Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	6018
Gene name	RLF zinc finger
Gene symbol	RLF
Synonyms (NCBI Gene)	ZN-15LZNF292L
Chromosome	1
Chromosome location	1p34.2

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019789	hsa-miR-375	Microarray	20215506
MIRT025096	hsa-miR-181a-5p	Microarray	17612493
MIRT027904	hsa-miR-96-5p	Sequencing	20371350
MIRT050968	hsa-miR-17-5p	CLASH	23622248
MIRT047185	hsa-miR-182-5p	CLASH	23622248
MIRT036823	hsa-miR-877-3p	CLASH	23622248
MIRT025096	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT137417	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT137418	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT137430	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT137414	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT137415	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT1307816	hsa-miR-125a-3p	CLIP-seq
MIRT1307817	hsa-miR-1297	CLIP-seq
MIRT1307818	hsa-miR-142-3p	CLIP-seq
MIRT1307819	hsa-miR-181a	CLIP-seq
MIRT1307820	hsa-miR-181b	CLIP-seq
MIRT1307821	hsa-miR-181c	CLIP-seq
MIRT1307822	hsa-miR-181d	CLIP-seq
MIRT1307823	hsa-miR-182	CLIP-seq
MIRT1307824	hsa-miR-26a	CLIP-seq
MIRT1307825	hsa-miR-26b	CLIP-seq
MIRT1307826	hsa-miR-29a	CLIP-seq
MIRT1307827	hsa-miR-29b	CLIP-seq
MIRT1307828	hsa-miR-29c	CLIP-seq
MIRT1307829	hsa-miR-3177-5p	CLIP-seq
MIRT1307830	hsa-miR-330-3p	CLIP-seq
MIRT1307831	hsa-miR-338-5p	CLIP-seq
MIRT1307832	hsa-miR-3934	CLIP-seq
MIRT1307833	hsa-miR-3941	CLIP-seq
MIRT1307834	hsa-miR-4262	CLIP-seq
MIRT1307835	hsa-miR-4280	CLIP-seq
MIRT1307836	hsa-miR-4444	CLIP-seq
MIRT1307837	hsa-miR-4465	CLIP-seq
MIRT1307838	hsa-miR-4470	CLIP-seq
MIRT1307839	hsa-miR-4474-3p	CLIP-seq
MIRT1307840	hsa-miR-4511	CLIP-seq
MIRT1307841	hsa-miR-466	CLIP-seq
MIRT1307842	hsa-miR-4672	CLIP-seq
MIRT1307843	hsa-miR-4715-5p	CLIP-seq
MIRT1307844	hsa-miR-4731-3p	CLIP-seq
MIRT1307845	hsa-miR-4801	CLIP-seq
MIRT1307846	hsa-miR-548b-3p	CLIP-seq
MIRT1307847	hsa-miR-571	CLIP-seq
MIRT1307848	hsa-miR-582-5p	CLIP-seq
MIRT1307849	hsa-miR-604	CLIP-seq
MIRT1307850	hsa-miR-644	CLIP-seq
MIRT1307851	hsa-miR-647	CLIP-seq
MIRT1307852	hsa-miR-656	CLIP-seq
MIRT1307853	hsa-miR-764	CLIP-seq
MIRT1307816	hsa-miR-125a-3p	CLIP-seq
MIRT1307817	hsa-miR-1297	CLIP-seq
MIRT1307819	hsa-miR-181a	CLIP-seq
MIRT1307820	hsa-miR-181b	CLIP-seq
MIRT1307821	hsa-miR-181c	CLIP-seq
MIRT1307822	hsa-miR-181d	CLIP-seq
MIRT1307823	hsa-miR-182	CLIP-seq
MIRT2315999	hsa-miR-185	CLIP-seq
MIRT2316000	hsa-miR-200b	CLIP-seq
MIRT2316001	hsa-miR-200c	CLIP-seq
MIRT1307824	hsa-miR-26a	CLIP-seq
MIRT1307825	hsa-miR-26b	CLIP-seq
MIRT2316002	hsa-miR-300	CLIP-seq
MIRT2316003	hsa-miR-3157-5p	CLIP-seq
MIRT2316004	hsa-miR-323b-3p	CLIP-seq
MIRT1307830	hsa-miR-330-3p	CLIP-seq
MIRT2316005	hsa-miR-376c	CLIP-seq
MIRT2316006	hsa-miR-381	CLIP-seq
MIRT1307832	hsa-miR-3934	CLIP-seq
MIRT1307834	hsa-miR-4262	CLIP-seq
MIRT2316007	hsa-miR-429	CLIP-seq
MIRT2316008	hsa-miR-4306	CLIP-seq
MIRT2316009	hsa-miR-4323	CLIP-seq
MIRT1307836	hsa-miR-4444	CLIP-seq
MIRT1307837	hsa-miR-4465	CLIP-seq
MIRT1307838	hsa-miR-4470	CLIP-seq
MIRT1307839	hsa-miR-4474-3p	CLIP-seq
MIRT1307840	hsa-miR-4511	CLIP-seq
MIRT2316010	hsa-miR-4644	CLIP-seq
