Gene Gene information from NCBI Gene database.
Entrez ID 60592
Gene name Short coiled-coil protein
Gene symbol SCOC
Synonyms (NCBI Gene)
HRIHFB2072SCOCOUNC-69
Chromosome 4
Chromosome location 4q31.1
Summary This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative spli
miRNA miRNA information provided by mirtarbase database.
459
miRTarBase ID miRNA Experiments Reference
MIRT042453 hsa-miR-424-5p CLASH 23622248
MIRT370986 hsa-miR-3681-5p HITS-CLIP 19536157
MIRT370989 hsa-miR-6849-5p HITS-CLIP 19536157
MIRT715669 hsa-miR-656-3p HITS-CLIP 19536157
MIRT715670 hsa-miR-1279 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0005515 Function Protein binding IPI 20195357, 22354037, 25416956, 32296183, 33961781
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IEA
GO:0005768 Component Endosome IDA 22354037
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UIL1
Protein name Short coiled-coil protein
Protein function Positive regulator of amino acid starvation-induced autophagy.
PDB 4BWD , 7AA7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10224 DUF2205 78 154 Short coiled-coil protein Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in brain, heart and skeletal muscle. {ECO:0000269|PubMed:11303027}.
Sequence
MRRRVFSSQDWRASGWDGMGFFSRRTFCGRSGRSCRGQLVQVSRPEVSAGSLLLPAPQAE
DHSSRILYPRPKSLLPKMMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDA
VKEENLKLKSENQVLGQYIENLMSASSVFQTTDT
KSKRK
Sequence length 159
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Retrograde transport at the Trans-Golgi-Network
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Papillary thyroid carcinoma Papillary thyroid carcinoma BEFREE 30539831
★☆☆☆☆
Found in Text Mining only
Thyroid Cancer Papillary Papillary thyroid cancer Pubtator 30539831 Associate
★☆☆☆☆
Found in Text Mining only