Gene Gene information from NCBI Gene database.
Entrez ID 63874
Gene name Abhydrolase domain containing 4, N-acyl phospholipase B
Gene symbol ABHD4
Synonyms (NCBI Gene)
ABH4
Chromosome 14
Chromosome location 14q11.2
miRNA miRNA information provided by mirtarbase database.
466
miRTarBase ID miRNA Experiments Reference
MIRT017840 hsa-miR-335-5p Microarray 18185580
MIRT019813 hsa-miR-375 Microarray 20215506
MIRT022630 hsa-miR-124-3p Microarray 18668037
MIRT482561 hsa-miR-4717-5p PAR-CLIP 23592263
MIRT482560 hsa-miR-4693-3p PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0004622 Function Phosphatidylcholine lysophospholipase activity IBA
GO:0005515 Function Protein binding IPI 32296183
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0005811 Component Lipid droplet IBA
GO:0006629 Process Lipid metabolic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619728 20154 ENSG00000100439
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TB40
Protein name (Lyso)-N-acylphosphatidylethanolamine lipase (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 4) (Abhydrolase domain-containing protein 4) (Alpha/beta-hydrolase 4)
Protein function Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethano
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00561 Abhydrolase_1 69 327 alpha/beta hydrolase fold Domain
Sequence
Sequence length 342
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Acyl chain remodelling of PE
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
VITILIGO GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Angina Unstable Angina pectoris Pubtator 34208452 Associate
★☆☆☆☆
Found in Text Mining only
Paraplegia Paraplegia Pubtator 31876103 Associate
★☆☆☆☆
Found in Text Mining only