Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6184
Gene name	Ribophorin I
Gene symbol	RPN1
Synonyms (NCBI Gene)	OST1RBPH1
Chromosome	3
Chromosome location	3q21.3
Summary	This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-S

201

Show/Hide all (201)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020068	hsa-miR-375	Microarray	20215506
MIRT030197	hsa-miR-26b-5p	Microarray	19088304
MIRT048357	hsa-miR-103a-3p	CLASH	23622248
MIRT020068	hsa-miR-375	Luciferase reporter assayWestern blottingqRT-PCRImmunoprecipitaion (IP)	37386831
MIRT1317077	hsa-miR-1236	CLIP-seq
MIRT1317078	hsa-miR-151-3p	CLIP-seq
MIRT1317079	hsa-miR-193a-3p	CLIP-seq
MIRT1317080	hsa-miR-193b	CLIP-seq
MIRT1317081	hsa-miR-2861	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT1317083	hsa-miR-3156-3p	CLIP-seq
MIRT1317084	hsa-miR-3176	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317086	hsa-miR-3918	CLIP-seq
MIRT1317087	hsa-miR-3922-3p	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT1317090	hsa-miR-4301	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317092	hsa-miR-4420	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT1317094	hsa-miR-4512	CLIP-seq
MIRT1317095	hsa-miR-4635	CLIP-seq
MIRT1317096	hsa-miR-4753-3p	CLIP-seq
MIRT1317097	hsa-miR-4757-5p	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT1317099	hsa-miR-4768-5p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317101	hsa-miR-502-5p	CLIP-seq
MIRT1317102	hsa-miR-532-3p	CLIP-seq
MIRT1317103	hsa-miR-587	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT1317079	hsa-miR-193a-3p	CLIP-seq
MIRT1317080	hsa-miR-193b	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT2094125	hsa-miR-342-3p	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT1317092	hsa-miR-4420	CLIP-seq
MIRT2094126	hsa-miR-4643	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317077	hsa-miR-1236	CLIP-seq
MIRT2318767	hsa-miR-1245b-5p	CLIP-seq
MIRT1317078	hsa-miR-151-3p	CLIP-seq
MIRT1317081	hsa-miR-2861	CLIP-seq
MIRT2318768	hsa-miR-3142	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT2094125	hsa-miR-342-3p	CLIP-seq
MIRT2318769	hsa-miR-3671	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317086	hsa-miR-3918	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT2318770	hsa-miR-4493	CLIP-seq
MIRT1317094	hsa-miR-4512	CLIP-seq
MIRT1317095	hsa-miR-4635	CLIP-seq
MIRT2094126	hsa-miR-4643	CLIP-seq
MIRT1317096	hsa-miR-4753-3p	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT1317099	hsa-miR-4768-5p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317101	hsa-miR-502-5p	CLIP-seq
MIRT2614356	hsa-miR-106a	CLIP-seq
MIRT2614357	hsa-miR-106b	CLIP-seq
MIRT2614358	hsa-miR-1207-5p	CLIP-seq
MIRT1317077	hsa-miR-1236	CLIP-seq
MIRT2318767	hsa-miR-1245b-5p	CLIP-seq
MIRT2614359	hsa-miR-1323	CLIP-seq
MIRT1317078	hsa-miR-151-3p	CLIP-seq
MIRT2614360	hsa-miR-17	CLIP-seq
MIRT2614361	hsa-miR-1909	CLIP-seq
MIRT1317079	hsa-miR-193a-3p	CLIP-seq
MIRT1317080	hsa-miR-193b	CLIP-seq
MIRT2614362	hsa-miR-20a	CLIP-seq
MIRT2614363	hsa-miR-20b	CLIP-seq
MIRT1317081	hsa-miR-2861	CLIP-seq
MIRT2614364	hsa-miR-296-5p	CLIP-seq
MIRT2614365	hsa-miR-3064-3p	CLIP-seq
MIRT2614366	hsa-miR-3120-3p	CLIP-seq
MIRT2614367	hsa-miR-3121-5p	CLIP-seq
MIRT2318768	hsa-miR-3142	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT1317083	hsa-miR-3156-3p	CLIP-seq
MIRT1317084	hsa-miR-3176	CLIP-seq
MIRT2614368	hsa-miR-331-3p	CLIP-seq
MIRT2614369	hsa-miR-3605-5p	CLIP-seq
MIRT2614370	hsa-miR-3620	CLIP-seq
MIRT2614371	hsa-miR-3647-3p	CLIP-seq
MIRT2318769	hsa-miR-3671	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317086	hsa-miR-3918	CLIP-seq
