Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6341
Gene name	Synthesis of cytochrome C oxidase 1
Gene symbol	SCO1
Synonyms (NCBI Gene)	MC4DN4SCOD1
Chromosome	17
Chromosome location	17p13.1
Summary	Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytoch

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SNP ID	Visualize variation	Clinical significance	Consequence
rs104894630	G>A	Pathogenic	Missense variant, coding sequence variant
rs587777220	C>T	Pathogenic	Coding sequence variant, missense variant
rs766454175	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs774730754	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant

356

Show/Hide all (356)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041476	hsa-miR-193b-3p	CLASH	23622248
MIRT696298	hsa-miR-942-3p	HITS-CLIP	23313552
MIRT696297	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT696296	hsa-miR-3926	HITS-CLIP	23313552
MIRT696295	hsa-miR-548s	HITS-CLIP	23313552
MIRT461583	hsa-miR-6753-5p	HITS-CLIP	23706177
MIRT461582	hsa-miR-1321	HITS-CLIP	23706177
MIRT461581	hsa-miR-4739	HITS-CLIP	23706177
MIRT461580	hsa-miR-4756-5p	HITS-CLIP	23706177
MIRT461579	hsa-miR-4270	HITS-CLIP	23706177
MIRT461578	hsa-miR-4441	HITS-CLIP	23706177
MIRT461577	hsa-miR-6754-5p	HITS-CLIP	23706177
MIRT461576	hsa-miR-7113-5p	HITS-CLIP	23706177
MIRT461575	hsa-miR-6134	HITS-CLIP	23706177
MIRT461574	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT461573	hsa-miR-6086	HITS-CLIP	23706177
MIRT677688	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT461572	hsa-miR-3689d	HITS-CLIP	23706177
MIRT461571	hsa-miR-6851-5p	HITS-CLIP	23706177
MIRT461569	hsa-miR-6880-5p	HITS-CLIP	23706177
MIRT461568	hsa-miR-7847-3p	HITS-CLIP	23706177
MIRT461567	hsa-miR-6807-5p	HITS-CLIP	23706177
MIRT461566	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681996	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT461565	hsa-miR-6808-5p	HITS-CLIP	23706177
MIRT677698	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT677697	hsa-miR-5693	HITS-CLIP	23824327
MIRT677696	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT677695	hsa-miR-1281	HITS-CLIP	23824327
MIRT677694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT677693	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT677692	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT677691	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT677690	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT677689	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT677688	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT677687	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677686	hsa-miR-4284	HITS-CLIP	23824327
MIRT677685	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT677684	hsa-miR-7641	HITS-CLIP	23824327
MIRT677683	hsa-miR-5698	HITS-CLIP	23824327
MIRT654011	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT654010	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT654009	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT654008	hsa-miR-3176	HITS-CLIP	23824327
MIRT654007	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT654006	hsa-miR-1291	HITS-CLIP	23824327
MIRT654005	hsa-miR-6775-3p	HITS-CLIP	23824327
MIRT654004	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT654003	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT344229	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT654002	hsa-miR-450b-3p	HITS-CLIP	23824327
MIRT654001	hsa-miR-769-3p	HITS-CLIP	23824327
MIRT654000	hsa-miR-6728-5p	HITS-CLIP	23824327
MIRT653999	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT638308	hsa-miR-5003-5p	HITS-CLIP	23824327
