Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	60680
Gene name	CUGBP Elav-like family member 5
Gene symbol	CELF5
Synonyms (NCBI Gene)	BRUNOL-5BRUNOL5CELF-5
Chromosome	19
Chromosome location	19p13.3
Summary	This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this

157

Show/Hide all (157)

miRTarBase ID	miRNA	Experiments
MIRT884173	hsa-miR-1200	CLIP-seq
MIRT884174	hsa-miR-1273g	CLIP-seq
MIRT884175	hsa-miR-147	CLIP-seq
MIRT884176	hsa-miR-3138	CLIP-seq
MIRT884177	hsa-miR-3140-5p	CLIP-seq
MIRT884178	hsa-miR-3162-3p	CLIP-seq
MIRT884179	hsa-miR-34a	CLIP-seq
MIRT884180	hsa-miR-34c-5p	CLIP-seq
MIRT884181	hsa-miR-361-3p	CLIP-seq
MIRT884182	hsa-miR-3618	CLIP-seq
MIRT884183	hsa-miR-3679-3p	CLIP-seq
MIRT884184	hsa-miR-3911	CLIP-seq
MIRT884185	hsa-miR-3977	CLIP-seq
MIRT884186	hsa-miR-4267	CLIP-seq
MIRT884187	hsa-miR-4286	CLIP-seq
MIRT884188	hsa-miR-4311	CLIP-seq
MIRT884189	hsa-miR-448	CLIP-seq
MIRT884190	hsa-miR-4496	CLIP-seq
MIRT884191	hsa-miR-449a	CLIP-seq
MIRT884192	hsa-miR-449b	CLIP-seq
MIRT884193	hsa-miR-4652-3p	CLIP-seq
MIRT884194	hsa-miR-644	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT884196	hsa-miR-934	CLIP-seq
MIRT884197	hsa-miR-1266	CLIP-seq
MIRT884198	hsa-miR-3127-5p	CLIP-seq
MIRT884199	hsa-miR-3141	CLIP-seq
MIRT884200	hsa-miR-3178	CLIP-seq
MIRT884201	hsa-miR-3918	CLIP-seq
MIRT884202	hsa-miR-4265	CLIP-seq
MIRT884203	hsa-miR-4296	CLIP-seq
MIRT884204	hsa-miR-4322	CLIP-seq
MIRT884205	hsa-miR-4417	CLIP-seq
MIRT884206	hsa-miR-4518	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT884188	hsa-miR-4311	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT884188	hsa-miR-4311	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT884174	hsa-miR-1273g	CLIP-seq
MIRT884175	hsa-miR-147	CLIP-seq
MIRT884181	hsa-miR-361-3p	CLIP-seq
MIRT884183	hsa-miR-3679-3p	CLIP-seq
MIRT884184	hsa-miR-3911	CLIP-seq
MIRT1921559	hsa-miR-4307	CLIP-seq
MIRT884188	hsa-miR-4311	CLIP-seq
MIRT884193	hsa-miR-4652-3p	CLIP-seq
MIRT884194	hsa-miR-644	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT884174	hsa-miR-1273g	CLIP-seq
MIRT884175	hsa-miR-147	CLIP-seq
MIRT884181	hsa-miR-361-3p	CLIP-seq
MIRT884183	hsa-miR-3679-3p	CLIP-seq
MIRT884184	hsa-miR-3911	CLIP-seq
MIRT1921559	hsa-miR-4307	CLIP-seq
MIRT884188	hsa-miR-4311	CLIP-seq
MIRT884193	hsa-miR-4652-3p	CLIP-seq
MIRT884194	hsa-miR-644	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT884174	hsa-miR-1273g	CLIP-seq
MIRT884175	hsa-miR-147	CLIP-seq
MIRT884181	hsa-miR-361-3p	CLIP-seq
MIRT884183	hsa-miR-3679-3p	CLIP-seq
MIRT884184	hsa-miR-3911	CLIP-seq
MIRT1921559	hsa-miR-4307	CLIP-seq
MIRT884188	hsa-miR-4311	CLIP-seq
MIRT884193	hsa-miR-4652-3p	CLIP-seq
MIRT884194	hsa-miR-644	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT884174	hsa-miR-1273g	CLIP-seq
MIRT884175	hsa-miR-147	CLIP-seq
MIRT884181	hsa-miR-361-3p	CLIP-seq
MIRT884183	hsa-miR-3679-3p	CLIP-seq
MIRT884184	hsa-miR-3911	CLIP-seq
MIRT1921559	hsa-miR-4307	CLIP-seq
MIRT884188	hsa-miR-4311	CLIP-seq
MIRT884193	hsa-miR-4652-3p	CLIP-seq
MIRT884194	hsa-miR-644	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT1962157	hsa-miR-1207-5p	CLIP-seq
