DPF2 (double PHD fingers 2)

Gene

• Entrez ID: 5977
• Gene name: Double PHD fingers 2
• Gene symbol: DPF2
• Synonyms (NCBI Gene): CSS7, REQ, SMARCG2, UBID4, ubi-d4
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival fa

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1555031372	G>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1555031500	C>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1555032044	A>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1555032051	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1555032074	G>A	Pathogenic	Splice donor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022792	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT032431	hsa-let-7b-5p	Proteomics	18668040
MIRT615267	hsa-miR-3126-3p	HITS-CLIP	23824327
MIRT615266	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT615265	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT615264	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT615263	hsa-miR-3128	HITS-CLIP	23824327
MIRT615262	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT615261	hsa-miR-4720-5p	HITS-CLIP	23824327
MIRT615260	hsa-miR-4799-3p	HITS-CLIP	23824327
MIRT615259	hsa-miR-5588-5p	HITS-CLIP	23824327
MIRT615258	hsa-miR-642b-5p	HITS-CLIP	23824327
MIRT615257	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT615256	hsa-miR-623	HITS-CLIP	23824327
MIRT615255	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT615254	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT615253	hsa-miR-4642	HITS-CLIP	23824327
MIRT615252	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT615251	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT439128	hsa-miR-10b-5p	3'LIFE	25074381
MIRT439128	hsa-miR-10b-5p	3'LIFE	25074381
MIRT615267	hsa-miR-3126-3p	HITS-CLIP	23824327
MIRT615266	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT615265	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT615264	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT615263	hsa-miR-3128	HITS-CLIP	23824327
MIRT615262	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT615261	hsa-miR-4720-5p	HITS-CLIP	23824327
MIRT615260	hsa-miR-4799-3p	HITS-CLIP	23824327
MIRT615259	hsa-miR-5588-5p	HITS-CLIP	23824327
MIRT615258	hsa-miR-642b-5p	HITS-CLIP	23824327
MIRT615257	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT615256	hsa-miR-623	HITS-CLIP	23824327
MIRT615255	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT615254	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT615253	hsa-miR-4642	HITS-CLIP	23824327
MIRT615252	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT615251	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT943749	hsa-miR-1204	CLIP-seq
MIRT943750	hsa-miR-150	CLIP-seq
MIRT943751	hsa-miR-185	CLIP-seq
MIRT943752	hsa-miR-190	CLIP-seq
MIRT943753	hsa-miR-190b	CLIP-seq
MIRT943754	hsa-miR-2110	CLIP-seq
MIRT943755	hsa-miR-22	CLIP-seq
MIRT943756	hsa-miR-2467-3p	CLIP-seq
MIRT943757	hsa-miR-2467-5p	CLIP-seq
MIRT943758	hsa-miR-3133	CLIP-seq
MIRT943759	hsa-miR-3137	CLIP-seq
MIRT943760	hsa-miR-3138	CLIP-seq
MIRT943761	hsa-miR-3150b-3p	CLIP-seq
MIRT943762	hsa-miR-3188	CLIP-seq
MIRT943763	hsa-miR-323-5p	CLIP-seq
MIRT943764	hsa-miR-345	CLIP-seq
MIRT943765	hsa-miR-3616-5p	CLIP-seq
MIRT943766	hsa-miR-3647-5p	CLIP-seq
