Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	60682
Gene name	Small ArfGAP 1
Gene symbol	SMAP1
Synonyms (NCBI Gene)	SMAP-1
Chromosome	6
Chromosome location	6q13
Summary	The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal ce

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050219	hsa-miR-25-3p	CLASH	23622248
MIRT1371311	hsa-miR-101	CLIP-seq
MIRT1371312	hsa-miR-127-5p	CLIP-seq
MIRT1371313	hsa-miR-130a	CLIP-seq
MIRT1371314	hsa-miR-130b	CLIP-seq
MIRT1371315	hsa-miR-144	CLIP-seq
MIRT1371316	hsa-miR-153	CLIP-seq
MIRT1371317	hsa-miR-15a	CLIP-seq
MIRT1371318	hsa-miR-15b	CLIP-seq
MIRT1371319	hsa-miR-16	CLIP-seq
MIRT1371320	hsa-miR-193a-3p	CLIP-seq
MIRT1371321	hsa-miR-193b	CLIP-seq
MIRT1371322	hsa-miR-195	CLIP-seq
MIRT1371323	hsa-miR-2355-3p	CLIP-seq
MIRT1371324	hsa-miR-298	CLIP-seq
MIRT1371325	hsa-miR-301a	CLIP-seq
MIRT1371326	hsa-miR-301b	CLIP-seq
MIRT1371327	hsa-miR-3159	CLIP-seq
MIRT1371328	hsa-miR-3170	CLIP-seq
MIRT1371329	hsa-miR-342-5p	CLIP-seq
MIRT1371330	hsa-miR-3666	CLIP-seq
MIRT1371331	hsa-miR-3667-3p	CLIP-seq
MIRT1371332	hsa-miR-3685	CLIP-seq
MIRT1371333	hsa-miR-424	CLIP-seq
MIRT1371334	hsa-miR-4260	CLIP-seq
MIRT1371335	hsa-miR-4295	CLIP-seq
MIRT1371336	hsa-miR-448	CLIP-seq
MIRT1371337	hsa-miR-454	CLIP-seq
MIRT1371338	hsa-miR-4646-3p	CLIP-seq
MIRT1371339	hsa-miR-4651	CLIP-seq
MIRT1371340	hsa-miR-4664-5p	CLIP-seq
MIRT1371341	hsa-miR-4671-3p	CLIP-seq
MIRT1371342	hsa-miR-4700-3p	CLIP-seq
MIRT1371343	hsa-miR-4705	CLIP-seq
MIRT1371344	hsa-miR-4724-3p	CLIP-seq
MIRT1371345	hsa-miR-4735-5p	CLIP-seq
MIRT1371346	hsa-miR-4775	CLIP-seq
MIRT1371347	hsa-miR-4794	CLIP-seq
MIRT1371348	hsa-miR-485-3p	CLIP-seq
MIRT1371349	hsa-miR-487a	CLIP-seq
MIRT1371350	hsa-miR-497	CLIP-seq
MIRT1371351	hsa-miR-548q	CLIP-seq
MIRT1371352	hsa-miR-582-3p	CLIP-seq
MIRT1371353	hsa-miR-590-3p	CLIP-seq
MIRT1371354	hsa-miR-608	CLIP-seq
MIRT1371355	hsa-miR-889	CLIP-seq
MIRT1371356	hsa-miR-892b	CLIP-seq
MIRT1371312	hsa-miR-127-5p	CLIP-seq
MIRT1371317	hsa-miR-15a	CLIP-seq
MIRT1371318	hsa-miR-15b	CLIP-seq
MIRT1371319	hsa-miR-16	CLIP-seq
MIRT1371322	hsa-miR-195	CLIP-seq
MIRT1371323	hsa-miR-2355-3p	CLIP-seq
MIRT1371333	hsa-miR-424	CLIP-seq
MIRT1371357	hsa-miR-4506	CLIP-seq
MIRT1371358	hsa-miR-4517	CLIP-seq
MIRT1371338	hsa-miR-4646-3p	CLIP-seq
MIRT1371343	hsa-miR-4705	CLIP-seq