MIRT884174	hsa-miR-1273g	CLIP-seq
MIRT1962158	hsa-miR-140-3p	CLIP-seq
MIRT884175	hsa-miR-147	CLIP-seq
MIRT1962159	hsa-miR-3170	CLIP-seq
MIRT1962160	hsa-miR-3175	CLIP-seq
MIRT1962161	hsa-miR-3179	CLIP-seq
MIRT1962162	hsa-miR-3184	CLIP-seq
MIRT884181	hsa-miR-361-3p	CLIP-seq
MIRT884183	hsa-miR-3679-3p	CLIP-seq
MIRT1962163	hsa-miR-3689d	CLIP-seq
MIRT884184	hsa-miR-3911	CLIP-seq
MIRT1962164	hsa-miR-423-5p	CLIP-seq
MIRT1962165	hsa-miR-4259	CLIP-seq
MIRT884188	hsa-miR-4311	CLIP-seq
MIRT1962166	hsa-miR-4323	CLIP-seq
MIRT1962167	hsa-miR-4447	CLIP-seq
MIRT1962168	hsa-miR-4472	CLIP-seq
MIRT884193	hsa-miR-4652-3p	CLIP-seq
MIRT1962169	hsa-miR-4667-5p	CLIP-seq
MIRT1962170	hsa-miR-4688	CLIP-seq
MIRT1962171	hsa-miR-4700-5p	CLIP-seq
MIRT1962172	hsa-miR-4716-3p	CLIP-seq
MIRT1962173	hsa-miR-4763-3p	CLIP-seq
MIRT1962174	hsa-miR-483-3p	CLIP-seq
MIRT1962175	hsa-miR-486-3p	CLIP-seq
MIRT1962176	hsa-miR-571	CLIP-seq
MIRT1962177	hsa-miR-615-5p	CLIP-seq
MIRT884194	hsa-miR-644	CLIP-seq
MIRT884195	hsa-miR-766	CLIP-seq
MIRT1962178	hsa-miR-936	CLIP-seq
MIRT1962157	hsa-miR-1207-5p	CLIP-seq
MIRT2198676	hsa-miR-1307	CLIP-seq
MIRT1962162	hsa-miR-3184	CLIP-seq
MIRT2198677	hsa-miR-342-5p	CLIP-seq
MIRT2198678	hsa-miR-3648	CLIP-seq
MIRT884183	hsa-miR-3679-3p	CLIP-seq
MIRT2198679	hsa-miR-3690	CLIP-seq
MIRT1962164	hsa-miR-423-5p	CLIP-seq
MIRT2198680	hsa-miR-4254	CLIP-seq
MIRT2198681	hsa-miR-4316	CLIP-seq
MIRT1962167	hsa-miR-4447	CLIP-seq
MIRT2198682	hsa-miR-4462	CLIP-seq
MIRT1962168	hsa-miR-4472	CLIP-seq
MIRT2198683	hsa-miR-4664-5p	CLIP-seq
MIRT1962170	hsa-miR-4688	CLIP-seq
MIRT2198684	hsa-miR-4710	CLIP-seq
MIRT2198685	hsa-miR-4712-5p	CLIP-seq
MIRT1962173	hsa-miR-4763-3p	CLIP-seq
MIRT2198686	hsa-miR-4767	CLIP-seq
MIRT1962175	hsa-miR-486-3p	CLIP-seq
MIRT2198687	hsa-miR-602	CLIP-seq
MIRT2198688	hsa-miR-770-5p	CLIP-seq
MIRT1962178	hsa-miR-936	CLIP-seq
MIRT1962157	hsa-miR-1207-5p	CLIP-seq
MIRT2385924	hsa-miR-3151	CLIP-seq
MIRT2198677	hsa-miR-342-5p	CLIP-seq
MIRT1962163	hsa-miR-3689d	CLIP-seq
MIRT2198679	hsa-miR-3690	CLIP-seq
MIRT2198680	hsa-miR-4254	CLIP-seq
MIRT1962167	hsa-miR-4447	CLIP-seq
MIRT1962168	hsa-miR-4472	CLIP-seq
MIRT2385925	hsa-miR-4651	CLIP-seq
MIRT2198683	hsa-miR-4664-5p	CLIP-seq
MIRT1962173	hsa-miR-4763-3p	CLIP-seq
MIRT2385926	hsa-miR-4774-5p	CLIP-seq
MIRT1962175	hsa-miR-486-3p	CLIP-seq
MIRT2385927	hsa-miR-608	CLIP-seq
MIRT884174	hsa-miR-1273g	CLIP-seq
MIRT884175	hsa-miR-147	CLIP-seq
MIRT884181	hsa-miR-361-3p	CLIP-seq
MIRT884183	hsa-miR-3679-3p	CLIP-seq
MIRT884184	hsa-miR-3911	CLIP-seq
MIRT884193	hsa-miR-4652-3p	CLIP-seq
MIRT884194	hsa-miR-644	CLIP-seq
MIRT2446823	hsa-miR-1280	CLIP-seq
MIRT884187	hsa-miR-4286	CLIP-seq
MIRT2446824	hsa-miR-4640-3p	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IBA
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IDA	11158314
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS	11158314
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006376	Process	MRNA splice site recognition	IBA
GO:0006397	Process	MRNA processing	IEA
GO:0036002	Function	Pre-mRNA binding	NAS	11158314
GO:1990904	Component	Ribonucleoprotein complex	IBA

