Gene Gene information from NCBI Gene database.
Entrez ID 6352
Gene name C-C motif chemokine ligand 5
Gene symbol CCL5
Synonyms (NCBI Gene)
D17S136ERANTESSCYA5SIS-deltaSISdTCP228eoCP
Chromosome 17
Chromosome location 17q12
Summary This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the
miRNA miRNA information provided by mirtarbase database.
417
miRTarBase ID miRNA Experiments Reference
MIRT005677 hsa-miR-98-5p ELISA 20589685
MIRT005678 hsa-miR-125a-5p ELISA 20589685
MIRT053786 hsa-miR-214-3p ELISAImmunohistochemistryLuciferase reporter assayqRT-PCR 23171795
MIRT437504 hsa-miR-146a-5p Luciferase reporter assay 24996260
MIRT685370 hsa-miR-106a-5p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
16
Transcription factor Regulation Reference
ATF3 Unknown 10760799
CREB1 Unknown 11413310
IRF1 Unknown 10385645
IRF3 Unknown 10385645;20483755
IRF7 Unknown 10385645
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
104
GO ID Ontology Definition Evidence Reference
GO:0002407 Process Dendritic cell chemotaxis TAS 18337562
GO:0002548 Process Monocyte chemotaxis IC 10660125
GO:0002676 Process Regulation of chronic inflammatory response TAS 10488085
GO:0004435 Function Phosphatidylinositol-4,5-bisphosphate phospholipase C activity IDA 10734056
GO:0004672 Function Protein kinase activity IDA 10734056
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
187011 10632 ENSG00000271503
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P13501
Protein name C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Protein function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major
PDB 1B3A , 1EQT , 1HRJ , 1RTN , 1RTO , 1U4L , 1U4M , 1U4P , 1U4R , 2L9H , 2VXW , 5CMD , 5COY , 5DNF , 5L2U , 5UIW , 6AEZ , 6C6D , 6FGP , 6LOG , 6STK , 7F1R , 7O7F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 31 88 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the follicular fluid (at protein level). T-cell and macrophage specific. {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:2456327}.
Sequence
Sequence length 91
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
TNF signaling pathway
Prion disease
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Chagas disease
Human cytomegalovirus infection
Influenza A
Herpes simplex virus 1 infection
Rheumatoid arthritis
Lipid and atherosclerosis
  Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
22
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Human immunodeficiency virus type 1, rapid disease progression with infection by Pathogenic rs2280789 RCV000013577
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE CHRONIC HEPATITIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE HEPATITIS WITH CENTRILOBULAR NECROSIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BILIARY CIRRHOSIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acne Acne BEFREE 28193081
★☆☆☆☆
Found in Text Mining only
Acne Vulgaris Acne BEFREE 28193081
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 15927671
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 17207890
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 30834503
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 12473593, 17653092, 21978170, 31221150
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 30867568
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 19874825
★☆☆☆☆
Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma B-cell Lymphoma BEFREE 24938715
★☆☆☆☆
Found in Text Mining only
Adult Hodgkin Lymphoma Hodgkin Lymphoma BEFREE 21767511
★☆☆☆☆
Found in Text Mining only