MIRT1371350	hsa-miR-497	CLIP-seq
MIRT1371351	hsa-miR-548q	CLIP-seq
MIRT1371359	hsa-miR-555	CLIP-seq
MIRT1371352	hsa-miR-582-3p	CLIP-seq
MIRT1371355	hsa-miR-889	CLIP-seq
MIRT1371311	hsa-miR-101	CLIP-seq
MIRT1371315	hsa-miR-144	CLIP-seq
MIRT1371320	hsa-miR-193a-3p	CLIP-seq
MIRT1371321	hsa-miR-193b	CLIP-seq
MIRT2110149	hsa-miR-30a	CLIP-seq
MIRT2110150	hsa-miR-30b	CLIP-seq
MIRT2110151	hsa-miR-30c	CLIP-seq
MIRT2110152	hsa-miR-30d	CLIP-seq
MIRT2110153	hsa-miR-30e	CLIP-seq
MIRT2110154	hsa-miR-3143	CLIP-seq
MIRT1371327	hsa-miR-3159	CLIP-seq
MIRT2110155	hsa-miR-3163	CLIP-seq
MIRT2110156	hsa-miR-339-5p	CLIP-seq
MIRT2110157	hsa-miR-34b	CLIP-seq
MIRT2110158	hsa-miR-3622a-5p	CLIP-seq
MIRT2110159	hsa-miR-3662	CLIP-seq
MIRT1371331	hsa-miR-3667-3p	CLIP-seq
MIRT1371332	hsa-miR-3685	CLIP-seq
MIRT2110160	hsa-miR-4275	CLIP-seq
MIRT2110161	hsa-miR-4423-3p	CLIP-seq
MIRT2110162	hsa-miR-4495	CLIP-seq
MIRT2110163	hsa-miR-4503	CLIP-seq
MIRT1371342	hsa-miR-4700-3p	CLIP-seq
MIRT1371344	hsa-miR-4724-3p	CLIP-seq
MIRT1371347	hsa-miR-4794	CLIP-seq
MIRT1371348	hsa-miR-485-3p	CLIP-seq
MIRT1371349	hsa-miR-487a	CLIP-seq
MIRT2110164	hsa-miR-543	CLIP-seq
MIRT2110165	hsa-miR-670	CLIP-seq
MIRT2110166	hsa-miR-767-5p	CLIP-seq
MIRT1371356	hsa-miR-892b	CLIP-seq
MIRT1371311	hsa-miR-101	CLIP-seq
MIRT1371312	hsa-miR-127-5p	CLIP-seq
MIRT1371315	hsa-miR-144	CLIP-seq
MIRT1371317	hsa-miR-15a	CLIP-seq
MIRT1371318	hsa-miR-15b	CLIP-seq
MIRT1371319	hsa-miR-16	CLIP-seq
MIRT1371320	hsa-miR-193a-3p	CLIP-seq
MIRT1371321	hsa-miR-193b	CLIP-seq
MIRT1371322	hsa-miR-195	CLIP-seq
MIRT2333723	hsa-miR-3134	CLIP-seq
MIRT2110154	hsa-miR-3143	CLIP-seq
MIRT1371327	hsa-miR-3159	CLIP-seq
MIRT2110155	hsa-miR-3163	CLIP-seq
MIRT1371328	hsa-miR-3170	CLIP-seq
MIRT2333724	hsa-miR-3198	CLIP-seq
MIRT2110156	hsa-miR-339-5p	CLIP-seq
MIRT1371329	hsa-miR-342-5p	CLIP-seq
MIRT2110157	hsa-miR-34b	CLIP-seq
MIRT2333725	hsa-miR-3655	CLIP-seq
MIRT2110159	hsa-miR-3662	CLIP-seq
MIRT1371331	hsa-miR-3667-3p	CLIP-seq
MIRT1371332	hsa-miR-3685	CLIP-seq
MIRT1371333	hsa-miR-424	CLIP-seq
MIRT1371334	hsa-miR-4260	CLIP-seq
MIRT2110160	hsa-miR-4275	CLIP-seq
MIRT2333726	hsa-miR-4309	CLIP-seq
MIRT2333727	hsa-miR-4502	CLIP-seq
MIRT2110163	hsa-miR-4503	CLIP-seq
MIRT1371358	hsa-miR-4517	CLIP-seq
MIRT2333728	hsa-miR-4534	CLIP-seq
MIRT1371339	hsa-miR-4651	CLIP-seq
