RIT1 (Ras like without CAAX 1)

Gene

• Entrez ID: 6016
• Gene name: Ras like without CAAX 1
• Gene symbol: RIT1
• Synonyms (NCBI Gene): NS8, RIBB, RIT, ROC1
• Chromosome: 1
• Chromosome location: 1q22
• Summary: This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal dev

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs483352822	C>A,G,T	Pathogenic, not-provided	Coding sequence variant, missense variant
rs563231684	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs672601334	G>C	Pathogenic	Coding sequence variant, missense variant
rs672601335	C>G	Pathogenic	Coding sequence variant, missense variant
rs730881014	A>C,G,T	Pathogenic	Synonymous variant, coding sequence variant, missense variant
rs777520196	C>A,T	Likely-pathogenic	Coding sequence variant, missense variant
rs868208063	A>C,G	Pathogenic	Missense variant, coding sequence variant
rs869025189	C>G	Pathogenic	Missense variant, coding sequence variant, intron variant
rs869025190	C>A	Likely-pathogenic	Missense variant, coding sequence variant
rs869025191	C>A,G,T	Pathogenic, likely-pathogenic, pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs869025192	C>G	Pathogenic	Missense variant, coding sequence variant
rs869025193	T>C	Pathogenic	Missense variant, coding sequence variant
rs869025194	A>C,G,T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs869025195	T>G	Pathogenic	Missense variant, coding sequence variant
rs869025196	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs869025197	A>G	Pathogenic	Missense variant, coding sequence variant
rs869312687	T>G	Conflicting-interpretations-of-pathogenicity, likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, intron variant
rs886041414	C>G	Pathogenic	Coding sequence variant, missense variant
rs1557960039	T>C	Pathogenic	Coding sequence variant, missense variant
rs1557960268	C>T	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1557962794	T>G	Pathogenic	Intron variant, coding sequence variant, missense variant
rs1571999498	C>G	Pathogenic	Intron variant, coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019637	hsa-miR-340-5p	Sequencing	20371350
MIRT024228	hsa-miR-218-5p	Sequencing	20371350
MIRT437587	hsa-miR-125a-5p	Microarray, qRT-PCR	22815788
MIRT1307669	hsa-miR-106a	CLIP-seq
MIRT1307670	hsa-miR-106b	CLIP-seq
MIRT1307671	hsa-miR-122	CLIP-seq
MIRT1307672	hsa-miR-1245	CLIP-seq
MIRT1307673	hsa-miR-125b	CLIP-seq
MIRT1307674	hsa-miR-1276	CLIP-seq
MIRT1307675	hsa-miR-1305	CLIP-seq
MIRT1307676	hsa-miR-142-5p	CLIP-seq
MIRT1307677	hsa-miR-145	CLIP-seq
MIRT1307678	hsa-miR-155	CLIP-seq
MIRT1307679	hsa-miR-17	CLIP-seq
MIRT1307680	hsa-miR-1825	CLIP-seq
MIRT1307681	hsa-miR-188-5p	CLIP-seq
MIRT1307682	hsa-miR-1915	CLIP-seq
MIRT1307683	hsa-miR-199a-5p	CLIP-seq
MIRT1307684	hsa-miR-199b-5p	CLIP-seq
MIRT1307685	hsa-miR-203	CLIP-seq
MIRT1307686	hsa-miR-2053	CLIP-seq
MIRT1307687	hsa-miR-20a	CLIP-seq
MIRT1307688	hsa-miR-20b	CLIP-seq
