Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6189
Gene name	Ribosomal protein S3A
Gene symbol	RPS3A
Synonyms (NCBI Gene)	FTE1MFTLS3AeS1
Chromosome	4
Chromosome location	4q31.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT032020	hsa-miR-16-5p	Proteomics	18668040
MIRT052412	hsa-let-7a-5p	CLASH	23622248
MIRT050354	hsa-miR-25-3p	CLASH	23622248
MIRT049447	hsa-miR-92a-3p	CLASH	23622248
MIRT047756	hsa-miR-7-5p	CLASH	23622248
MIRT046394	hsa-miR-15b-5p	CLASH	23622248
MIRT045970	hsa-miR-125b-5p	CLASH	23622248
MIRT043671	hsa-miR-342-3p	CLASH	23622248
MIRT040576	hsa-miR-92b-3p	CLASH	23622248
MIRT1317984	hsa-miR-3064-3p	CLIP-seq
MIRT1317985	hsa-miR-3616-5p	CLIP-seq
MIRT1317986	hsa-miR-3647-5p	CLIP-seq
MIRT1317987	hsa-miR-4252	CLIP-seq
MIRT1317988	hsa-miR-4539	CLIP-seq
MIRT1317989	hsa-miR-4715-3p	CLIP-seq
MIRT1317990	hsa-miR-4776-3p	CLIP-seq
MIRT1317991	hsa-miR-573	CLIP-seq
MIRT1317984	hsa-miR-3064-3p	CLIP-seq
MIRT1317985	hsa-miR-3616-5p	CLIP-seq
MIRT1317986	hsa-miR-3647-5p	CLIP-seq
MIRT1317987	hsa-miR-4252	CLIP-seq
MIRT1317988	hsa-miR-4539	CLIP-seq
MIRT1317989	hsa-miR-4715-3p	CLIP-seq
MIRT1317990	hsa-miR-4776-3p	CLIP-seq
MIRT1317991	hsa-miR-573	CLIP-seq
MIRT1317984	hsa-miR-3064-3p	CLIP-seq
MIRT1317985	hsa-miR-3616-5p	CLIP-seq
MIRT1317986	hsa-miR-3647-5p	CLIP-seq
MIRT1317987	hsa-miR-4252	CLIP-seq
MIRT1317988	hsa-miR-4539	CLIP-seq
MIRT1317989	hsa-miR-4715-3p	CLIP-seq
MIRT2318990	hsa-miR-4719	CLIP-seq
MIRT1317990	hsa-miR-4776-3p	CLIP-seq
MIRT1317991	hsa-miR-573	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
GABPA	Unknown	12463423
GABPB2	Unknown	12463423
SP1	Unknown	12463423

Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	NAS	1398113
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	11823430, 16169070, 24965446, 25416956, 28514442, 30021884, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IDA	15572026
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IDA	11823430
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	IMP	8877097
GO:0006412	Process	Translation	NAS	1398113
GO:0006413	Process	Translational initiation	TAS	9566973
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0030154	Process	Cell differentiation	IEA
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0043066	Process	Negative regulation of apoptotic process	IMP	9566973
GO:0045202	Component	Synapse	IEA
GO:0048027	Function	MRNA 5'-UTR binding	IDA	16213212
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661, 18809582
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
180478	10421	ENSG00000145425

P61247

Protein name

Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1)

Protein function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryo

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01015	Ribosomal_S3Ae	16 → 221	Ribosomal S3Ae family	Family

Sequence

MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASD
GLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTM
IEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTND
LKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGK
ATGDETGAKVERADGYEPPVQESV

Sequence length

264

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	16385451, 34225819, 35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	36195955	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease, Late Onset	Alzheimer disease	BEFREE	16385451		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	21857917	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	21857917	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	36195955	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30664178	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	30131868		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	21857917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	15889794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vasculitis	Vasculitis	BEFREE	25410188		★★★★★ ★☆☆☆☆ Found in Text Mining only

RPS3A (ribosomal protein S3A)