MIRT943767	hsa-miR-3664-5p	CLIP-seq
MIRT943768	hsa-miR-3665	CLIP-seq
MIRT943769	hsa-miR-3908	CLIP-seq
MIRT943770	hsa-miR-3918	CLIP-seq
MIRT943771	hsa-miR-3975	CLIP-seq
MIRT943772	hsa-miR-3977	CLIP-seq
MIRT943773	hsa-miR-4253	CLIP-seq
MIRT943774	hsa-miR-4257	CLIP-seq
MIRT943775	hsa-miR-4271	CLIP-seq
MIRT943776	hsa-miR-4306	CLIP-seq
MIRT943777	hsa-miR-4316	CLIP-seq
MIRT943778	hsa-miR-4426	CLIP-seq
MIRT943779	hsa-miR-4436b-3p	CLIP-seq
MIRT943780	hsa-miR-4448	CLIP-seq
MIRT943781	hsa-miR-4459	CLIP-seq
MIRT943782	hsa-miR-4517	CLIP-seq
MIRT943783	hsa-miR-4644	CLIP-seq
MIRT943784	hsa-miR-4647	CLIP-seq
MIRT943785	hsa-miR-4662b	CLIP-seq
MIRT943786	hsa-miR-4688	CLIP-seq
MIRT943787	hsa-miR-4690-5p	CLIP-seq
MIRT943788	hsa-miR-4704-3p	CLIP-seq
MIRT943789	hsa-miR-4708-3p	CLIP-seq
MIRT943790	hsa-miR-4710	CLIP-seq
MIRT943791	hsa-miR-4715-3p	CLIP-seq
MIRT943792	hsa-miR-4725-3p	CLIP-seq
MIRT943793	hsa-miR-4752	CLIP-seq
MIRT943794	hsa-miR-4757-5p	CLIP-seq
MIRT943795	hsa-miR-4768-3p	CLIP-seq
MIRT943796	hsa-miR-4779	CLIP-seq
MIRT943797	hsa-miR-4784	CLIP-seq
MIRT943798	hsa-miR-4793-5p	CLIP-seq
MIRT943799	hsa-miR-4795-5p	CLIP-seq
MIRT943800	hsa-miR-4800-5p	CLIP-seq
MIRT943801	hsa-miR-485-5p	CLIP-seq
MIRT943802	hsa-miR-491-5p	CLIP-seq
MIRT943803	hsa-miR-508-5p	CLIP-seq
MIRT943804	hsa-miR-516b	CLIP-seq
MIRT943805	hsa-miR-539	CLIP-seq
MIRT943806	hsa-miR-542-5p	CLIP-seq
MIRT943807	hsa-miR-558	CLIP-seq
MIRT943808	hsa-miR-573	CLIP-seq
MIRT943809	hsa-miR-583	CLIP-seq
MIRT943810	hsa-miR-621	CLIP-seq
MIRT943811	hsa-miR-634	CLIP-seq
MIRT943812	hsa-miR-665	CLIP-seq
MIRT943813	hsa-miR-765	CLIP-seq
MIRT943814	hsa-miR-873	CLIP-seq
MIRT943815	hsa-miR-935	CLIP-seq
MIRT1548015	hsa-let-7a	CLIP-seq
MIRT1548016	hsa-let-7b	CLIP-seq
MIRT1548017	hsa-let-7c	CLIP-seq
MIRT1548018	hsa-let-7d	CLIP-seq
MIRT1548019	hsa-let-7e	CLIP-seq
MIRT1548020	hsa-let-7f	CLIP-seq
MIRT1548021	hsa-let-7g	CLIP-seq
MIRT1548022	hsa-let-7i	CLIP-seq
MIRT1548023	hsa-miR-1290	CLIP-seq
MIRT1548024	hsa-miR-129-5p	CLIP-seq
MIRT1548025	hsa-miR-3119	CLIP-seq
MIRT1548026	hsa-miR-3152-3p	CLIP-seq
MIRT1548027	hsa-miR-3689d	CLIP-seq
MIRT1548028	hsa-miR-4443	CLIP-seq
MIRT1548029	hsa-miR-4450	CLIP-seq
MIRT1548030	hsa-miR-4458	CLIP-seq
MIRT1548031	hsa-miR-4500	CLIP-seq
MIRT1548032	hsa-miR-98	CLIP-seq
MIRT1548015	hsa-let-7a	CLIP-seq
MIRT1548016	hsa-let-7b	CLIP-seq
MIRT1548017	hsa-let-7c	CLIP-seq
MIRT1548018	hsa-let-7d	CLIP-seq
MIRT1548019	hsa-let-7e	CLIP-seq
MIRT1548020	hsa-let-7f	CLIP-seq
MIRT1548021	hsa-let-7g	CLIP-seq
MIRT1548022	hsa-let-7i	CLIP-seq
MIRT1979466	hsa-miR-1252	CLIP-seq
MIRT1548023	hsa-miR-1290	CLIP-seq
MIRT1548024	hsa-miR-129-5p	CLIP-seq
MIRT1979467	hsa-miR-1302	CLIP-seq
MIRT943750	hsa-miR-150	CLIP-seq
MIRT1979468	hsa-miR-2278	CLIP-seq
MIRT1979469	hsa-miR-2861	CLIP-seq
MIRT1979470	hsa-miR-299-3p	CLIP-seq
MIRT1548025	hsa-miR-3119	CLIP-seq
MIRT1979471	hsa-miR-3135	CLIP-seq
MIRT943759	hsa-miR-3137	CLIP-seq
MIRT1979472	hsa-miR-3145-5p	CLIP-seq
MIRT1979473	hsa-miR-3152-5p	CLIP-seq
MIRT1979474	hsa-miR-3153	CLIP-seq
MIRT1979475	hsa-miR-3154	CLIP-seq
MIRT1979476	hsa-miR-3160-3p	CLIP-seq
MIRT1979477	hsa-miR-3167	CLIP-seq
MIRT1979478	hsa-miR-3174	CLIP-seq
MIRT1979479	hsa-miR-3185	CLIP-seq
MIRT1979480	hsa-miR-326	CLIP-seq
MIRT1979481	hsa-miR-330-5p	CLIP-seq