MIRT1307689	hsa-miR-21	CLIP-seq
MIRT1307690	hsa-miR-2114	CLIP-seq
MIRT1307691	hsa-miR-218	CLIP-seq
MIRT1307692	hsa-miR-219-5p	CLIP-seq
MIRT1307693	hsa-miR-221	CLIP-seq
MIRT1307694	hsa-miR-222	CLIP-seq
MIRT1307695	hsa-miR-2467-3p	CLIP-seq
MIRT1307696	hsa-miR-2682	CLIP-seq
MIRT1307697	hsa-miR-302a	CLIP-seq
MIRT1307698	hsa-miR-302b	CLIP-seq
MIRT1307699	hsa-miR-302c	CLIP-seq
MIRT1307700	hsa-miR-302d	CLIP-seq
MIRT1307701	hsa-miR-302e	CLIP-seq
MIRT1307702	hsa-miR-3140-3p	CLIP-seq
MIRT1307703	hsa-miR-3140-5p	CLIP-seq
MIRT1307704	hsa-miR-3160-3p	CLIP-seq
MIRT1307705	hsa-miR-3168	CLIP-seq
MIRT1307706	hsa-miR-3173-3p	CLIP-seq
MIRT1307707	hsa-miR-3192	CLIP-seq
MIRT1307708	hsa-miR-320a	CLIP-seq
MIRT1307709	hsa-miR-320b	CLIP-seq
MIRT1307710	hsa-miR-320c	CLIP-seq
MIRT1307711	hsa-miR-320d	CLIP-seq
MIRT1307712	hsa-miR-323-3p	CLIP-seq
MIRT1307713	hsa-miR-340	CLIP-seq
MIRT1307714	hsa-miR-3612	CLIP-seq
MIRT1307715	hsa-miR-365	CLIP-seq
MIRT1307716	hsa-miR-3653	CLIP-seq
MIRT1307717	hsa-miR-3678-3p	CLIP-seq
MIRT1307718	hsa-miR-372	CLIP-seq
MIRT1307719	hsa-miR-373	CLIP-seq
MIRT1307720	hsa-miR-3920	CLIP-seq
MIRT1307721	hsa-miR-3923	CLIP-seq
MIRT1307722	hsa-miR-3938	CLIP-seq
MIRT1307723	hsa-miR-409-3p	CLIP-seq
MIRT1307724	hsa-miR-421	CLIP-seq
MIRT1307725	hsa-miR-4272	CLIP-seq
MIRT1307726	hsa-miR-4290	CLIP-seq
MIRT1307727	hsa-miR-4311	CLIP-seq
MIRT1307728	hsa-miR-4314	CLIP-seq
MIRT1307729	hsa-miR-4319	CLIP-seq
MIRT1307730	hsa-miR-4330	CLIP-seq
MIRT1307731	hsa-miR-4426	CLIP-seq
MIRT1307732	hsa-miR-4429	CLIP-seq
MIRT1307733	hsa-miR-4445	CLIP-seq
MIRT1307734	hsa-miR-4477a	CLIP-seq
MIRT1307735	hsa-miR-4487	CLIP-seq
MIRT1307736	hsa-miR-4490	CLIP-seq
MIRT1307737	hsa-miR-4491	CLIP-seq
MIRT1307738	hsa-miR-449c	CLIP-seq
MIRT1307739	hsa-miR-4646-5p	CLIP-seq
MIRT1307740	hsa-miR-4647	CLIP-seq
MIRT1307741	hsa-miR-4657	CLIP-seq
MIRT1307742	hsa-miR-4662b	CLIP-seq
MIRT1307743	hsa-miR-4680-3p	CLIP-seq
MIRT1307744	hsa-miR-4695-5p	CLIP-seq
MIRT1307745	hsa-miR-4709-5p	CLIP-seq
MIRT1307746	hsa-miR-4726-3p	CLIP-seq
MIRT1307747	hsa-miR-4731-3p	CLIP-seq
MIRT1307748	hsa-miR-4732-3p	CLIP-seq
MIRT1307749	hsa-miR-4768-5p	CLIP-seq
MIRT1307750	hsa-miR-4774-5p	CLIP-seq
MIRT1307751	hsa-miR-4775	CLIP-seq
MIRT1307752	hsa-miR-4782-3p	CLIP-seq
MIRT1307753	hsa-miR-4801	CLIP-seq
MIRT1307754	hsa-miR-487a	CLIP-seq
MIRT1307755	hsa-miR-508-3p	CLIP-seq
MIRT1307756	hsa-miR-515-3p	CLIP-seq
MIRT1307757	hsa-miR-519d	CLIP-seq
MIRT1307758	hsa-miR-519e	CLIP-seq
MIRT1307759	hsa-miR-520a-3p	CLIP-seq
MIRT1307760	hsa-miR-520b	CLIP-seq
MIRT1307761	hsa-miR-520c-3p	CLIP-seq
MIRT1307762	hsa-miR-520d-3p	CLIP-seq
MIRT1307763	hsa-miR-520e	CLIP-seq
MIRT1307764	hsa-miR-520g	CLIP-seq
MIRT1307765	hsa-miR-520h	CLIP-seq
MIRT1307766	hsa-miR-548ae	CLIP-seq
MIRT1307767	hsa-miR-548aj	CLIP-seq
MIRT1307768	hsa-miR-548am	CLIP-seq
MIRT1307769	hsa-miR-548v	CLIP-seq
MIRT1307770	hsa-miR-548x	CLIP-seq