MIRT1371340	hsa-miR-4664-5p	CLIP-seq
MIRT2333729	hsa-miR-4693-5p	CLIP-seq
MIRT1371342	hsa-miR-4700-3p	CLIP-seq
MIRT1371343	hsa-miR-4705	CLIP-seq
MIRT1371344	hsa-miR-4724-3p	CLIP-seq
MIRT1371345	hsa-miR-4735-5p	CLIP-seq
MIRT1371346	hsa-miR-4775	CLIP-seq
MIRT1371347	hsa-miR-4794	CLIP-seq
MIRT1371348	hsa-miR-485-3p	CLIP-seq
MIRT1371349	hsa-miR-487a	CLIP-seq
MIRT1371350	hsa-miR-497	CLIP-seq
MIRT2110164	hsa-miR-543	CLIP-seq
MIRT2333730	hsa-miR-578	CLIP-seq
MIRT1371352	hsa-miR-582-3p	CLIP-seq
MIRT1371353	hsa-miR-590-3p	CLIP-seq
MIRT1371354	hsa-miR-608	CLIP-seq
MIRT2110165	hsa-miR-670	CLIP-seq
MIRT1371355	hsa-miR-889	CLIP-seq
MIRT1371356	hsa-miR-892b	CLIP-seq
MIRT1371312	hsa-miR-127-5p	CLIP-seq
MIRT1371317	hsa-miR-15a	CLIP-seq
MIRT1371318	hsa-miR-15b	CLIP-seq
MIRT1371319	hsa-miR-16	CLIP-seq
MIRT1371322	hsa-miR-195	CLIP-seq
MIRT1371323	hsa-miR-2355-3p	CLIP-seq
MIRT2110156	hsa-miR-339-5p	CLIP-seq
MIRT2110157	hsa-miR-34b	CLIP-seq
MIRT1371333	hsa-miR-424	CLIP-seq
MIRT2110163	hsa-miR-4503	CLIP-seq
MIRT1371338	hsa-miR-4646-3p	CLIP-seq
MIRT1371350	hsa-miR-497	CLIP-seq
MIRT1371351	hsa-miR-548q	CLIP-seq
MIRT1371352	hsa-miR-582-3p	CLIP-seq
MIRT2110165	hsa-miR-670	CLIP-seq
MIRT2459988	hsa-miR-197	CLIP-seq
MIRT2459989	hsa-miR-204	CLIP-seq
MIRT2459990	hsa-miR-211	CLIP-seq
MIRT2459991	hsa-miR-3125	CLIP-seq
MIRT2459992	hsa-miR-3140-3p	CLIP-seq
MIRT2459993	hsa-miR-3157-3p	CLIP-seq
MIRT2110155	hsa-miR-3163	CLIP-seq
MIRT2110159	hsa-miR-3662	CLIP-seq
MIRT2459994	hsa-miR-3916	CLIP-seq
MIRT2459995	hsa-miR-4461	CLIP-seq
MIRT1371336	hsa-miR-448	CLIP-seq
MIRT1371357	hsa-miR-4506	CLIP-seq
MIRT1371358	hsa-miR-4517	CLIP-seq
MIRT1371343	hsa-miR-4705	CLIP-seq
MIRT2459996	hsa-miR-4714-3p	CLIP-seq
MIRT1371344	hsa-miR-4724-3p	CLIP-seq
MIRT2459997	hsa-miR-4755-5p	CLIP-seq
MIRT1371346	hsa-miR-4775	CLIP-seq
MIRT2459998	hsa-miR-5096	CLIP-seq
MIRT2459999	hsa-miR-515-5p	CLIP-seq
MIRT1371359	hsa-miR-555	CLIP-seq
MIRT2460000	hsa-miR-586	CLIP-seq
MIRT1371353	hsa-miR-590-3p	CLIP-seq
MIRT2460001	hsa-miR-606	CLIP-seq
MIRT2460002	hsa-miR-623	CLIP-seq
MIRT2460003	hsa-miR-874	CLIP-seq
MIRT1371355	hsa-miR-889	CLIP-seq
MIRT2460004	hsa-miR-938	CLIP-seq
MIRT2459993	hsa-miR-3157-3p	CLIP-seq
MIRT2459999	hsa-miR-515-5p	CLIP-seq
MIRT2460003	hsa-miR-874	CLIP-seq
MIRT2460004	hsa-miR-938	CLIP-seq
MIRT2627925	hsa-miR-1	CLIP-seq