MIRT1979482	hsa-miR-34a	CLIP-seq
MIRT1979483	hsa-miR-34c-5p	CLIP-seq
MIRT1979484	hsa-miR-3611	CLIP-seq
MIRT943765	hsa-miR-3616-5p	CLIP-seq
MIRT943766	hsa-miR-3647-5p	CLIP-seq
MIRT1979485	hsa-miR-365	CLIP-seq
MIRT943767	hsa-miR-3664-5p	CLIP-seq
MIRT1548027	hsa-miR-3689d	CLIP-seq
MIRT943769	hsa-miR-3908	CLIP-seq
MIRT943770	hsa-miR-3918	CLIP-seq
MIRT1979486	hsa-miR-3919	CLIP-seq
MIRT1979487	hsa-miR-4268	CLIP-seq
MIRT943775	hsa-miR-4271	CLIP-seq
MIRT1979488	hsa-miR-4292	CLIP-seq
MIRT1979489	hsa-miR-4298	CLIP-seq
MIRT1979490	hsa-miR-4302	CLIP-seq
MIRT943778	hsa-miR-4426	CLIP-seq
MIRT1979491	hsa-miR-4428	CLIP-seq
MIRT1548028	hsa-miR-4443	CLIP-seq
MIRT943780	hsa-miR-4448	CLIP-seq
MIRT1548029	hsa-miR-4450	CLIP-seq
MIRT1548030	hsa-miR-4458	CLIP-seq
MIRT1979492	hsa-miR-4487	CLIP-seq
MIRT1979493	hsa-miR-4491	CLIP-seq
MIRT1979494	hsa-miR-449a	CLIP-seq
MIRT1979495	hsa-miR-449b	CLIP-seq
MIRT1548031	hsa-miR-4500	CLIP-seq
MIRT1979496	hsa-miR-4512	CLIP-seq
MIRT1979497	hsa-miR-4640-5p	CLIP-seq
MIRT943784	hsa-miR-4647	CLIP-seq
MIRT1979498	hsa-miR-4657	CLIP-seq
MIRT943785	hsa-miR-4662b	CLIP-seq
MIRT943786	hsa-miR-4688	CLIP-seq
MIRT943787	hsa-miR-4690-5p	CLIP-seq
MIRT1979499	hsa-miR-4713-5p	CLIP-seq
MIRT943792	hsa-miR-4725-3p	CLIP-seq
MIRT1979500	hsa-miR-4726-3p	CLIP-seq
MIRT1979501	hsa-miR-4726-5p	CLIP-seq
MIRT943795	hsa-miR-4768-3p	CLIP-seq
MIRT1979502	hsa-miR-4782-5p	CLIP-seq
MIRT943799	hsa-miR-4795-5p	CLIP-seq
MIRT1979503	hsa-miR-4796-5p	CLIP-seq
MIRT1979504	hsa-miR-486-3p	CLIP-seq
MIRT943804	hsa-miR-516b	CLIP-seq
MIRT943807	hsa-miR-558	CLIP-seq
MIRT943808	hsa-miR-573	CLIP-seq
MIRT943812	hsa-miR-665	CLIP-seq
MIRT1979505	hsa-miR-758	CLIP-seq
MIRT943813	hsa-miR-765	CLIP-seq
MIRT943814	hsa-miR-873	CLIP-seq
MIRT1979506	hsa-miR-876-5p	CLIP-seq
MIRT1548032	hsa-miR-98	CLIP-seq
MIRT1548015	hsa-let-7a	CLIP-seq
MIRT1548016	hsa-let-7b	CLIP-seq
MIRT1548017	hsa-let-7c	CLIP-seq
MIRT1548018	hsa-let-7d	CLIP-seq
MIRT1548019	hsa-let-7e	CLIP-seq
MIRT1548020	hsa-let-7f	CLIP-seq
MIRT1548021	hsa-let-7g	CLIP-seq
MIRT1548022	hsa-let-7i	CLIP-seq
MIRT2214559	hsa-miR-1	CLIP-seq
MIRT943749	hsa-miR-1204	CLIP-seq
MIRT2214560	hsa-miR-1224-5p	CLIP-seq
MIRT2214561	hsa-miR-1269	CLIP-seq
MIRT2214562	hsa-miR-1269b	CLIP-seq
MIRT2214563	hsa-miR-1288	CLIP-seq
MIRT1548023	hsa-miR-1290	CLIP-seq
MIRT1979467	hsa-miR-1302	CLIP-seq
MIRT2214564	hsa-miR-148a	CLIP-seq
MIRT2214565	hsa-miR-148b	CLIP-seq
MIRT2214566	hsa-miR-152	CLIP-seq
MIRT943751	hsa-miR-185	CLIP-seq
MIRT943752	hsa-miR-190	CLIP-seq
MIRT943753	hsa-miR-190b	CLIP-seq
MIRT2214567	hsa-miR-206	CLIP-seq
MIRT2214568	hsa-miR-223	CLIP-seq
MIRT1979468	hsa-miR-2278	CLIP-seq
MIRT943757	hsa-miR-2467-5p	CLIP-seq
MIRT1979470	hsa-miR-299-3p	CLIP-seq
MIRT1548025	hsa-miR-3119	CLIP-seq
MIRT943758	hsa-miR-3133	CLIP-seq
MIRT943759	hsa-miR-3137	CLIP-seq
MIRT943760	hsa-miR-3138	CLIP-seq
MIRT1979472	hsa-miR-3145-5p	CLIP-seq
MIRT1979477	hsa-miR-3167	CLIP-seq
MIRT1979478	hsa-miR-3174	CLIP-seq
MIRT943762	hsa-miR-3188	CLIP-seq
MIRT2214569	hsa-miR-342-5p	CLIP-seq
MIRT1979484	hsa-miR-3611	CLIP-seq
MIRT2214570	hsa-miR-3622b-5p	CLIP-seq
MIRT1979485	hsa-miR-365	CLIP-seq
MIRT943767	hsa-miR-3664-5p	CLIP-seq
MIRT943768	hsa-miR-3665	CLIP-seq
MIRT2214571	hsa-miR-3673	CLIP-seq
MIRT1548027	hsa-miR-3689d	CLIP-seq