MIRT1307771	hsa-miR-556-5p	CLIP-seq
MIRT1307772	hsa-miR-558	CLIP-seq
MIRT1307773	hsa-miR-569	CLIP-seq
MIRT1307774	hsa-miR-577	CLIP-seq
MIRT1307775	hsa-miR-583	CLIP-seq
MIRT1307776	hsa-miR-590-3p	CLIP-seq
MIRT1307777	hsa-miR-590-5p	CLIP-seq
MIRT1307778	hsa-miR-627	CLIP-seq
MIRT1307779	hsa-miR-628-3p	CLIP-seq
MIRT1307780	hsa-miR-633	CLIP-seq
MIRT1307781	hsa-miR-636	CLIP-seq
MIRT1307782	hsa-miR-645	CLIP-seq
MIRT1307783	hsa-miR-650	CLIP-seq
MIRT1307784	hsa-miR-660	CLIP-seq
MIRT1307785	hsa-miR-670	CLIP-seq
MIRT1307786	hsa-miR-924	CLIP-seq
MIRT1307787	hsa-miR-93	CLIP-seq
MIRT1307788	hsa-miR-940	CLIP-seq
MIRT1553113	hsa-miR-3117-5p	CLIP-seq
MIRT1307672	hsa-miR-1245	CLIP-seq
MIRT1307692	hsa-miR-219-5p	CLIP-seq
MIRT2091172	hsa-miR-2276	CLIP-seq
MIRT2091173	hsa-miR-23a	CLIP-seq
MIRT2091174	hsa-miR-23b	CLIP-seq
MIRT2091175	hsa-miR-23c	CLIP-seq
MIRT2091176	hsa-miR-27a	CLIP-seq
MIRT2091177	hsa-miR-27b	CLIP-seq
MIRT2091178	hsa-miR-29a	CLIP-seq
MIRT2091179	hsa-miR-29b	CLIP-seq
MIRT2091180	hsa-miR-29c	CLIP-seq
MIRT2091181	hsa-miR-300	CLIP-seq
MIRT1553113	hsa-miR-3117-5p	CLIP-seq
MIRT2091182	hsa-miR-3129-3p	CLIP-seq
MIRT2091183	hsa-miR-3148	CLIP-seq
MIRT2091184	hsa-miR-3149	CLIP-seq
MIRT1307706	hsa-miR-3173-3p	CLIP-seq
MIRT1307708	hsa-miR-320a	CLIP-seq
MIRT1307709	hsa-miR-320b	CLIP-seq
MIRT1307710	hsa-miR-320c	CLIP-seq
MIRT1307711	hsa-miR-320d	CLIP-seq
MIRT1307714	hsa-miR-3612	CLIP-seq
MIRT2091185	hsa-miR-361-5p	CLIP-seq
MIRT2091186	hsa-miR-3680	CLIP-seq
MIRT2091187	hsa-miR-3688-3p	CLIP-seq
MIRT2091188	hsa-miR-374c	CLIP-seq
MIRT2091189	hsa-miR-381	CLIP-seq
MIRT2091190	hsa-miR-3934	CLIP-seq
MIRT2091191	hsa-miR-3974	CLIP-seq
MIRT2091192	hsa-miR-410	CLIP-seq
MIRT2091193	hsa-miR-412	CLIP-seq
MIRT1307724	hsa-miR-421	CLIP-seq
MIRT1307725	hsa-miR-4272	CLIP-seq
MIRT2091194	hsa-miR-4276	CLIP-seq
MIRT1307730	hsa-miR-4330	CLIP-seq
MIRT1307732	hsa-miR-4429	CLIP-seq
MIRT1307733	hsa-miR-4445	CLIP-seq
MIRT2091195	hsa-miR-448	CLIP-seq
MIRT2091196	hsa-miR-4667-3p	CLIP-seq
MIRT1307744	hsa-miR-4695-5p	CLIP-seq
MIRT2091197	hsa-miR-4699-3p	CLIP-seq
MIRT1307745	hsa-miR-4709-5p	CLIP-seq
MIRT2091198	hsa-miR-4772-3p	CLIP-seq
MIRT1307752	hsa-miR-4782-3p	CLIP-seq
MIRT2091199	hsa-miR-485-3p	CLIP-seq
MIRT1307754	hsa-miR-487a	CLIP-seq
MIRT2091200	hsa-miR-491-3p	CLIP-seq
MIRT1307755	hsa-miR-508-3p	CLIP-seq
MIRT2091201	hsa-miR-513a-5p	CLIP-seq
MIRT2091202	hsa-miR-519a	CLIP-seq
MIRT2091203	hsa-miR-519b-3p	CLIP-seq
MIRT2091204	hsa-miR-519c-3p	CLIP-seq
MIRT2091205	hsa-miR-548g	CLIP-seq
MIRT2091206	hsa-miR-549	CLIP-seq
MIRT2091207	hsa-miR-552	CLIP-seq
MIRT2091208	hsa-miR-561	CLIP-seq
MIRT2091209	hsa-miR-586	CLIP-seq
MIRT1307776	hsa-miR-590-3p	CLIP-seq
MIRT2091210	hsa-miR-624	CLIP-seq
MIRT1307778	hsa-miR-627	CLIP-seq
MIRT2091211	hsa-miR-640	CLIP-seq
MIRT2091212	hsa-miR-642a	CLIP-seq
MIRT1307783	hsa-miR-650	CLIP-seq
MIRT2091213	hsa-miR-655	CLIP-seq
MIRT1307784	hsa-miR-660	CLIP-seq