MIRT2627926	hsa-miR-1255a	CLIP-seq
MIRT2627927	hsa-miR-1255b	CLIP-seq
MIRT2627928	hsa-miR-125a-3p	CLIP-seq
MIRT2627929	hsa-miR-1299	CLIP-seq
MIRT2459988	hsa-miR-197	CLIP-seq
MIRT2459989	hsa-miR-204	CLIP-seq
MIRT2627930	hsa-miR-206	CLIP-seq
MIRT2459990	hsa-miR-211	CLIP-seq
MIRT2627931	hsa-miR-28-3p	CLIP-seq
MIRT2459991	hsa-miR-3125	CLIP-seq
MIRT2459992	hsa-miR-3140-3p	CLIP-seq
MIRT2110155	hsa-miR-3163	CLIP-seq
MIRT2627932	hsa-miR-3168	CLIP-seq
MIRT2110159	hsa-miR-3662	CLIP-seq
MIRT2627933	hsa-miR-371-5p	CLIP-seq
MIRT2627934	hsa-miR-371b-5p	CLIP-seq
MIRT2459994	hsa-miR-3916	CLIP-seq
MIRT2627935	hsa-miR-3934	CLIP-seq
MIRT2627936	hsa-miR-4291	CLIP-seq
MIRT2459995	hsa-miR-4461	CLIP-seq
MIRT2627937	hsa-miR-4468	CLIP-seq
MIRT2627938	hsa-miR-4471	CLIP-seq
MIRT1371336	hsa-miR-448	CLIP-seq
MIRT1371357	hsa-miR-4506	CLIP-seq
MIRT2627939	hsa-miR-450b-5p	CLIP-seq
MIRT1371358	hsa-miR-4517	CLIP-seq
MIRT2627940	hsa-miR-4536	CLIP-seq
MIRT1371343	hsa-miR-4705	CLIP-seq
MIRT2459996	hsa-miR-4714-3p	CLIP-seq
MIRT2459997	hsa-miR-4755-5p	CLIP-seq
MIRT1371346	hsa-miR-4775	CLIP-seq
MIRT2627941	hsa-miR-4782-5p	CLIP-seq
MIRT2627942	hsa-miR-507	CLIP-seq
MIRT2459998	hsa-miR-5096	CLIP-seq
MIRT2627943	hsa-miR-513c	CLIP-seq
MIRT2627944	hsa-miR-514b-5p	CLIP-seq
MIRT2627945	hsa-miR-516b	CLIP-seq
MIRT2627946	hsa-miR-545	CLIP-seq
MIRT2627947	hsa-miR-548a-3p	CLIP-seq
MIRT2627948	hsa-miR-548e	CLIP-seq
MIRT2627949	hsa-miR-548f	CLIP-seq
MIRT1371359	hsa-miR-555	CLIP-seq
MIRT2627950	hsa-miR-557	CLIP-seq
MIRT2460000	hsa-miR-586	CLIP-seq
MIRT1371353	hsa-miR-590-3p	CLIP-seq
MIRT2460001	hsa-miR-606	CLIP-seq
MIRT2627951	hsa-miR-613	CLIP-seq
MIRT2460002	hsa-miR-623	CLIP-seq
MIRT2627952	hsa-miR-646	CLIP-seq
MIRT2627953	hsa-miR-764	CLIP-seq
MIRT1371355	hsa-miR-889	CLIP-seq
MIRT2459989	hsa-miR-204	CLIP-seq
MIRT2459990	hsa-miR-211	CLIP-seq
MIRT2459991	hsa-miR-3125	CLIP-seq
MIRT2627933	hsa-miR-371-5p	CLIP-seq
MIRT2627934	hsa-miR-371b-5p	CLIP-seq
MIRT2459994	hsa-miR-3916	CLIP-seq
MIRT2459995	hsa-miR-4461	CLIP-seq
MIRT2627937	hsa-miR-4468	CLIP-seq
MIRT1371357	hsa-miR-4506	CLIP-seq
MIRT2627939	hsa-miR-450b-5p	CLIP-seq
MIRT1371358	hsa-miR-4517	CLIP-seq
MIRT1371343	hsa-miR-4705	CLIP-seq
MIRT2459997	hsa-miR-4755-5p	CLIP-seq
MIRT1371346	hsa-miR-4775	CLIP-seq
MIRT2627942	hsa-miR-507	CLIP-seq
MIRT2627943	hsa-miR-513c	CLIP-seq