MIRT943769	hsa-miR-3908	CLIP-seq
MIRT2214572	hsa-miR-3915	CLIP-seq
MIRT943770	hsa-miR-3918	CLIP-seq
MIRT2214573	hsa-miR-3928	CLIP-seq
MIRT2214574	hsa-miR-3929	CLIP-seq
MIRT943771	hsa-miR-3975	CLIP-seq
MIRT2214575	hsa-miR-4286	CLIP-seq
MIRT1979489	hsa-miR-4298	CLIP-seq
MIRT2214576	hsa-miR-4301	CLIP-seq
MIRT943776	hsa-miR-4306	CLIP-seq
MIRT943777	hsa-miR-4316	CLIP-seq
MIRT2214577	hsa-miR-4419b	CLIP-seq
MIRT2214578	hsa-miR-4424	CLIP-seq
MIRT943779	hsa-miR-4436b-3p	CLIP-seq
MIRT1548028	hsa-miR-4443	CLIP-seq
MIRT943780	hsa-miR-4448	CLIP-seq
MIRT1548029	hsa-miR-4450	CLIP-seq
MIRT2214579	hsa-miR-4455	CLIP-seq
MIRT1548030	hsa-miR-4458	CLIP-seq
MIRT943781	hsa-miR-4459	CLIP-seq
MIRT2214580	hsa-miR-4478	CLIP-seq
MIRT1979493	hsa-miR-4491	CLIP-seq
MIRT1548031	hsa-miR-4500	CLIP-seq
MIRT2214581	hsa-miR-4515	CLIP-seq
MIRT2214582	hsa-miR-4523	CLIP-seq
MIRT943783	hsa-miR-4644	CLIP-seq
MIRT2214583	hsa-miR-4651	CLIP-seq
MIRT1979498	hsa-miR-4657	CLIP-seq
MIRT2214584	hsa-miR-4664-5p	CLIP-seq
MIRT2214585	hsa-miR-4685-5p	CLIP-seq
MIRT2214586	hsa-miR-4689	CLIP-seq
MIRT943787	hsa-miR-4690-5p	CLIP-seq
MIRT2214587	hsa-miR-4695-5p	CLIP-seq
MIRT2214588	hsa-miR-4697-3p	CLIP-seq
MIRT943789	hsa-miR-4708-3p	CLIP-seq
MIRT943790	hsa-miR-4710	CLIP-seq
MIRT2214589	hsa-miR-4722-5p	CLIP-seq
MIRT1979500	hsa-miR-4726-3p	CLIP-seq
MIRT2214590	hsa-miR-4736	CLIP-seq
MIRT2214591	hsa-miR-4740-5p	CLIP-seq
MIRT943793	hsa-miR-4752	CLIP-seq
MIRT943795	hsa-miR-4768-3p	CLIP-seq
MIRT943796	hsa-miR-4779	CLIP-seq
MIRT1979502	hsa-miR-4782-5p	CLIP-seq
MIRT1979503	hsa-miR-4796-5p	CLIP-seq
MIRT943800	hsa-miR-4800-5p	CLIP-seq
MIRT943801	hsa-miR-485-5p	CLIP-seq
MIRT1979504	hsa-miR-486-3p	CLIP-seq
MIRT943803	hsa-miR-508-5p	CLIP-seq
MIRT943804	hsa-miR-516b	CLIP-seq
MIRT943809	hsa-miR-583	CLIP-seq
MIRT2214592	hsa-miR-602	CLIP-seq
MIRT2214593	hsa-miR-608	CLIP-seq
MIRT2214594	hsa-miR-613	CLIP-seq
MIRT943810	hsa-miR-621	CLIP-seq
MIRT943811	hsa-miR-634	CLIP-seq
MIRT943812	hsa-miR-665	CLIP-seq
MIRT1979505	hsa-miR-758	CLIP-seq
MIRT943813	hsa-miR-765	CLIP-seq
MIRT1979506	hsa-miR-876-5p	CLIP-seq
MIRT1548032	hsa-miR-98	CLIP-seq
MIRT1979471	hsa-miR-3135	CLIP-seq
MIRT1979472	hsa-miR-3145-5p	CLIP-seq
MIRT1979482	hsa-miR-34a	CLIP-seq
MIRT1979483	hsa-miR-34c-5p	CLIP-seq
MIRT943772	hsa-miR-3977	CLIP-seq
MIRT1979487	hsa-miR-4268	CLIP-seq
MIRT943775	hsa-miR-4271	CLIP-seq
MIRT2214576	hsa-miR-4301	CLIP-seq
MIRT1979490	hsa-miR-4302	CLIP-seq
MIRT943780	hsa-miR-4448	CLIP-seq
MIRT1979494	hsa-miR-449a	CLIP-seq
MIRT1979495	hsa-miR-449b	CLIP-seq
MIRT1979496	hsa-miR-4512	CLIP-seq
MIRT2214585	hsa-miR-4685-5p	CLIP-seq
MIRT943786	hsa-miR-4688	CLIP-seq
MIRT943788	hsa-miR-4704-3p	CLIP-seq
MIRT1979499	hsa-miR-4713-5p	CLIP-seq
MIRT943792	hsa-miR-4725-3p	CLIP-seq
MIRT1979504	hsa-miR-486-3p	CLIP-seq
MIRT943803	hsa-miR-508-5p	CLIP-seq
MIRT2448499	hsa-miR-1827	CLIP-seq
MIRT2448500	hsa-miR-3612	CLIP-seq
MIRT2448501	hsa-miR-650	CLIP-seq
MIRT943749	hsa-miR-1204	CLIP-seq
MIRT1979466	hsa-miR-1252	CLIP-seq
MIRT1548023	hsa-miR-1290	CLIP-seq
MIRT2518838	hsa-miR-1293	CLIP-seq
MIRT2518839	hsa-miR-1301	CLIP-seq
MIRT2518840	hsa-miR-1321	CLIP-seq
MIRT2448499	hsa-miR-1827	CLIP-seq
MIRT943751	hsa-miR-185	CLIP-seq
MIRT943752	hsa-miR-190	CLIP-seq
MIRT943753	hsa-miR-190b	CLIP-seq
MIRT943754	hsa-miR-2110	CLIP-seq
