SCN2B (sodium voltage-gated channel beta subunit 2)

Gene

• Entrez ID: 6327
• Gene name: Sodium voltage-gated channel beta subunit 2
• Gene symbol: SCN2B
• Synonyms (NCBI Gene): ATFB14
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs17121819	G>A	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs72544145	C>T	Pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT699822	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT699821	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT699820	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT699819	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT699818	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT699817	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT699816	hsa-miR-1976	HITS-CLIP	23313552
MIRT699815	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT699814	hsa-miR-4279	HITS-CLIP	23313552
MIRT699813	hsa-miR-5585-3p	HITS-CLIP	23313552
MIRT641418	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT641417	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT641416	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT641415	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT641414	hsa-miR-4770	HITS-CLIP	23824327
MIRT641413	hsa-miR-6088	HITS-CLIP	23824327
MIRT641412	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT641411	hsa-miR-1273f	HITS-CLIP	23824327
MIRT641410	hsa-miR-4534	HITS-CLIP	23824327
MIRT641409	hsa-miR-8082	HITS-CLIP	23824327
MIRT641408	hsa-miR-1289	HITS-CLIP	23824327
MIRT641407	hsa-miR-4294	HITS-CLIP	23824327
MIRT641406	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT641405	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT641404	hsa-miR-3198	HITS-CLIP	23824327
MIRT641403	hsa-miR-4309	HITS-CLIP	23824327
MIRT641402	hsa-miR-8055	HITS-CLIP	23824327
MIRT641401	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT641418	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT641415	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT641414	hsa-miR-4770	HITS-CLIP	23824327
MIRT641413	hsa-miR-6088	HITS-CLIP	23824327
MIRT641412	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT641411	hsa-miR-1273f	HITS-CLIP	23824327
MIRT641410	hsa-miR-4534	HITS-CLIP	23824327
MIRT641409	hsa-miR-8082	HITS-CLIP	23824327
MIRT641408	hsa-miR-1289	HITS-CLIP	23824327
MIRT641407	hsa-miR-4294	HITS-CLIP	23824327
MIRT641404	hsa-miR-3198	HITS-CLIP	23824327
MIRT641403	hsa-miR-4309	HITS-CLIP	23824327
MIRT641402	hsa-miR-8055	HITS-CLIP	23824327
MIRT641401	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT654020	hsa-miR-4640-3p	HITS-CLIP	23824327
MIRT654019	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT654018	hsa-miR-4421	HITS-CLIP	23824327
MIRT654016	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT654017	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT654015	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT654014	hsa-miR-7975	HITS-CLIP	23824327
MIRT654013	hsa-miR-3685	HITS-CLIP	23824327
MIRT654012	hsa-miR-384	HITS-CLIP	23824327
MIRT641418	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT641417	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT641416	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT641415	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT641414	hsa-miR-4770	HITS-CLIP	23824327
MIRT641413	hsa-miR-6088	HITS-CLIP	23824327
MIRT641412	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT641411	hsa-miR-1273f	HITS-CLIP	23824327
MIRT641410	hsa-miR-4534	HITS-CLIP	23824327
MIRT641409	hsa-miR-8082	HITS-CLIP	23824327
MIRT641408	hsa-miR-1289	HITS-CLIP	23824327
MIRT641407	hsa-miR-4294	HITS-CLIP	23824327
