Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5980
Gene name	REV3 like, DNA directed polymerase zeta catalytic subunit
Gene symbol	REV3L
Synonyms (NCBI Gene)	POLZREV3
Chromosome	6
Chromosome location	6q21
Summary	The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause o

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1057519367	T>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant

350

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019556	hsa-miR-340-5p	Sequencing	20371350
MIRT025031	hsa-miR-183-5p	Sequencing	20371350
MIRT028057	hsa-miR-93-5p	Sequencing	20371350
MIRT030718	hsa-miR-21-5p	Microarray	18591254
MIRT054928	hsa-miR-25-3p	Luciferase reporter assay	22349819
MIRT054929	hsa-miR-32-5p	Luciferase reporter assay	22349819
MIRT566049	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT054928	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT054929	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT566048	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT566047	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT566046	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT098316	hsa-miR-4282	PAR-CLIP	20371350
MIRT566045	hsa-miR-548av-5p	PAR-CLIP	20371350
MIRT566044	hsa-miR-548k	PAR-CLIP	20371350
MIRT566042	hsa-miR-8054	PAR-CLIP	20371350
MIRT566043	hsa-miR-548l	PAR-CLIP	20371350
MIRT566040	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT566041	hsa-miR-3163	PAR-CLIP	20371350
MIRT566039	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT566038	hsa-miR-4470	PAR-CLIP	20371350
MIRT566037	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT566036	hsa-miR-2113	PAR-CLIP	20371350
MIRT566035	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT439783	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439783	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT726769	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726768	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726767	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726766	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726765	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT566046	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT566049	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT054929	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT566049	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT054928	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT054929	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT566048	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT566047	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT566046	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT098316	hsa-miR-4282	PAR-CLIP	20371350
MIRT566045	hsa-miR-548av-5p	PAR-CLIP	20371350
MIRT566044	hsa-miR-548k	PAR-CLIP	20371350
MIRT566042	hsa-miR-8054	PAR-CLIP	20371350
MIRT566043	hsa-miR-548l	PAR-CLIP	20371350
MIRT566040	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT566041	hsa-miR-3163	PAR-CLIP	20371350
MIRT566039	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT566038	hsa-miR-4470	PAR-CLIP	20371350
MIRT566037	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT566036	hsa-miR-2113	PAR-CLIP	20371350
MIRT566035	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT1301135	hsa-miR-105	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301138	hsa-miR-1243	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301140	hsa-miR-1264	CLIP-seq
MIRT1301141	hsa-miR-1284	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT1301144	hsa-miR-145	CLIP-seq
MIRT1301145	hsa-miR-148a	CLIP-seq
MIRT1301146	hsa-miR-148b	CLIP-seq
MIRT1301147	hsa-miR-152	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT1301149	hsa-miR-194	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301152	hsa-miR-25	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301156	hsa-miR-300	CLIP-seq
MIRT1301157	hsa-miR-30a	CLIP-seq
