Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	60626
Gene name	RIC8 guanine nucleotide exchange factor A
Gene symbol	RIC8A
Synonyms (NCBI Gene)	RIC8
Chromosome	11
Chromosome location	11p15.5

130

Show/Hide all (130)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049571	hsa-miR-92a-3p	CLASH	23622248
MIRT526127	hsa-miR-603	PAR-CLIP	22012620
MIRT526125	hsa-miR-6757-3p	PAR-CLIP	22012620
MIRT526126	hsa-miR-892b	PAR-CLIP	22012620
MIRT526124	hsa-miR-648	PAR-CLIP	22012620
MIRT526122	hsa-miR-4302	PAR-CLIP	22012620
MIRT526123	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT526121	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT526120	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT526119	hsa-miR-4769-3p	PAR-CLIP	22012620
MIRT526118	hsa-miR-6817-5p	PAR-CLIP	22012620
MIRT526117	hsa-miR-149-5p	PAR-CLIP	22012620
MIRT526115	hsa-miR-3194-3p	PAR-CLIP	22012620
MIRT526116	hsa-miR-6822-3p	PAR-CLIP	22012620
MIRT526114	hsa-miR-760	PAR-CLIP	22012620
MIRT526113	hsa-miR-1227-3p	PAR-CLIP	22012620
MIRT526112	hsa-miR-4727-5p	PAR-CLIP	22012620
MIRT526111	hsa-miR-192-3p	PAR-CLIP	22012620
MIRT526110	hsa-miR-8057	PAR-CLIP	22012620
MIRT526127	hsa-miR-603	PAR-CLIP	22012620
MIRT526125	hsa-miR-6757-3p	PAR-CLIP	22012620
MIRT526126	hsa-miR-892b	PAR-CLIP	22012620
MIRT526124	hsa-miR-648	PAR-CLIP	22012620
MIRT526122	hsa-miR-4302	PAR-CLIP	22012620
MIRT526123	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT526121	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT526120	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT526119	hsa-miR-4769-3p	PAR-CLIP	22012620
MIRT526118	hsa-miR-6817-5p	PAR-CLIP	22012620
MIRT526117	hsa-miR-149-5p	PAR-CLIP	22012620
MIRT526115	hsa-miR-3194-3p	PAR-CLIP	22012620
MIRT526116	hsa-miR-6822-3p	PAR-CLIP	22012620
MIRT526114	hsa-miR-760	PAR-CLIP	22012620
MIRT526113	hsa-miR-1227-3p	PAR-CLIP	22012620
MIRT526112	hsa-miR-4727-5p	PAR-CLIP	22012620
MIRT526111	hsa-miR-192-3p	PAR-CLIP	22012620
MIRT526110	hsa-miR-8057	PAR-CLIP	22012620
MIRT1306444	hsa-miR-103a	CLIP-seq
MIRT1306445	hsa-miR-107	CLIP-seq
MIRT1306446	hsa-miR-1299	CLIP-seq
MIRT1306447	hsa-miR-15a	CLIP-seq
MIRT1306448	hsa-miR-15b	CLIP-seq
MIRT1306449	hsa-miR-16	CLIP-seq
MIRT1306450	hsa-miR-1910	CLIP-seq
MIRT1306451	hsa-miR-195	CLIP-seq
MIRT1306452	hsa-miR-29a	CLIP-seq
MIRT1306453	hsa-miR-29b	CLIP-seq
MIRT1306454	hsa-miR-29c	CLIP-seq
MIRT1306455	hsa-miR-3065-3p	CLIP-seq
MIRT1306456	hsa-miR-3184	CLIP-seq
MIRT1306457	hsa-miR-326	CLIP-seq
MIRT1306458	hsa-miR-330-5p	CLIP-seq
MIRT1306459	hsa-miR-3613-5p	CLIP-seq
MIRT1306460	hsa-miR-3944-5p	CLIP-seq
MIRT1306461	hsa-miR-423-5p	CLIP-seq
MIRT1306462	hsa-miR-424	CLIP-seq
MIRT1306463	hsa-miR-4280	CLIP-seq
MIRT1306464	hsa-miR-4287	CLIP-seq
MIRT1306465	hsa-miR-4292	CLIP-seq
MIRT1306466	hsa-miR-4308	CLIP-seq
MIRT1306467	hsa-miR-4469	CLIP-seq
MIRT1306468	hsa-miR-4646-5p	CLIP-seq
MIRT1306469	hsa-miR-4685-3p	CLIP-seq
MIRT1306470	hsa-miR-4688	CLIP-seq
MIRT1306471	hsa-miR-4713-5p	CLIP-seq
MIRT1306472	hsa-miR-4747-5p	CLIP-seq
MIRT1306473	hsa-miR-497	CLIP-seq
MIRT1306474	hsa-miR-502-5p	CLIP-seq
MIRT1306475	hsa-miR-519a	CLIP-seq
MIRT1306476	hsa-miR-519b-3p	CLIP-seq
MIRT1306477	hsa-miR-519c-3p	CLIP-seq
MIRT1306478	hsa-miR-593	CLIP-seq
MIRT1306479	hsa-miR-595	CLIP-seq
MIRT1306480	hsa-miR-671-5p	CLIP-seq
MIRT1306481	hsa-miR-875-3p	CLIP-seq
MIRT2090769	hsa-miR-1323	CLIP-seq
MIRT2090770	hsa-miR-147	CLIP-seq
MIRT2090771	hsa-miR-299-3p	CLIP-seq
MIRT2090772	hsa-miR-3200-3p	CLIP-seq
MIRT2090773	hsa-miR-3202	CLIP-seq
MIRT2090774	hsa-miR-3650	CLIP-seq
MIRT2090775	hsa-miR-3691-5p	CLIP-seq
MIRT2090776	hsa-miR-3911	CLIP-seq
MIRT2090777	hsa-miR-3929	CLIP-seq
MIRT2090778	hsa-miR-4293	CLIP-seq
MIRT2090779	hsa-miR-4419b	CLIP-seq
MIRT2090780	hsa-miR-4436a	CLIP-seq
MIRT2090781	hsa-miR-4455	CLIP-seq
MIRT2090782	hsa-miR-4474-3p	CLIP-seq
MIRT2090783	hsa-miR-4478	CLIP-seq
MIRT2090784	hsa-miR-4491	CLIP-seq
MIRT2090785	hsa-miR-4533	CLIP-seq
MIRT2090786	hsa-miR-4536	CLIP-seq
MIRT2090787	hsa-miR-4652-3p	CLIP-seq