MIRT641406	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT641405	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT641404	hsa-miR-3198	HITS-CLIP	23824327
MIRT641403	hsa-miR-4309	HITS-CLIP	23824327
MIRT641402	hsa-miR-8055	HITS-CLIP	23824327
MIRT641401	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT500043	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT500042	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT570100	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT570099	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT570098	hsa-miR-4489	PAR-CLIP	20371350
MIRT570097	hsa-miR-4283	PAR-CLIP	20371350
MIRT570096	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT570095	hsa-miR-3151-5p	PAR-CLIP	20371350
MIRT570094	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT500042	hsa-miR-4746-3p	PAR-CLIP	20371350
MIRT570100	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT570099	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT570098	hsa-miR-4489	PAR-CLIP	20371350
MIRT570097	hsa-miR-4283	PAR-CLIP	20371350
MIRT570096	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT570095	hsa-miR-3151-5p	PAR-CLIP	20371350
MIRT570094	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT500042	hsa-miR-4746-3p	PAR-CLIP	22012620
MIRT500043	hsa-miR-4708-3p	PAR-CLIP	24398324
MIRT500042	hsa-miR-4746-3p	PAR-CLIP	24398324
MIRT641411	hsa-miR-1273f	HITS-CLIP	27418678
MIRT641408	hsa-miR-1289	HITS-CLIP	27418678
MIRT641408	hsa-miR-1289	HITS-CLIP	27418678
MIRT641401	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT641415	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT641415	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT641404	hsa-miR-3198	HITS-CLIP	27418678
MIRT641404	hsa-miR-3198	HITS-CLIP	27418678
MIRT641407	hsa-miR-4294	HITS-CLIP	27418678
MIRT641407	hsa-miR-4294	HITS-CLIP	27418678
MIRT641403	hsa-miR-4309	HITS-CLIP	27418678
MIRT641403	hsa-miR-4309	HITS-CLIP	27418678
MIRT641410	hsa-miR-4534	HITS-CLIP	27418678
MIRT641410	hsa-miR-4534	HITS-CLIP	27418678
MIRT641412	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT641414	hsa-miR-4770	HITS-CLIP	27418678
MIRT641414	hsa-miR-4770	HITS-CLIP	27418678
MIRT641413	hsa-miR-6088	HITS-CLIP	27418678
MIRT641413	hsa-miR-6088	HITS-CLIP	27418678
MIRT641418	hsa-miR-6514-5p	HITS-CLIP	27418678
MIRT641418	hsa-miR-6514-5p	HITS-CLIP	27418678
MIRT641416	hsa-miR-6817-3p	HITS-CLIP	27418678
MIRT641405	hsa-miR-6873-3p	HITS-CLIP	27418678
MIRT641406	hsa-miR-6895-3p	HITS-CLIP	27418678
MIRT641417	hsa-miR-7110-3p	HITS-CLIP	27418678
MIRT641402	hsa-miR-8055	HITS-CLIP	27418678
MIRT641402	hsa-miR-8055	HITS-CLIP	27418678
MIRT641409	hsa-miR-8082	HITS-CLIP	27418678
MIRT641409	hsa-miR-8082	HITS-CLIP	27418678
MIRT699822	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT699821	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT699820	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT699819	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT699818	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT699817	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT699816	hsa-miR-1976	HITS-CLIP	23313552
MIRT699815	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT699814	hsa-miR-4279	HITS-CLIP	23313552
MIRT699813	hsa-miR-5585-3p	HITS-CLIP	23313552
MIRT641418	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT641417	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT641416	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT641415	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT641414	hsa-miR-4770	HITS-CLIP	23824327
MIRT641413	hsa-miR-6088	HITS-CLIP	23824327