MIRT2091214	hsa-miR-889	CLIP-seq
MIRT1307786	hsa-miR-924	CLIP-seq
MIRT2315962	hsa-miR-1179	CLIP-seq
MIRT1307672	hsa-miR-1245	CLIP-seq
MIRT2315963	hsa-miR-1279	CLIP-seq
MIRT2315964	hsa-miR-1285	CLIP-seq
MIRT2315965	hsa-miR-129-5p	CLIP-seq
MIRT2315966	hsa-miR-1343	CLIP-seq
MIRT2315967	hsa-miR-1976	CLIP-seq
MIRT2315968	hsa-miR-204	CLIP-seq
MIRT2315969	hsa-miR-211	CLIP-seq
MIRT1307692	hsa-miR-219-5p	CLIP-seq
MIRT2091176	hsa-miR-27a	CLIP-seq
MIRT2091177	hsa-miR-27b	CLIP-seq
MIRT2091178	hsa-miR-29a	CLIP-seq
MIRT2091179	hsa-miR-29b	CLIP-seq
MIRT2091180	hsa-miR-29c	CLIP-seq
MIRT2091181	hsa-miR-300	CLIP-seq
MIRT1553113	hsa-miR-3117-5p	CLIP-seq
MIRT2315970	hsa-miR-3120-3p	CLIP-seq
MIRT1307706	hsa-miR-3173-3p	CLIP-seq
MIRT2315971	hsa-miR-3179	CLIP-seq
MIRT2315972	hsa-miR-3187-5p	CLIP-seq
MIRT2315973	hsa-miR-33a	CLIP-seq
MIRT2315974	hsa-miR-33b	CLIP-seq
MIRT1307713	hsa-miR-340	CLIP-seq
MIRT2315975	hsa-miR-3606	CLIP-seq
MIRT2315976	hsa-miR-3611	CLIP-seq
MIRT1307714	hsa-miR-3612	CLIP-seq
MIRT2315977	hsa-miR-374a	CLIP-seq
MIRT2315978	hsa-miR-374b	CLIP-seq
MIRT2091189	hsa-miR-381	CLIP-seq
MIRT2091192	hsa-miR-410	CLIP-seq
MIRT2315979	hsa-miR-425	CLIP-seq
MIRT2091194	hsa-miR-4276	CLIP-seq
MIRT2315980	hsa-miR-4279	CLIP-seq
MIRT2315981	hsa-miR-4418	CLIP-seq
MIRT1307733	hsa-miR-4445	CLIP-seq
MIRT1307736	hsa-miR-4490	CLIP-seq
MIRT2315982	hsa-miR-4495	CLIP-seq
MIRT2315983	hsa-miR-450b-5p	CLIP-seq
MIRT2315984	hsa-miR-4643	CLIP-seq
MIRT1307744	hsa-miR-4695-5p	CLIP-seq
MIRT2091197	hsa-miR-4699-3p	CLIP-seq
MIRT2315985	hsa-miR-4717-3p	CLIP-seq
MIRT2315986	hsa-miR-4755-5p	CLIP-seq
MIRT1307750	hsa-miR-4774-5p	CLIP-seq
MIRT2315987	hsa-miR-4780	CLIP-seq
MIRT1307752	hsa-miR-4782-3p	CLIP-seq
MIRT1307754	hsa-miR-487a	CLIP-seq
MIRT2091200	hsa-miR-491-3p	CLIP-seq
MIRT2315988	hsa-miR-507	CLIP-seq
MIRT1307755	hsa-miR-508-3p	CLIP-seq
MIRT2315989	hsa-miR-509-3-5p	CLIP-seq
MIRT2315990	hsa-miR-509-5p	CLIP-seq
MIRT2091201	hsa-miR-513a-5p	CLIP-seq
MIRT2315991	hsa-miR-543	CLIP-seq
MIRT2315992	hsa-miR-548ac	CLIP-seq
MIRT1307766	hsa-miR-548ae	CLIP-seq
MIRT1307767	hsa-miR-548aj	CLIP-seq
MIRT1307768	hsa-miR-548am	CLIP-seq
MIRT2315993	hsa-miR-548d-3p	CLIP-seq
MIRT1307770	hsa-miR-548x	CLIP-seq
MIRT2315994	hsa-miR-548z	CLIP-seq
MIRT2315995	hsa-miR-557	CLIP-seq
MIRT2091209	hsa-miR-586	CLIP-seq
MIRT2315996	hsa-miR-612	CLIP-seq
MIRT2315997	hsa-miR-623	CLIP-seq
MIRT1307783	hsa-miR-650	CLIP-seq
MIRT2315998	hsa-miR-661	CLIP-seq
MIRT1307730	hsa-miR-4330	CLIP-seq
MIRT2315981	hsa-miR-4418	CLIP-seq
MIRT2315989	hsa-miR-509-3-5p	CLIP-seq
MIRT2315990	hsa-miR-509-5p	CLIP-seq
MIRT2432757	hsa-miR-1324	CLIP-seq
MIRT2432758	hsa-miR-3166	CLIP-seq
MIRT1553113	hsa-miR-3117-5p	CLIP-seq
MIRT2091200	hsa-miR-491-3p	CLIP-seq
MIRT2091209	hsa-miR-586	CLIP-seq
MIRT2458273	hsa-miR-1273e	CLIP-seq
MIRT2315970	hsa-miR-3120-3p	CLIP-seq
MIRT2458274	hsa-miR-3135	CLIP-seq
MIRT2458275	hsa-miR-3689a-3p	CLIP-seq