MIM	HGNC	e!Ensembl
612680	14058	ENSG00000161082

Q8N6W0

Protein name

CUGBP Elav-like family member 5 (CELF-5) (Bruno-like protein 5) (CUG-BP- and ETR-3-like factor 5) (RNA-binding protein BRUNOL-5)

Protein function

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activate

PDB

2DNH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	47 → 116	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	136 → 204	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	402 → 472	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain. {ECO:0000269|PubMed:11158314}.

Sequence

MARLTESEARRQQQQLLQPRPSPVGSSGPEPPGGQPDGMKDLDAIKLFVGQIPRHLDEKD
LKPLFEQFGRIYELTVLKDPYTGMHKGCAFLTYCARDSAIKAQTALHEQKTLPGMARPIQ
VKPADSESRGGRDRKLFVGMLNKQQSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAFVK
FSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGILTPSLTLP
FSPYSAYAQALMQQQTTVLSTSGSYLSPGVAFSPCHIQQIGAVSLNGLPATPIAPASGLH
SPPLLGTTAVPGLVAPITNGFAGVVPFPGGHPALETVYANGLVPYPAQSPTVAETLHPAF
SGVQQYTAMYPTAAITPIAHSVPQPPPLLQQQQREGPEGCNLFIYHLPQEFGDTELTQMF
LPFGNIISSKVFMDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKD
PGHPY

Sequence length

485

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IGA GLOMERULONEPHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
nervous system disorder	Nervous System Disorder	BEFREE	29328469		★★★★★ ★☆☆☆☆ Found in Text Mining only

CELF5 (CUGBP Elav-like family member 5)