MIRT1317087	hsa-miR-3922-3p	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT2614372	hsa-miR-4254	CLIP-seq
MIRT2614373	hsa-miR-4269	CLIP-seq
MIRT2614374	hsa-miR-4292	CLIP-seq
MIRT1317090	hsa-miR-4301	CLIP-seq
MIRT2614375	hsa-miR-4308	CLIP-seq
MIRT2614376	hsa-miR-4313	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317092	hsa-miR-4420	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT2318770	hsa-miR-4493	CLIP-seq
MIRT1317094	hsa-miR-4512	CLIP-seq
MIRT1317095	hsa-miR-4635	CLIP-seq
MIRT2614377	hsa-miR-4722-3p	CLIP-seq
MIRT1317096	hsa-miR-4753-3p	CLIP-seq
MIRT1317097	hsa-miR-4757-5p	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT2614378	hsa-miR-4763-3p	CLIP-seq
MIRT2614379	hsa-miR-4763-5p	CLIP-seq
MIRT2614380	hsa-miR-4767	CLIP-seq
MIRT1317099	hsa-miR-4768-5p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317101	hsa-miR-502-5p	CLIP-seq
MIRT2614381	hsa-miR-519a	CLIP-seq
MIRT2614382	hsa-miR-519b-3p	CLIP-seq
MIRT2614383	hsa-miR-519c-3p	CLIP-seq
MIRT2614384	hsa-miR-519d	CLIP-seq
MIRT2614385	hsa-miR-520g	CLIP-seq
MIRT2614386	hsa-miR-520h	CLIP-seq
MIRT1317102	hsa-miR-532-3p	CLIP-seq
MIRT2614387	hsa-miR-545	CLIP-seq
MIRT2614388	hsa-miR-548o	CLIP-seq
MIRT2614389	hsa-miR-765	CLIP-seq
MIRT2614390	hsa-miR-93	CLIP-seq
MIRT2614356	hsa-miR-106a	CLIP-seq
MIRT2614357	hsa-miR-106b	CLIP-seq
MIRT2614358	hsa-miR-1207-5p	CLIP-seq
MIRT1317077	hsa-miR-1236	CLIP-seq
MIRT2318767	hsa-miR-1245b-5p	CLIP-seq
MIRT2614359	hsa-miR-1323	CLIP-seq
MIRT1317078	hsa-miR-151-3p	CLIP-seq
MIRT2614360	hsa-miR-17	CLIP-seq
MIRT2614361	hsa-miR-1909	CLIP-seq
MIRT1317079	hsa-miR-193a-3p	CLIP-seq
MIRT1317080	hsa-miR-193b	CLIP-seq
MIRT2689950	hsa-miR-2052	CLIP-seq
MIRT2614362	hsa-miR-20a	CLIP-seq
MIRT2614363	hsa-miR-20b	CLIP-seq
MIRT1317081	hsa-miR-2861	CLIP-seq
MIRT2614364	hsa-miR-296-5p	CLIP-seq
MIRT2614365	hsa-miR-3064-3p	CLIP-seq
MIRT2614366	hsa-miR-3120-3p	CLIP-seq
MIRT2614367	hsa-miR-3121-5p	CLIP-seq
MIRT2318768	hsa-miR-3142	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT1317083	hsa-miR-3156-3p	CLIP-seq
MIRT1317084	hsa-miR-3176	CLIP-seq
MIRT2614368	hsa-miR-331-3p	CLIP-seq
MIRT2614369	hsa-miR-3605-5p	CLIP-seq
MIRT2614370	hsa-miR-3620	CLIP-seq
MIRT2614371	hsa-miR-3647-3p	CLIP-seq
MIRT2318769	hsa-miR-3671	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317086	hsa-miR-3918	CLIP-seq
MIRT1317087	hsa-miR-3922-3p	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT2614372	hsa-miR-4254	CLIP-seq
MIRT2614373	hsa-miR-4269	CLIP-seq
MIRT2614374	hsa-miR-4292	CLIP-seq
MIRT1317090	hsa-miR-4301	CLIP-seq
MIRT2689951	hsa-miR-4307	CLIP-seq
MIRT2614375	hsa-miR-4308	CLIP-seq
MIRT2614376	hsa-miR-4313	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317092	hsa-miR-4420	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT2318770	hsa-miR-4493	CLIP-seq
MIRT1317094	hsa-miR-4512	CLIP-seq
MIRT1317095	hsa-miR-4635	CLIP-seq
MIRT2614377	hsa-miR-4722-3p	CLIP-seq
MIRT1317096	hsa-miR-4753-3p	CLIP-seq
MIRT1317097	hsa-miR-4757-5p	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT2614378	hsa-miR-4763-3p	CLIP-seq
MIRT2614379	hsa-miR-4763-5p	CLIP-seq
MIRT2614380	hsa-miR-4767	CLIP-seq
MIRT1317099	hsa-miR-4768-5p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317101	hsa-miR-502-5p	CLIP-seq
MIRT2614381	hsa-miR-519a	CLIP-seq
MIRT2614382	hsa-miR-519b-3p	CLIP-seq
MIRT2614383	hsa-miR-519c-3p	CLIP-seq
MIRT2614384	hsa-miR-519d	CLIP-seq
MIRT2614385	hsa-miR-520g	CLIP-seq
MIRT2614386	hsa-miR-520h	CLIP-seq
MIRT1317102	hsa-miR-532-3p	CLIP-seq
MIRT2614387	hsa-miR-545	CLIP-seq
MIRT2614388	hsa-miR-548o	CLIP-seq
MIRT2614389	hsa-miR-765	CLIP-seq
MIRT2614390	hsa-miR-93	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0004579	Function	Dolichyl-diphosphooligosaccharide-protein glycotransferase activity	TAS	15835887
GO:0005515	Function	Protein binding	IPI	19167329, 22988243, 25416956, 30021884, 31515488, 31831667, 32296183, 32707033, 35271311
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	31831667
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	IDA	9642163
GO:0006487	Process	Protein N-linked glycosylation	NAS	31831667
GO:0008250	Component	Oligosaccharyltransferase complex	IBA
GO:0008250	Component	Oligosaccharyltransferase complex	IDA	9642163
GO:0008250	Component	Oligosaccharyltransferase complex	IEA
GO:0008250	Component	Oligosaccharyltransferase complex	IPI	31831667
GO:0008250	Component	Oligosaccharyltransferase complex	NAS	31831667
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IBA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IMP	17264154
GO:0042470	Component	Melanosome	IEA
GO:0160226	Component	Oligosaccharyltransferase complex A	IDA	31831667, 36697828, 38670073
GO:0160227	Component	Oligosaccharyltransferase complex B	IDA	31831667

MIM	HGNC	e!Ensembl
180470	10381	ENSG00000163902

P04843

Protein name

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)

Protein function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr

PDB

6S7O , 6S7T , 8B6L , 8PN9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04597	Ribophorin_I	31 → 457	Ribophorin I	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues tested. {ECO:0000269|PubMed:12887896}.

Sequence

MEAPAAGLFLLLLLGTWAPAPGSASSEAPPLINEDVKRTVDLSSHLAKVTAEVVLAHLGG
GSTSRATSFLLALEPELEARLAHLGVQVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVA
LDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASR
NVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWG
NIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNV
STSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVF
DEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQH
IQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITE
QVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTE
GSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKI
DHILDAL

Sequence length

607

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum		Asparagine N-linked glycosylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary breast ovarian cancer syndrome	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYELOPROLIFERATIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Myeloid Leukemia With Inv(3)(Q21q26.2) Or T(3;3)(Q21;Q26.2)	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	30170727		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36378050	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	23314186		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	23314186		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Disease	Coronary artery disease	Pubtator	23314186	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	23314186		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	39993959	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	GWASCAT_DG	31178898		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	12557231		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	20556821, 7919381	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	20556821, 7919381		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	35192775	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RPN1 (ribophorin I)