MIRT1301158	hsa-miR-30b	CLIP-seq
MIRT1301159	hsa-miR-30c	CLIP-seq
MIRT1301160	hsa-miR-30d	CLIP-seq
MIRT1301161	hsa-miR-30e	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT1301163	hsa-miR-3140-3p	CLIP-seq
MIRT1301164	hsa-miR-3180-5p	CLIP-seq
MIRT1301165	hsa-miR-3189-5p	CLIP-seq
MIRT1301166	hsa-miR-32	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301170	hsa-miR-362-5p	CLIP-seq
MIRT1301171	hsa-miR-363	CLIP-seq
MIRT1301172	hsa-miR-3646	CLIP-seq
MIRT1301173	hsa-miR-3647-3p	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301175	hsa-miR-3654	CLIP-seq
MIRT1301176	hsa-miR-3658	CLIP-seq
MIRT1301177	hsa-miR-3662	CLIP-seq
MIRT1301178	hsa-miR-3667-3p	CLIP-seq
MIRT1301179	hsa-miR-367	CLIP-seq
MIRT1301180	hsa-miR-376a	CLIP-seq
MIRT1301181	hsa-miR-376b	CLIP-seq
MIRT1301182	hsa-miR-381	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301184	hsa-miR-3942-3p	CLIP-seq
MIRT1301185	hsa-miR-4268	CLIP-seq
MIRT1301186	hsa-miR-4276	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT1301188	hsa-miR-4422	CLIP-seq
MIRT1301189	hsa-miR-4426	CLIP-seq
MIRT1301190	hsa-miR-4436b-5p	CLIP-seq
MIRT1301191	hsa-miR-4448	CLIP-seq
MIRT1301192	hsa-miR-4464	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT1301194	hsa-miR-4528	CLIP-seq
MIRT1301195	hsa-miR-4646-5p	CLIP-seq
MIRT1301196	hsa-miR-4647	CLIP-seq
MIRT1301197	hsa-miR-4662b	CLIP-seq
MIRT1301198	hsa-miR-4666-3p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT1301200	hsa-miR-4699-3p	CLIP-seq
MIRT1301201	hsa-miR-4719	CLIP-seq
MIRT1301202	hsa-miR-4747-5p	CLIP-seq
MIRT1301203	hsa-miR-4748	CLIP-seq
MIRT1301204	hsa-miR-4758-3p	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301208	hsa-miR-4796-5p	CLIP-seq
MIRT1301209	hsa-miR-495	CLIP-seq
MIRT1301210	hsa-miR-500b	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301212	hsa-miR-511	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301214	hsa-miR-520d-5p	CLIP-seq
MIRT1301215	hsa-miR-524-5p	CLIP-seq
MIRT1301216	hsa-miR-548a-5p	CLIP-seq
MIRT1301217	hsa-miR-548ab	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT1301219	hsa-miR-548ak	CLIP-seq
MIRT1301220	hsa-miR-548b-5p	CLIP-seq
MIRT1301221	hsa-miR-548c-5p	CLIP-seq
MIRT1301222	hsa-miR-548d-5p	CLIP-seq
MIRT1301223	hsa-miR-548h	CLIP-seq
MIRT1301224	hsa-miR-548i	CLIP-seq
MIRT1301225	hsa-miR-548j	CLIP-seq
MIRT1301226	hsa-miR-548w	CLIP-seq
MIRT1301227	hsa-miR-548y	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301229	hsa-miR-559	CLIP-seq
MIRT1301230	hsa-miR-570	CLIP-seq
MIRT1301231	hsa-miR-579	CLIP-seq
MIRT1301232	hsa-miR-633	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT1301234	hsa-miR-802	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT1301236	hsa-miR-888	CLIP-seq
MIRT1301237	hsa-miR-92a	CLIP-seq
MIRT1301238	hsa-miR-92b	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301144	hsa-miR-145	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT1301164	hsa-miR-3180-5p	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT2089447	hsa-miR-548p	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT1301135	hsa-miR-105	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301140	hsa-miR-1264	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT2314353	hsa-miR-140-5p	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301152	hsa-miR-25	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301157	hsa-miR-30a	CLIP-seq
MIRT1301158	hsa-miR-30b	CLIP-seq
MIRT1301159	hsa-miR-30c	CLIP-seq
MIRT1301160	hsa-miR-30d	CLIP-seq
MIRT1301161	hsa-miR-30e	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT2314357	hsa-miR-3145-3p	CLIP-seq
MIRT1301165	hsa-miR-3189-5p	CLIP-seq
MIRT1301166	hsa-miR-32	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT2314358	hsa-miR-3545-5p	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301170	hsa-miR-362-5p	CLIP-seq
MIRT1301171	hsa-miR-363	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301178	hsa-miR-3667-3p	CLIP-seq
