Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6203
Gene name	Ribosomal protein S9
Gene symbol	RPS9
Synonyms (NCBI Gene)	S9uS4
Chromosome	19
Chromosome location	19q13.42
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT047594	hsa-miR-10a-5p	CLASH	23622248
MIRT047453	hsa-miR-10b-5p	CLASH	23622248
MIRT045647	hsa-miR-149-5p	CLASH	23622248
MIRT043770	hsa-miR-328-3p	CLASH	23622248
MIRT043674	hsa-miR-342-3p	CLASH	23622248
MIRT043338	hsa-miR-331-3p	CLASH	23622248
MIRT042287	hsa-miR-484	CLASH	23622248
MIRT039014	hsa-miR-766-3p	CLASH	23622248
MIRT038095	hsa-miR-423-5p	CLASH	23622248
MIRT036686	hsa-miR-935	CLASH	23622248
MIRT036124	hsa-miR-1296-5p	CLASH	23622248
MIRT716365	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT716364	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT716363	hsa-miR-1248	HITS-CLIP	19536157
MIRT716362	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT721078	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT721077	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT721076	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT716360	hsa-miR-1256	HITS-CLIP	19536157
MIRT716358	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT716357	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT716356	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT716355	hsa-miR-4642	HITS-CLIP	19536157
MIRT716354	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT716365	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT716364	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT716363	hsa-miR-1248	HITS-CLIP	19536157
MIRT716362	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT716361	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT716360	hsa-miR-1256	HITS-CLIP	19536157
MIRT716359	hsa-miR-6851-3p	HITS-CLIP	19536157
MIRT716358	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT716357	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT716356	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT716355	hsa-miR-4642	HITS-CLIP	19536157
MIRT716354	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT526722	hsa-miR-6888-5p	PAR-CLIP	22012620
MIRT526721	hsa-miR-153-3p	PAR-CLIP	22012620
MIRT716365	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT716364	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT716363	hsa-miR-1248	HITS-CLIP	19536157
MIRT716362	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT721078	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT721077	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT721076	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT716360	hsa-miR-1256	HITS-CLIP	19536157
MIRT716358	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT716357	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT716356	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT716355	hsa-miR-4642	HITS-CLIP	19536157
MIRT716354	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT716365	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT716364	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT716363	hsa-miR-1248	HITS-CLIP	19536157
MIRT716362	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT716361	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT716360	hsa-miR-1256	HITS-CLIP	19536157
MIRT716359	hsa-miR-6851-3p	HITS-CLIP	19536157
MIRT716358	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT716357	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT716356	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT716355	hsa-miR-4642	HITS-CLIP	19536157
MIRT716354	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT526722	hsa-miR-6888-5p	PAR-CLIP	22012620
MIRT526721	hsa-miR-153-3p	PAR-CLIP	22012620
MIRT1319033	hsa-miR-1207-5p	CLIP-seq
MIRT1319034	hsa-miR-1271	CLIP-seq
MIRT1319035	hsa-miR-182	CLIP-seq
MIRT1319036	hsa-miR-3126-5p	CLIP-seq
MIRT1319037	hsa-miR-338-3p	CLIP-seq
MIRT1319038	hsa-miR-4459	CLIP-seq
MIRT1319039	hsa-miR-4530	CLIP-seq
MIRT1319040	hsa-miR-4690-3p	CLIP-seq
MIRT1319041	hsa-miR-4736	CLIP-seq
MIRT1319042	hsa-miR-4763-3p	CLIP-seq
MIRT1319043	hsa-miR-4779	CLIP-seq
MIRT1319044	hsa-miR-518a-3p	CLIP-seq
MIRT1319045	hsa-miR-518b	CLIP-seq
