Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	6050
Gene name	Ribonuclease/angiogenin inhibitor 1
Gene symbol	RNH1
Synonyms (NCBI Gene)	IIAE12RAIRNH
Chromosome	11
Chromosome location	11p15.5
Summary	Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049793	hsa-miR-92a-3p	CLASH	23622248
MIRT045994	hsa-miR-125b-5p	CLASH	23622248
MIRT726720	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726719	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726718	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726717	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT1313974	hsa-miR-106a	CLIP-seq
MIRT1313975	hsa-miR-106b	CLIP-seq
MIRT1313976	hsa-miR-142-5p	CLIP-seq
MIRT1313977	hsa-miR-17	CLIP-seq
MIRT1313978	hsa-miR-193a-3p	CLIP-seq
MIRT1313979	hsa-miR-193b	CLIP-seq
MIRT1313980	hsa-miR-20a	CLIP-seq
MIRT1313981	hsa-miR-20b	CLIP-seq
MIRT1313982	hsa-miR-302a	CLIP-seq
MIRT1313983	hsa-miR-302b	CLIP-seq
MIRT1313984	hsa-miR-302c	CLIP-seq
MIRT1313985	hsa-miR-302d	CLIP-seq
MIRT1313986	hsa-miR-302e	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1313988	hsa-miR-340	CLIP-seq
MIRT1313989	hsa-miR-3609	CLIP-seq
MIRT1313990	hsa-miR-372	CLIP-seq
MIRT1313991	hsa-miR-373	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1313993	hsa-miR-4480	CLIP-seq
MIRT1313994	hsa-miR-4722-3p	CLIP-seq
MIRT1313995	hsa-miR-4796-3p	CLIP-seq
MIRT1313996	hsa-miR-519d	CLIP-seq
MIRT1313997	hsa-miR-520a-3p	CLIP-seq
MIRT1313998	hsa-miR-520b	CLIP-seq
MIRT1313999	hsa-miR-520c-3p	CLIP-seq
MIRT1314000	hsa-miR-520d-3p	CLIP-seq
MIRT1314001	hsa-miR-520e	CLIP-seq
MIRT1314002	hsa-miR-520f	CLIP-seq
MIRT1314003	hsa-miR-548ah	CLIP-seq
MIRT1314004	hsa-miR-892b	CLIP-seq
MIRT1314005	hsa-miR-93	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT1314007	hsa-miR-15a	CLIP-seq
MIRT1314008	hsa-miR-15b	CLIP-seq
MIRT1314009	hsa-miR-16	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1314011	hsa-miR-1915	CLIP-seq
MIRT1314012	hsa-miR-195	CLIP-seq
MIRT1314013	hsa-miR-214	CLIP-seq
MIRT1314014	hsa-miR-296-3p	CLIP-seq
MIRT1314015	hsa-miR-3152-5p	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1314017	hsa-miR-3619-5p	CLIP-seq
MIRT1314018	hsa-miR-424	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1314019	hsa-miR-4423-5p	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq
MIRT1314023	hsa-miR-497	CLIP-seq
MIRT1314024	hsa-miR-761	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT1314007	hsa-miR-15a	CLIP-seq
MIRT1314008	hsa-miR-15b	CLIP-seq
MIRT1314009	hsa-miR-16	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1314012	hsa-miR-195	CLIP-seq
MIRT1314013	hsa-miR-214	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1314017	hsa-miR-3619-5p	CLIP-seq
MIRT1314018	hsa-miR-424	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq
MIRT1314023	hsa-miR-497	CLIP-seq
MIRT1314024	hsa-miR-761	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT1314007	hsa-miR-15a	CLIP-seq
MIRT1314008	hsa-miR-15b	CLIP-seq
MIRT1314009	hsa-miR-16	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1314012	hsa-miR-195	CLIP-seq
MIRT1314013	hsa-miR-214	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1314017	hsa-miR-3619-5p	CLIP-seq
MIRT1314018	hsa-miR-424	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq
MIRT1314023	hsa-miR-497	CLIP-seq
MIRT1314024	hsa-miR-761	CLIP-seq
MIRT2613697	hsa-miR-1207-5p	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT2613698	hsa-miR-138	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1314011	hsa-miR-1915	CLIP-seq
MIRT1314014	hsa-miR-296-3p	CLIP-seq
MIRT2613699	hsa-miR-296-5p	CLIP-seq
MIRT1314015	hsa-miR-3152-5p	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1314019	hsa-miR-4423-5p	CLIP-seq
MIRT2613700	hsa-miR-4456	CLIP-seq
MIRT2613701	hsa-miR-4492	CLIP-seq
MIRT2613702	hsa-miR-4498	CLIP-seq
MIRT2613703	hsa-miR-4736	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT2613704	hsa-miR-4763-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq
MIRT2613705	hsa-miR-541	CLIP-seq
MIRT2613706	hsa-miR-654-5p	CLIP-seq
MIRT2613707	hsa-miR-762	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IDA	38718836
GO:0005515	Function	Protein binding	IPI	2742853, 3064806, 3470787, 10413501, 17350650, 25416956, 28514442, 29892012, 29997244, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	23843625
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	23843625
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0006402	Process	MRNA catabolic process	NAS	2081593
GO:0008428	Function	Ribonuclease inhibitor activity	IBA
GO:0008428	Function	Ribonuclease inhibitor activity	IDA	3219362, 3243277, 3470787, 9050852, 12578357, 23843625
GO:0016477	Process	Cell migration	IBA
GO:0030027	Component	Lamellipodium	IBA
GO:0032055	Process	Negative regulation of translation in response to stress	IDA	38718836
GO:0032311	Component	Angiogenin-PRI complex	IBA
GO:0032311	Component	Angiogenin-PRI complex	IPI	3470787
GO:0034315	Process	Regulation of Arp2/3 complex-mediated actin nucleation	IBA
GO:0036416	Process	TRNA stabilization	IDA	23843625
GO:0045765	Process	Regulation of angiogenesis	IBA
GO:0045765	Process	Regulation of angiogenesis	IDA	3470787
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145

MIM	HGNC	e!Ensembl
173320	10074	ENSG00000023191

P13489

Protein name

Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI)

Protein function

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inh

PDB

1A4Y , 1Z7X , 2BEX , 2Q4G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18779	LRR_RI_capping	1 → 35	Capping Ribonuclease inhibitor Leucine Rich Repeat	Repeat
PF13516	LRR_6	111 → 134	Leucine Rich repeat	Repeat
PF13516	LRR_6	396 → 419	Leucine Rich repeat	Repeat

Sequence

MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS

Sequence length

461

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Encephalitis, acute, infection-induced, susceptibility to, 12	Uncertain significance; risk factor	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RNH1-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

RNH1 (ribonuclease/angiogenin inhibitor 1)