MIRT2316011	hsa-miR-4666-3p	CLIP-seq
MIRT1307842	hsa-miR-4672	CLIP-seq
MIRT2316012	hsa-miR-4684-3p	CLIP-seq
MIRT2316013	hsa-miR-4691-3p	CLIP-seq
MIRT1307843	hsa-miR-4715-5p	CLIP-seq
MIRT2316014	hsa-miR-4716-5p	CLIP-seq
MIRT2316015	hsa-miR-4775	CLIP-seq
MIRT2316016	hsa-miR-4789-5p	CLIP-seq
MIRT2316017	hsa-miR-512-5p	CLIP-seq
MIRT1307846	hsa-miR-548b-3p	CLIP-seq
MIRT1307847	hsa-miR-571	CLIP-seq
MIRT2316018	hsa-miR-587	CLIP-seq
MIRT1307849	hsa-miR-604	CLIP-seq
MIRT2316019	hsa-miR-610	CLIP-seq
MIRT2316020	hsa-miR-628-5p	CLIP-seq
MIRT1307850	hsa-miR-644	CLIP-seq
MIRT1307851	hsa-miR-647	CLIP-seq
MIRT1307852	hsa-miR-656	CLIP-seq
MIRT2316021	hsa-miR-671-5p	CLIP-seq
MIRT1307853	hsa-miR-764	CLIP-seq
MIRT1307819	hsa-miR-181a	CLIP-seq
MIRT1307820	hsa-miR-181b	CLIP-seq
MIRT1307821	hsa-miR-181c	CLIP-seq
MIRT1307822	hsa-miR-181d	CLIP-seq
MIRT2316005	hsa-miR-376c	CLIP-seq
MIRT1307834	hsa-miR-4262	CLIP-seq
MIRT2439917	hsa-miR-4495	CLIP-seq
MIRT2316016	hsa-miR-4789-5p	CLIP-seq
MIRT1307852	hsa-miR-656	CLIP-seq
MIRT1307819	hsa-miR-181a	CLIP-seq
MIRT1307820	hsa-miR-181b	CLIP-seq
MIRT1307821	hsa-miR-181c	CLIP-seq
MIRT1307822	hsa-miR-181d	CLIP-seq
MIRT1307823	hsa-miR-182	CLIP-seq
MIRT2316005	hsa-miR-376c	CLIP-seq
MIRT1307834	hsa-miR-4262	CLIP-seq
MIRT1307836	hsa-miR-4444	CLIP-seq
MIRT1307838	hsa-miR-4470	CLIP-seq
MIRT1307839	hsa-miR-4474-3p	CLIP-seq
MIRT2439917	hsa-miR-4495	CLIP-seq
MIRT1307842	hsa-miR-4672	CLIP-seq
MIRT2612054	hsa-miR-4676-5p	CLIP-seq
MIRT2316012	hsa-miR-4684-3p	CLIP-seq
MIRT1307843	hsa-miR-4715-5p	CLIP-seq
MIRT2316014	hsa-miR-4716-5p	CLIP-seq
MIRT2316016	hsa-miR-4789-5p	CLIP-seq
MIRT1307847	hsa-miR-571	CLIP-seq
MIRT2612055	hsa-miR-575	CLIP-seq
MIRT1307849	hsa-miR-604	CLIP-seq
MIRT2612056	hsa-miR-622	CLIP-seq
MIRT1307850	hsa-miR-644	CLIP-seq
MIRT1307851	hsa-miR-647	CLIP-seq
MIRT1307852	hsa-miR-656	CLIP-seq
MIRT1307819	hsa-miR-181a	CLIP-seq
MIRT1307820	hsa-miR-181b	CLIP-seq
MIRT1307821	hsa-miR-181c	CLIP-seq
MIRT1307822	hsa-miR-181d	CLIP-seq
MIRT1307823	hsa-miR-182	CLIP-seq
MIRT2316005	hsa-miR-376c	CLIP-seq
MIRT1307834	hsa-miR-4262	CLIP-seq
MIRT1307836	hsa-miR-4444	CLIP-seq
MIRT1307838	hsa-miR-4470	CLIP-seq
MIRT1307839	hsa-miR-4474-3p	CLIP-seq
MIRT2439917	hsa-miR-4495	CLIP-seq
MIRT1307842	hsa-miR-4672	CLIP-seq
MIRT2612054	hsa-miR-4676-5p	CLIP-seq
MIRT2316012	hsa-miR-4684-3p	CLIP-seq
MIRT1307843	hsa-miR-4715-5p	CLIP-seq
MIRT2316014	hsa-miR-4716-5p	CLIP-seq
MIRT2316016	hsa-miR-4789-5p	CLIP-seq
MIRT1307847	hsa-miR-571	CLIP-seq
MIRT2612055	hsa-miR-575	CLIP-seq
MIRT1307849	hsa-miR-604	CLIP-seq
MIRT1307850	hsa-miR-644	CLIP-seq
MIRT1307851	hsa-miR-647	CLIP-seq
MIRT1307852	hsa-miR-656	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	ISS	8545128
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	10545207, 24136289
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS	8545128
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0031452	Process	Negative regulation of heterochromatin formation	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS	8545128
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS	8545128
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
180610	10025	ENSG00000117000

