CCDC81 (coiled-coil domain containing 81)

Gene

• Entrez ID: 60494
• Gene name: Coiled-coil domain containing 81
• Gene symbol: CCDC81
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11q14.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT526066	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT526065	hsa-miR-4705	PAR-CLIP	22012620
MIRT526064	hsa-miR-513b-5p	PAR-CLIP	22012620
MIRT526063	hsa-miR-6802-3p	PAR-CLIP	22012620
MIRT526066	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT526065	hsa-miR-4705	PAR-CLIP	22012620
MIRT526064	hsa-miR-513b-5p	PAR-CLIP	22012620
MIRT526063	hsa-miR-6802-3p	PAR-CLIP	22012620
MIRT869863	hsa-miR-1324	CLIP-seq
MIRT869864	hsa-miR-137	CLIP-seq
MIRT869865	hsa-miR-3064-3p	CLIP-seq
MIRT869866	hsa-miR-3619-3p	CLIP-seq
MIRT869867	hsa-miR-3664-3p	CLIP-seq
MIRT869868	hsa-miR-3689a-3p	CLIP-seq
MIRT869869	hsa-miR-3689c	CLIP-seq
MIRT869870	hsa-miR-4252	CLIP-seq
MIRT869871	hsa-miR-4433	CLIP-seq
MIRT869872	hsa-miR-4436a	CLIP-seq
MIRT869873	hsa-miR-4452	CLIP-seq
MIRT869874	hsa-miR-4715-3p	CLIP-seq
MIRT869875	hsa-miR-4722-5p	CLIP-seq
MIRT869876	hsa-miR-4728-5p	CLIP-seq
MIRT869877	hsa-miR-4795-3p	CLIP-seq
MIRT869878	hsa-miR-513b	CLIP-seq
MIRT869879	hsa-miR-664	CLIP-seq
MIRT869864	hsa-miR-137	CLIP-seq
MIRT869865	hsa-miR-3064-3p	CLIP-seq
MIRT869870	hsa-miR-4252	CLIP-seq
MIRT869874	hsa-miR-4715-3p	CLIP-seq
MIRT869877	hsa-miR-4795-3p	CLIP-seq
MIRT869879	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21930792
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	25074808
GO:0005813	Component	Centrosome	IEA
GO:0005815	Component	Microtubule organizing center	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0036064	Component	Ciliary basal body	IDA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6ZN84
• Protein name: Coiled-coil domain-containing protein 81
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14908	HU-CCDC81_euk_1	6 → 93	CCDC81 eukaryotic HU domain 1	Domain
  PF18289	HU-CCDC81_euk_2	103 → 177	CCDC81 eukaryotic HU domain 2	Domain

• Sequence:

  MLDTIARALQDLGRQVLPTLPSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFI
  RQKLEVGNNKFILIQRPVFIMVEKLVQIHGLKQNKVYTPGEIPIVPLNFVMISLEGPFNR
  DVVEGCVKETLLFLSRSISMKQNVEFTFKGIGVLMIRDSKVKMRFYKDFLCTMDGSGALA
  KALANRPGTVDSVLSSREALRKWPSSVLAFPRIELKEMENKLPMETLVEECGENRERKCK
  LKDQSDKEEGTRDISSPKRLRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSC
  LKHDSEMKPQTSPACQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQM
  LKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPAL
  NALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEET
  QCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHK
  RKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE
  DKAFERASDKLFLLDQCEKYRRCKQCQRRTSNVGESNLWPLNKFLPGSRLLV

• Sequence length: 652

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Eosinophilic esophagitis	Eosinophilia	GWASCAT_DG	25017104		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	31770211	Associate	★☆☆☆☆ Found in Text Mining only