MIRT638307	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT638306	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT638305	hsa-miR-5087	HITS-CLIP	23824327
MIRT638304	hsa-miR-8068	HITS-CLIP	23824327
MIRT638303	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT540784	hsa-miR-5680	HITS-CLIP	23824327
MIRT616037	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT616036	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT616035	hsa-miR-2117	HITS-CLIP	23824327
MIRT616034	hsa-miR-4273	HITS-CLIP	23824327
MIRT616033	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT540786	hsa-miR-495-3p	PAR-CLIP	21572407
MIRT540785	hsa-miR-5688	PAR-CLIP	21572407
MIRT540784	hsa-miR-5680	PAR-CLIP	21572407
MIRT540783	hsa-miR-3914	PAR-CLIP	21572407
MIRT540782	hsa-miR-589-3p	PAR-CLIP	21572407
MIRT540781	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT540780	hsa-miR-6508-5p	PAR-CLIP	21572407
MIRT540779	hsa-miR-8067	PAR-CLIP	21572407
MIRT540778	hsa-miR-384	PAR-CLIP	21572407
MIRT519177	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT519176	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT519175	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT519174	hsa-miR-544b	PAR-CLIP	23446348
MIRT519173	hsa-miR-7162-3p	PAR-CLIP	23446348
MIRT519172	hsa-miR-4693-3p	PAR-CLIP	23446348
MIRT519171	hsa-miR-655-5p	PAR-CLIP	23446348
MIRT461574	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT461573	hsa-miR-6086	PAR-CLIP	23446348
MIRT497934	hsa-miR-4704-5p	PAR-CLIP	22291592
MIRT497933	hsa-miR-3117-5p	PAR-CLIP	22291592
MIRT497932	hsa-miR-498	PAR-CLIP	22291592
MIRT497931	hsa-miR-514a-3p	PAR-CLIP	22291592
MIRT497930	hsa-miR-514b-3p	PAR-CLIP	22291592
MIRT461583	hsa-miR-6753-5p	PAR-CLIP	23592263
MIRT461582	hsa-miR-1321	PAR-CLIP	23592263
MIRT461581	hsa-miR-4739	PAR-CLIP	23592263
MIRT461580	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT461579	hsa-miR-4270	PAR-CLIP	23592263
MIRT461578	hsa-miR-4441	PAR-CLIP	23592263
MIRT461577	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT461576	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT461575	hsa-miR-6134	PAR-CLIP	23592263
MIRT461574	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461573	hsa-miR-6086	PAR-CLIP	23592263
MIRT461572	hsa-miR-3689d	PAR-CLIP	23592263
MIRT461571	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT461570	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT461569	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT461568	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT461567	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT461566	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT461565	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT461582	hsa-miR-1321	PAR-CLIP	27292025
MIRT461582	hsa-miR-1321	PAR-CLIP	27292025
MIRT461579	hsa-miR-4270	PAR-CLIP	27292025
MIRT461579	hsa-miR-4270	PAR-CLIP	27292025
MIRT461578	hsa-miR-4441	PAR-CLIP	27292025
MIRT461578	hsa-miR-4441	PAR-CLIP	27292025
MIRT461581	hsa-miR-4739	PAR-CLIP	27292025
MIRT461581	hsa-miR-4739	PAR-CLIP	27292025
MIRT461580	hsa-miR-4756-5p	PAR-CLIP	27292025
MIRT461580	hsa-miR-4756-5p	PAR-CLIP	27292025
MIRT677688	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT681996	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT461583	hsa-miR-6753-5p	PAR-CLIP	27292025
MIRT461583	hsa-miR-6753-5p	PAR-CLIP	27292025
MIRT461577	hsa-miR-6754-5p	PAR-CLIP	27292025
MIRT461577	hsa-miR-6754-5p	PAR-CLIP	27292025
