)