Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6168
Gene name	Ribosomal protein L37a
Gene symbol	RPL37A
Synonyms (NCBI Gene)	L37AeL43
Chromosome	2
Chromosome location	2q35
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049877	hsa-miR-31-5p	CLASH	23622248
MIRT048692	hsa-miR-99a-5p	CLASH	23622248
MIRT039731	hsa-miR-615-3p	CLASH	23622248
MIRT039039	hsa-miR-766-3p	CLASH	23622248
MIRT038552	hsa-miR-106b-3p	CLASH	23622248
MIRT690367	hsa-miR-3163	HITS-CLIP	23313552
MIRT690366	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT690365	hsa-miR-3973	HITS-CLIP	23313552
MIRT690364	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT690363	hsa-miR-520h	HITS-CLIP	23313552
MIRT690362	hsa-miR-499b-5p	HITS-CLIP	23313552
MIRT498756	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT498755	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT498754	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT498753	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT498752	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT690361	hsa-miR-6868-5p	HITS-CLIP	23313552
MIRT690360	hsa-miR-4468	HITS-CLIP	23313552
MIRT690359	hsa-miR-4771	HITS-CLIP	23313552
MIRT690358	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690357	hsa-miR-6081	HITS-CLIP	23313552
MIRT690356	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT690355	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT690354	hsa-miR-4736	HITS-CLIP	23313552
MIRT690353	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT690352	hsa-miR-7150	HITS-CLIP	23313552
MIRT671292	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT671291	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT671290	hsa-miR-4486	HITS-CLIP	23824327
MIRT671289	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT671288	hsa-miR-4284	HITS-CLIP	23824327
MIRT671287	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671286	hsa-miR-4505	HITS-CLIP	23824327
MIRT671285	hsa-miR-5787	HITS-CLIP	23824327
MIRT671284	hsa-miR-585-3p	HITS-CLIP	23824327
MIRT671283	hsa-miR-1268a	HITS-CLIP	23824327
MIRT671282	hsa-miR-1268b	HITS-CLIP	23824327
MIRT671280	hsa-miR-7977	HITS-CLIP	23824327
MIRT671281	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT498757	hsa-miR-4717-5p	PAR-CLIP	24398324
MIRT498758	hsa-miR-15a-3p	PAR-CLIP	24398324
MIRT300347	hsa-miR-1295b-3p	PAR-CLIP	24398324
MIRT498756	hsa-miR-371b-5p	PAR-CLIP	24398324
MIRT498755	hsa-miR-373-5p	PAR-CLIP	24398324
MIRT498754	hsa-miR-616-5p	PAR-CLIP	24398324
MIRT498753	hsa-miR-371a-5p	PAR-CLIP	24398324
MIRT498752	hsa-miR-372-5p	PAR-CLIP	24398324
MIRT300344	hsa-miR-219b-5p	PAR-CLIP	24398324
MIRT300348	hsa-miR-5704	PAR-CLIP	24398324
MIRT690367	hsa-miR-3163	HITS-CLIP	23313552
MIRT690366	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT690365	hsa-miR-3973	HITS-CLIP	23313552
MIRT690364	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT690363	hsa-miR-520h	HITS-CLIP	23313552
MIRT690362	hsa-miR-499b-5p	HITS-CLIP	23313552
MIRT498756	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT498755	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT498754	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT498753	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT498752	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT690361	hsa-miR-6868-5p	HITS-CLIP	23313552
MIRT690360	hsa-miR-4468	HITS-CLIP	23313552
MIRT690359	hsa-miR-4771	HITS-CLIP	23313552
MIRT690358	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690357	hsa-miR-6081	HITS-CLIP	23313552
MIRT690356	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT690355	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT690354	hsa-miR-4736	HITS-CLIP	23313552
