Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6187
Gene name	Ribosomal protein S2
Gene symbol	RPS2
Synonyms (NCBI Gene)	LLREP3S2uS5
Chromosome	16
Chromosome location	16p13.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (57)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031671	hsa-miR-16-5p	Proteomics	18668040
MIRT050452	hsa-miR-22-3p	CLASH	23622248
MIRT048173	hsa-miR-196a-5p	CLASH	23622248
MIRT047364	hsa-miR-34a-5p	CLASH	23622248
MIRT046672	hsa-miR-222-3p	CLASH	23622248
MIRT045736	hsa-miR-125a-5p	CLASH	23622248
MIRT045205	hsa-miR-186-5p	CLASH	23622248
MIRT044194	hsa-miR-99b-5p	CLASH	23622248
MIRT044087	hsa-miR-361-5p	CLASH	23622248
MIRT043827	hsa-miR-330-3p	CLASH	23622248
MIRT043802	hsa-miR-328-3p	CLASH	23622248
MIRT043266	hsa-miR-331-3p	CLASH	23622248
MIRT043266	hsa-miR-331-3p	CLASH	23622248
MIRT043266	hsa-miR-331-3p	CLASH	23622248
MIRT043030	hsa-miR-324-5p	CLASH	23622248
MIRT043030	hsa-miR-324-5p	CLASH	23622248
MIRT042586	hsa-miR-423-3p	CLASH	23622248
MIRT040839	hsa-miR-18a-3p	CLASH	23622248
MIRT040163	hsa-miR-615-3p	CLASH	23622248
MIRT038957	hsa-miR-25-5p	CLASH	23622248
MIRT038274	hsa-miR-361-3p	CLASH	23622248
MIRT038055	hsa-miR-423-5p	CLASH	23622248
MIRT037900	hsa-miR-455-3p	CLASH	23622248
MIRT036761	hsa-miR-760	CLASH	23622248
MIRT036604	hsa-miR-940	CLASH	23622248
MIRT036012	hsa-miR-1301-3p	CLASH	23622248
MIRT035864	hsa-miR-1250-5p	CLASH	23622248
MIRT052895	hsa-miR-3943	CLASH	23622248
MIRT1317799	hsa-miR-3163	CLIP-seq
MIRT1317800	hsa-miR-4760-3p	CLIP-seq
MIRT1317801	hsa-miR-548ac	CLIP-seq
MIRT1317802	hsa-miR-548ae	CLIP-seq
MIRT1317803	hsa-miR-548aj	CLIP-seq
MIRT1317804	hsa-miR-548am	CLIP-seq
MIRT1317805	hsa-miR-548d-3p	CLIP-seq
MIRT1317806	hsa-miR-548x	CLIP-seq
MIRT1317807	hsa-miR-548z	CLIP-seq
MIRT1317808	hsa-miR-568	CLIP-seq
MIRT1317809	hsa-miR-578	CLIP-seq
MIRT1317810	hsa-miR-643	CLIP-seq
MIRT1317799	hsa-miR-3163	CLIP-seq
MIRT1317800	hsa-miR-4760-3p	CLIP-seq
MIRT1317801	hsa-miR-548ac	CLIP-seq
MIRT1317802	hsa-miR-548ae	CLIP-seq
MIRT1317803	hsa-miR-548aj	CLIP-seq
MIRT1317804	hsa-miR-548am	CLIP-seq
MIRT1317805	hsa-miR-548d-3p	CLIP-seq
MIRT1317806	hsa-miR-548x	CLIP-seq
MIRT1317807	hsa-miR-548z	CLIP-seq
MIRT1317808	hsa-miR-568	CLIP-seq
MIRT1317809	hsa-miR-578	CLIP-seq
MIRT1317810	hsa-miR-643	CLIP-seq
MIRT1317799	hsa-miR-3163	CLIP-seq
MIRT1317800	hsa-miR-4760-3p	CLIP-seq
MIRT1317808	hsa-miR-568	CLIP-seq
MIRT1317809	hsa-miR-578	CLIP-seq
MIRT1317810	hsa-miR-643	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IDA	18464793
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	24725412, 24965446, 24981860, 25737013, 28514442, 30021884, 31046837, 32296183, 33961781, 35512704
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	16061210, 16263090
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	16061210, 16263090
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IBA
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0017134	Function	Fibroblast growth factor binding	IPI	16263090
GO:0019899	Function	Enzyme binding	IPI	18573314
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0051443	Process	Positive regulation of ubiquitin-protein transferase activity	IDA	18573314
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603624	10404	ENSG00000140988

P15880

Protein name

Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3)

Protein function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6G18 , 6G4S , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00333	Ribosomal_S5	102 → 166	Ribosomal protein S5, N-terminal domain	Domain
PF03719	Ribosomal_S5_C	185 → 256	Ribosomal protein S5, C-terminal domain	Domain

Sequence

MADDAGAAGGPGGPGGPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEW
MPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQ
RTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTV
PCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKAT
FDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT

Sequence length

293

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation RMTs methylate histone arginines Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Protein methylation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOXIA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (33)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acidosis Lactic	Lactic acidosis	Pubtator	34991560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	21811019, 35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	31309679		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	GWASCAT_DG	29892015		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Atrial Fibrillation	Atrial Fibrillation	CTD_human_DG	29892015		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Carcinoma	Colorectal Cancer	BEFREE	20473941		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	20473941	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	29576219	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Duodenal Ulcer	Duodenal ulcer	Pubtator	23493000	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastritis	Gastritis	Pubtator	23493000	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	26781422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gonadal Dysgenesis, 45,X	Gonadal Dysgenesis	BEFREE	8358435, 8808278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatomegaly	Hepatomegaly	Pubtator	37603533	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	1774960		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	Pubtator	29576219, 34991560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infertility Male	Male infertility	Pubtator	38012716	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	37603533	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	35035819	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	Pubtator	37603533	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	19138403, 21148031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19138403		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	31567589		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	31567589	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Necrosis	Pubtator	37603533	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19138403		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	35212607	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	34248836	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	CTD_human_DG	29892015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	19138403, 21148031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	21148031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Kaposi	Sarcoma	Pubtator	40016701	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	23493000	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Turner Syndrome	Turner Syndrome	BEFREE	8358435, 8808278		★★★★★ ★☆☆☆☆ Found in Text Mining only

RPS2 (ribosomal protein S2)