SAA2 (serum amyloid A2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 6289
Gene name Serum amyloid A2
Gene symbol SAA2
Synonyms (NCBI Gene)
SAASAA1
Chromosome 11
Chromosome location 11p15.1
Summary This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflamm
miRNA miRNA information provided by mirtarbase database.
56
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1324574 hsa-miR-1237 CLIP-seq
MIRT1324575 hsa-miR-1238 CLIP-seq
MIRT1324576 hsa-miR-1248 CLIP-seq
MIRT1324577 hsa-miR-1299 CLIP-seq
MIRT1324578 hsa-miR-136 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
CEBPB Activation 8244997
RELA Activation 8244997
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0006953 Process Acute-phase response IEA
GO:0034364 Component High-density lipoprotein particle IEA
GO:0070062 Component Extracellular exosome HDA 23533145
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
104751 10514 ENSG00000134339
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P0DJI9
Protein name Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)]
Protein function Major acute phase reactant.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00277 SAA 22 → 122 Serum amyloid A protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma. {ECO:0000269|PubMed:3183061}.
Sequence
Sequence length 122
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (3)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (186)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
AA amyloidosis AA amyloidosis BEFREE 10036584, 10543406, 11407685, 12762135, 16076608, 16874691, 16980401, 17039310, 17968686, 18369528, 19339884, 19657764, 20440529, 20536400, 21627560
View all (14 more)
★★★★★
★☆☆☆☆
Found in Text Mining only
AA amyloidosis AA amyloidosis Orphanet
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 29369476
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 38605603 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer disease, familial, type 3 Alzheimer disease BEFREE 28708859
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloid nephropathy Amyloid Nephropathy BEFREE 11017802, 12687559, 15170927, 16118480, 19888326
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloid nephropathy Amyloid Nephropathy HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloid Neuropathies, Familial AMYLOID CARDIOMYOPATHY BEFREE 6090552
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 10036584, 10524286, 10543406, 12270922, 12687559, 12762135, 12762136, 12832747, 12836090, 15018633, 15170927, 15316120, 16011988, 16076608, 16118480
View all (17 more)
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis Pubtator 12270922, 12687559, 15018633, 25394530 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only