Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6165
Gene name	Ribosomal protein L35a
Gene symbol	RPL35A
Synonyms (NCBI Gene)	DBA5L35AeL33
Chromosome	3
Chromosome location	3q29
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (90)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052577	hsa-let-7a-5p	CLASH	23622248
MIRT050460	hsa-miR-22-3p	CLASH	23622248
MIRT050460	hsa-miR-22-3p	CLASH	23622248
MIRT046045	hsa-miR-125b-5p	CLASH	23622248
MIRT045742	hsa-miR-125a-5p	CLASH	23622248
MIRT042955	hsa-miR-324-3p	CLASH	23622248
MIRT039535	hsa-miR-652-3p	CLASH	23622248
MIRT039034	hsa-miR-766-3p	CLASH	23622248
MIRT038604	hsa-miR-193a-5p	CLASH	23622248
MIRT036061	hsa-miR-1301-3p	CLASH	23622248
MIRT035868	hsa-miR-1247-5p	CLASH	23622248
MIRT521364	hsa-miR-3173-3p	PAR-CLIP	23446348
MIRT521363	hsa-miR-6891-5p	PAR-CLIP	23446348
MIRT496174	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT521362	hsa-miR-4476	PAR-CLIP	23446348
MIRT521361	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT521360	hsa-miR-6830-5p	PAR-CLIP	23446348
MIRT521359	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT521358	hsa-miR-665	PAR-CLIP	23446348
MIRT521357	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT496172	hsa-miR-4786-3p	PAR-CLIP	23446348
MIRT521356	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT521355	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT521354	hsa-miR-4533	PAR-CLIP	23446348
MIRT521353	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT496170	hsa-miR-7843-3p	PAR-CLIP	23446348
MIRT496169	hsa-miR-127-5p	PAR-CLIP	23446348
MIRT521352	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT521351	hsa-miR-1273e	PAR-CLIP	23446348
MIRT496174	hsa-miR-6858-3p	PAR-CLIP	22291592
MIRT496173	hsa-miR-338-3p	PAR-CLIP	22291592
MIRT496172	hsa-miR-4786-3p	PAR-CLIP	22291592
MIRT496171	hsa-miR-31-5p	PAR-CLIP	22291592
MIRT496170	hsa-miR-7843-3p	PAR-CLIP	22291592
MIRT496169	hsa-miR-127-5p	PAR-CLIP	22291592
MIRT521364	hsa-miR-3173-3p	PAR-CLIP	23446348
MIRT521363	hsa-miR-6891-5p	PAR-CLIP	23446348
MIRT496174	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT521362	hsa-miR-4476	PAR-CLIP	23446348
MIRT521361	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT521360	hsa-miR-6830-5p	PAR-CLIP	23446348
MIRT521359	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT521358	hsa-miR-665	PAR-CLIP	23446348
MIRT521357	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT496172	hsa-miR-4786-3p	PAR-CLIP	23446348
MIRT521356	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT521355	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT521354	hsa-miR-4533	PAR-CLIP	23446348
MIRT521353	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT496170	hsa-miR-7843-3p	PAR-CLIP	23446348
MIRT496169	hsa-miR-127-5p	PAR-CLIP	23446348
MIRT521352	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT521351	hsa-miR-1273e	PAR-CLIP	23446348
MIRT496174	hsa-miR-6858-3p	PAR-CLIP	22291592
MIRT496173	hsa-miR-338-3p	PAR-CLIP	22291592
MIRT496172	hsa-miR-4786-3p	PAR-CLIP	22291592
MIRT496171	hsa-miR-31-5p	PAR-CLIP	22291592
MIRT496170	hsa-miR-7843-3p	PAR-CLIP	22291592
MIRT496169	hsa-miR-127-5p	PAR-CLIP	22291592
MIRT1316754	hsa-miR-196a	CLIP-seq
MIRT1316755	hsa-miR-196b	CLIP-seq
MIRT1316756	hsa-miR-300	CLIP-seq
MIRT1316757	hsa-miR-335	CLIP-seq
MIRT1316758	hsa-miR-381	CLIP-seq
MIRT1316759	hsa-miR-4436b-5p	CLIP-seq
MIRT1316760	hsa-miR-4719	CLIP-seq
MIRT1316761	hsa-miR-4729	CLIP-seq
MIRT1316762	hsa-miR-548c-3p	CLIP-seq
MIRT1316756	hsa-miR-300	CLIP-seq
MIRT1316757	hsa-miR-335	CLIP-seq
MIRT1316758	hsa-miR-381	CLIP-seq
MIRT1316759	hsa-miR-4436b-5p	CLIP-seq
MIRT1316760	hsa-miR-4719	CLIP-seq
MIRT1316761	hsa-miR-4729	CLIP-seq
MIRT1316756	hsa-miR-300	CLIP-seq
MIRT1316757	hsa-miR-335	CLIP-seq
MIRT1316758	hsa-miR-381	CLIP-seq
MIRT1316760	hsa-miR-4719	CLIP-seq
MIRT1316761	hsa-miR-4729	CLIP-seq
MIRT1316762	hsa-miR-548c-3p	CLIP-seq
MIRT1316756	hsa-miR-300	CLIP-seq
MIRT1316757	hsa-miR-335	CLIP-seq
MIRT1316758	hsa-miR-381	CLIP-seq
MIRT1316759	hsa-miR-4436b-5p	CLIP-seq
MIRT1316760	hsa-miR-4719	CLIP-seq
MIRT1316761	hsa-miR-4729	CLIP-seq
MIRT1316762	hsa-miR-548c-3p	CLIP-seq
MIRT1316757	hsa-miR-335	CLIP-seq
MIRT1316760	hsa-miR-4719	CLIP-seq
MIRT1316761	hsa-miR-4729	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IEA
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	24965446, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0042273	Process	Ribosomal large subunit biogenesis	IBA
GO:0042273	Process	Ribosomal large subunit biogenesis	IMP	18697920
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
180468	10345	ENSG00000182899