MIRT461570	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT461567	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT461567	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT461565	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT461565	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT461576	hsa-miR-7113-5p	PAR-CLIP	27292025
MIRT461576	hsa-miR-7113-5p	PAR-CLIP	27292025
MIRT696298	hsa-miR-942-3p	HITS-CLIP	23313552
MIRT696297	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT696296	hsa-miR-3926	HITS-CLIP	23313552
MIRT696295	hsa-miR-548s	HITS-CLIP	23313552
MIRT461583	hsa-miR-6753-5p	HITS-CLIP	23706177
MIRT461582	hsa-miR-1321	HITS-CLIP	23706177
MIRT461581	hsa-miR-4739	HITS-CLIP	23706177
MIRT461580	hsa-miR-4756-5p	HITS-CLIP	23706177
MIRT461579	hsa-miR-4270	HITS-CLIP	23706177
MIRT461578	hsa-miR-4441	HITS-CLIP	23706177
MIRT461577	hsa-miR-6754-5p	HITS-CLIP	23706177
MIRT461576	hsa-miR-7113-5p	HITS-CLIP	23706177
MIRT461575	hsa-miR-6134	HITS-CLIP	23706177
MIRT461574	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT461573	hsa-miR-6086	HITS-CLIP	23706177
MIRT677688	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT461572	hsa-miR-3689d	HITS-CLIP	23706177
MIRT461571	hsa-miR-6851-5p	HITS-CLIP	23706177
MIRT461569	hsa-miR-6880-5p	HITS-CLIP	23706177
MIRT461568	hsa-miR-7847-3p	HITS-CLIP	23706177
MIRT461567	hsa-miR-6807-5p	HITS-CLIP	23706177
MIRT461566	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681996	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT461565	hsa-miR-6808-5p	HITS-CLIP	23706177
MIRT677698	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT677697	hsa-miR-5693	HITS-CLIP	23824327
MIRT677696	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT677695	hsa-miR-1281	HITS-CLIP	23824327
MIRT677694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT677693	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT677692	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT677691	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT677690	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT677689	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT677688	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT677687	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677686	hsa-miR-4284	HITS-CLIP	23824327
MIRT677685	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT677684	hsa-miR-7641	HITS-CLIP	23824327
MIRT677683	hsa-miR-5698	HITS-CLIP	23824327
MIRT654011	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT654010	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT654009	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT654008	hsa-miR-3176	HITS-CLIP	23824327
MIRT654007	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT654006	hsa-miR-1291	HITS-CLIP	23824327
MIRT654005	hsa-miR-6775-3p	HITS-CLIP	23824327
MIRT654004	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT654003	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT344229	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT654002	hsa-miR-450b-3p	HITS-CLIP	23824327
MIRT654001	hsa-miR-769-3p	HITS-CLIP	23824327
MIRT654000	hsa-miR-6728-5p	HITS-CLIP	23824327
MIRT653999	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT638308	hsa-miR-5003-5p	HITS-CLIP	23824327
MIRT638307	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT638306	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT638305	hsa-miR-5087	HITS-CLIP	23824327
MIRT638304	hsa-miR-8068	HITS-CLIP	23824327
MIRT638303	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT540784	hsa-miR-5680	HITS-CLIP	23824327
MIRT616037	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT616036	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT616035	hsa-miR-2117	HITS-CLIP	23824327
