Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	60625
Gene name	DEAH-box helicase 35
Gene symbol	DHX35
Synonyms (NCBI Gene)	C20orf15DDX35KAIA0875
Chromosome	20
Chromosome location	20q11.23-q12
Summary	DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mi

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030327	hsa-miR-26b-5p	Microarray	19088304
MIRT051221	hsa-miR-16-5p	CLASH	23622248
MIRT532153	hsa-miR-3120-3p	PAR-CLIP	22012620
MIRT532152	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT532151	hsa-miR-545-3p	PAR-CLIP	22012620
MIRT532153	hsa-miR-3120-3p	PAR-CLIP	22012620
MIRT532152	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT532151	hsa-miR-545-3p	PAR-CLIP	22012620
MIRT935522	hsa-miR-103a	CLIP-seq
MIRT935523	hsa-miR-107	CLIP-seq
MIRT935524	hsa-miR-1200	CLIP-seq
MIRT935525	hsa-miR-1228	CLIP-seq
MIRT935526	hsa-miR-1257	CLIP-seq
MIRT935527	hsa-miR-1296	CLIP-seq
MIRT935528	hsa-miR-15a	CLIP-seq
MIRT935529	hsa-miR-15b	CLIP-seq
MIRT935530	hsa-miR-16	CLIP-seq
MIRT935531	hsa-miR-195	CLIP-seq
MIRT935532	hsa-miR-2909	CLIP-seq
MIRT935533	hsa-miR-3126-3p	CLIP-seq
MIRT935534	hsa-miR-3128	CLIP-seq
MIRT935535	hsa-miR-3148	CLIP-seq
MIRT935536	hsa-miR-3150b-3p	CLIP-seq
MIRT935537	hsa-miR-3158-5p	CLIP-seq
MIRT935538	hsa-miR-34c-3p	CLIP-seq
MIRT935539	hsa-miR-3611	CLIP-seq
MIRT935540	hsa-miR-3622b-5p	CLIP-seq
MIRT935541	hsa-miR-377	CLIP-seq
MIRT935542	hsa-miR-3936	CLIP-seq
MIRT935543	hsa-miR-3974	CLIP-seq
MIRT935544	hsa-miR-424	CLIP-seq
MIRT935545	hsa-miR-4324	CLIP-seq
MIRT935546	hsa-miR-4326	CLIP-seq
MIRT935547	hsa-miR-4436b-3p	CLIP-seq
MIRT935548	hsa-miR-4446-3p	CLIP-seq
MIRT935549	hsa-miR-4477a	CLIP-seq
MIRT935550	hsa-miR-4666-5p	CLIP-seq
MIRT935551	hsa-miR-4668-5p	CLIP-seq
MIRT935552	hsa-miR-4688	CLIP-seq
MIRT935553	hsa-miR-4699-3p	CLIP-seq
MIRT935554	hsa-miR-4716-3p	CLIP-seq
MIRT935555	hsa-miR-4720-5p	CLIP-seq
MIRT935556	hsa-miR-4756-3p	CLIP-seq
MIRT935557	hsa-miR-4761-3p	CLIP-seq
MIRT935558	hsa-miR-4784	CLIP-seq
MIRT935559	hsa-miR-4795-3p	CLIP-seq
MIRT935560	hsa-miR-4799-3p	CLIP-seq
MIRT935561	hsa-miR-4802-5p	CLIP-seq
MIRT935562	hsa-miR-486-3p	CLIP-seq
MIRT935563	hsa-miR-494	CLIP-seq
MIRT935564	hsa-miR-497	CLIP-seq
MIRT935565	hsa-miR-544b	CLIP-seq
MIRT935566	hsa-miR-548c-3p	CLIP-seq
MIRT935567	hsa-miR-548g	CLIP-seq
MIRT935568	hsa-miR-548m	CLIP-seq
MIRT935569	hsa-miR-548v	CLIP-seq
MIRT935570	hsa-miR-577	CLIP-seq
MIRT935571	hsa-miR-610	CLIP-seq
MIRT935572	hsa-miR-616	CLIP-seq
MIRT935573	hsa-miR-625	CLIP-seq
MIRT935574	hsa-miR-765	CLIP-seq
MIRT935575	hsa-miR-3617	CLIP-seq
MIRT935576	hsa-miR-3689a-3p	CLIP-seq
MIRT935577	hsa-miR-3689c	CLIP-seq
MIRT935578	hsa-miR-4648	CLIP-seq
MIRT935579	hsa-miR-4654	CLIP-seq
MIRT935553	hsa-miR-4699-3p	CLIP-seq
MIRT935580	hsa-miR-4728-5p	CLIP-seq
MIRT935581	hsa-miR-4769-5p	CLIP-seq
MIRT935582	hsa-miR-4796-3p	CLIP-seq
MIRT935583	hsa-miR-548t	CLIP-seq
MIRT935584	hsa-miR-641	CLIP-seq
MIRT935585	hsa-miR-7	CLIP-seq
MIRT935522	hsa-miR-103a	CLIP-seq
MIRT935523	hsa-miR-107	CLIP-seq
MIRT935528	hsa-miR-15a	CLIP-seq
MIRT935529	hsa-miR-15b	CLIP-seq
MIRT935530	hsa-miR-16	CLIP-seq
MIRT935531	hsa-miR-195	CLIP-seq
MIRT1547969	hsa-miR-3649	CLIP-seq
MIRT935544	hsa-miR-424	CLIP-seq
MIRT935552	hsa-miR-4688	CLIP-seq
MIRT935561	hsa-miR-4802-5p	CLIP-seq
MIRT935562	hsa-miR-486-3p	CLIP-seq
MIRT935564	hsa-miR-497	CLIP-seq
MIRT1976949	hsa-miR-3661	CLIP-seq
MIRT1976950	hsa-miR-492	CLIP-seq
MIRT1976951	hsa-miR-631	CLIP-seq
MIRT2212299	hsa-miR-4641	CLIP-seq
MIRT2212300	hsa-miR-4763-5p	CLIP-seq
MIRT2515985	hsa-miR-10a	CLIP-seq
MIRT2515986	hsa-miR-10b	CLIP-seq
MIRT935524	hsa-miR-1200	CLIP-seq
MIRT935527	hsa-miR-1296	CLIP-seq
MIRT2515987	hsa-miR-1305	CLIP-seq
MIRT2515988	hsa-miR-1324	CLIP-seq
MIRT2515989	hsa-miR-1914	CLIP-seq
MIRT935532	hsa-miR-2909	CLIP-seq
MIRT2515990	hsa-miR-3074-3p	CLIP-seq
MIRT2515991	hsa-miR-3122	CLIP-seq
