Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6164
Gene name	Ribosomal protein L34
Gene symbol	RPL34
Synonyms (NCBI Gene)	L34eL34
Chromosome	4
Chromosome location	4q25
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT043342	hsa-miR-331-3p	CLASH	23622248
MIRT721657	hsa-miR-892b	HITS-CLIP	19536157
MIRT721656	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT721655	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT721654	hsa-miR-8064	HITS-CLIP	19536157
MIRT721653	hsa-miR-6822-3p	HITS-CLIP	19536157
MIRT721652	hsa-miR-760	HITS-CLIP	19536157
MIRT721651	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT721650	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT721649	hsa-miR-8057	HITS-CLIP	19536157
MIRT679857	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT629435	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629434	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629433	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT629432	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT629431	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT629430	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT629428	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629425	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629435	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629434	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629433	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT629432	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT629431	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT629430	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT629429	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629428	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629427	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629426	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629425	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629424	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629423	hsa-miR-4284	HITS-CLIP	23824327
MIRT629435	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629434	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629429	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629428	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629427	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629426	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629425	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629424	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629423	hsa-miR-4284	HITS-CLIP	23824327
MIRT629435	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629434	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629433	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT629432	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT629431	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT629430	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT629429	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629428	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629427	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629426	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629425	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629424	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629423	hsa-miR-4284	HITS-CLIP	23824327
MIRT721657	hsa-miR-892b	HITS-CLIP	19536157
MIRT721656	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT721655	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT721654	hsa-miR-8064	HITS-CLIP	19536157
MIRT721653	hsa-miR-6822-3p	HITS-CLIP	19536157
MIRT721652	hsa-miR-760	HITS-CLIP	19536157
MIRT721651	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT721650	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT721649	hsa-miR-8057	HITS-CLIP	19536157
MIRT679857	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT629435	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629434	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629433	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT629432	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT629431	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT629430	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT629428	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629425	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629435	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629434	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629433	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT629432	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT629431	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT629430	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT629429	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629428	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629427	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629426	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629425	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629424	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629423	hsa-miR-4284	HITS-CLIP	23824327
MIRT629435	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629434	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629429	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629428	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629427	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629426	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629425	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629424	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629423	hsa-miR-4284	HITS-CLIP	23824327
MIRT629435	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629434	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629433	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT629432	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT629431	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT629430	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT629429	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629428	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629427	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629426	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629425	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629424	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629423	hsa-miR-4284	HITS-CLIP	23824327
MIRT1316740	hsa-miR-149	CLIP-seq
MIRT1316741	hsa-miR-2277-3p	CLIP-seq
MIRT1316742	hsa-miR-3613-3p	CLIP-seq
MIRT1316743	hsa-miR-371b-5p	CLIP-seq
MIRT1316744	hsa-miR-4311	CLIP-seq
MIRT1316745	hsa-miR-4520a-3p	CLIP-seq
MIRT1316746	hsa-miR-4520b-3p	CLIP-seq
MIRT1316747	hsa-miR-4708-5p	CLIP-seq
MIRT1316748	hsa-miR-556-3p	CLIP-seq
MIRT1316749	hsa-miR-561	CLIP-seq
MIRT1316750	hsa-miR-579	CLIP-seq
MIRT1316751	hsa-miR-888	CLIP-seq
MIRT2689947	hsa-miR-216a	CLIP-seq
MIRT2689948	hsa-miR-4480	CLIP-seq
MIRT2689949	hsa-miR-513c	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	TAS	7490091
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	7490091
GO:0005515	Function	Protein binding	IPI	24725412, 30021884, 31046837, 35271311
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	7490091
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	7490091
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0045202	Component	Synapse	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
616862	10340	ENSG00000109475

P49207

Protein name

Large ribosomal subunit protein eL34 (60S ribosomal protein L34)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6MTD , 6MTE , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7XNX , 7XNY , 8A3D , 8FKY , 8FKZ , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01199	Ribosomal_L34e	1 → 96	Ribosomal protein L34e	Family

Sequence

MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGVRAVR
PKVLMRLSKTKKHVSRAYGGSMCAKCVRDRIKRAFLIEEQKIVVKVLKAQAQSQKAK

Sequence length

117

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (31)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	38176923	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	39742384	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31574377	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	30103068		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	28109079		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	28109079		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	31574377	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	36162992	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30216512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37689361	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	31574377	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	30103068		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	28109079		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	27845896		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	26323242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26323242, 28109079		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	34275924	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	30103068		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27845896, 28109079		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	26526135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	27883047		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	27883047	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	27845896		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	10616211		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	26323242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Diseases	Stomach disease	Pubtator	26323242	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	26237576, 26323242	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31574377	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
synovial sarcoma	Synovial sarcoma	BEFREE	11423977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	BEFREE	30103068		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vitiligo	Vitiligo	Pubtator	33463119	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RPL34 (ribosomal protein L34)