MIRT616034	hsa-miR-4273	HITS-CLIP	23824327
MIRT616033	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT540786	hsa-miR-495-3p	PAR-CLIP	21572407
MIRT540785	hsa-miR-5688	PAR-CLIP	21572407
MIRT540784	hsa-miR-5680	PAR-CLIP	21572407
MIRT540783	hsa-miR-3914	PAR-CLIP	21572407
MIRT540782	hsa-miR-589-3p	PAR-CLIP	21572407
MIRT540781	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT540780	hsa-miR-6508-5p	PAR-CLIP	21572407
MIRT540779	hsa-miR-8067	PAR-CLIP	21572407
MIRT540778	hsa-miR-384	PAR-CLIP	21572407
MIRT519177	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT519176	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT519175	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT519174	hsa-miR-544b	PAR-CLIP	23446348
MIRT519173	hsa-miR-7162-3p	PAR-CLIP	23446348
MIRT519172	hsa-miR-4693-3p	PAR-CLIP	23446348
MIRT519171	hsa-miR-655-5p	PAR-CLIP	23446348
MIRT461574	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT461573	hsa-miR-6086	PAR-CLIP	23446348
MIRT497934	hsa-miR-4704-5p	PAR-CLIP	22291592
MIRT497933	hsa-miR-3117-5p	PAR-CLIP	22291592
MIRT497932	hsa-miR-498	PAR-CLIP	22291592
MIRT497931	hsa-miR-514a-3p	PAR-CLIP	22291592
MIRT497930	hsa-miR-514b-3p	PAR-CLIP	22291592
MIRT461583	hsa-miR-6753-5p	PAR-CLIP	23592263
MIRT461582	hsa-miR-1321	PAR-CLIP	23592263
MIRT461581	hsa-miR-4739	PAR-CLIP	23592263
MIRT461580	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT461579	hsa-miR-4270	PAR-CLIP	23592263
MIRT461578	hsa-miR-4441	PAR-CLIP	23592263
MIRT461577	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT461576	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT461575	hsa-miR-6134	PAR-CLIP	23592263
MIRT461574	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461573	hsa-miR-6086	PAR-CLIP	23592263
MIRT461572	hsa-miR-3689d	PAR-CLIP	23592263
MIRT461571	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT461570	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT461569	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT461568	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT461567	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT461566	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT461565	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT1330463	hsa-miR-141	CLIP-seq
MIRT1330464	hsa-miR-200a	CLIP-seq
MIRT1330465	hsa-miR-200b	CLIP-seq
MIRT1330466	hsa-miR-200c	CLIP-seq
MIRT1330467	hsa-miR-217	CLIP-seq
MIRT1330468	hsa-miR-298	CLIP-seq
MIRT1330469	hsa-miR-3123	CLIP-seq
MIRT1330470	hsa-miR-3133	CLIP-seq
MIRT1330471	hsa-miR-3137	CLIP-seq
MIRT1330472	hsa-miR-324-5p	CLIP-seq
MIRT1330473	hsa-miR-335	CLIP-seq
MIRT1330474	hsa-miR-338-3p	CLIP-seq
MIRT1330475	hsa-miR-3667-3p	CLIP-seq
MIRT1330476	hsa-miR-3686	CLIP-seq
MIRT1330477	hsa-miR-3688-3p	CLIP-seq
MIRT1330478	hsa-miR-3925-5p	CLIP-seq
MIRT1330479	hsa-miR-3973	CLIP-seq
MIRT1330480	hsa-miR-429	CLIP-seq
MIRT1330481	hsa-miR-4307	CLIP-seq
MIRT1330482	hsa-miR-4310	CLIP-seq
MIRT1330483	hsa-miR-4418	CLIP-seq
MIRT1330484	hsa-miR-4493	CLIP-seq
MIRT1330485	hsa-miR-451b	CLIP-seq
MIRT1330486	hsa-miR-4530	CLIP-seq
MIRT1330487	hsa-miR-4636	CLIP-seq
MIRT1330488	hsa-miR-4712-5p	CLIP-seq
MIRT1330489	hsa-miR-4732-5p	CLIP-seq
MIRT1330490	hsa-miR-4753-5p	CLIP-seq
MIRT1330491	hsa-miR-4766-3p	CLIP-seq
MIRT1330492	hsa-miR-4778-5p	CLIP-seq
MIRT1330493	hsa-miR-509-3-5p	CLIP-seq
MIRT1330494	hsa-miR-509-5p	CLIP-seq
MIRT1330495	hsa-miR-510	CLIP-seq
MIRT1330496	hsa-miR-512-5p	CLIP-seq
MIRT1330497	hsa-miR-539	CLIP-seq
MIRT1330498	hsa-miR-548b-3p	CLIP-seq
MIRT1330499	hsa-miR-548c-3p	CLIP-seq
MIRT1330500	hsa-miR-548k	CLIP-seq
MIRT1330501	hsa-miR-548m	CLIP-seq
