RPS14 (ribosomal protein S14)

Gene

• Entrez ID: 6208
• Gene name: Ribosomal protein S14
• Gene symbol: RPS14
• Synonyms (NCBI Gene): EMTB, S14, uS11
• Chromosome: 5
• Chromosome location: 5q33.1
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050273	hsa-miR-25-3p	CLASH	23622248
MIRT049275	hsa-miR-92a-3p	CLASH	23622248
MIRT044278	hsa-miR-106b-5p	CLASH	23622248
MIRT043360	hsa-miR-331-3p	CLASH	23622248
MIRT043360	hsa-miR-331-3p	CLASH	23622248
MIRT041923	hsa-miR-484	CLASH	23622248
MIRT041170	hsa-miR-181d-5p	CLASH	23622248
MIRT040719	hsa-miR-92b-3p	CLASH	23622248
MIRT037567	hsa-miR-744-5p	CLASH	23622248
MIRT468959	hsa-miR-8060	PAR-CLIP	20371350
MIRT468957	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT468956	hsa-miR-4493	PAR-CLIP	20371350
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT468949	hsa-miR-4477a	PAR-CLIP	20371350
MIRT468948	hsa-miR-6126	PAR-CLIP	20371350
MIRT468959	hsa-miR-8060	PAR-CLIP	20371350
MIRT468957	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT468956	hsa-miR-4493	PAR-CLIP	20371350
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT468949	hsa-miR-4477a	PAR-CLIP	20371350
MIRT468948	hsa-miR-6126	PAR-CLIP	20371350
MIRT563169	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT563168	hsa-miR-4464	PAR-CLIP	20371350
MIRT563167	hsa-miR-4748	PAR-CLIP	20371350
MIRT563166	hsa-miR-455-5p	PAR-CLIP	20371350
MIRT563165	hsa-miR-3665	PAR-CLIP	20371350
MIRT563164	hsa-miR-657	PAR-CLIP	20371350
MIRT563163	hsa-miR-5087	PAR-CLIP	20371350
MIRT563162	hsa-miR-1227-3p	PAR-CLIP	20371350
MIRT563161	hsa-miR-8068	PAR-CLIP	20371350
MIRT563160	hsa-miR-3924	PAR-CLIP	20371350
MIRT563159	hsa-miR-4659a-5p	PAR-CLIP	20371350
MIRT563158	hsa-miR-4659b-5p	PAR-CLIP	20371350
MIRT468959	hsa-miR-8060	PAR-CLIP	23446348
MIRT468958	hsa-miR-494-3p	PAR-CLIP	23446348
MIRT468957	hsa-miR-605-3p	PAR-CLIP	23446348
MIRT468956	hsa-miR-4493	PAR-CLIP	23446348
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	23446348
MIRT468949	hsa-miR-4477a	PAR-CLIP	23446348
MIRT468948	hsa-miR-6126	PAR-CLIP	23446348
MIRT468947	hsa-miR-510-3p	PAR-CLIP	23446348
MIRT468959	hsa-miR-8060	PAR-CLIP	23592263
MIRT468958	hsa-miR-494-3p	PAR-CLIP	23592263
MIRT468957	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT468956	hsa-miR-4493	PAR-CLIP	23592263
MIRT468955	hsa-miR-219a-1-3p	PAR-CLIP	23592263
MIRT468954	hsa-miR-3135b	PAR-CLIP	23592263
MIRT468953	hsa-miR-4653-3p	PAR-CLIP	23592263
MIRT468952	hsa-miR-3652	PAR-CLIP	23592263
MIRT468951	hsa-miR-4430	PAR-CLIP	23592263
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	23592263
MIRT468949	hsa-miR-4477a	PAR-CLIP	23592263
MIRT468948	hsa-miR-6126	PAR-CLIP	23592263
MIRT468947	hsa-miR-510-3p	PAR-CLIP	23592263
MIRT468959	hsa-miR-8060	PAR-CLIP	20371350
MIRT468957	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT468956	hsa-miR-4493	PAR-CLIP	20371350
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT468949	hsa-miR-4477a	PAR-CLIP	20371350
MIRT468948	hsa-miR-6126	PAR-CLIP	20371350
MIRT468959	hsa-miR-8060	PAR-CLIP	20371350
MIRT468957	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT468956	hsa-miR-4493	PAR-CLIP	20371350
