RLN1 (relaxin 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6013
Gene name Relaxin 1
Gene symbol RLN1
Synonyms (NCBI Gene)
H1H1RLXRLXH1bA12D24.3.1bA12D24.3.2
Chromosome 9
Chromosome location 9p24.1
Summary Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by th
miRNA miRNA information provided by mirtarbase database.
27
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (27)
miRTarBase ID miRNA Experiments Reference
MIRT023279 hsa-miR-122-5p Other 20859956
MIRT719937 hsa-miR-1183 HITS-CLIP 19536157
MIRT719936 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT724914 hsa-miR-1258 HITS-CLIP 19536157
MIRT719935 hsa-miR-331-5p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (2)
Transcription factor Regulation Reference
NR3C1 Unknown 15149733
PGR Unknown 15149733
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (6)
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005179 Function Hormone activity TAS 6298628
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0007165 Process Signal transduction NAS 6298628
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
179730 10026 ENSG00000107018
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P04808
Protein name Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]
Protein function Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00049 Insulin 32 → 185 Insulin/IGF/Relaxin family Domain
Tissue specificity TISSUE SPECIFICITY: Prostate. Not expressed in placenta, decidua or ovary. {ECO:0000269|PubMed:8735594}.
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  Neuroactive ligand-receptor interaction
Relaxin signaling pathway 		 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HYPERTROPHY — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (14)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Coronary Arteriosclerosis Coronary Arteriosclerosis BEFREE 31231242
★★★★★
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Coronary artery disease BEFREE 31231242
★★★★★
★☆☆☆☆
Found in Text Mining only
Coronary heart disease Coronary Heart Disease BEFREE 31231242
★★★★★
★☆☆☆☆
Found in Text Mining only
Hypertensive disease Hypertension LHGDN 16172427
★★★★★
★☆☆☆☆
Found in Text Mining only
Intervertebral Disc Degeneration Intervertebral disc disease Pubtator 36081453 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 26499396
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 17363522, 21696394
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant Testicular Germ Cell Tumor Malignant testicular germ cell tumor BEFREE 21696394
★★★★★
★☆☆☆☆
Found in Text Mining only
Prostate carcinoma Prostate cancer BEFREE 26499396
★★★★★
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Prostatic Neoplasms LHGDN 17363522
★★★★★
★☆☆☆☆
Found in Text Mining only