MIRT2627944	hsa-miR-514b-5p	CLIP-seq
MIRT2627947	hsa-miR-548a-3p	CLIP-seq
MIRT2627948	hsa-miR-548e	CLIP-seq
MIRT2627949	hsa-miR-548f	CLIP-seq
MIRT1371359	hsa-miR-555	CLIP-seq
MIRT2627950	hsa-miR-557	CLIP-seq
MIRT1371353	hsa-miR-590-3p	CLIP-seq
MIRT2460001	hsa-miR-606	CLIP-seq
MIRT2460002	hsa-miR-623	CLIP-seq
MIRT2627952	hsa-miR-646	CLIP-seq
MIRT1371355	hsa-miR-889	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0030276	Function	Clathrin binding	IEA
GO:0045648	Process	Positive regulation of erythrocyte differentiation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:2000369	Process	Regulation of clathrin-dependent endocytosis	IBA
GO:2000369	Process	Regulation of clathrin-dependent endocytosis	IEA

MIM	HGNC	e!Ensembl
611372	19651	ENSG00000112305

Q8IYB5

Protein name

Stromal membrane-associated protein 1

Protein function

GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity).

PDB

2CRR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01412	ArfGap	18 → 132	Putative GTPase activating protein for Arf	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in bone marrow, adrenal gland, trachea, lymph node, spinal cord, peripheral blood leukocytes, thyroid and stomach. {ECO:0000269|PubMed:12119110}.

Sequence

MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIH
RNLGVHISRVKSVNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIR
DKYEKKKYYDKNAIAITNISSSDAPLQPLVSSPSLQAAVDKNKLEKEKEKKKEEKKREKE
PEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLN
DDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQL
SKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVM
GQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWS
LSQMNQQMAGMSISSATPTAGFGQPSSTTAGWSGSSSGQTLSTQLWK

Sequence length

467

Interactions

View interactions

	KEGG
	Endocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OCULAR HYPOTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23752192		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36494580	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23752192		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa 25	Retinitis Pigmentosa	BEFREE	16273301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Venous Thromboembolism	Venous thromboembolism	Pubtator	28011674	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SMAP1 (small ArfGAP 1)