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT468949	hsa-miR-4477a	PAR-CLIP	20371350
MIRT468948	hsa-miR-6126	PAR-CLIP	20371350
MIRT563169	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT563168	hsa-miR-4464	PAR-CLIP	20371350
MIRT563167	hsa-miR-4748	PAR-CLIP	20371350
MIRT563166	hsa-miR-455-5p	PAR-CLIP	20371350
MIRT563165	hsa-miR-3665	PAR-CLIP	20371350
MIRT563164	hsa-miR-657	PAR-CLIP	20371350
MIRT563163	hsa-miR-5087	PAR-CLIP	20371350
MIRT563162	hsa-miR-1227-3p	PAR-CLIP	20371350
MIRT563161	hsa-miR-8068	PAR-CLIP	20371350
MIRT563160	hsa-miR-3924	PAR-CLIP	20371350
MIRT563159	hsa-miR-4659a-5p	PAR-CLIP	20371350
MIRT563158	hsa-miR-4659b-5p	PAR-CLIP	20371350
MIRT468959	hsa-miR-8060	PAR-CLIP	23446348
MIRT468958	hsa-miR-494-3p	PAR-CLIP	23446348
MIRT468957	hsa-miR-605-3p	PAR-CLIP	23446348
MIRT468956	hsa-miR-4493	PAR-CLIP	23446348
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	23446348
MIRT468949	hsa-miR-4477a	PAR-CLIP	23446348
MIRT468948	hsa-miR-6126	PAR-CLIP	23446348
MIRT468947	hsa-miR-510-3p	PAR-CLIP	23446348
MIRT468959	hsa-miR-8060	PAR-CLIP	23592263
MIRT468958	hsa-miR-494-3p	PAR-CLIP	23592263
MIRT468957	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT468956	hsa-miR-4493	PAR-CLIP	23592263
MIRT468955	hsa-miR-219a-1-3p	PAR-CLIP	23592263
MIRT468954	hsa-miR-3135b	PAR-CLIP	23592263
MIRT468953	hsa-miR-4653-3p	PAR-CLIP	23592263
MIRT468952	hsa-miR-3652	PAR-CLIP	23592263
MIRT468951	hsa-miR-4430	PAR-CLIP	23592263
MIRT468950	hsa-miR-4666a-5p	PAR-CLIP	23592263
MIRT468949	hsa-miR-4477a	PAR-CLIP	23592263
MIRT468948	hsa-miR-6126	PAR-CLIP	23592263
MIRT468947	hsa-miR-510-3p	PAR-CLIP	23592263
MIRT1317710	hsa-miR-4666-5p	CLIP-seq
MIRT1317711	hsa-miR-494	CLIP-seq
MIRT2094424	hsa-miR-1224-5p	CLIP-seq
MIRT2094425	hsa-miR-1304	CLIP-seq
MIRT2094426	hsa-miR-3915	CLIP-seq
MIRT2094427	hsa-miR-3928	CLIP-seq
MIRT2094428	hsa-miR-4689	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000028	Process	Ribosomal small subunit assembly	IBA
GO:0000028	Process	Ribosomal small subunit assembly	ISS
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7867928
GO:0002181	Process	Cytoplasmic translation	IC	3785212, 8706699, 15883184, 23636399
GO:0002181	Process	Cytoplasmic translation	IMP	3683397, 9152021
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	ISS
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 24965446, 25009770, 25416956, 28514442, 30021884, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	9152021
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IBA
GO:0006412	Process	Translation	IEA
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0016020	Component	Membrane	HDA	19946888
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699, 9152021
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0030218	Process	Erythrocyte differentiation	IMP	18202658
GO:0030490	Process	Maturation of SSU-rRNA	ISS
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0045202	Component	Synapse	IEA
GO:0048027	Function	MRNA 5'-UTR binding	IDA	7867928
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 130620
• HGNC: 10387
• e!Ensembl: ENSG00000164587