Q13129

Protein name

Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein)

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00096	zf-C2H2	1172 → 1195	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues.

Sequence

MADGKGDAAAVAGAGAEAPAVAGAGDGVETESMVRGHRPVSPAPGASGLRPCLWQLETEL
REQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIQSFASARPYLTTECE
DVLLVLGRLVLSCFELLLSVSESELPCEVWLPFLQSLQESHDALLEFGNNNLQILVHVTK
EGVWKNPVLLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAE
SKEISNVSSFQQAYITCLCSMLPNEDAIKEIAKVDCKEVLDIICNLESEGQDNTAFVLCT
TYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLDTFLERCRQFGVIAKTQQHLFCLIRVI
QTEAQDAGLGVSILLCVRALQLRSSEDEEMKASVCKTIACLLPEDLEVRRACQLTEFLIE
PSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCH
QLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDEGKEDKQYRRRDLTDQHKEKRDKKP
IGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKEMFVPH
VMEHVKMPPSRRDRSKKKLLLKGSQKGICPKSPSAIPEQNHSLNDQAKGESHEYVTFSKL
EDCHLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCR
RHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNI
VFSDLGQLYHHEAQHFRDASYTCNFLGCKKFYYSKIEYQNHLSMHNVENSNGDIKKSVKL
EESATGEKQDCINQPHLLNQTDKSHLPEDLFCAESANSQIDTETAENLKENSDSNSSDQL
SHSSSASMNEELIDTLDHSETMQDVLLSNEKVFGPSSLKEKCSSMAVCFDGTKFTCGFDG
CGSTYKNARGMQKHLRKVHPYHFKPKKIKTKDLFPSLGNEHNQTTEKLDAEPKPCSDTNS
DSPDEGLDHNIHIKCKREHQGYSSESSICASKRPCTEDTMLELLLRLKHLSLKNSITHGS
FSGSLQGYPSSGAKSLQSVSSISDLNFQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVT
REALLMHYLKKHNYSKEKVLQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYKNKHQIGSD
RATHKLLDNEKCDHEGPCSVDRLKGDCSAELGGDPSSNSEKPHCHPKKDECSSETDLESS
CEETESKTSDISSPIGSHREEQEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSS
FTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKYKECNKRFLCSKALA
KHCSDSHNLDHIEEPKVLSEAGSAARFSCNQPQCPAVFYTFNKLKHHLMEQHNIEGEIHS
DYEIHCDLNGCGQIFTHRSNYSQHVYYRHKDYYDDLFRSQKVANERLLRSEKVCQTADTQ
GHEHQTTRRSFNAKSKKCGLIKEKKAPISFKTRAEALHMCVEHSEHTQYPCMVQGCLSVV
KLESSIVRHYKRTHQMSSAYLEQQMENLVVCVKYGTKIKEEPPSEADPCIKKEENRSCES
ERTEHSHSPGDSSAPIQNTDCCHSSERDGGQKGCIESSSVFDADTLLYRGTLKCNHSSKT
TSLEQCNIVQPPPPCKIENSIPNPNGTESGTYFTSFQLPLPRIKESETRQHSSGQENTVK
NPTHVPKENFRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKEDDFDDWEPSEHLTLSN
SSQSSNDLTGNVVANNMVNDSEPEVDIPHSSSDSTIHENLTAIPPLIVAETTTVPSLENL
RVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS

Sequence length

1914

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Congenital Heart Defects	Congenital heart defects	BEFREE	27930960		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	BEFREE	739329		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	22941189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	22941189	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RLF (RLF zinc finger)