MIRT2090788	hsa-miR-4657	CLIP-seq
MIRT2090789	hsa-miR-4663	CLIP-seq
MIRT2090790	hsa-miR-4682	CLIP-seq
MIRT2090791	hsa-miR-4700-3p	CLIP-seq
MIRT2090792	hsa-miR-4752	CLIP-seq
MIRT2090793	hsa-miR-4762-3p	CLIP-seq
MIRT2090794	hsa-miR-4778-3p	CLIP-seq
MIRT2090795	hsa-miR-485-5p	CLIP-seq
MIRT2090796	hsa-miR-498	CLIP-seq
MIRT1306475	hsa-miR-519a	CLIP-seq
MIRT1306476	hsa-miR-519b-3p	CLIP-seq
MIRT1306477	hsa-miR-519c-3p	CLIP-seq
MIRT2090797	hsa-miR-548o	CLIP-seq
MIRT2090798	hsa-miR-644	CLIP-seq
MIRT2090799	hsa-miR-873	CLIP-seq
MIRT2315453	hsa-miR-146a	CLIP-seq
MIRT2315454	hsa-miR-146b-5p	CLIP-seq
MIRT2090770	hsa-miR-147	CLIP-seq
MIRT2315455	hsa-miR-1539	CLIP-seq
MIRT2090771	hsa-miR-299-3p	CLIP-seq
MIRT2315456	hsa-miR-3173-5p	CLIP-seq
MIRT1306456	hsa-miR-3184	CLIP-seq
MIRT2090775	hsa-miR-3691-5p	CLIP-seq
MIRT2090776	hsa-miR-3911	CLIP-seq
MIRT1306461	hsa-miR-423-5p	CLIP-seq
MIRT2315457	hsa-miR-4276	CLIP-seq
MIRT2315458	hsa-miR-4318	CLIP-seq
MIRT2090782	hsa-miR-4474-3p	CLIP-seq
MIRT2090784	hsa-miR-4491	CLIP-seq
MIRT2090786	hsa-miR-4536	CLIP-seq
MIRT2090787	hsa-miR-4652-3p	CLIP-seq
MIRT2090788	hsa-miR-4657	CLIP-seq
MIRT1306470	hsa-miR-4688	CLIP-seq
MIRT2090792	hsa-miR-4752	CLIP-seq
MIRT2315459	hsa-miR-548aa	CLIP-seq
MIRT2090798	hsa-miR-644	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0001944	Process	Vasculature development	IEA
GO:0001965	Function	G-protein alpha-subunit binding	IBA
GO:0001965	Function	G-protein alpha-subunit binding	IEA
GO:0001965	Function	G-protein alpha-subunit binding	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 21516116, 21988832, 25074811, 25416956, 28119500, 29892012, 29966094, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005938	Component	Cell cortex	IEA
GO:0006457	Process	Protein folding	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007369	Process	Gastrulation	IEA
GO:0008542	Process	Visual learning	IEA
GO:0009416	Process	Response to light stimulus	IEA
GO:0016020	Component	Membrane	IEA
GO:0042074	Process	Cell migration involved in gastrulation	IEA
GO:0044183	Function	Protein folding chaperone	IEA
GO:0044183	Function	Protein folding chaperone	ISS
GO:0070586	Process	Cell-cell adhesion involved in gastrulation	IEA
GO:0071711	Process	Basement membrane organization	IEA

MIM	HGNC	e!Ensembl
609146	29550	ENSG00000177963

Q9NPQ8

Protein name

Chaperone Ric-8A (Synembryn-A)

Protein function

Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10165	Ric8	66 → 506	Guanine nucleotide exchange factor synembryn	Family

Sequence

MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPP
SHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKC
LCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQ
QLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEV
DEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDST
EFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPL
RDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLL
AARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEA
MKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Sequence length

531

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATARACT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autistic Disorder	Autism	BEFREE	28119500		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cobblestone Lissencephaly	Cobblestone Lissencephaly	BEFREE	29380551		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fragile X Syndrome	Fragile X Syndrome	BEFREE	28119500, 29966094		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31118521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	29762745	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuromuscular Diseases	Neuromuscular Diseases	BEFREE	29380551		★★★★★ ★☆☆☆☆ Found in Text Mining only
Plexiform leiomyoma	Plexiform leiomyoma	GWASCAT_DG	30194396, 31649266		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	GWASCAT_DG	30194396, 31649266		★★★★★ ★☆☆☆☆ Found in Text Mining only

RIC8A (RIC8 guanine nucleotide exchange factor A)