MIRT2518841	hsa-miR-2117	CLIP-seq
MIRT943755	hsa-miR-22	CLIP-seq
MIRT943757	hsa-miR-2467-5p	CLIP-seq
MIRT2518842	hsa-miR-298	CLIP-seq
MIRT943758	hsa-miR-3133	CLIP-seq
MIRT943759	hsa-miR-3137	CLIP-seq
MIRT943760	hsa-miR-3138	CLIP-seq
MIRT943761	hsa-miR-3150b-3p	CLIP-seq
MIRT1979473	hsa-miR-3152-5p	CLIP-seq
MIRT1979474	hsa-miR-3153	CLIP-seq
MIRT1979475	hsa-miR-3154	CLIP-seq
MIRT1979477	hsa-miR-3167	CLIP-seq
MIRT2518843	hsa-miR-3176	CLIP-seq
MIRT1979479	hsa-miR-3185	CLIP-seq
MIRT943762	hsa-miR-3188	CLIP-seq
MIRT2518844	hsa-miR-3202	CLIP-seq
MIRT1979480	hsa-miR-326	CLIP-seq
MIRT1979481	hsa-miR-330-5p	CLIP-seq
MIRT1979484	hsa-miR-3611	CLIP-seq
MIRT2448500	hsa-miR-3612	CLIP-seq
MIRT943765	hsa-miR-3616-5p	CLIP-seq
MIRT943766	hsa-miR-3647-5p	CLIP-seq
MIRT943767	hsa-miR-3664-5p	CLIP-seq
MIRT943768	hsa-miR-3665	CLIP-seq
MIRT2518845	hsa-miR-3667-3p	CLIP-seq
MIRT2518846	hsa-miR-3714	CLIP-seq
MIRT943770	hsa-miR-3918	CLIP-seq
MIRT2518847	hsa-miR-3922-3p	CLIP-seq
MIRT943771	hsa-miR-3975	CLIP-seq
MIRT943772	hsa-miR-3977	CLIP-seq
MIRT943773	hsa-miR-4253	CLIP-seq
MIRT2518848	hsa-miR-4267	CLIP-seq
MIRT943775	hsa-miR-4271	CLIP-seq
MIRT2214575	hsa-miR-4286	CLIP-seq
MIRT1979488	hsa-miR-4292	CLIP-seq
MIRT943776	hsa-miR-4306	CLIP-seq
MIRT2518849	hsa-miR-4308	CLIP-seq
MIRT2518850	hsa-miR-4313	CLIP-seq
MIRT943777	hsa-miR-4316	CLIP-seq
MIRT2518851	hsa-miR-4327	CLIP-seq
MIRT943778	hsa-miR-4426	CLIP-seq
MIRT1979491	hsa-miR-4428	CLIP-seq
MIRT943780	hsa-miR-4448	CLIP-seq
MIRT2518852	hsa-miR-4474-3p	CLIP-seq
MIRT2518853	hsa-miR-4476	CLIP-seq
MIRT2518854	hsa-miR-4483	CLIP-seq
MIRT943782	hsa-miR-4517	CLIP-seq
MIRT943783	hsa-miR-4644	CLIP-seq
MIRT943784	hsa-miR-4647	CLIP-seq
MIRT2518855	hsa-miR-4660	CLIP-seq
MIRT943785	hsa-miR-4662b	CLIP-seq
MIRT943786	hsa-miR-4688	CLIP-seq
MIRT943787	hsa-miR-4690-5p	CLIP-seq
MIRT2518856	hsa-miR-4701-5p	CLIP-seq
MIRT943790	hsa-miR-4710	CLIP-seq
MIRT943791	hsa-miR-4715-3p	CLIP-seq
MIRT943792	hsa-miR-4725-3p	CLIP-seq
MIRT2518857	hsa-miR-4739	CLIP-seq
MIRT943793	hsa-miR-4752	CLIP-seq
MIRT2518858	hsa-miR-4756-5p	CLIP-seq
MIRT943794	hsa-miR-4757-5p	CLIP-seq
MIRT1979502	hsa-miR-4782-5p	CLIP-seq
MIRT943797	hsa-miR-4784	CLIP-seq
MIRT943799	hsa-miR-4795-5p	CLIP-seq
MIRT943800	hsa-miR-4800-5p	CLIP-seq
MIRT943801	hsa-miR-485-5p	CLIP-seq
MIRT943802	hsa-miR-491-5p	CLIP-seq
MIRT2518859	hsa-miR-5047	CLIP-seq
MIRT943803	hsa-miR-508-5p	CLIP-seq
MIRT943804	hsa-miR-516b	CLIP-seq
MIRT943805	hsa-miR-539	CLIP-seq
MIRT943806	hsa-miR-542-5p	CLIP-seq
MIRT2518860	hsa-miR-548aa	CLIP-seq
MIRT2518861	hsa-miR-548an	CLIP-seq
MIRT943807	hsa-miR-558	CLIP-seq
MIRT943808	hsa-miR-573	CLIP-seq
MIRT943809	hsa-miR-583	CLIP-seq
MIRT2518862	hsa-miR-588	CLIP-seq
MIRT2448501	hsa-miR-650	CLIP-seq
MIRT2518863	hsa-miR-663b	CLIP-seq
MIRT1979505	hsa-miR-758	CLIP-seq
MIRT943813	hsa-miR-765	CLIP-seq
MIRT943814	hsa-miR-873	CLIP-seq
MIRT1979506	hsa-miR-876-5p	CLIP-seq
MIRT2518864	hsa-miR-939	CLIP-seq
MIRT2518865	hsa-miR-940	CLIP-seq
MIRT943749	hsa-miR-1204	CLIP-seq
MIRT1979466	hsa-miR-1252	CLIP-seq
MIRT1548023	hsa-miR-1290	CLIP-seq
MIRT2518839	hsa-miR-1301	CLIP-seq
MIRT2518840	hsa-miR-1321	CLIP-seq
MIRT2448499	hsa-miR-1827	CLIP-seq
MIRT943751	hsa-miR-185	CLIP-seq
MIRT943752	hsa-miR-190	CLIP-seq
MIRT943753	hsa-miR-190b	CLIP-seq