MIRT641412	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT641411	hsa-miR-1273f	HITS-CLIP	23824327
MIRT641410	hsa-miR-4534	HITS-CLIP	23824327
MIRT641409	hsa-miR-8082	HITS-CLIP	23824327
MIRT641408	hsa-miR-1289	HITS-CLIP	23824327
MIRT641407	hsa-miR-4294	HITS-CLIP	23824327
MIRT641406	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT641405	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT641404	hsa-miR-3198	HITS-CLIP	23824327
MIRT641403	hsa-miR-4309	HITS-CLIP	23824327
MIRT641402	hsa-miR-8055	HITS-CLIP	23824327
MIRT641401	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT641418	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT641415	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT641414	hsa-miR-4770	HITS-CLIP	23824327
MIRT641413	hsa-miR-6088	HITS-CLIP	23824327
MIRT641412	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT641411	hsa-miR-1273f	HITS-CLIP	23824327
MIRT641410	hsa-miR-4534	HITS-CLIP	23824327
MIRT641409	hsa-miR-8082	HITS-CLIP	23824327
MIRT641408	hsa-miR-1289	HITS-CLIP	23824327
MIRT641407	hsa-miR-4294	HITS-CLIP	23824327
MIRT641404	hsa-miR-3198	HITS-CLIP	23824327
MIRT641403	hsa-miR-4309	HITS-CLIP	23824327
MIRT641402	hsa-miR-8055	HITS-CLIP	23824327
MIRT641401	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT654020	hsa-miR-4640-3p	HITS-CLIP	23824327
MIRT654019	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT654018	hsa-miR-4421	HITS-CLIP	23824327
MIRT654016	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT654017	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT654015	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT654014	hsa-miR-7975	HITS-CLIP	23824327
MIRT654013	hsa-miR-3685	HITS-CLIP	23824327
MIRT654012	hsa-miR-384	HITS-CLIP	23824327
MIRT641418	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT641417	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT641416	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT641415	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT641414	hsa-miR-4770	HITS-CLIP	23824327
MIRT641413	hsa-miR-6088	HITS-CLIP	23824327
MIRT641412	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT641411	hsa-miR-1273f	HITS-CLIP	23824327
MIRT641410	hsa-miR-4534	HITS-CLIP	23824327
MIRT641409	hsa-miR-8082	HITS-CLIP	23824327
MIRT641408	hsa-miR-1289	HITS-CLIP	23824327
MIRT641407	hsa-miR-4294	HITS-CLIP	23824327
MIRT641406	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT641405	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT641404	hsa-miR-3198	HITS-CLIP	23824327
MIRT641403	hsa-miR-4309	HITS-CLIP	23824327
MIRT641402	hsa-miR-8055	HITS-CLIP	23824327
MIRT641401	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT500043	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT500042	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT570100	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT570099	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT570098	hsa-miR-4489	PAR-CLIP	20371350
MIRT570097	hsa-miR-4283	PAR-CLIP	20371350
MIRT570096	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT570095	hsa-miR-3151-5p	PAR-CLIP	20371350
MIRT570094	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT500042	hsa-miR-4746-3p	PAR-CLIP	20371350
MIRT570100	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT570099	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT570098	hsa-miR-4489	PAR-CLIP	20371350
MIRT570097	hsa-miR-4283	PAR-CLIP	20371350
MIRT570096	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT570095	hsa-miR-3151-5p	PAR-CLIP	20371350
MIRT570094	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT500042	hsa-miR-4746-3p	PAR-CLIP	22012620
MIRT500043	hsa-miR-4708-3p	PAR-CLIP	24398324
