Gene Gene information from NCBI Gene database.
Entrez ID 599
Gene name BCL2 like 2
Gene symbol BCL2L2
Synonyms (NCBI Gene)
BCL-WBCL2-L-2BCLWPPP1R51
Chromosome 14
Chromosome location 14q11.2
Summary This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cyt
miRNA miRNA information provided by mirtarbase database.
539
miRTarBase ID miRNA Experiments Reference
MIRT001076 hsa-miR-133b Western blot 19654003
MIRT001076 hsa-miR-133b Luciferase reporter assay 19654003
MIRT004364 hsa-miR-122-5p Luciferase reporter assayqRT-PCRWestern blot 18692484
MIRT001076 hsa-miR-133b Luciferase reporter assay 19654003
MIRT001076 hsa-miR-133b Luciferase reporter assayWestern blot 20056941
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0001836 Process Release of cytochrome c from mitochondria IBA
GO:0003006 Process Developmental process involved in reproduction IEA
GO:0005515 Function Protein binding IPI 15694340, 16697956, 17289999, 17428862, 18448430, 18719108, 18981409, 21199865, 22000515, 23055042, 25416956, 27107012, 28514442, 32296183, 33961781, 35512704
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601931 995 ENSG00000129473
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92843
Protein name Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)
Protein function Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
PDB 1MK3 , 1O0L , 1ZY3 , 2Y6W , 4CIM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02180 BH4 6 31 Bcl-2 homology region 4 Family
PF00452 Bcl-2 46 144 Apoptosis regulator proteins, Bcl-2 family Family
Tissue specificity TISSUE SPECIFICITY: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary
Sequence
Sequence length 193
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  MicroRNAs in cancer  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TRANSIENT ISCHEMIC ATTACK Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 19654003
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 17459056
★☆☆☆☆
Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma B-cell Lymphoma BEFREE 28094768
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 15147516 Associate
★☆☆☆☆
Found in Text Mining only
Arthritis Juvenile Juvenile arthritis Pubtator 20462799 Associate
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 28094768, 28855351, 29361709, 29620207, 30008912
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 20062536
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 20062536, 29222472 Associate
★☆☆☆☆
Found in Text Mining only
Burkitt Lymphoma Burkitt`s Lymphoma BEFREE 28094768, 28855351
★☆☆☆☆
Found in Text Mining only
Burkitt Lymphoma Burkitt lymphoma Pubtator 28855351 Stimulate
★☆☆☆☆
Found in Text Mining only