MIRT1301179	hsa-miR-367	CLIP-seq
MIRT2314360	hsa-miR-3689a-5p	CLIP-seq
MIRT2314361	hsa-miR-3689b	CLIP-seq
MIRT2314362	hsa-miR-3689e	CLIP-seq
MIRT2314363	hsa-miR-3689f	CLIP-seq
MIRT1301180	hsa-miR-376a	CLIP-seq
MIRT1301181	hsa-miR-376b	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301184	hsa-miR-3942-3p	CLIP-seq
MIRT1301185	hsa-miR-4268	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314365	hsa-miR-4310	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT1301188	hsa-miR-4422	CLIP-seq
MIRT1301190	hsa-miR-4436b-5p	CLIP-seq
MIRT1301191	hsa-miR-4448	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT2314368	hsa-miR-4517	CLIP-seq
MIRT2314369	hsa-miR-451b	CLIP-seq
MIRT1301194	hsa-miR-4528	CLIP-seq
MIRT1301195	hsa-miR-4646-5p	CLIP-seq
MIRT2314370	hsa-miR-466	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314373	hsa-miR-4696	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301202	hsa-miR-4747-5p	CLIP-seq
MIRT1301204	hsa-miR-4758-3p	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301210	hsa-miR-500b	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301216	hsa-miR-548a-5p	CLIP-seq
MIRT1301217	hsa-miR-548ab	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT1301219	hsa-miR-548ak	CLIP-seq
MIRT1301220	hsa-miR-548b-5p	CLIP-seq
MIRT1301221	hsa-miR-548c-5p	CLIP-seq
MIRT1301222	hsa-miR-548d-5p	CLIP-seq
MIRT1301223	hsa-miR-548h	CLIP-seq
MIRT1301224	hsa-miR-548i	CLIP-seq
MIRT1301225	hsa-miR-548j	CLIP-seq
MIRT2089447	hsa-miR-548p	CLIP-seq
MIRT1301226	hsa-miR-548w	CLIP-seq
MIRT1301227	hsa-miR-548y	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301229	hsa-miR-559	CLIP-seq
MIRT2314376	hsa-miR-584	CLIP-seq
MIRT2314377	hsa-miR-590-3p	CLIP-seq
MIRT2314378	hsa-miR-627	CLIP-seq
MIRT1301232	hsa-miR-633	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT1301234	hsa-miR-802	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT2314379	hsa-miR-889	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq
MIRT1301237	hsa-miR-92a	CLIP-seq
MIRT1301238	hsa-miR-92b	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301156	hsa-miR-300	CLIP-seq
MIRT1301182	hsa-miR-381	CLIP-seq
MIRT2432677	hsa-miR-3941	CLIP-seq
MIRT2432678	hsa-miR-452	CLIP-seq
MIRT2314370	hsa-miR-466	CLIP-seq
MIRT1301198	hsa-miR-4666-3p	CLIP-seq
MIRT2432679	hsa-miR-4672	CLIP-seq
MIRT2432680	hsa-miR-4676-3p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT2432681	hsa-miR-4789-5p	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT2314353	hsa-miR-140-5p	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT2314357	hsa-miR-3145-3p	CLIP-seq
MIRT2314358	hsa-miR-3545-5p	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT2314360	hsa-miR-3689a-5p	CLIP-seq
MIRT2314361	hsa-miR-3689b	CLIP-seq
MIRT2314362	hsa-miR-3689e	CLIP-seq
MIRT2314363	hsa-miR-3689f	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000731	Process	DNA synthesis involved in DNA repair	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA
GO:0003887	Function	DNA-directed DNA polymerase activity	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	TAS	9618506
GO:0005515	Function	Protein binding	IPI	22828282
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0006260	Process	DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	TAS	9618506
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016035	Component	Zeta DNA polymerase complex	IBA
GO:0016035	Component	Zeta DNA polymerase complex	IDA	20164194, 22465957
GO:0016035	Component	Zeta DNA polymerase complex	IEA
GO:0016035	Component	Zeta DNA polymerase complex	IPI	24449906
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0019985	Process	Translesion synthesis	IEA
GO:0031981	Component	Nuclear lumen	IEA
GO:0034061	Function	DNA polymerase activity	IEA
GO:0042276	Process	Error-prone translesion synthesis	IBA
GO:0042276	Process	Error-prone translesion synthesis	IDA	24449906
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA

MIM	HGNC	e!Ensembl
602776	9968	ENSG00000009413

O60673

Protein name

DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)

Protein function

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.

PDB

3ABD , 3ABE , 3VU7 , 4EXT , 4GK0 , 4GK5 , 5O8K , 6BC8 , 6BCD , 6BI7 , 6EKM , 6KEA , 6WS0 , 6WS5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03104	DNA_pol_B_exo1	43 → 203	DNA polymerase family B, exonuclease domain	Family
PF15735	DUF4683	746 → 1133	Domain of unknown function (DUF4683)	Family
PF03104	DNA_pol_B_exo1	2221 → 2484	DNA polymerase family B, exonuclease domain	Family
PF00136	DNA_pol_B	2549 → 3001	DNA polymerase family B	Family
PF14260	zf-C4pol	3042 → 3110	C4-type zinc-finger of DNA polymerase delta	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed.

Sequence

MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPY
LYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKER
HFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDA
VAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKK
FQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKD
KESSKGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAG
LESDGYRGERNRMPSPCRSFGNNKYPQNSDDEENEPQIEKEEMELSLVMSQRWDSNIEEH
CAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNEN
SRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLS
QTNKNTEKGLDNSVTSFTNESTYSMKYPGSLSSTVHSENSHKENSKKEILPVSSCESSIF
DYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVS
SEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQ
EHKTEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQPGNKPSRLKLNKRKLAGH
QETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFG
DGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLK
SRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPL
KDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKR
SHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIM
AAAEKEAMLFKGPNVYKKTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKL
VDDGKKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQL
LFKQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHP
SVVCNSIGPGVSKINVQRPHNQSAMFTLKESTLIQKNIFDLSNHLSQVAQNTQISSGMSS
KIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSE
TCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAI
SQTKALSQCKNRNVSTPSAFGEGQSGLAVLKELLQKRQQKAQNANTTQDPLSNKHQPNKN
ISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDS
PIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSD
AVQDLFPGQAIEKNEFLSHDNQKCDEDKHHTTDSASWIRSGTLSPEIFEKSTIDSNENRR
HNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ
GHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTS
SPSQSKNGSFTPRTANILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPR
EIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRSGQGVVNKGS
SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAENFSSS
VNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQTASESQMLPPVASA
SDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENF
LKPIKDGIQKSPCSEPQEPLVISPINTRARTGKCESLCFHSTPIIQRKLLERLPEAPGLS
PLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKV
SIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTEKT
ELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDI
LLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINIVG
RITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHY
VSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVT
PSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENL
GKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMV
KQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETL
ERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF
EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFET
RDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRR
SEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSL
IGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQ
PQHVAVILNQEIRELERQQEQLVKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKA
PYLRQLLDQF

Sequence length

3130

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance Fanconi anemia pathway		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Carcinoma of colon	Likely pathogenic	rs1057519367	RCV000416681	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (21)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANNABIS DEPENDENCE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY SKIN DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOBIUS SYNDROME	—	Disgenet, GenCC Disgenet, GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIATIC ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
REV3L-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (75)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anemia Hemolytic	Hemolytic anemia	Pubtator	31915374	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	25014791	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	GWASCAT_DG	30552173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthrogryposis	Arthrogryposis multiplex congenita	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	19289490, 25781640		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Brachydactyly	Brachydactyly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21455670, 26462070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Byzanthine arch palate	High palate	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cafe au lait spots, multiple	Cafe-au-lait spot	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	18622427		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	22349819, 26165320, 29307819		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinomatosis of peritoneal cavity	Peritoneal Carcinomatosis	BEFREE	31267590		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	25781640		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	25781640		★★★★★ ★☆☆☆☆ Found in Text Mining only
Clinodactyly of the 5th finger	Camptodactyly of fingers	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Clumsiness - motor delay	Motor delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29435169		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	CLINVAR_DG	27165003		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	27165003, 30591675	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital absence of breast	Breast aplasia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital clubfoot	Congenital Clubfoot	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Deglutition Disorders	Dysphagia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	28729637	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	28729637	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28729637		★★★★★ ★☆☆☆☆ Found in Text Mining only
Facial paralysis	Facial paralysis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi Anemia	BEFREE	27165003		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi anemia	Pubtator	27165003	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	Anemia	BEFREE	27165003		★★★★★ ★☆☆☆☆ Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP D2	Fanconi Anemia	BEFREE	23303771		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	26450587		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	26450587		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	19289490		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	19289490	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	22028621	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypogonadotropic hypogonadism	Hypogonadotropic Hypogonadism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	22028621	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	25113059, 29307819	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21455670, 26462070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	22349819, 26165320, 29307819		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	12717825		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11115544, 19289490, 22028621, 29307819, 29435169		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	25781640		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29435169		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	26462070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma	Mesothelioma	BEFREE	22028621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Microdontia (disorder)	Microdontia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Micrognathism	Micrognathism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mobius II syndrome	Mobius Syndrome	ORPHANET_DG	26068067		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mobius Syndrome	Mobius Syndrome	BEFREE	26068067, 27884122, 31033088		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mobius Syndrome	Mobius Syndrome	ORPHANET_DG	26068067		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mobius Syndrome	Mobius syndrome	Pubtator	27884122, 31033088	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moebius syndrome	Moebius Syndrome	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11115544, 18622427, 19289490, 22028621, 30535450, 31832811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	26165320, 28075014, 30535450		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	25748439		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	25748439	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASCAT_DG	20953190, 25574825, 25903422		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	GWASDB_DG	20953190		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	25014791		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31072625		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	26790612	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	26790612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	12717825		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Diseases	Stomach disease	Pubtator	32838755	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	12717825, 32838755	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Syndactyly of fingers	Syndactyly of fingers	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	39237917	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	25781640	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum	Xeroderma pigmentosum	Pubtator	35328096	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)