MIRT500042	hsa-miR-4746-3p	PAR-CLIP	24398324
MIRT1329822	hsa-miR-1	CLIP-seq
MIRT1329823	hsa-miR-106a	CLIP-seq
MIRT1329824	hsa-miR-106b	CLIP-seq
MIRT1329825	hsa-miR-1179	CLIP-seq
MIRT1329826	hsa-miR-1205	CLIP-seq
MIRT1329827	hsa-miR-1207-5p	CLIP-seq
MIRT1329828	hsa-miR-1208	CLIP-seq
MIRT1329829	hsa-miR-1229	CLIP-seq
MIRT1329830	hsa-miR-1233	CLIP-seq
MIRT1329831	hsa-miR-1254	CLIP-seq
MIRT1329832	hsa-miR-1275	CLIP-seq
MIRT1329833	hsa-miR-129-3p	CLIP-seq
MIRT1329834	hsa-miR-1343	CLIP-seq
MIRT1329835	hsa-miR-149	CLIP-seq
MIRT1329836	hsa-miR-150	CLIP-seq
MIRT1329837	hsa-miR-17	CLIP-seq
MIRT1329838	hsa-miR-1827	CLIP-seq
MIRT1329839	hsa-miR-188-5p	CLIP-seq
MIRT1329840	hsa-miR-1909	CLIP-seq
MIRT1329841	hsa-miR-1913	CLIP-seq
MIRT1329842	hsa-miR-204	CLIP-seq
MIRT1329843	hsa-miR-206	CLIP-seq
MIRT1329844	hsa-miR-20a	CLIP-seq
MIRT1329845	hsa-miR-20b	CLIP-seq
MIRT1329846	hsa-miR-211	CLIP-seq
MIRT1329847	hsa-miR-219-2-3p	CLIP-seq
MIRT1329848	hsa-miR-2392	CLIP-seq
MIRT1329849	hsa-miR-24	CLIP-seq
MIRT1329850	hsa-miR-2467-5p	CLIP-seq
MIRT1329851	hsa-miR-2964a-3p	CLIP-seq
MIRT1329852	hsa-miR-302a	CLIP-seq
MIRT1329853	hsa-miR-302b	CLIP-seq
MIRT1329854	hsa-miR-302c	CLIP-seq
MIRT1329855	hsa-miR-302d	CLIP-seq
MIRT1329856	hsa-miR-302e	CLIP-seq
MIRT1329857	hsa-miR-3064-5p	CLIP-seq
MIRT1329858	hsa-miR-3065-3p	CLIP-seq
MIRT1329859	hsa-miR-3074-5p	CLIP-seq
MIRT1329860	hsa-miR-3116	CLIP-seq
MIRT1329861	hsa-miR-3140-3p	CLIP-seq
MIRT1329862	hsa-miR-3141	CLIP-seq
MIRT1329863	hsa-miR-3143	CLIP-seq
MIRT1329864	hsa-miR-3176	CLIP-seq
MIRT1329865	hsa-miR-3180-5p	CLIP-seq
MIRT1329866	hsa-miR-3184	CLIP-seq
MIRT1329867	hsa-miR-3192	CLIP-seq
MIRT1329868	hsa-miR-324-3p	CLIP-seq
MIRT1329869	hsa-miR-335	CLIP-seq
MIRT1329870	hsa-miR-3612	CLIP-seq
MIRT1329871	hsa-miR-3652	CLIP-seq
MIRT1329872	hsa-miR-3665	CLIP-seq
MIRT1329873	hsa-miR-3673	CLIP-seq
MIRT1329874	hsa-miR-3679-3p	CLIP-seq
MIRT1329875	hsa-miR-3689a-3p	CLIP-seq
MIRT1329876	hsa-miR-3689c	CLIP-seq
MIRT1329877	hsa-miR-3691-3p	CLIP-seq
MIRT1329878	hsa-miR-372	CLIP-seq
MIRT1329879	hsa-miR-373	CLIP-seq
MIRT1329880	hsa-miR-378g	CLIP-seq
MIRT1329881	hsa-miR-3918	CLIP-seq
MIRT1329882	hsa-miR-3922-3p	CLIP-seq
MIRT1329883	hsa-miR-3929	CLIP-seq
MIRT1329884	hsa-miR-423-5p	CLIP-seq
MIRT1329885	hsa-miR-4252	CLIP-seq
MIRT1329886	hsa-miR-4263	CLIP-seq
MIRT1329887	hsa-miR-4268	CLIP-seq
MIRT1329888	hsa-miR-4269	CLIP-seq
MIRT1329889	hsa-miR-4274	CLIP-seq
MIRT1329890	hsa-miR-4284	CLIP-seq
MIRT1329891	hsa-miR-4300	CLIP-seq
MIRT1329892	hsa-miR-4323	CLIP-seq
MIRT1329893	hsa-miR-4419b	CLIP-seq
MIRT1329894	hsa-miR-4420	CLIP-seq
MIRT1329895	hsa-miR-4430	CLIP-seq
MIRT1329896	hsa-miR-4437	CLIP-seq
MIRT1329897	hsa-miR-4438	CLIP-seq
MIRT1329898	hsa-miR-4446-5p	CLIP-seq
MIRT1329899	hsa-miR-4478	CLIP-seq
MIRT1329900	hsa-miR-4492	CLIP-seq
MIRT1329901	hsa-miR-4498	CLIP-seq
MIRT1329902	hsa-miR-4505	CLIP-seq
MIRT1329903	hsa-miR-4514	CLIP-seq
MIRT1329904	hsa-miR-4525	CLIP-seq
MIRT1329905	hsa-miR-4530	CLIP-seq
MIRT1329906	hsa-miR-4660	CLIP-seq
MIRT1329907	hsa-miR-4665-5p	CLIP-seq
MIRT1329908	hsa-miR-4674	CLIP-seq
MIRT1329909	hsa-miR-4680-3p	CLIP-seq
MIRT1329910	hsa-miR-4681	CLIP-seq
MIRT1329911	hsa-miR-4692	CLIP-seq
MIRT1329912	hsa-miR-4709-3p	CLIP-seq
MIRT1329913	hsa-miR-4723-5p	CLIP-seq
MIRT1329914	hsa-miR-4728-5p	CLIP-seq
MIRT1329915	hsa-miR-4731-5p	CLIP-seq
MIRT1329916	hsa-miR-4736	CLIP-seq
MIRT1329917	hsa-miR-4749-3p	CLIP-seq
MIRT1329918	hsa-miR-4763-3p	CLIP-seq
MIRT1329919	hsa-miR-4768-5p	CLIP-seq
MIRT1329920	hsa-miR-4786-3p	CLIP-seq
MIRT1329921	hsa-miR-4793-5p	CLIP-seq
MIRT1329922	hsa-miR-485-5p	CLIP-seq
MIRT1329923	hsa-miR-5095	CLIP-seq
MIRT1329924	hsa-miR-512-3p	CLIP-seq