MIRT943754	hsa-miR-2110	CLIP-seq
MIRT2518841	hsa-miR-2117	CLIP-seq
MIRT943755	hsa-miR-22	CLIP-seq
MIRT943757	hsa-miR-2467-5p	CLIP-seq
MIRT2518842	hsa-miR-298	CLIP-seq
MIRT943758	hsa-miR-3133	CLIP-seq
MIRT943759	hsa-miR-3137	CLIP-seq
MIRT943760	hsa-miR-3138	CLIP-seq
MIRT943761	hsa-miR-3150b-3p	CLIP-seq
MIRT1979474	hsa-miR-3153	CLIP-seq
MIRT1979475	hsa-miR-3154	CLIP-seq
MIRT1979477	hsa-miR-3167	CLIP-seq
MIRT2518843	hsa-miR-3176	CLIP-seq
MIRT1979479	hsa-miR-3185	CLIP-seq
MIRT943762	hsa-miR-3188	CLIP-seq
MIRT2518844	hsa-miR-3202	CLIP-seq
MIRT1979480	hsa-miR-326	CLIP-seq
MIRT1979481	hsa-miR-330-5p	CLIP-seq
MIRT1979484	hsa-miR-3611	CLIP-seq
MIRT2448500	hsa-miR-3612	CLIP-seq
MIRT943765	hsa-miR-3616-5p	CLIP-seq
MIRT943766	hsa-miR-3647-5p	CLIP-seq
MIRT943767	hsa-miR-3664-5p	CLIP-seq
MIRT943768	hsa-miR-3665	CLIP-seq
MIRT2518845	hsa-miR-3667-3p	CLIP-seq
MIRT2518846	hsa-miR-3714	CLIP-seq
MIRT943770	hsa-miR-3918	CLIP-seq
MIRT2518847	hsa-miR-3922-3p	CLIP-seq
MIRT943771	hsa-miR-3975	CLIP-seq
MIRT943773	hsa-miR-4253	CLIP-seq
MIRT2518848	hsa-miR-4267	CLIP-seq
MIRT943775	hsa-miR-4271	CLIP-seq
MIRT2214575	hsa-miR-4286	CLIP-seq
MIRT1979488	hsa-miR-4292	CLIP-seq
MIRT943776	hsa-miR-4306	CLIP-seq
MIRT2518849	hsa-miR-4308	CLIP-seq
MIRT2518850	hsa-miR-4313	CLIP-seq
MIRT943777	hsa-miR-4316	CLIP-seq
MIRT2518851	hsa-miR-4327	CLIP-seq
MIRT943778	hsa-miR-4426	CLIP-seq
MIRT1979491	hsa-miR-4428	CLIP-seq
MIRT943780	hsa-miR-4448	CLIP-seq
MIRT2518852	hsa-miR-4474-3p	CLIP-seq
MIRT2518853	hsa-miR-4476	CLIP-seq
MIRT943782	hsa-miR-4517	CLIP-seq
MIRT943783	hsa-miR-4644	CLIP-seq
MIRT943784	hsa-miR-4647	CLIP-seq
MIRT2518855	hsa-miR-4660	CLIP-seq
MIRT943785	hsa-miR-4662b	CLIP-seq
MIRT943786	hsa-miR-4688	CLIP-seq
MIRT943787	hsa-miR-4690-5p	CLIP-seq
MIRT943790	hsa-miR-4710	CLIP-seq
MIRT943791	hsa-miR-4715-3p	CLIP-seq
MIRT943792	hsa-miR-4725-3p	CLIP-seq
MIRT2518857	hsa-miR-4739	CLIP-seq
MIRT943793	hsa-miR-4752	CLIP-seq
MIRT2518858	hsa-miR-4756-5p	CLIP-seq
MIRT943794	hsa-miR-4757-5p	CLIP-seq
MIRT1979502	hsa-miR-4782-5p	CLIP-seq
MIRT943797	hsa-miR-4784	CLIP-seq
MIRT943799	hsa-miR-4795-5p	CLIP-seq
MIRT943800	hsa-miR-4800-5p	CLIP-seq
MIRT943801	hsa-miR-485-5p	CLIP-seq
MIRT943802	hsa-miR-491-5p	CLIP-seq
MIRT2518859	hsa-miR-5047	CLIP-seq
MIRT943803	hsa-miR-508-5p	CLIP-seq
MIRT943804	hsa-miR-516b	CLIP-seq
MIRT943805	hsa-miR-539	CLIP-seq
MIRT943806	hsa-miR-542-5p	CLIP-seq
MIRT2518860	hsa-miR-548aa	CLIP-seq
MIRT2518861	hsa-miR-548an	CLIP-seq
MIRT943807	hsa-miR-558	CLIP-seq
MIRT943808	hsa-miR-573	CLIP-seq
MIRT943809	hsa-miR-583	CLIP-seq
MIRT2448501	hsa-miR-650	CLIP-seq
MIRT2518863	hsa-miR-663b	CLIP-seq
MIRT1979505	hsa-miR-758	CLIP-seq
MIRT943813	hsa-miR-765	CLIP-seq
MIRT943814	hsa-miR-873	CLIP-seq
MIRT1979506	hsa-miR-876-5p	CLIP-seq
MIRT2518864	hsa-miR-939	CLIP-seq
MIRT2518865	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	TAS	28533407
GO:0000785	Component	Chromatin	HDA	16217013
GO:0000785	Component	Chromatin	IDA	28533407
GO:0000785	Component	Chromatin	NAS	12192000
GO:0003714	Function	Transcription corepressor activity	TAS	28533407
GO:0005515	Function	Protein binding	IPI	25416956, 28533407, 32296183
GO:0005634	Component	Nucleus	IDA	29429572
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	NAS	10078207