MIRT2458276	hsa-miR-3689c	CLIP-seq
MIRT2315981	hsa-miR-4418	CLIP-seq
MIRT2458277	hsa-miR-4728-5p	CLIP-seq
MIRT2315989	hsa-miR-509-3-5p	CLIP-seq
MIRT2315990	hsa-miR-509-5p	CLIP-seq
MIRT2315962	hsa-miR-1179	CLIP-seq
MIRT2612009	hsa-miR-1193	CLIP-seq
MIRT2612010	hsa-miR-1229	CLIP-seq
MIRT2612011	hsa-miR-1237	CLIP-seq
MIRT1307672	hsa-miR-1245	CLIP-seq
MIRT2612012	hsa-miR-1248	CLIP-seq
MIRT1307674	hsa-miR-1276	CLIP-seq
MIRT2315964	hsa-miR-1285	CLIP-seq
MIRT2315965	hsa-miR-129-5p	CLIP-seq
MIRT2612013	hsa-miR-132	CLIP-seq
MIRT2612014	hsa-miR-1322	CLIP-seq
MIRT2612015	hsa-miR-1323	CLIP-seq
MIRT2432757	hsa-miR-1324	CLIP-seq
MIRT2612016	hsa-miR-140-3p	CLIP-seq
MIRT2612017	hsa-miR-1910	CLIP-seq
MIRT2612018	hsa-miR-197	CLIP-seq
MIRT2612019	hsa-miR-200b	CLIP-seq
MIRT2612020	hsa-miR-200c	CLIP-seq
MIRT1307690	hsa-miR-2114	CLIP-seq
MIRT2612021	hsa-miR-212	CLIP-seq
MIRT2612022	hsa-miR-216a	CLIP-seq
MIRT1307692	hsa-miR-219-5p	CLIP-seq
MIRT2091172	hsa-miR-2276	CLIP-seq
MIRT2091176	hsa-miR-27a	CLIP-seq
MIRT2091177	hsa-miR-27b	CLIP-seq
MIRT2612023	hsa-miR-2964a-5p	CLIP-seq
MIRT2091178	hsa-miR-29a	CLIP-seq
MIRT2091179	hsa-miR-29b	CLIP-seq
MIRT2091180	hsa-miR-29c	CLIP-seq
MIRT2091181	hsa-miR-300	CLIP-seq
MIRT1553113	hsa-miR-3117-5p	CLIP-seq
MIRT2315970	hsa-miR-3120-3p	CLIP-seq
MIRT2612024	hsa-miR-3128	CLIP-seq
MIRT2091182	hsa-miR-3129-3p	CLIP-seq
MIRT2432758	hsa-miR-3166	CLIP-seq
MIRT1307706	hsa-miR-3173-3p	CLIP-seq
MIRT2315972	hsa-miR-3187-5p	CLIP-seq
MIRT2612025	hsa-miR-325	CLIP-seq
MIRT2315973	hsa-miR-33a	CLIP-seq
MIRT2315974	hsa-miR-33b	CLIP-seq
MIRT2315975	hsa-miR-3606	CLIP-seq
MIRT1307714	hsa-miR-3612	CLIP-seq
MIRT2091185	hsa-miR-361-5p	CLIP-seq
MIRT2612026	hsa-miR-362-5p	CLIP-seq
MIRT2612027	hsa-miR-3651	CLIP-seq
MIRT2091186	hsa-miR-3680	CLIP-seq
MIRT2091188	hsa-miR-374c	CLIP-seq
MIRT2091189	hsa-miR-381	CLIP-seq
MIRT2091191	hsa-miR-3974	CLIP-seq
MIRT2091192	hsa-miR-410	CLIP-seq
MIRT1307724	hsa-miR-421	CLIP-seq
MIRT2315979	hsa-miR-425	CLIP-seq
MIRT1307725	hsa-miR-4272	CLIP-seq
MIRT2612028	hsa-miR-429	CLIP-seq
MIRT2612029	hsa-miR-4305	CLIP-seq
MIRT1307730	hsa-miR-4330	CLIP-seq
MIRT2315981	hsa-miR-4418	CLIP-seq
MIRT2612030	hsa-miR-4427	CLIP-seq
MIRT1307733	hsa-miR-4445	CLIP-seq
MIRT2612031	hsa-miR-4452	CLIP-seq
MIRT2091195	hsa-miR-448	CLIP-seq
MIRT2612032	hsa-miR-4504	CLIP-seq
MIRT2315983	hsa-miR-450b-5p	CLIP-seq
MIRT2612033	hsa-miR-452	CLIP-seq
MIRT2612034	hsa-miR-4539	CLIP-seq
MIRT2612035	hsa-miR-4645-3p	CLIP-seq
MIRT2612036	hsa-miR-4676-3p	CLIP-seq
MIRT1307743	hsa-miR-4680-3p	CLIP-seq
MIRT1307744	hsa-miR-4695-5p	CLIP-seq
MIRT2091197	hsa-miR-4699-3p	CLIP-seq
MIRT1307745	hsa-miR-4709-5p	CLIP-seq
MIRT2612037	hsa-miR-4720-5p	CLIP-seq
MIRT2612038	hsa-miR-4762-5p	CLIP-seq
MIRT2091198	hsa-miR-4772-3p	CLIP-seq
MIRT2612039	hsa-miR-4777-5p	CLIP-seq
MIRT1307752	hsa-miR-4782-3p	CLIP-seq
MIRT2612040	hsa-miR-4799-3p	CLIP-seq
MIRT2612041	hsa-miR-4799-5p	CLIP-seq