MIRT1329925	hsa-miR-518a-3p	CLIP-seq
MIRT1329926	hsa-miR-518b	CLIP-seq
MIRT1329927	hsa-miR-518c	CLIP-seq
MIRT1329928	hsa-miR-518d-3p	CLIP-seq
MIRT1329929	hsa-miR-518f	CLIP-seq
MIRT1329930	hsa-miR-519a	CLIP-seq
MIRT1329931	hsa-miR-519b-3p	CLIP-seq
MIRT1329932	hsa-miR-519c-3p	CLIP-seq
MIRT1329933	hsa-miR-519d	CLIP-seq
MIRT1329934	hsa-miR-520a-3p	CLIP-seq
MIRT1329935	hsa-miR-520a-5p	CLIP-seq
MIRT1329936	hsa-miR-520b	CLIP-seq
MIRT1329937	hsa-miR-520c-3p	CLIP-seq
MIRT1329938	hsa-miR-520d-3p	CLIP-seq
MIRT1329939	hsa-miR-520e	CLIP-seq
MIRT1329940	hsa-miR-520g	CLIP-seq
MIRT1329941	hsa-miR-520h	CLIP-seq
MIRT1329942	hsa-miR-525-5p	CLIP-seq
MIRT1329943	hsa-miR-550a	CLIP-seq
MIRT1329944	hsa-miR-578	CLIP-seq
MIRT1329945	hsa-miR-604	CLIP-seq
MIRT1329946	hsa-miR-613	CLIP-seq
MIRT1329947	hsa-miR-625	CLIP-seq
MIRT1329948	hsa-miR-637	CLIP-seq
MIRT1329949	hsa-miR-643	CLIP-seq
MIRT1329950	hsa-miR-647	CLIP-seq
MIRT1329951	hsa-miR-650	CLIP-seq
MIRT1329952	hsa-miR-661	CLIP-seq
MIRT1329953	hsa-miR-762	CLIP-seq
MIRT1329954	hsa-miR-885-3p	CLIP-seq
MIRT1329955	hsa-miR-920	CLIP-seq
MIRT1329956	hsa-miR-93	CLIP-seq
MIRT1329957	hsa-miR-940	CLIP-seq
MIRT1329916	hsa-miR-4736	CLIP-seq
MIRT1329919	hsa-miR-4768-5p	CLIP-seq
MIRT2097760	hsa-miR-1207-3p	CLIP-seq
MIRT1329831	hsa-miR-1254	CLIP-seq
MIRT2097761	hsa-miR-128	CLIP-seq
MIRT1329840	hsa-miR-1909	CLIP-seq
MIRT1329841	hsa-miR-1913	CLIP-seq
MIRT2097762	hsa-miR-1972	CLIP-seq
MIRT1329847	hsa-miR-219-2-3p	CLIP-seq
MIRT2097763	hsa-miR-2467-3p	CLIP-seq
MIRT1329851	hsa-miR-2964a-3p	CLIP-seq
MIRT1329852	hsa-miR-302a	CLIP-seq
MIRT1329853	hsa-miR-302b	CLIP-seq
MIRT1329854	hsa-miR-302c	CLIP-seq
MIRT1329855	hsa-miR-302d	CLIP-seq
MIRT1329856	hsa-miR-302e	CLIP-seq
MIRT1329860	hsa-miR-3116	CLIP-seq
MIRT2097764	hsa-miR-3125	CLIP-seq
MIRT1329864	hsa-miR-3176	CLIP-seq
MIRT2097765	hsa-miR-3183	CLIP-seq
MIRT1329868	hsa-miR-324-3p	CLIP-seq
MIRT2097766	hsa-miR-34c-3p	CLIP-seq
MIRT1329878	hsa-miR-372	CLIP-seq
MIRT1329879	hsa-miR-373	CLIP-seq
MIRT2097767	hsa-miR-3916	CLIP-seq
MIRT1329881	hsa-miR-3918	CLIP-seq
MIRT1329882	hsa-miR-3922-3p	CLIP-seq
MIRT1329883	hsa-miR-3929	CLIP-seq
MIRT2097768	hsa-miR-4264	CLIP-seq
MIRT2097769	hsa-miR-4313	CLIP-seq
MIRT1329893	hsa-miR-4419b	CLIP-seq
MIRT2097770	hsa-miR-4476	CLIP-seq
MIRT1329899	hsa-miR-4478	CLIP-seq
MIRT1329902	hsa-miR-4505	CLIP-seq
MIRT2097771	hsa-miR-4511	CLIP-seq
MIRT2097772	hsa-miR-451b	CLIP-seq
MIRT2097773	hsa-miR-4667-3p	CLIP-seq
MIRT1329909	hsa-miR-4680-3p	CLIP-seq
MIRT2097774	hsa-miR-4723-3p	CLIP-seq
MIRT1329915	hsa-miR-4731-5p	CLIP-seq
MIRT2097775	hsa-miR-4757-5p	CLIP-seq
MIRT1329924	hsa-miR-512-3p	CLIP-seq
MIRT1329934	hsa-miR-520a-3p	CLIP-seq
MIRT1329936	hsa-miR-520b	CLIP-seq
MIRT1329937	hsa-miR-520c-3p	CLIP-seq
MIRT1329938	hsa-miR-520d-3p	CLIP-seq
MIRT1329939	hsa-miR-520e	CLIP-seq
MIRT1329943	hsa-miR-550a	CLIP-seq
MIRT1329944	hsa-miR-578	CLIP-seq
MIRT2097776	hsa-miR-622	CLIP-seq
MIRT1329952	hsa-miR-661	CLIP-seq
MIRT1329823	hsa-miR-106a	CLIP-seq
MIRT1329824	hsa-miR-106b	CLIP-seq
MIRT1329827	hsa-miR-1207-5p	CLIP-seq
MIRT1329831	hsa-miR-1254	CLIP-seq
MIRT1329836	hsa-miR-150	CLIP-seq
MIRT1329837	hsa-miR-17	CLIP-seq
MIRT1329840	hsa-miR-1909	CLIP-seq
MIRT1329844	hsa-miR-20a	CLIP-seq
MIRT1329845	hsa-miR-20b	CLIP-seq
MIRT2322059	hsa-miR-2115	CLIP-seq
MIRT2097763	hsa-miR-2467-3p	CLIP-seq
MIRT1329852	hsa-miR-302a	CLIP-seq
MIRT1329853	hsa-miR-302b	CLIP-seq
MIRT1329854	hsa-miR-302c	CLIP-seq
MIRT1329855	hsa-miR-302d	CLIP-seq
MIRT1329856	hsa-miR-302e	CLIP-seq
MIRT1329860	hsa-miR-3116	CLIP-seq
MIRT1329864	hsa-miR-3176	CLIP-seq
MIRT1329867	hsa-miR-3192	CLIP-seq
MIRT2322060	hsa-miR-3678-3p	CLIP-seq
