Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6235
Gene name	Ribosomal protein S29
Gene symbol	RPS29
Synonyms (NCBI Gene)	DBA13S29uS14
Chromosome	14
Chromosome location	14q21.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016617	hsa-miR-484	Sequencing	20371350
MIRT027890	hsa-miR-96-5p	Sequencing	20371350
MIRT047627	hsa-miR-10a-5p	CLASH	23622248
MIRT039486	hsa-miR-652-3p	CLASH	23622248
MIRT1317956	hsa-miR-135a	CLIP-seq
MIRT1317957	hsa-miR-135b	CLIP-seq
MIRT1317958	hsa-miR-3119	CLIP-seq
MIRT1317959	hsa-miR-3124-3p	CLIP-seq
MIRT1317960	hsa-miR-4426	CLIP-seq
MIRT1317961	hsa-miR-4647	CLIP-seq
MIRT1317962	hsa-miR-4662b	CLIP-seq
MIRT1317963	hsa-miR-105	CLIP-seq
MIRT1317964	hsa-miR-1252	CLIP-seq
MIRT1317965	hsa-miR-1305	CLIP-seq
MIRT1317966	hsa-miR-186	CLIP-seq
MIRT1317967	hsa-miR-2681	CLIP-seq
MIRT1317968	hsa-miR-300	CLIP-seq
MIRT1317969	hsa-miR-3179	CLIP-seq
MIRT1317970	hsa-miR-3671	CLIP-seq
MIRT1317971	hsa-miR-381	CLIP-seq
MIRT1317972	hsa-miR-4666-3p	CLIP-seq
MIRT1317973	hsa-miR-500a	CLIP-seq
MIRT1317974	hsa-miR-520d-5p	CLIP-seq
MIRT1317975	hsa-miR-524-5p	CLIP-seq
MIRT1317976	hsa-miR-607	CLIP-seq
MIRT1317963	hsa-miR-105	CLIP-seq
MIRT1317970	hsa-miR-3671	CLIP-seq
MIRT1317976	hsa-miR-607	CLIP-seq
MIRT2094468	hsa-miR-1178	CLIP-seq
MIRT2094469	hsa-miR-1226	CLIP-seq
MIRT2094470	hsa-miR-1285	CLIP-seq
MIRT2094471	hsa-miR-150	CLIP-seq
MIRT2094472	hsa-miR-1587	CLIP-seq
MIRT2094473	hsa-miR-218	CLIP-seq
MIRT1317959	hsa-miR-3124-3p	CLIP-seq
MIRT2094474	hsa-miR-3138	CLIP-seq
MIRT2094475	hsa-miR-3147	CLIP-seq
MIRT2094476	hsa-miR-3180-5p	CLIP-seq
MIRT2094477	hsa-miR-3187-5p	CLIP-seq
MIRT2094478	hsa-miR-3619-3p	CLIP-seq
MIRT2094479	hsa-miR-3945	CLIP-seq
MIRT2094480	hsa-miR-409-3p	CLIP-seq
MIRT2094481	hsa-miR-4252	CLIP-seq
MIRT2094482	hsa-miR-4253	CLIP-seq
MIRT2094483	hsa-miR-4425	CLIP-seq
MIRT2094484	hsa-miR-455-5p	CLIP-seq
MIRT2094485	hsa-miR-4713-5p	CLIP-seq
MIRT2094486	hsa-miR-4733-3p	CLIP-seq
MIRT2094487	hsa-miR-4752	CLIP-seq
MIRT2094488	hsa-miR-4776-5p	CLIP-seq
MIRT2094489	hsa-miR-4781-3p	CLIP-seq
MIRT2094490	hsa-miR-4786-3p	CLIP-seq
MIRT2094491	hsa-miR-4800-5p	CLIP-seq
MIRT2094492	hsa-miR-511	CLIP-seq
MIRT2094493	hsa-miR-520a-5p	CLIP-seq
MIRT2094494	hsa-miR-525-5p	CLIP-seq
MIRT2094495	hsa-miR-532-3p	CLIP-seq
MIRT2094496	hsa-miR-612	CLIP-seq
MIRT2094497	hsa-miR-634	CLIP-seq
MIRT2094498	hsa-miR-636	CLIP-seq
MIRT2094499	hsa-miR-873	CLIP-seq
MIRT2094468	hsa-miR-1178	CLIP-seq
MIRT2094469	hsa-miR-1226	CLIP-seq
MIRT2318981	hsa-miR-1266	CLIP-seq
MIRT2094471	hsa-miR-150	CLIP-seq
MIRT2094472	hsa-miR-1587	CLIP-seq
MIRT2318982	hsa-miR-2392	CLIP-seq
MIRT2094475	hsa-miR-3147	CLIP-seq
MIRT2318983	hsa-miR-3187-3p	CLIP-seq
MIRT2318984	hsa-miR-3664-3p	CLIP-seq
MIRT2318985	hsa-miR-3682-3p	CLIP-seq
MIRT2094480	hsa-miR-409-3p	CLIP-seq
MIRT2094483	hsa-miR-4425	CLIP-seq
MIRT2318986	hsa-miR-4518	CLIP-seq
MIRT2318987	hsa-miR-4529-5p	CLIP-seq
MIRT2318988	hsa-miR-4674	CLIP-seq
MIRT2094485	hsa-miR-4713-5p	CLIP-seq
MIRT2094486	hsa-miR-4733-3p	CLIP-seq
MIRT2094489	hsa-miR-4781-3p	CLIP-seq
MIRT2094495	hsa-miR-532-3p	CLIP-seq
MIRT2094497	hsa-miR-634	CLIP-seq
MIRT2318989	hsa-miR-635	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IDA	25957688
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	8781548, 25957688
GO:0008270	Function	Zinc ion binding	IEA
GO:0015935	Component	Small ribosomal subunit	HDA	15883184
GO:0022626	Component	Cytosolic ribosome	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699, 23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0098556	Component	Cytoplasmic side of rough endoplasmic reticulum membrane	ISS
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603633	10419	ENSG00000213741