MIRT2515992	hsa-miR-3129-3p	CLIP-seq
MIRT2515993	hsa-miR-3163	CLIP-seq
MIRT2515994	hsa-miR-3183	CLIP-seq
MIRT2515995	hsa-miR-323-5p	CLIP-seq
MIRT2515996	hsa-miR-3613-3p	CLIP-seq
MIRT935576	hsa-miR-3689a-3p	CLIP-seq
MIRT935577	hsa-miR-3689c	CLIP-seq
MIRT2515997	hsa-miR-3909	CLIP-seq
MIRT2515998	hsa-miR-3913-5p	CLIP-seq
MIRT2515999	hsa-miR-3921	CLIP-seq
MIRT935543	hsa-miR-3974	CLIP-seq
MIRT2516000	hsa-miR-4251	CLIP-seq
MIRT2516001	hsa-miR-4252	CLIP-seq
MIRT2516002	hsa-miR-4286	CLIP-seq
MIRT935545	hsa-miR-4324	CLIP-seq
MIRT935546	hsa-miR-4326	CLIP-seq
MIRT2516003	hsa-miR-4329	CLIP-seq
MIRT935547	hsa-miR-4436b-3p	CLIP-seq
MIRT2212299	hsa-miR-4641	CLIP-seq
MIRT2516004	hsa-miR-4653-5p	CLIP-seq
MIRT2516005	hsa-miR-4696	CLIP-seq
MIRT2516006	hsa-miR-4714-5p	CLIP-seq
MIRT2516007	hsa-miR-4723-3p	CLIP-seq
MIRT2516008	hsa-miR-4725-5p	CLIP-seq
MIRT935556	hsa-miR-4756-3p	CLIP-seq
MIRT935557	hsa-miR-4761-3p	CLIP-seq
MIRT2516009	hsa-miR-4786-3p	CLIP-seq
MIRT935582	hsa-miR-4796-3p	CLIP-seq
MIRT935563	hsa-miR-494	CLIP-seq
MIRT2516010	hsa-miR-495	CLIP-seq
MIRT2516011	hsa-miR-498	CLIP-seq
MIRT2516012	hsa-miR-504	CLIP-seq
MIRT2516013	hsa-miR-513a-3p	CLIP-seq
MIRT935565	hsa-miR-544b	CLIP-seq
MIRT2516014	hsa-miR-548b-3p	CLIP-seq
MIRT935566	hsa-miR-548c-3p	CLIP-seq
MIRT935567	hsa-miR-548g	CLIP-seq
MIRT935568	hsa-miR-548m	CLIP-seq
MIRT935583	hsa-miR-548t	CLIP-seq
MIRT935569	hsa-miR-548v	CLIP-seq
MIRT935571	hsa-miR-610	CLIP-seq
MIRT935572	hsa-miR-616	CLIP-seq
MIRT2516015	hsa-miR-629	CLIP-seq
MIRT2516016	hsa-miR-876-3p	CLIP-seq
MIRT2516017	hsa-miR-889	CLIP-seq
MIRT2516018	hsa-miR-9	CLIP-seq
MIRT2516019	hsa-miR-938	CLIP-seq
MIRT2515994	hsa-miR-3183	CLIP-seq
MIRT2515997	hsa-miR-3909	CLIP-seq
MIRT2515999	hsa-miR-3921	CLIP-seq
MIRT2516000	hsa-miR-4251	CLIP-seq
MIRT2516003	hsa-miR-4329	CLIP-seq
MIRT2516004	hsa-miR-4653-5p	CLIP-seq
MIRT2516006	hsa-miR-4714-5p	CLIP-seq
MIRT2516007	hsa-miR-4723-3p	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0001701	Process	In utero embryonic development	IEA
GO:0003723	Function	RNA binding	IBA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9H5Z1

Protein name

Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35)

Protein function

May be involved in pre-mRNA splicing.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00271	Helicase_C	258 → 398	Helicase conserved C-terminal domain	Family
PF04408	HA2	459 → 568	Helicase associated domain (HA2)	Domain
PF07717	OB_NTP_bind	606 → 685	Oligonucleotide/oligosaccharide-binding (OB)-fold	Domain

Sequence

MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLR
NHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRV
AEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHE
RTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVEG
RTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARA
LARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDC
GFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVP
EMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLG
MRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAV
EEGDHLTMLNIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSE
GDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQ
TSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDP

Sequence length

703

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BASAL CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATINOCYTE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26474385	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	21546767	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Neuropathy Ischemic	Optic neuropathy	Pubtator	39273537	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	30569177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	33551988	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DHX35 (DEAH-box helicase 35)