Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6191
Gene name	Ribosomal protein S4 X-linked
Gene symbol	RPS4X
Synonyms (NCBI Gene)	CCG2DXS306RPS4S4SCARSCR10eS4
Chromosome	X
Chromosome location	Xq13.1
Summary	Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosom

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Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052498	hsa-let-7a-5p	CLASH	23622248
MIRT052233	hsa-let-7b-5p	CLASH	23622248
MIRT050453	hsa-miR-22-3p	CLASH	23622248
MIRT050453	hsa-miR-22-3p	CLASH	23622248
MIRT050403	hsa-miR-23a-3p	CLASH	23622248
MIRT049977	hsa-miR-29a-3p	CLASH	23622248
MIRT048379	hsa-miR-29b-3p	CLASH	23622248
MIRT047191	hsa-miR-182-5p	CLASH	23622248
MIRT046132	hsa-miR-30b-5p	CLASH	23622248
MIRT045173	hsa-miR-186-5p	CLASH	23622248
MIRT044434	hsa-miR-320a	CLASH	23622248
MIRT043831	hsa-miR-330-3p	CLASH	23622248
MIRT040631	hsa-miR-92b-3p	CLASH	23622248
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517854	hsa-miR-4698	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	20371350
MIRT517847	hsa-miR-3660	PAR-CLIP	20371350
MIRT517846	hsa-miR-4526	PAR-CLIP	20371350
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT517843	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	20371350
MIRT517847	hsa-miR-3660	PAR-CLIP	20371350
MIRT517846	hsa-miR-4526	PAR-CLIP	20371350
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT517843	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	23446348
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT517855	hsa-miR-338-5p	PAR-CLIP	23446348
MIRT517854	hsa-miR-4698	PAR-CLIP	23446348
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	23446348
MIRT517852	hsa-miR-195-3p	PAR-CLIP	23446348
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	23446348
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	23446348
MIRT517847	hsa-miR-3660	PAR-CLIP	23446348
MIRT517846	hsa-miR-4526	PAR-CLIP	23446348
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	23446348
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	23446348
MIRT517843	hsa-miR-524-5p	PAR-CLIP	23446348
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	23446348
MIRT439733	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT439732	hsa-miR-409-5p	HITS-CLIP	24374217
MIRT439731	hsa-miR-154-5p	HITS-CLIP	24374217
MIRT439729	hsa-miR-487a-3p	HITS-CLIP	24374217
MIRT439730	hsa-miR-485-3p	HITS-CLIP	24374217
MIRT439728	hsa-miR-539-5p	HITS-CLIP	24374217
MIRT439733	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT439732	hsa-miR-409-5p	HITS-CLIP	24374217
MIRT439731	hsa-miR-154-5p	HITS-CLIP	24374217
MIRT439729	hsa-miR-487a-3p	HITS-CLIP	24374217
MIRT439730	hsa-miR-485-3p	HITS-CLIP	24374217
MIRT439728	hsa-miR-539-5p	HITS-CLIP	24374217
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517854	hsa-miR-4698	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	20371350
MIRT517847	hsa-miR-3660	PAR-CLIP	20371350
MIRT517846	hsa-miR-4526	PAR-CLIP	20371350
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT517843	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	20371350
MIRT517847	hsa-miR-3660	PAR-CLIP	20371350
MIRT517846	hsa-miR-4526	PAR-CLIP	20371350
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT517843	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	23446348
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT517855	hsa-miR-338-5p	PAR-CLIP	23446348
MIRT517854	hsa-miR-4698	PAR-CLIP	23446348
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	23446348
MIRT517852	hsa-miR-195-3p	PAR-CLIP	23446348
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	23446348
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	23446348
MIRT517847	hsa-miR-3660	PAR-CLIP	23446348
MIRT517846	hsa-miR-4526	PAR-CLIP	23446348
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	23446348
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	23446348
MIRT517843	hsa-miR-524-5p	PAR-CLIP	23446348
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	23446348
MIRT1317992	hsa-miR-1915	CLIP-seq
MIRT1317993	hsa-miR-500a	CLIP-seq
MIRT1317994	hsa-miR-660	CLIP-seq
MIRT1317995	hsa-miR-711	CLIP-seq
MIRT1317992	hsa-miR-1915	CLIP-seq
MIRT1317994	hsa-miR-660	CLIP-seq
MIRT1317995	hsa-miR-711	CLIP-seq
MIRT1317992	hsa-miR-1915	CLIP-seq
MIRT1317994	hsa-miR-660	CLIP-seq
MIRT1317995	hsa-miR-711	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	IMP	8358435
GO:0005515	Function	Protein binding	IPI	24965446, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	HDA	15883184
GO:0005840	Component	Ribosome	IDA	8139551
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IBA
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	IMP	8358435
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	1795030
GO:0015935	Component	Small ribosomal subunit	IDA	8139551
GO:0016020	Component	Membrane	HDA	19946888
GO:0019843	Function	RRNA binding	IEA
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	2124517, 8358435
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA	15121898
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0045727	Process	Positive regulation of translation	IMP	1795030
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
312760	10424	ENSG00000198034

P62701

Protein name

Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein)

Protein function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryo

PDB

4UG0 , 4V6X , 5A2Q , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLI , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ , 6ZXD , 6ZXE , 6ZXF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08071	RS4NT	3 → 39	RS4NT (NUC023) domain	Domain
PF01479	S4	42 → 90	S4 domain	Domain
PF00900	Ribosomal_S4e	95 → 169	Ribosomal family S4e	Family
PF00467	KOW	177 → 211	KOW motif	Family
PF16121	40S_S4_C	212 → 259	40S ribosomal protein S4 C-terminus	Family

Sequence

MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDE
VKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAK
YKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNL
CMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPR
GKGIRLTIAEERDKRLAAKQSSG

Sequence length

263

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (27)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	31309679		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ataxia, Spinocerebellar	Spinocerebellar Ataxia	BEFREE	31617442		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atypical Hemolytic Uremic Syndrome	Hemolytic uremic syndrome	Pubtator	37373158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	Pubtator	34738918	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21466612, 28410206		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21466612	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	23800275	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	21304002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gonadal Dysgenesis, 45,X	Gonadal Dysgenesis	BEFREE	8358435, 8808278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intrahepatic Cholangiocarcinoma	Intrahepatic Cholangiocarcinoma	BEFREE	28693133		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21466612, 28410206		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	21304002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	14625084		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21304002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	31617442		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	29344651	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	23800275	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	23480184		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Kaposi	Sarcoma	Pubtator	40016701	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ST segment elevation myocardial infarction	ST Segment Elevation Myocardial Infarction	BEFREE	31181983		★★★★★ ★☆☆☆☆ Found in Text Mining only
Turner Syndrome	Turner Syndrome	BEFREE	1587534, 2034290, 8358435, 8557258, 8808278		★★★★★ ★☆☆☆☆ Found in Text Mining only

RPS4X (ribosomal protein S4 X-linked)