Protein

• UniProt ID: P62263
• Protein name: Small ribosomal subunit protein uS11 (40S ribosomal protein S14)
• Protein function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subu
• PDB: 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6FEC, 6G18, 6G4S, 6G4W, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBD, 6YBW, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOK, 6ZON, 6ZP4, 6ZUO, 6ZV6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00411	Ribosomal_S11	29 → 147	Ribosomal protein S11	Family

• Sequence:

  MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGM
  KVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALA
  RSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

• Sequence length: 151

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHROMOSOME 5Q DELETION SYNDROME	—	CTD, HPO CTD, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOXIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYELODYSPLASTIC SYNDROME ASSOCIATED WITH ISOLATED DEL CHROMOSOME ABNORMALITY	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUTROPENIA	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
5q-syndrome	5q-syndrome	BEFREE	17916100, 18202658, 18477045, 19016715, 19322210, 20211165, 20378560, 20491881, 20733155, 20980806, 21068437, 21435510, 21536236, 21873545, 21943668, 22571696, 22709827, 23943650, 24074450, 25645650, 30458760, 30651631		★☆☆☆☆ Found in Text Mining only
5q-syndrome	5q-syndrome	ORPHANET_DG	22571696		★☆☆☆☆ Found in Text Mining only
5q-syndrome	5q-syndrome	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
5q-syndrome	5q-syndrome	GENOMICS_ENGLAND_DG			★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★☆☆☆☆ Found in Text Mining only
Anaplastic carcinoma	Anaplastic Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	Pubtator	23943650	Associate	★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	25645650		★☆☆☆☆ Found in Text Mining only
Anemia Macrocytic	Macrocytic anemia	Pubtator	31540902	Associate	★☆☆☆☆ Found in Text Mining only
Anemia, Diamond-Blackfan	Anemia	BEFREE	18202658, 21068437, 21130407, 22734070, 23943650		★☆☆☆☆ Found in Text Mining only
Anemia, Macrocytic	Anemia	BEFREE	19966810, 21943668, 22709827, 31540902		★☆☆☆☆ Found in Text Mining only
Anemia, Macrocytic	Anemia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Autosomal dominant contiguous gene syndrome	Contiguous gene syndrome	HPO_DG			★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	16300755, 19116881, 9618526		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29081411, 33305312	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	CTD_human_DG	16316942		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32627011	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	25702669		★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	24457517	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Spindle-Cell	Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only
Chromosome 5q Deletion Syndrome	Chromosome 5q deletion syndrome	Pubtator	17916100, 18202658, 18477045, 20378560, 22391559, 23943650, 32327500	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35127345	Associate	★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	20491881		★☆☆☆☆ Found in Text Mining only
Erythroid hypoplasia	Erythroid hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	36535509	Stimulate	★☆☆☆☆ Found in Text Mining only
Hypoplastic anemia	Hypoplastic anemia	BEFREE	22525275		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	24074450	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	24074450		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	HPO_DG			★☆☆☆☆ Found in Text Mining only
liposarcoma	Liposarcoma	BEFREE	19116881		★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	8093911		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	16300755, 19116881, 9618526, 9777755		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	21536236		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	16300755		★☆☆☆☆ Found in Text Mining only
Mandibulofacial Dysostosis	Mandibulofacial Dysostosis	BEFREE	8037214		★☆☆☆☆ Found in Text Mining only
Miller Dieker syndrome	Miller Dieker Syndrome	BEFREE	19794090, 23506134, 24074450, 31540902		★☆☆☆☆ Found in Text Mining only
Multiple lineage myelodysplasia	Multiple lineage myelodysplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Myelodysplasia	Myelodysplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	19794090, 20491881, 21902648, 22525275, 22929976, 23506134, 23943650, 24074450, 24192547, 25645650, 26878232, 28240607, 29222326, 31540902		★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	HPO_DG			★☆☆☆☆ Found in Text Mining only
Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality	Myelodysplastic Syndrome Associated With Isolated Del(5q) Chromosome Abnormality	Orphanet			★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndrome with Isolated del(5q)	Myelodysplastic syndrome	BEFREE	17916100, 18202658, 18477045, 19016715, 19322210, 20211165, 20378560, 20491881, 20733155, 20980806, 21068437, 21435510, 21536236, 21873545, 21943668, 22571696, 22709827, 23943650, 24074450, 25645650, 30458760, 30651631		★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndrome with Isolated del(5q)	Myelodysplastic syndrome	ORPHANET_DG	22571696		★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	19794090, 23943650, 24074450, 29286619, 31540902, 36735910	Associate	★☆☆☆☆ Found in Text Mining only
Myelofibrosis	Myelofibrosis	BEFREE	28622305		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17916100		★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	CTD_human_DG	27725143		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancytopenia	Pancytopenia	BEFREE	18202658, 29222326		★☆☆☆☆ Found in Text Mining only
Primary Myelofibrosis	Myelofibrosis	BEFREE	28622305		★☆☆☆☆ Found in Text Mining only
Refractory macrocytic anemia	Macrocytic anemia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	24457517		★☆☆☆☆ Found in Text Mining only
Thrombocytosis	Thrombocytosis	BEFREE	21873545		★☆☆☆☆ Found in Text Mining only
Thrombocytosis	Thrombocytosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	33305312	Associate	★☆☆☆☆ Found in Text Mining only
Undifferentiated carcinoma	Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only