MIRT1329878	hsa-miR-372	CLIP-seq
MIRT1329879	hsa-miR-373	CLIP-seq
MIRT1329882	hsa-miR-3922-3p	CLIP-seq
MIRT1329885	hsa-miR-4252	CLIP-seq
MIRT1329888	hsa-miR-4269	CLIP-seq
MIRT2322061	hsa-miR-431	CLIP-seq
MIRT1329896	hsa-miR-4437	CLIP-seq
MIRT1329897	hsa-miR-4438	CLIP-seq
MIRT2322062	hsa-miR-4532	CLIP-seq
MIRT2322063	hsa-miR-4694-3p	CLIP-seq
MIRT2322064	hsa-miR-4711-3p	CLIP-seq
MIRT1329915	hsa-miR-4731-5p	CLIP-seq
MIRT2097775	hsa-miR-4757-5p	CLIP-seq
MIRT1329918	hsa-miR-4763-3p	CLIP-seq
MIRT2322065	hsa-miR-4772-3p	CLIP-seq
MIRT1329923	hsa-miR-5095	CLIP-seq
MIRT1329924	hsa-miR-512-3p	CLIP-seq
MIRT2322066	hsa-miR-516a-3p	CLIP-seq
MIRT1329925	hsa-miR-518a-3p	CLIP-seq
MIRT1329926	hsa-miR-518b	CLIP-seq
MIRT1329927	hsa-miR-518c	CLIP-seq
MIRT1329928	hsa-miR-518d-3p	CLIP-seq
MIRT1329929	hsa-miR-518f	CLIP-seq
MIRT1329933	hsa-miR-519d	CLIP-seq
MIRT1329934	hsa-miR-520a-3p	CLIP-seq
MIRT1329936	hsa-miR-520b	CLIP-seq
MIRT1329937	hsa-miR-520c-3p	CLIP-seq
MIRT1329938	hsa-miR-520d-3p	CLIP-seq
MIRT1329939	hsa-miR-520e	CLIP-seq
MIRT1329940	hsa-miR-520g	CLIP-seq
MIRT1329941	hsa-miR-520h	CLIP-seq
MIRT2322067	hsa-miR-522	CLIP-seq
MIRT1329943	hsa-miR-550a	CLIP-seq
MIRT1329952	hsa-miR-661	CLIP-seq
MIRT1329956	hsa-miR-93	CLIP-seq
MIRT1329831	hsa-miR-1254	CLIP-seq
MIRT1329847	hsa-miR-219-2-3p	CLIP-seq
MIRT1329851	hsa-miR-2964a-3p	CLIP-seq
MIRT1329860	hsa-miR-3116	CLIP-seq
MIRT1329864	hsa-miR-3176	CLIP-seq
MIRT1329882	hsa-miR-3922-3p	CLIP-seq
MIRT1329883	hsa-miR-3929	CLIP-seq
MIRT1329885	hsa-miR-4252	CLIP-seq
MIRT1329893	hsa-miR-4419b	CLIP-seq
MIRT1329897	hsa-miR-4438	CLIP-seq
MIRT1329899	hsa-miR-4478	CLIP-seq
MIRT1329909	hsa-miR-4680-3p	CLIP-seq
MIRT2322063	hsa-miR-4694-3p	CLIP-seq
MIRT1329923	hsa-miR-5095	CLIP-seq
MIRT2322067	hsa-miR-522	CLIP-seq
MIRT1329943	hsa-miR-550a	CLIP-seq
MIRT1329952	hsa-miR-661	CLIP-seq
MIRT2458936	hsa-miR-1197	CLIP-seq
MIRT2458937	hsa-miR-3151	CLIP-seq
MIRT2458938	hsa-miR-4436a	CLIP-seq
MIRT1329917	hsa-miR-4749-3p	CLIP-seq
MIRT2458936	hsa-miR-1197	CLIP-seq
MIRT2458938	hsa-miR-4436a	CLIP-seq
MIRT1329917	hsa-miR-4749-3p	CLIP-seq
MIRT2458936	hsa-miR-1197	CLIP-seq
MIRT2097763	hsa-miR-2467-3p	CLIP-seq
MIRT2097764	hsa-miR-3125	CLIP-seq
MIRT2618483	hsa-miR-3127-5p	CLIP-seq
MIRT2618484	hsa-miR-3148	CLIP-seq
MIRT2618485	hsa-miR-383	CLIP-seq
MIRT2097767	hsa-miR-3916	CLIP-seq
MIRT1329881	hsa-miR-3918	CLIP-seq
MIRT1329888	hsa-miR-4269	CLIP-seq
MIRT2458938	hsa-miR-4436a	CLIP-seq
MIRT2618486	hsa-miR-4436b-3p	CLIP-seq
MIRT1329897	hsa-miR-4438	CLIP-seq
MIRT1329917	hsa-miR-4749-3p	CLIP-seq
MIRT2618487	hsa-miR-4772-5p	CLIP-seq
MIRT1329923	hsa-miR-5095	CLIP-seq
MIRT2458936	hsa-miR-1197	CLIP-seq
MIRT2458938	hsa-miR-4436a	CLIP-seq
MIRT1329917	hsa-miR-4749-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001518	Component	Voltage-gated sodium channel complex	IBA
GO:0001518	Component	Voltage-gated sodium channel complex	IDA	19808477, 35277491, 36823201
GO:0001518	Component	Voltage-gated sodium channel complex	TAS	9295116
GO:0005248	Function	Voltage-gated sodium channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	35277491
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	9295116
GO:0007399	Process	Nervous system development	IEA
GO:0009408	Process	Response to heat	IEA
GO:0010467	Process	Gene expression	IEA
GO:0010765	Process	Positive regulation of sodium ion transport	IDA	19808477
GO:0016020	Component	Membrane	IEA
GO:0017080	Function	Sodium channel regulator activity	IBA
GO:0017080	Function	Sodium channel regulator activity	IDA	19808477
GO:0017080	Function	Sodium channel regulator activity	IEA
GO:0030315	Component	T-tubule	IEA
GO:0030424	Component	Axon	IEA