MIRT1330502	hsa-miR-563	CLIP-seq
MIRT1330503	hsa-miR-582-5p	CLIP-seq
MIRT1330504	hsa-miR-659	CLIP-seq
MIRT1330505	hsa-miR-770-5p	CLIP-seq
MIRT1330506	hsa-miR-887	CLIP-seq
MIRT2097852	hsa-miR-2054	CLIP-seq
MIRT1330471	hsa-miR-3137	CLIP-seq
MIRT2097853	hsa-miR-3192	CLIP-seq
MIRT1330475	hsa-miR-3667-3p	CLIP-seq
MIRT1330476	hsa-miR-3686	CLIP-seq
MIRT2097854	hsa-miR-3692	CLIP-seq
MIRT2097855	hsa-miR-3940-5p	CLIP-seq
MIRT2097856	hsa-miR-412	CLIP-seq
MIRT2097857	hsa-miR-4258	CLIP-seq
MIRT1330481	hsa-miR-4307	CLIP-seq
MIRT2097858	hsa-miR-4417	CLIP-seq
MIRT2097859	hsa-miR-4420	CLIP-seq
MIRT2097860	hsa-miR-4437	CLIP-seq
MIRT1330484	hsa-miR-4493	CLIP-seq
MIRT2097861	hsa-miR-4507	CLIP-seq
MIRT1330485	hsa-miR-451b	CLIP-seq
MIRT2097862	hsa-miR-4674	CLIP-seq
MIRT1330489	hsa-miR-4732-5p	CLIP-seq
MIRT1330490	hsa-miR-4753-5p	CLIP-seq
MIRT1330492	hsa-miR-4778-5p	CLIP-seq
MIRT2097863	hsa-miR-541	CLIP-seq
MIRT2097864	hsa-miR-552	CLIP-seq
MIRT2097865	hsa-miR-654-5p	CLIP-seq
MIRT2097866	hsa-miR-892b	CLIP-seq
MIRT1330463	hsa-miR-141	CLIP-seq
MIRT1330464	hsa-miR-200a	CLIP-seq
MIRT1330465	hsa-miR-200b	CLIP-seq
MIRT1330466	hsa-miR-200c	CLIP-seq
MIRT1330467	hsa-miR-217	CLIP-seq
MIRT1330468	hsa-miR-298	CLIP-seq
MIRT1330469	hsa-miR-3123	CLIP-seq
MIRT1330470	hsa-miR-3133	CLIP-seq
MIRT1330471	hsa-miR-3137	CLIP-seq
MIRT1330472	hsa-miR-324-5p	CLIP-seq
MIRT1330474	hsa-miR-338-3p	CLIP-seq
MIRT1330475	hsa-miR-3667-3p	CLIP-seq
MIRT1330476	hsa-miR-3686	CLIP-seq
MIRT1330478	hsa-miR-3925-5p	CLIP-seq
MIRT2322191	hsa-miR-3941	CLIP-seq
MIRT1330479	hsa-miR-3973	CLIP-seq
MIRT1330480	hsa-miR-429	CLIP-seq
MIRT1330481	hsa-miR-4307	CLIP-seq
MIRT1330483	hsa-miR-4418	CLIP-seq
MIRT1330484	hsa-miR-4493	CLIP-seq
MIRT1330485	hsa-miR-451b	CLIP-seq
MIRT1330486	hsa-miR-4530	CLIP-seq
MIRT2322192	hsa-miR-466	CLIP-seq
MIRT2322193	hsa-miR-4672	CLIP-seq
MIRT1330488	hsa-miR-4712-5p	CLIP-seq
MIRT2322194	hsa-miR-4731-3p	CLIP-seq
MIRT1330489	hsa-miR-4732-5p	CLIP-seq
MIRT1330490	hsa-miR-4753-5p	CLIP-seq
MIRT1330491	hsa-miR-4766-3p	CLIP-seq
MIRT1330492	hsa-miR-4778-5p	CLIP-seq
MIRT2322195	hsa-miR-4801	CLIP-seq
MIRT1330493	hsa-miR-509-3-5p	CLIP-seq
MIRT1330494	hsa-miR-509-5p	CLIP-seq
MIRT1330497	hsa-miR-539	CLIP-seq
MIRT1330498	hsa-miR-548b-3p	CLIP-seq
MIRT1330500	hsa-miR-548k	CLIP-seq
MIRT1330505	hsa-miR-770-5p	CLIP-seq
MIRT2097866	hsa-miR-892b	CLIP-seq
MIRT2394099	hsa-miR-4427	CLIP-seq
MIRT2394100	hsa-miR-4680-3p	CLIP-seq
MIRT2394101	hsa-miR-4714-5p	CLIP-seq
MIRT2394102	hsa-miR-4790-3p	CLIP-seq
MIRT1330469	hsa-miR-3123	CLIP-seq
MIRT1330470	hsa-miR-3133	CLIP-seq
MIRT1330478	hsa-miR-3925-5p	CLIP-seq
MIRT1330498	hsa-miR-548b-3p	CLIP-seq
MIRT1330499	hsa-miR-548c-3p	CLIP-seq
MIRT1330499	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005507	Function	Copper ion binding	IEA
GO:0005515	Function	Protein binding	IPI	18458339, 24403053, 26160915, 28330871, 29154948, 29381136, 29568061, 32296183, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	9878253
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	15229189
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006878	Process	Intracellular copper ion homeostasis	IEA
GO:0008535	Process	Respiratory chain complex IV assembly	IEA
GO:0016020	Component	Membrane	IEA
GO:0016531	Function	Copper chaperone activity	IEA
GO:0030016	Component	Myofibril	IDA	20864674
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IBA
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IEA
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IMP	15229189
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
603644	10603	ENSG00000133028