GO:0006357	Process	Regulation of transcription by RNA polymerase II	NAS	18809673
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	8812431
GO:0007399	Process	Nervous system development	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016514	Component	SWI/SNF complex	NAS	8804307
GO:0030071	Process	Regulation of mitotic metaphase/anaphase transition	NAS	25066234
GO:0046872	Function	Metal ion binding	IEA
GO:0062072	Function	Histone H3K9me2/3 reader activity	IDA	29429572
GO:0070316	Process	Regulation of G0 to G1 transition	NAS	11790558
GO:0071565	Component	NBAF complex	IBA
GO:0097190	Process	Apoptotic signaling pathway	TAS	7961935
GO:0140015	Function	Histone H3K14ac reader activity	IDA	28533407
GO:0140046	Function	Histone H4K16ac reader activity	IDA	28533407
GO:1902459	Process	Positive regulation of stem cell population maintenance	NAS	19279220
GO:1905454	Process	Negative regulation of myeloid progenitor cell differentiation	IMP	28533407
GO:2000045	Process	Regulation of G1/S transition of mitotic cell cycle	NAS	10778858
GO:2000781	Process	Positive regulation of double-strand break repair	NAS	25066234
GO:2000819	Process	Regulation of nucleotide-excision repair	NAS	12215535

Other IDs

• MIM: 601671
• HGNC: 9964
• e!Ensembl: ENSG00000133884

Protein

• UniProt ID: Q92785
• Protein name: Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)
• Protein function: Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have
• PDB: 3IUF, 5B79, 5VDC, 6LTH, 6LTJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14051	Requiem_N	13 → 84	N-terminal domain of DPF2/REQ.	Family
  PF00628	PHD	272 → 330	PHD-finger	Domain
  PF00628	PHD	329 → 376	PHD-finger	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MAAVVENVVKLLGEQYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKR
  HRGPGLASGQLYSYPARRWRKKRRAHPPEDPRLSFPSIKPDTDQTLKKEGLISQDGSSLE
  ALLRTDPLEKRGAPDPRVDDDSLGEFPVTNSRARKRILEPDDFLDDLDDEDYEEDTPKRR
  GKGKSKGKGVGSARKKLDASILEDRDKPYACDICGKRYKNRPGLSYHYAHSHLAEEEGED
  KEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGR
  SGHPSCLQFTPVMMAAVKTYRWQCIECKCCNICGTSENDDQLLFCDDCDRGYHMYCLTPS
  MSEPPEGSWSCHLCLDLLKEKASIYQNQNSS

• Sequence length: 391

Pathways

KEGG:

ATP-dependent chromatin remodeling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Coffin-Siris syndrome 1	Pathogenic	rs1555031372	RCV000664329	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Coffin-Siris syndrome 7	Pathogenic; Likely pathogenic	rs2137711041, rs2137711145, rs2495413705, rs35405661, rs2495407169, rs1555031372, rs1555031500, rs1555032051, rs1555032044, rs1555032074	RCV001527371 RCV002221832 RCV002470268 RCV003148493 RCV003989273 RCV000656717 RCV000656718 RCV000656719 RCV000656720 RCV000656721	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Autism spectrum disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COFFIN-SIRIS SYNDROME	—	CTD, ClinGen, Disgenet, Orphanet CTD, ClinGen, Disgenet, Orphanet CTD, ClinGen, Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DESBUQUOIS SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DPF2-related disorder	Likely benign; Benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Blepharoptosis	Ptosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Brachydactyly	Brachydactyly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	HPO_DG			★☆☆☆☆ Found in Text Mining only