MIRT1307754	hsa-miR-487a	CLIP-seq
MIRT2091200	hsa-miR-491-3p	CLIP-seq
MIRT2612042	hsa-miR-500b	CLIP-seq
MIRT2612043	hsa-miR-501-5p	CLIP-seq
MIRT2315988	hsa-miR-507	CLIP-seq
MIRT1307755	hsa-miR-508-3p	CLIP-seq
MIRT2315989	hsa-miR-509-3-5p	CLIP-seq
MIRT2315990	hsa-miR-509-5p	CLIP-seq
MIRT2091201	hsa-miR-513a-5p	CLIP-seq
MIRT2612044	hsa-miR-518d-5p	CLIP-seq
MIRT2612045	hsa-miR-519b-5p	CLIP-seq
MIRT2612046	hsa-miR-519c-5p	CLIP-seq
MIRT2612047	hsa-miR-520c-5p	CLIP-seq
MIRT2612048	hsa-miR-526a	CLIP-seq
MIRT2315992	hsa-miR-548ac	CLIP-seq
MIRT1307766	hsa-miR-548ae	CLIP-seq
MIRT1307767	hsa-miR-548aj	CLIP-seq
MIRT1307768	hsa-miR-548am	CLIP-seq
MIRT2315993	hsa-miR-548d-3p	CLIP-seq
MIRT2612049	hsa-miR-548o	CLIP-seq
MIRT1307770	hsa-miR-548x	CLIP-seq
MIRT2315994	hsa-miR-548z	CLIP-seq
MIRT2091206	hsa-miR-549	CLIP-seq
MIRT2315995	hsa-miR-557	CLIP-seq
MIRT2612050	hsa-miR-578	CLIP-seq
MIRT2612051	hsa-miR-580	CLIP-seq
MIRT2091209	hsa-miR-586	CLIP-seq
MIRT1307776	hsa-miR-590-3p	CLIP-seq
MIRT2315996	hsa-miR-612	CLIP-seq
MIRT2091210	hsa-miR-624	CLIP-seq
MIRT1307778	hsa-miR-627	CLIP-seq
MIRT2091212	hsa-miR-642a	CLIP-seq
MIRT1307783	hsa-miR-650	CLIP-seq
MIRT2091213	hsa-miR-655	CLIP-seq
MIRT1307784	hsa-miR-660	CLIP-seq
MIRT2315998	hsa-miR-661	CLIP-seq
MIRT2612052	hsa-miR-767-5p	CLIP-seq
MIRT2091214	hsa-miR-889	CLIP-seq
MIRT1307786	hsa-miR-924	CLIP-seq
MIRT2612053	hsa-miR-935	CLIP-seq
MIRT2315962	hsa-miR-1179	CLIP-seq
MIRT2612009	hsa-miR-1193	CLIP-seq
MIRT2689781	hsa-miR-1236	CLIP-seq
MIRT2612011	hsa-miR-1237	CLIP-seq
MIRT1307672	hsa-miR-1245	CLIP-seq
MIRT2612012	hsa-miR-1248	CLIP-seq
MIRT2315964	hsa-miR-1285	CLIP-seq
MIRT2315965	hsa-miR-129-5p	CLIP-seq
MIRT2612013	hsa-miR-132	CLIP-seq
MIRT2612014	hsa-miR-1322	CLIP-seq
MIRT2612015	hsa-miR-1323	CLIP-seq
MIRT2432757	hsa-miR-1324	CLIP-seq
MIRT2612016	hsa-miR-140-3p	CLIP-seq
MIRT2612017	hsa-miR-1910	CLIP-seq
MIRT2612019	hsa-miR-200b	CLIP-seq
MIRT2612020	hsa-miR-200c	CLIP-seq
MIRT2612021	hsa-miR-212	CLIP-seq
MIRT1307692	hsa-miR-219-5p	CLIP-seq
MIRT2612023	hsa-miR-2964a-5p	CLIP-seq
MIRT2091178	hsa-miR-29a	CLIP-seq
MIRT2091179	hsa-miR-29b	CLIP-seq
MIRT2091180	hsa-miR-29c	CLIP-seq
MIRT2091181	hsa-miR-300	CLIP-seq
MIRT1553113	hsa-miR-3117-5p	CLIP-seq
MIRT2612024	hsa-miR-3128	CLIP-seq
MIRT2091182	hsa-miR-3129-3p	CLIP-seq
MIRT2432758	hsa-miR-3166	CLIP-seq
MIRT1307706	hsa-miR-3173-3p	CLIP-seq
MIRT2689782	hsa-miR-3182	CLIP-seq
MIRT2315972	hsa-miR-3187-5p	CLIP-seq
MIRT2612025	hsa-miR-325	CLIP-seq
MIRT2315973	hsa-miR-33a	CLIP-seq
MIRT2315974	hsa-miR-33b	CLIP-seq
MIRT2315975	hsa-miR-3606	CLIP-seq
MIRT1307714	hsa-miR-3612	CLIP-seq
MIRT2091185	hsa-miR-361-5p	CLIP-seq
MIRT2612026	hsa-miR-362-5p	CLIP-seq
MIRT2091186	hsa-miR-3680	CLIP-seq
MIRT2689783	hsa-miR-3686	CLIP-seq
MIRT2091187	hsa-miR-3688-3p	CLIP-seq
MIRT2091188	hsa-miR-374c	CLIP-seq
MIRT2091189	hsa-miR-381	CLIP-seq
MIRT2091191	hsa-miR-3974	CLIP-seq
