Gene Gene information from NCBI Gene database.
Entrez ID 624
Gene name Bradykinin receptor B2
Gene symbol BDKRB2
Synonyms (NCBI Gene)
B2RBK-2BK2BKR2BRB2
Chromosome 14
Chromosome location 14q32.2
Summary This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as tr
miRNA miRNA information provided by mirtarbase database.
931
miRTarBase ID miRNA Experiments Reference
MIRT054128 hsa-miR-129-5p Luciferase reporter assayqRT-PCR 25008064
MIRT054128 hsa-miR-129-5p Luciferase reporter assayqRT-PCR 25008064
MIRT723809 hsa-miR-6892-3p HITS-CLIP 19536157
MIRT723808 hsa-miR-2276-5p HITS-CLIP 19536157
MIRT723807 hsa-miR-1237-3p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
CREB1 Unknown 15632413
KLF4 Activation 15632413
TP53 Activation 15632413
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 17077303
GO:0003008 Process System process IEA
GO:0004435 Function Phosphatidylinositol-4,5-bisphosphate phospholipase C activity TAS 8302267
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004947 Function Bradykinin receptor activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
113503 1030 ENSG00000168398
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30411
Protein name B2 bradykinin receptor (B2R) (BK-2 receptor)
Protein function Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
PDB 7F2O , 7F6H , 7F6I
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 74 332 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Widespread in normal smooth muscle tissue and neurons. {ECO:0000269|PubMed:7835885}.
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Calcium signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Endocrine and other factor-regulated calcium reabsorption
Chagas disease
Pathways in cancer
  Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
26
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANGIOEDEMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTHRITIS, RHEUMATOID CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
ABLEPHARON-MACROSTOMIA SYNDROME Ablepharon macrostomia syndrome BEFREE 20511677
★☆☆☆☆
Found in Text Mining only
Acute Kidney Insufficiency Acute Kidney Insufficiency CTD_human_DG 24975837
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 15086970
★☆☆☆☆
Found in Text Mining only
Angioedema Angioedema Pubtator 23730990 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Angioedemas, Hereditary Angioedema BEFREE 8287604, 9003221
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 30847343
★☆☆☆☆
Found in Text Mining only
Arthritis, Gouty Gouty arthritis GWASCAT_DG 22179738
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 26880163 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Astrocytoma Astrocytoma Pubtator 36348016 Associate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 30847343
★☆☆☆☆
Found in Text Mining only