O75880

Protein name

Protein SCO1 homolog, mitochondrial

Protein function

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved i

PDB

1WP0 , 2GGT , 2GQK , 2GQL , 2GQM , 2GT5 , 2GT6 , 2GVP , 2HRF , 2HRN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02630	SCO1-SenC	137 → 273	SCO1/SenC	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain. {ECO:0000269|PubMed:9878253}.

Sequence

MAMLVLVPGRVMRPLGGQLWRFLPRGLEFWGPAEGTARVLLRQFCARQAEAWRASGRPGY
CLGTRPLSTARPPPPWSQKGPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKA
EKLEKERQRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKM
IQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARA
YRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKK
S

Sequence length

301

Interactions

View interactions

	Reactome
			TP53 Regulates Metabolic Genes Respiratory electron transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Mitochondrial complex IV deficiency, nuclear type 1	Pathogenic	rs1176555010	RCV001336710	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Mitochondrial complex IV deficiency, nuclear type 4	Pathogenic; Likely pathogenic	rs587777220, rs587776629, rs104894630, rs766454175, rs770131276	RCV000106300 RCV000006554 RCV000006555 RCV004800369 RCV001536014	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BRAIN DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CYTOCHROME-C OXIDASE DEFICIENCY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FATAL INFANTILE CYTOCHROME C OXIDASE DEFICIENCY	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Infantile encephalopathy	not provided; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leigh syndrome	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER FAILURE, ACUTE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL DISEASE	—	ClinGen, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCO1-related disorder	Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (51)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adult Fanconi syndrome	Fanconi syndrome	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	1672728, 8100139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	11013136, 19295170	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Byzanthine arch palate	High palate	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency	Cardioencephalomyopathy	ORPHANET_DG	11013136, 19295170, 23878101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	25792727		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	28330871	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Hypertrophic	Hypertrophic cardiomyopathy	Pubtator	19295170	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Clumsiness - motor delay	Motor delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cytochrome c Oxidase Deficiency	Cytochrome c oxidase deficiency	Pubtator	11013136	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	BEFREE	11013136, 11027508, 20864674, 23878101		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	UNIPROT_DG	11013136, 17182746, 17189203, 19336478		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	GENOMICS_ENGLAND_DG	15023375, 19353847		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	CTD_human_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	CLINVAR_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	1672728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28647369		★★★★★ ★☆☆☆☆ Found in Text Mining only
Electron Transport Chain Deficiencies, Mitochondrial	Mitochondrial Electron Transport Chain Deficiencies	CTD_human_DG	17182746		★★★★★ ★☆☆☆☆ Found in Text Mining only
Encephalopathies	Epileptic encephalopathy	BEFREE	11013136, 23878101, 31352446		★★★★★ ★☆☆☆☆ Found in Text Mining only
Encephalopathies	Epileptic encephalopathy	CTD_human_DG	23345593		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatal infantile cytochrome C oxidase deficiency	Fatal Cytochrome C Oxidase Deficiency	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma	Glioblastoma	BEFREE	20683904		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	20683904		★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart Diseases	CTD_human_DG	23345593		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	19295170, 23878101, 28973536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertrophic obstructive cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	19295170, 23878101, 28973536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypocupremia	Hypocupremia	BEFREE	28647369		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukoencephalopathy	Leukoencephalopathy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	BEFREE	11013136, 11579424		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	Pubtator	11013136	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure, Acute	Liver failure	CTD_human_DG	20864674		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	1672728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial Diseases	CTD_human_DG	17182746		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial Diseases	Mitochondrial Diseases	BEFREE	20864674, 31352446		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial Diseases	Mitochondrial Diseases	GENOMICS_ENGLAND_DG	27604308		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial Respiratory Chain Deficiencies	Mitochondrial Respiratory Chain Deficiencies	CTD_human_DG	17182746		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myasthenia Gravis	Myasthenia Gravis	BEFREE	1672728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Oxidative Phosphorylation Deficiencies	Oxidative Phosphorylation Deficiency	CTD_human_DG	17182746		★★★★★ ★☆☆☆☆ Found in Text Mining only
Phosphate Diabetes	Phosphate Diabetes	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	39324181	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal tubular disorder	Renal Tubular Disorder	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis Pigmentosa	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Spinocerebellar Ataxias	Spinocerebellar ataxia	Pubtator	19295170	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SCO1 (synthesis of cytochrome C oxidase 1)