MIRT2091192	hsa-miR-410	CLIP-seq
MIRT1307724	hsa-miR-421	CLIP-seq
MIRT2315979	hsa-miR-425	CLIP-seq
MIRT1307725	hsa-miR-4272	CLIP-seq
MIRT2612028	hsa-miR-429	CLIP-seq
MIRT1307730	hsa-miR-4330	CLIP-seq
MIRT2612030	hsa-miR-4427	CLIP-seq
MIRT1307733	hsa-miR-4445	CLIP-seq
MIRT2612031	hsa-miR-4452	CLIP-seq
MIRT2091195	hsa-miR-448	CLIP-seq
MIRT2315983	hsa-miR-450b-5p	CLIP-seq
MIRT2612033	hsa-miR-452	CLIP-seq
MIRT2612034	hsa-miR-4539	CLIP-seq
MIRT2612035	hsa-miR-4645-3p	CLIP-seq
MIRT2612036	hsa-miR-4676-3p	CLIP-seq
MIRT1307743	hsa-miR-4680-3p	CLIP-seq
MIRT1307744	hsa-miR-4695-5p	CLIP-seq
MIRT2091197	hsa-miR-4699-3p	CLIP-seq
MIRT1307745	hsa-miR-4709-5p	CLIP-seq
MIRT2612037	hsa-miR-4720-5p	CLIP-seq
MIRT2689784	hsa-miR-4742-3p	CLIP-seq
MIRT1307752	hsa-miR-4782-3p	CLIP-seq
MIRT2612040	hsa-miR-4799-3p	CLIP-seq
MIRT2612041	hsa-miR-4799-5p	CLIP-seq
MIRT1307754	hsa-miR-487a	CLIP-seq
MIRT2091200	hsa-miR-491-3p	CLIP-seq
MIRT2612042	hsa-miR-500b	CLIP-seq
MIRT2612043	hsa-miR-501-5p	CLIP-seq
MIRT2315988	hsa-miR-507	CLIP-seq
MIRT1307755	hsa-miR-508-3p	CLIP-seq
MIRT2315992	hsa-miR-548ac	CLIP-seq
MIRT1307766	hsa-miR-548ae	CLIP-seq
MIRT1307767	hsa-miR-548aj	CLIP-seq
MIRT1307768	hsa-miR-548am	CLIP-seq
MIRT2315993	hsa-miR-548d-3p	CLIP-seq
MIRT2612049	hsa-miR-548o	CLIP-seq
MIRT1307770	hsa-miR-548x	CLIP-seq
MIRT2315994	hsa-miR-548z	CLIP-seq
MIRT2091206	hsa-miR-549	CLIP-seq
MIRT2315995	hsa-miR-557	CLIP-seq
MIRT2612051	hsa-miR-580	CLIP-seq
MIRT2091209	hsa-miR-586	CLIP-seq
MIRT1307776	hsa-miR-590-3p	CLIP-seq
MIRT2689785	hsa-miR-593	CLIP-seq
MIRT2315996	hsa-miR-612	CLIP-seq
MIRT2091210	hsa-miR-624	CLIP-seq
MIRT1307778	hsa-miR-627	CLIP-seq
MIRT2091212	hsa-miR-642a	CLIP-seq
MIRT1307783	hsa-miR-650	CLIP-seq
MIRT2091213	hsa-miR-655	CLIP-seq
MIRT1307784	hsa-miR-660	CLIP-seq
MIRT2315998	hsa-miR-661	CLIP-seq
MIRT2091214	hsa-miR-889	CLIP-seq
MIRT1307786	hsa-miR-924	CLIP-seq
MIRT2612053	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	10545207
GO:0003924	Function	GTPase activity	IEA
GO:0003925	Function	G protein activity	IEA
GO:0005515	Function	Protein binding	IPI	10545207, 29734338, 32296183
GO:0005516	Function	Calmodulin binding	IBA
GO:0005516	Function	Calmodulin binding	TAS	8918462
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IDA	10545207
GO:0005525	Function	GTP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	8918462
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	IDA	23791108
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019003	Function	GDP binding	IBA

Other IDs

• MIM: 609591
• HGNC: 10023
• e!Ensembl: ENSG00000143622

Protein

• UniProt ID: Q92963
• Protein name: GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)
• Protein function: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a
• PDB: 4KLZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	23 → 184	Ras family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tissues.