MIRT690353	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT690352	hsa-miR-7150	HITS-CLIP	23313552
MIRT671292	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT671291	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT671290	hsa-miR-4486	HITS-CLIP	23824327
MIRT671289	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT671288	hsa-miR-4284	HITS-CLIP	23824327
MIRT671287	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671286	hsa-miR-4505	HITS-CLIP	23824327
MIRT671285	hsa-miR-5787	HITS-CLIP	23824327
MIRT671284	hsa-miR-585-3p	HITS-CLIP	23824327
MIRT671283	hsa-miR-1268a	HITS-CLIP	23824327
MIRT671282	hsa-miR-1268b	HITS-CLIP	23824327
MIRT671280	hsa-miR-7977	HITS-CLIP	23824327
MIRT671281	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT498757	hsa-miR-4717-5p	PAR-CLIP	24398324
MIRT498758	hsa-miR-15a-3p	PAR-CLIP	24398324
MIRT300347	hsa-miR-1295b-3p	PAR-CLIP	24398324
MIRT498756	hsa-miR-371b-5p	PAR-CLIP	24398324
MIRT498755	hsa-miR-373-5p	PAR-CLIP	24398324
MIRT498754	hsa-miR-616-5p	PAR-CLIP	24398324
MIRT498753	hsa-miR-371a-5p	PAR-CLIP	24398324
MIRT498752	hsa-miR-372-5p	PAR-CLIP	24398324
MIRT300344	hsa-miR-219b-5p	PAR-CLIP	24398324
MIRT300348	hsa-miR-5704	PAR-CLIP	24398324
MIRT1316928	hsa-miR-1273d	CLIP-seq
MIRT1316929	hsa-miR-2964a-5p	CLIP-seq
MIRT1316930	hsa-miR-3125	CLIP-seq
MIRT1316931	hsa-miR-371-5p	CLIP-seq
MIRT1316932	hsa-miR-3916	CLIP-seq
MIRT1316933	hsa-miR-4729	CLIP-seq
MIRT1316934	hsa-miR-4795-3p	CLIP-seq
MIRT1316935	hsa-miR-660	CLIP-seq
MIRT1316936	hsa-miR-877	CLIP-seq
MIRT1316928	hsa-miR-1273d	CLIP-seq
MIRT1316929	hsa-miR-2964a-5p	CLIP-seq
MIRT1316930	hsa-miR-3125	CLIP-seq
MIRT1316931	hsa-miR-371-5p	CLIP-seq
MIRT1316932	hsa-miR-3916	CLIP-seq
MIRT1316933	hsa-miR-4729	CLIP-seq
MIRT1316934	hsa-miR-4795-3p	CLIP-seq
MIRT1316935	hsa-miR-660	CLIP-seq
MIRT1316936	hsa-miR-877	CLIP-seq
MIRT1316928	hsa-miR-1273d	CLIP-seq
MIRT1316929	hsa-miR-2964a-5p	CLIP-seq
MIRT1316931	hsa-miR-371-5p	CLIP-seq
MIRT1316933	hsa-miR-4729	CLIP-seq
MIRT1316934	hsa-miR-4795-3p	CLIP-seq
MIRT1316935	hsa-miR-660	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0008270	Function	Zinc ion binding	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
613314	10348	ENSG00000197756

P61513

Protein name

Large ribosomal subunit protein eL43 (60S ribosomal protein L37a)

Protein function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7XNX , 7XNY , 8A3D , 8FKZ , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB , 8FLC , 8FLD , 8FLE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01780	Ribosomal_L37ae	4 → 88	Ribosomal L37ae protein family	Family

Sequence

MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSC
MKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	39252332	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	37946148	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	35830453	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	21649900	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	16264227		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	27411053	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	19927161, 28791303		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	28791303	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28791303		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	29344651, 32255771	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	CTD_human_DG	21411543		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	32729067, 35830453	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	GWASCAT_DG	26776603		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sclerocystic Ovaries	Sclerocystic Ovaries	CTD_human_DG	21411543		★★★★★ ★☆☆☆☆ Found in Text Mining only

RPL37A (ribosomal protein L37a)