MIRT1319046	hsa-miR-518c	CLIP-seq
MIRT1319047	hsa-miR-518d-3p	CLIP-seq
MIRT1319048	hsa-miR-518e	CLIP-seq
MIRT1319049	hsa-miR-518f	CLIP-seq
MIRT1319050	hsa-miR-548ad	CLIP-seq
MIRT1319051	hsa-miR-552	CLIP-seq
MIRT1319052	hsa-miR-665	CLIP-seq
MIRT1319053	hsa-miR-96	CLIP-seq
MIRT1319033	hsa-miR-1207-5p	CLIP-seq
MIRT1319034	hsa-miR-1271	CLIP-seq
MIRT1319035	hsa-miR-182	CLIP-seq
MIRT1319041	hsa-miR-4736	CLIP-seq
MIRT1319042	hsa-miR-4763-3p	CLIP-seq
MIRT1319044	hsa-miR-518a-3p	CLIP-seq
MIRT1319045	hsa-miR-518b	CLIP-seq
MIRT1319046	hsa-miR-518c	CLIP-seq
MIRT1319047	hsa-miR-518d-3p	CLIP-seq
MIRT1319048	hsa-miR-518e	CLIP-seq
MIRT1319049	hsa-miR-518f	CLIP-seq
MIRT1319050	hsa-miR-548ad	CLIP-seq
MIRT1319053	hsa-miR-96	CLIP-seq
MIRT1319033	hsa-miR-1207-5p	CLIP-seq
MIRT1319034	hsa-miR-1271	CLIP-seq
MIRT1319035	hsa-miR-182	CLIP-seq
MIRT1319036	hsa-miR-3126-5p	CLIP-seq
MIRT1319037	hsa-miR-338-3p	CLIP-seq
MIRT1319038	hsa-miR-4459	CLIP-seq
MIRT1319039	hsa-miR-4530	CLIP-seq
MIRT1319040	hsa-miR-4690-3p	CLIP-seq
MIRT1319041	hsa-miR-4736	CLIP-seq
MIRT1319042	hsa-miR-4763-3p	CLIP-seq
MIRT1319043	hsa-miR-4779	CLIP-seq
MIRT1319050	hsa-miR-548ad	CLIP-seq
MIRT1319051	hsa-miR-552	CLIP-seq
MIRT1319052	hsa-miR-665	CLIP-seq
MIRT1319053	hsa-miR-96	CLIP-seq
MIRT1319033	hsa-miR-1207-5p	CLIP-seq
MIRT1319034	hsa-miR-1271	CLIP-seq
MIRT1319035	hsa-miR-182	CLIP-seq
MIRT1319037	hsa-miR-338-3p	CLIP-seq
MIRT1319039	hsa-miR-4530	CLIP-seq
MIRT1319041	hsa-miR-4736	CLIP-seq
MIRT1319042	hsa-miR-4763-3p	CLIP-seq
MIRT1319050	hsa-miR-548ad	CLIP-seq
MIRT1319053	hsa-miR-96	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	8706699, 15883184, 23636399
GO:0002181	Process	Cytoplasmic translation	IMP	18420587
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	18420587, 21988832, 30021884, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	18420587
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	18420587
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	NAS	7772601
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0019843	Function	RRNA binding	IBA
GO:0019843	Function	RRNA binding	IEA
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0042274	Process	Ribosomal small subunit biogenesis	IBA
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603631	10442	ENSG00000170889

P46781

Protein name

Small ribosomal subunit protein uS4 (40S ribosomal protein S9)

Protein function

Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00163	Ribosomal_S4	9 → 107	Ribosomal protein S4/S9 N-terminal domain	Family
PF01479	S4	108 → 154	S4 domain	Domain

Sequence

MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAAREL
LTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLA
KSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKK
GQGGAGAGDDEEED

Sequence length

194

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RPS9-related disorder	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (17)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	18382789		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29081411, 33305312	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	24457517	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24009741	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	20221446	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	31159745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	31159745	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	35035819	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	31159745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18382789		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18382789		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	28928861		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa 11	Retinitis pigmentosa	Pubtator	9802568	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Takayasu Arteritis	Takayasu Arteritis	BEFREE	25604533		★★★★★ ★☆☆☆☆ Found in Text Mining only
Takayasu Arteritis	Takayasu Arteritis	GWASCAT_DG	25604533		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	33305312	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RPS9 (ribosomal protein S9)