P62273

Protein name

Small ribosomal subunit protein uS14 (40S ribosomal protein S29)

Protein function

Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ , 6ZXD , 6ZXE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00253	Ribosomal_S14	6 → 55	Ribosomal protein S14p/S29e	Family

Sequence

MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diamond-Blackfan anemia 13	Pathogenic; Likely pathogenic	rs587777568, rs587777569	RCV000128850 RCV000128851	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANEMIA, DIAMOND-BLACKFAN	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIAMOND-BLACKFAN ANEMIA	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RPS29-related disorder	Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aase Smith syndrome 2	Aase-Smith syndrome	ORPHANET_DG	24829207		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute leukemia	Leukemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	34326892	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Diamond-Blackfan	Anemia	BEFREE	24829207		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	GENOMICS_ENGLAND_DG	24829207, 28297620		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	ORPHANET_DG	24829207		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Macrocytic	Anemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Blackfan-Diamond anemia	Blackfan-Diamond Anemia	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	8781548		★★★★★ ★☆☆☆☆ Found in Text Mining only
DIAMOND-BLACKFAN ANEMIA 13	Diamond-Blackfan anemia	GENOMICS_ENGLAND_DG	24829207		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
DIAMOND-BLACKFAN ANEMIA 13	Diamond-Blackfan anemia	UNIPROT_DG	24829207		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
DIAMOND-BLACKFAN ANEMIA 13	Diamond-Blackfan anemia	CLINVAR_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
DIAMOND-BLACKFAN ANEMIA 13	Diamond-Blackfan anemia	CTD_human_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	12625830		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of penis	Penile cancer	BEFREE	30674687		★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
NEUROTICISM	Neuroticism	BEFREE	25994864		★★★★★ ★☆☆☆☆ Found in Text Mining only
Normocytic anemia	Anemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	19650912	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	19650912		★★★★★ ★☆☆☆☆ Found in Text Mining only

RPS29 (ribosomal protein S29)