Clinodactyly	Clinodactyly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Clinodactyly of fingers	Clinodactyly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Coffin-Siris syndrome	Coffin-Siris Syndrome	BEFREE	29429572, 31207137, 31706665		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coffin-Siris syndrome	Coffin-Siris Syndrome	ORPHANET_DG	29429572		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coffin-Siris syndrome	Coffin-Siris Syndrome	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COFFIN-SIRIS SYNDROME 7	Coffin-Siris syndrome	GENOMICS_ENGLAND_DG	29429572		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
COFFIN-SIRIS SYNDROME 7	Coffin-Siris syndrome	UNIPROT_DG	29429572		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
COFFIN-SIRIS SYNDROME 7	Coffin-Siris syndrome	BEFREE	31706665		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
COFFIN-SIRIS SYNDROME 7	Coffin-Siris syndrome	CLINVAR_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Congenital diaphragmatic hernia	Congenital diaphragmatic hernia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cutis marmorata	Cutis marmorata	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dandy-Walker Syndrome	Dandy-Walker Syndrome	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ectopic kidney	Ectopic kidney	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29373718		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	29373718	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29373718		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29373718		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	29373718	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Heart Septal Defects	Heart Septal Defects	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hydronephrosis	Hydronephrosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hyperopia	Hyperopia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	29429572		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	28533407	Inhibit	★☆☆☆☆ Found in Text Mining only
Macrostomia	Macrostomia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Macrotia	Macrotia	HPO_DG			★☆☆☆☆ Found in Text Mining only
MENTAL RETARDATION, AUTOSOMAL DOMINANT 12	Mental retardation	CLINVAR_DG	29429572		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Microdontia (disorder)	Microdontia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Obsessive compulsive behavior	Obsessive-Compulsive Disorder	HPO_DG			★☆☆☆☆ Found in Text Mining only
Partial agenesis of corpus callosum	Partial Agenesis Of Corpus Callosum	HPO_DG			★☆☆☆☆ Found in Text Mining only
Posteriorly rotated ear	Posteriorly Rotated Ear	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Recurrent otitis media	Otitis media	HPO_DG			★☆☆☆☆ Found in Text Mining only
Sagittal craniosynostosis	Sagittal craniosynostosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Scoliosis, unspecified	Scoliosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Spina Bifida Occulta	Spina bifida occulta	HPO_DG			★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Trigonocephaly	Trigonocephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only