GO:0033268	Component	Node of Ranvier	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043194	Component	Axon initial segment	IEA
GO:0045202	Component	Synapse	IEA
GO:0046684	Process	Response to pyrethroid	IEA
GO:0060048	Process	Cardiac muscle contraction	IMP	19808477
GO:0060371	Process	Regulation of atrial cardiac muscle cell membrane depolarization	IMP	19808477
GO:0061337	Process	Cardiac conduction	IBA
GO:0061337	Process	Cardiac conduction	IEA
GO:0086002	Process	Cardiac muscle cell action potential involved in contraction	IBA
GO:0086002	Process	Cardiac muscle cell action potential involved in contraction	IMP	19808477
GO:0086006	Function	Voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IEA
GO:0086010	Process	Membrane depolarization during action potential	IDA	35277491
GO:0086012	Process	Membrane depolarization during cardiac muscle cell action potential	IBA
GO:0086012	Process	Membrane depolarization during cardiac muscle cell action potential	IMP	19808477
GO:0086091	Process	Regulation of heart rate by cardiac conduction	IMP	19808477
GO:0098915	Process	Membrane repolarization during ventricular cardiac muscle cell action potential	IEA
GO:1902282	Function	Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IEA

Other IDs

• MIM: 601327
• HGNC: 10589
• e!Ensembl: ENSG00000149575

Protein

• UniProt ID: O60939
• Protein name: Sodium channel regulatory subunit beta-2
• Protein function: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed:3682320
• PDB: 5FDY, 5FEB, 6J8E, 6J8G, 6J8H, 6J8I, 6J8J, 6VRR, 7W77, 7W7F, 7W9K, 7W9L, 7W9M, 7W9P, 7W9T, 7XM9, 7XMF, 7XMG, 7XVE, 7XVF, 8G1A, 8GZ1, 8GZ2, 8I5B, 8I5G, 8I5X, 8I5Y, 8S9B, 8S9C, 8THG, 8THH, 8XMN, 8XMO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	33 → 147	Immunoglobulin V-set domain	Domain

• Sequence:

  MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNH
  KQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPE
  DEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVV
  KCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK

• Sequence length: 215

Pathways

Reactome:

Phase 0 - rapid depolarisation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION, FAMILIAL 1	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 10	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 11	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 12	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 13	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Atrial fibrillation, familial, 14	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar CTD, ClinVar, Disgenet, GenCC, HPO CTD, ClinVar, Disgenet, GenCC, HPO CTD, ClinVar, Disgenet, GenCC, HPO CTD, ClinVar, Disgenet, GenCC, HPO	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
ATRIAL FIBRILLATION, FAMILIAL, 15	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 2	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 3	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 4	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 5	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 6	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 7	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 8	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION, FAMILIAL, 9	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRUGADA SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRUGADA SYNDROME 1	—	ClinGen, Disgenet ClinGen, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiovascular phenotype	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL ATRIAL FIBRILLATION	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEREDITARY ATRIAL FIBRILLATION	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PREECLAMPSIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary dilated cardiomyopathy	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCN2B-related disorder	Benign; Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Variant of unknown significance	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atrial Fibrillation	Atrial Fibrillation	BEFREE	19808477, 20558140, 23604097, 30821358		★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	20558140, 30821358, 34332113	Associate	★☆☆☆☆ Found in Text Mining only
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	Atrial Fibrillation	ORPHANET_DG	19808477		★☆☆☆☆ Found in Text Mining only
ATRIAL FIBRILLATION, FAMILIAL, 14	Atrial Fibrillation	UNIPROT_DG	19808477		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
ATRIAL FIBRILLATION, FAMILIAL, 14	Atrial Fibrillation	CTD_human_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
ATRIAL FIBRILLATION, FAMILIAL, 14	Atrial Fibrillation	CLINVAR_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Brugada syndrome	Brugada Syndrome	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brugada Syndrome	Brugada syndrome	Pubtator	26173111	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brugada Syndrome (disorder)	Brugada Syndrome	CLINGEN_DG	19808477, 23559163, 26173111, 26179811, 27932425		★☆☆☆☆ Found in Text Mining only
Brugada Syndrome (disorder)	Brugada Syndrome	BEFREE	23559163		★☆☆☆☆ Found in Text Mining only
Brugada Syndrome (disorder)	Brugada Syndrome	ORPHANET_DG	23559163		★☆☆☆☆ Found in Text Mining only
Brugada Syndrome 1	Brugada Syndrome	CLINGEN_DG	19808477, 23559163, 26173111, 26179811, 27932425		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder)	Cardiac conduction disease	CLINGEN_DG	19808477, 23559163, 26173111, 26179811, 27932425		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	24339868	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	BEFREE	24339868		★☆☆☆☆ Found in Text Mining only
Charcot-Marie-Tooth disease, Type 4B1	Charcot-Marie-Tooth Disease	BEFREE	9887383		★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	36406589	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	23195492, 24337656		★☆☆☆☆ Found in Text Mining only
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2	Epileptic encephalopathy	BEFREE	23195492, 30921204		★☆☆☆☆ Found in Text Mining only
Familial atrial fibrillation	Atrial Fibrillation	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
First degree atrioventricular block	Atrioventricular block	HPO_DG			★☆☆☆☆ Found in Text Mining only
Infantile Severe Myoclonic Epilepsy	Myoclonic Epilepsy	BEFREE	23195492, 30921204		★☆☆☆☆ Found in Text Mining only
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Paroxysmal ventricular tachycardia	Paroxysmal ventricular tachycardia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Right bundle branch block	Bundle Branch Block	HPO_DG			★☆☆☆☆ Found in Text Mining only
Sick Sinus Syndrome	Sick Sinus Syndrome	HPO_DG			★☆☆☆☆ Found in Text Mining only
Sinus Node Dysfunction (disorder)	Sinus Node Dysfunction	CLINGEN_DG	19808477, 23559163, 26173111, 26179811, 27932425		★☆☆☆☆ Found in Text Mining only
Supraventricular tachycardia	Supraventricular tachycardia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Tonic - clonic seizures	Seizure	BEFREE	20730464		★☆☆☆☆ Found in Text Mining only
Trifascicular block	Trifascicular block	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ventricular Fibrillation	Ventricular Fibrillation	HPO_DG			★☆☆☆☆ Found in Text Mining only