P18077

Protein name

Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (Cell growth-inhibiting gene 33 protein)

Protein function

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Required for the proliferati

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01247	Ribosomal_L35Ae	5 → 104	Ribosomal protein L35Ae	Domain

Sequence

MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTP
GGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI

Sequence length

110

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diamond-Blackfan anemia	Likely pathogenic; Pathogenic	rs2530430943, rs1560120302	RCV002403664 RCV002332516	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Diamond-Blackfan anemia 5	Pathogenic; Likely pathogenic	rs116840808, rs116840809, rs2530415161, rs1553811551, rs1560120302, rs1581106084, rs113752862, rs1720051488	RCV000013875 RCV000013877 RCV003514872 RCV000646032 RCV000707343 RCV000995859 RCV001045886 RCV001305334 View all (3 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANEMIA, DIAMOND-BLACKFAN	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RPL35A-related disorder	Conflicting classifications of pathogenicity; Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (31)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute leukemia	Leukemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	35766008, 38176923	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	36195955	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	Pubtator	32241839	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Diamond-Blackfan	Anemia	BEFREE	18535205, 19773262, 20378560, 21435509, 22045982, 22510774, 28432740		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	LHGDN	18535205		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	GENOMICS_ENGLAND_DG	18535205, 28297620		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	CLINVAR_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Macrocytic	Anemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Anhedonia	Anhedonia	Pubtator	20378560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Blackfan-Diamond anemia	Blackfan-Diamond Anemia	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	12175552		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	12521301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromosome 5q Deletion Syndrome	Chromosome 5q deletion syndrome	Pubtator	20378560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Craniofacial Abnormalities	Craniofacial abnormalities	Pubtator	32241839	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diamond-Blackfan Anemia 5	Diamond-Blackfan anemia	CLINVAR_DG	18535205, 25946618		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Diamond-Blackfan Anemia 5	Diamond-Blackfan anemia	UNIPROT_DG	18535205		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Diamond-Blackfan Anemia 5	Diamond-Blackfan anemia	GENOMICS_ENGLAND_DG	18535205		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Diamond-Blackfan Anemia 5	Diamond-Blackfan anemia	CTD_human_DG			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Erythroid hypoplasia	Erythroid hypoplasia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	12175552		★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	32241839	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	12521301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	Pubtator	32241839	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	38256104	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ventricular Septal Defects	Ventricular septal defect	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only

RPL35A (ribosomal protein L35a)