Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6141
Gene name	Ribosomal protein L18
Gene symbol	RPL18
Synonyms (NCBI Gene)	DBA18L18eL18
Chromosome	19
Chromosome location	19q13.33
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051955	hsa-let-7b-5p	CLASH	23622248
MIRT045664	hsa-miR-149-5p	CLASH	23622248
MIRT044312	hsa-miR-106b-5p	CLASH	23622248
MIRT037632	hsa-miR-744-5p	CLASH	23622248
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT514581	hsa-miR-548p	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	20371350
MIRT514579	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT514581	hsa-miR-548p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT514580	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT514579	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT514581	hsa-miR-548p	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	20371350
MIRT514579	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT514581	hsa-miR-548p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT514580	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT514579	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT1316209	hsa-miR-545	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	TAS	8218404
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	8218404
GO:0005515	Function	Protein binding	IPI	30021884, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	8218404
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	8218404
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
604179	10310	ENSG00000063177

Q07020

Protein name

Large ribosomal subunit protein eL18 (60S ribosomal protein L18)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZVK , 7A01 , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17135	Ribosomal_L18	2 → 188	Ribosomal protein 60S L18 and 50S L18e	Family

Sequence

MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPP
LSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKI
LTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGR
RASRGYKN

Sequence length

188

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diamond-Blackfan anemia 18	Pathogenic	rs1568425218	RCV000754828	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANEMIA, DIAMOND-BLACKFAN	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIAMOND-BLACKFAN ANEMIA	—	GWAS catalog, Orphanet GWAS catalog, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RPL18-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aase Smith syndrome 2	Aase-Smith syndrome	ORPHANET_DG	28280134		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute leukemia	Leukemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Agranulocytosis	Agranulocytosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Diamond-Blackfan	Anemia	ORPHANET_DG	28280134		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	GENOMICS_ENGLAND_DG	28280134		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Macrocytic	Anemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Blackfan-Diamond anemia	Blackfan-Diamond Anemia	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	8218404		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral disc disease	Pubtator	31124977	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28253842		★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Kaposi	Sarcoma	Pubtator	40016701	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

RPL18 (ribosomal protein L18)