• Sequence:

  MDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKI
  RIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYR
  VRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAYRYYIDDVFHALVR
  EIRRKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSVT

• Sequence length: 219

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Cardiovascular phenotype	Likely pathogenic; Pathogenic	rs869025196, rs869025194, rs483352822, rs869312687, rs886041414, rs730881014, rs672601334, rs672601335, rs1673399238	RCV003162683 RCV002453562 RCV004020021 RCV003372654 RCV003167957 RCV003372696 RCV002399414 RCV002433549 RCV003372960	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Congenital heart disease	Likely pathogenic; Pathogenic	rs730881014	RCV003483526	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Downslanted palpebral fissures	Likely pathogenic; Pathogenic	rs869312687	RCV000626786	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hypertelorism	Likely pathogenic; Pathogenic	rs869312687	RCV000626786	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Megalencephaly-capillary malformation-polymicrogyria syndrome	Likely pathogenic; Pathogenic	rs777520196	RCV002051722	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Melanoma	Likely pathogenic; Pathogenic	rs869025192	RCV005888596	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neoplasm	Likely pathogenic; Pathogenic	rs869025192	RCV004668820	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Non-immune hydrops fetalis	Pathogenic; Likely pathogenic	rs2102584825, rs730881014	RCV001375991 RCV001375970	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Noonan syndrome	Likely pathogenic; Pathogenic	rs483352822, rs730881014, rs869025197, rs869025196, rs869025195, rs869025194, rs869025193, rs869025192, rs869025191, rs869025189, rs1557960039, rs672601334, rs672601335, rs1673398956, rs2102590960	RCV000220792 RCV000207343 RCV000207342 RCV000207351 RCV000207345 RCV000207352 RCV000207346 RCV000207338 RCV000207350 RCV000207347 RCV000207340 RCV000207341 RCV000218943 RCV001261143 RCV000207349 RCV000207348 RCV001261142 RCV001261139	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan syndrome 1	Pathogenic; Likely pathogenic	rs869025195, rs869025191, rs730881014, rs1557962794, rs868208063, rs1571999498, rs672601334, rs672601335	RCV000856766 RCV000856755 RCV000856765 RCV003453398 RCV000856799 RCV000856764 RCV000856810 RCV000856747 RCV003450918	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan syndrome 8	Likely pathogenic; Pathogenic	rs483352822, rs869312687, rs730881014, rs869025197, rs869025196, rs869025195, rs869025194, rs869025193, rs869025192, rs869025191, rs869025189, rs777520196, rs886041414, rs868208063, rs1557960039, rs1557962794, rs1571999498, rs672601334, rs672601335, rs1673399238, rs1673398956, rs2102590960	RCV000106331 RCV002265526 RCV000054406 RCV000707713 RCV001384932 RCV001384933 RCV000170492 RCV001850287 RCV000226825 RCV000054405 RCV006449269 RCV000578238 RCV000475746 RCV000170493 RCV000209835 RCV000467706 RCV000722172 RCV001037285 RCV001855060 RCV000408903 RCV001782888 RCV000762859 RCV001861885 RCV000704832 RCV003581735 RCV000054404 RCV000054407 RCV001054701 RCV001253561 RCV001880009 RCV002541575	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan syndrome and Noonan-related syndrome	Likely pathogenic; Pathogenic	rs483352822, rs730881014, rs869025197, rs869025194, rs869025193, rs777520196, rs886041414, rs1557960039, rs672601334, rs672601335	RCV001813378 RCV001813414 RCV001813421 RCV001813420 RCV001813419 RCV001813418 RCV001813422 RCV001813444 RCV001813441 RCV001813544 RCV001813373 RCV001813374	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Pedal edema	Likely pathogenic; Pathogenic	rs869312687	RCV000626786	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
RASopathy	Likely pathogenic; Pathogenic	rs483352822, rs730881014, rs869025196, rs869025195, rs869025194, rs869025193, rs869025191, rs869025189, rs868208063, rs1557960039, rs672601334, rs672601335	RCV001844039 RCV001255602 RCV005406858 RCV001175490 RCV001778757 RCV003317110 RCV001174556 RCV003114309 RCV003235080 RCV005237632 RCV005238808 RCV004701458 RCV001192383 RCV001731346 RCV001192384	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
RIT1-related disorder	Likely pathogenic; Pathogenic	rs730881014, rs869025197, rs869025194, rs869025193, rs869025191, rs483352822, rs868208063, rs1571999498, rs672601334, rs672601335	RCV003398818 RCV003965185 RCV003927532 RCV004745234 RCV004745233 RCV003416059 RCV003418096 RCV003396492 RCV003390753 RCV003915017	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Sarcoma	Likely pathogenic; Pathogenic	rs869025191	RCV006253909	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Short stature	Likely pathogenic; Pathogenic	rs869312687	RCV000626786	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cardio-facio-cutaneous syndrome	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONDUCT DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL MALFORMATION SYNDROMES ASSOCIATED WITH SHORT STATURE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DESBUQUOIS SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Fibrous dysplasia of jaw	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYDROPS FETALIS, NON-IMMUNE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations