Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	5955
Gene name	Reticulocalbin 2
Gene symbol	RCN2
Synonyms (NCBI Gene)	E6BPERC-55ERC55TCBP49
Chromosome	15
Chromosome location	15q24.3
Summary	The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bard

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Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001507	hsa-miR-155-5p	pSILAC	18668040
MIRT019940	hsa-miR-375	Microarray	20215506
MIRT001507	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT025032	hsa-miR-183-5p	Sequencing	20371350
MIRT029831	hsa-miR-26b-5p	Microarray	19088304
MIRT048612	hsa-miR-99a-5p	CLASH	23622248
MIRT048556	hsa-miR-100-5p	CLASH	23622248
MIRT001507	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT001507	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT1298364	hsa-miR-101	CLIP-seq
MIRT1298365	hsa-miR-1237	CLIP-seq
MIRT1298366	hsa-miR-1248	CLIP-seq
MIRT1298367	hsa-miR-1284	CLIP-seq
MIRT1298368	hsa-miR-1297	CLIP-seq
MIRT1298369	hsa-miR-1305	CLIP-seq
MIRT1298370	hsa-miR-144	CLIP-seq
MIRT1298371	hsa-miR-155	CLIP-seq
MIRT1298372	hsa-miR-183	CLIP-seq
MIRT1298373	hsa-miR-26a	CLIP-seq
MIRT1298374	hsa-miR-26b	CLIP-seq
MIRT1298375	hsa-miR-3121-3p	CLIP-seq
MIRT1298376	hsa-miR-320a	CLIP-seq
MIRT1298377	hsa-miR-320b	CLIP-seq
MIRT1298378	hsa-miR-320c	CLIP-seq
MIRT1298379	hsa-miR-320d	CLIP-seq
MIRT1298380	hsa-miR-320e	CLIP-seq
MIRT1298381	hsa-miR-323-3p	CLIP-seq
MIRT1298382	hsa-miR-338-5p	CLIP-seq
MIRT1298383	hsa-miR-340	CLIP-seq
MIRT1298384	hsa-miR-3671	CLIP-seq
MIRT1298385	hsa-miR-3675-3p	CLIP-seq
MIRT1298386	hsa-miR-3688-3p	CLIP-seq
MIRT1298387	hsa-miR-3692	CLIP-seq
MIRT1298388	hsa-miR-423-3p	CLIP-seq
MIRT1298389	hsa-miR-4269	CLIP-seq
MIRT1298390	hsa-miR-4282	CLIP-seq
MIRT1298391	hsa-miR-4307	CLIP-seq
MIRT1298392	hsa-miR-4429	CLIP-seq
MIRT1298393	hsa-miR-4436b-5p	CLIP-seq
MIRT1298394	hsa-miR-4464	CLIP-seq
MIRT1298395	hsa-miR-4465	CLIP-seq
MIRT1298396	hsa-miR-4490	CLIP-seq
MIRT1298397	hsa-miR-4496	CLIP-seq
MIRT1298398	hsa-miR-4509	CLIP-seq
MIRT1298399	hsa-miR-4514	CLIP-seq
MIRT1298400	hsa-miR-4520a-3p	CLIP-seq
MIRT1298401	hsa-miR-4520b-3p	CLIP-seq
MIRT1298402	hsa-miR-4529-3p	CLIP-seq
MIRT1298403	hsa-miR-4534	CLIP-seq
MIRT1298404	hsa-miR-4668-3p	CLIP-seq
MIRT1298405	hsa-miR-4691-5p	CLIP-seq
MIRT1298406	hsa-miR-4692	CLIP-seq
MIRT1298407	hsa-miR-4716-5p	CLIP-seq
MIRT1298408	hsa-miR-4719	CLIP-seq
MIRT1298409	hsa-miR-4742-5p	CLIP-seq
MIRT1298410	hsa-miR-4744	CLIP-seq
MIRT1298411	hsa-miR-4748	CLIP-seq
MIRT1298412	hsa-miR-4773	CLIP-seq
MIRT1298413	hsa-miR-4789-5p	CLIP-seq
MIRT1298414	hsa-miR-4799-5p	CLIP-seq
MIRT1298415	hsa-miR-495	CLIP-seq
MIRT1298416	hsa-miR-496	CLIP-seq
MIRT1298417	hsa-miR-498	CLIP-seq
MIRT1298418	hsa-miR-548a-5p	CLIP-seq
MIRT1298419	hsa-miR-548ab	CLIP-seq
MIRT1298420	hsa-miR-548ak	CLIP-seq
MIRT1298421	hsa-miR-548b-5p	CLIP-seq
MIRT1298422	hsa-miR-548c-5p	CLIP-seq
MIRT1298423	hsa-miR-548d-5p	CLIP-seq
MIRT1298424	hsa-miR-548h	CLIP-seq
MIRT1298425	hsa-miR-548i	CLIP-seq
MIRT1298426	hsa-miR-548j	CLIP-seq
MIRT1298427	hsa-miR-548m	CLIP-seq
MIRT1298428	hsa-miR-548n	CLIP-seq
MIRT1298429	hsa-miR-548u	CLIP-seq
MIRT1298430	hsa-miR-548w	CLIP-seq
MIRT1298431	hsa-miR-548y	CLIP-seq
MIRT1298432	hsa-miR-559	CLIP-seq
MIRT1298433	hsa-miR-651	CLIP-seq
MIRT1298434	hsa-miR-888	CLIP-seq
MIRT1298435	hsa-miR-889	CLIP-seq
MIRT1298365	hsa-miR-1237	CLIP-seq
MIRT1298366	hsa-miR-1248	CLIP-seq
MIRT1298371	hsa-miR-155	CLIP-seq
MIRT1298372	hsa-miR-183	CLIP-seq
MIRT1298381	hsa-miR-323-3p	CLIP-seq
MIRT1298382	hsa-miR-338-5p	CLIP-seq
MIRT1298383	hsa-miR-340	CLIP-seq
MIRT2088767	hsa-miR-34b	CLIP-seq
MIRT1298393	hsa-miR-4436b-5p	CLIP-seq
MIRT1298394	hsa-miR-4464	CLIP-seq
MIRT1298398	hsa-miR-4509	CLIP-seq
MIRT1298400	hsa-miR-4520a-3p	CLIP-seq
MIRT1298401	hsa-miR-4520b-3p	CLIP-seq
MIRT1298402	hsa-miR-4529-3p	CLIP-seq
MIRT1298410	hsa-miR-4744	CLIP-seq
MIRT1298411	hsa-miR-4748	CLIP-seq
MIRT1298413	hsa-miR-4789-5p	CLIP-seq
MIRT1298414	hsa-miR-4799-5p	CLIP-seq
MIRT1298427	hsa-miR-548m	CLIP-seq
MIRT1298429	hsa-miR-548u	CLIP-seq
MIRT1298435	hsa-miR-889	CLIP-seq
MIRT1298364	hsa-miR-101	CLIP-seq
MIRT2313691	hsa-miR-125a-3p	CLIP-seq
MIRT2313692	hsa-miR-1294	CLIP-seq
MIRT1298370	hsa-miR-144	CLIP-seq
MIRT1298371	hsa-miR-155	CLIP-seq
MIRT2313693	hsa-miR-181a	CLIP-seq
MIRT2313694	hsa-miR-181b	CLIP-seq
MIRT2313695	hsa-miR-181c	CLIP-seq
MIRT2313696	hsa-miR-181d	CLIP-seq
MIRT1298372	hsa-miR-183	CLIP-seq
MIRT2313697	hsa-miR-3163	CLIP-seq
MIRT1298376	hsa-miR-320a	CLIP-seq
MIRT1298377	hsa-miR-320b	CLIP-seq
MIRT1298378	hsa-miR-320c	CLIP-seq
MIRT1298379	hsa-miR-320d	CLIP-seq
MIRT1298380	hsa-miR-320e	CLIP-seq
MIRT1298381	hsa-miR-323-3p	CLIP-seq
MIRT1298382	hsa-miR-338-5p	CLIP-seq
MIRT1298383	hsa-miR-340	CLIP-seq
MIRT1298384	hsa-miR-3671	CLIP-seq
MIRT1298387	hsa-miR-3692	CLIP-seq
MIRT2313698	hsa-miR-3934	CLIP-seq
MIRT2313699	hsa-miR-3977	CLIP-seq
MIRT2313700	hsa-miR-4262	CLIP-seq
MIRT2313701	hsa-miR-4275	CLIP-seq
MIRT1298390	hsa-miR-4282	CLIP-seq
MIRT2313702	hsa-miR-4316	CLIP-seq
MIRT1298392	hsa-miR-4429	CLIP-seq
MIRT1298393	hsa-miR-4436b-5p	CLIP-seq
MIRT1298394	hsa-miR-4464	CLIP-seq
MIRT1298396	hsa-miR-4490	CLIP-seq
MIRT1298397	hsa-miR-4496	CLIP-seq
MIRT2313703	hsa-miR-4501	CLIP-seq
MIRT2313704	hsa-miR-4503	CLIP-seq
MIRT2313705	hsa-miR-4517	CLIP-seq
MIRT1298400	hsa-miR-4520a-3p	CLIP-seq
MIRT1298401	hsa-miR-4520b-3p	CLIP-seq
MIRT1298402	hsa-miR-4529-3p	CLIP-seq
MIRT1298403	hsa-miR-4534	CLIP-seq
MIRT1298408	hsa-miR-4719	CLIP-seq
MIRT1298411	hsa-miR-4748	CLIP-seq
MIRT1298413	hsa-miR-4789-5p	CLIP-seq
MIRT1298415	hsa-miR-495	CLIP-seq
MIRT1298416	hsa-miR-496	CLIP-seq
MIRT2313706	hsa-miR-513c	CLIP-seq
MIRT2313707	hsa-miR-514b-5p	CLIP-seq
MIRT1298418	hsa-miR-548a-5p	CLIP-seq
MIRT1298419	hsa-miR-548ab	CLIP-seq
MIRT1298420	hsa-miR-548ak	CLIP-seq
MIRT1298421	hsa-miR-548b-5p	CLIP-seq
MIRT1298422	hsa-miR-548c-5p	CLIP-seq
MIRT1298423	hsa-miR-548d-5p	CLIP-seq
MIRT1298424	hsa-miR-548h	CLIP-seq
MIRT1298425	hsa-miR-548i	CLIP-seq
MIRT1298426	hsa-miR-548j	CLIP-seq
MIRT1298428	hsa-miR-548n	CLIP-seq
MIRT1298429	hsa-miR-548u	CLIP-seq
MIRT1298430	hsa-miR-548w	CLIP-seq
MIRT1298431	hsa-miR-548y	CLIP-seq
MIRT1298432	hsa-miR-559	CLIP-seq
MIRT2313708	hsa-miR-592	CLIP-seq
MIRT2313709	hsa-miR-597	CLIP-seq
MIRT1298433	hsa-miR-651	CLIP-seq
MIRT2313710	hsa-miR-764	CLIP-seq
MIRT1298435	hsa-miR-889	CLIP-seq
MIRT1298364	hsa-miR-101	CLIP-seq
MIRT1298370	hsa-miR-144	CLIP-seq
MIRT1298384	hsa-miR-3671	CLIP-seq
MIRT1298387	hsa-miR-3692	CLIP-seq
MIRT1298408	hsa-miR-4719	CLIP-seq
MIRT1298408	hsa-miR-4719	CLIP-seq
MIRT2457990	hsa-miR-223	CLIP-seq
MIRT2457991	hsa-miR-2355-3p	CLIP-seq
MIRT2457992	hsa-miR-4277	CLIP-seq
MIRT2457993	hsa-miR-4421	CLIP-seq
MIRT2457994	hsa-miR-4697-3p	CLIP-seq
MIRT2457995	hsa-miR-548ac	CLIP-seq
MIRT2457996	hsa-miR-548ae	CLIP-seq
MIRT2457997	hsa-miR-548aj	CLIP-seq
MIRT2457998	hsa-miR-548am	CLIP-seq
MIRT2457999	hsa-miR-548d-3p	CLIP-seq
MIRT2458000	hsa-miR-548x	CLIP-seq
MIRT2458001	hsa-miR-548z	CLIP-seq
MIRT2458002	hsa-miR-676	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	TAS	8034671
GO:0005515	Function	Protein binding	IPI	7624774, 20562859, 21900206, 32296183, 32814053, 36217030
GO:0005730	Component	Nucleolus	IDA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	8034671
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
602584	9935	ENSG00000117906

Q14257

Protein name

Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP)

Protein function

Not known. Binds calcium.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13202	EF-hand_5	66 → 91	EF hand	Domain
PF13202	EF-hand_5	191 → 215	EF hand	Domain
PF13202	EF-hand_5	237 → 253	EF hand	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MRLGPRTAALGLLLLCAAAAGAGKAEELHYPLGERRSDYDREALLGVQEDVDEYVKLGHE
EQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVTWD
EYNIQMYDRVIDFDENTALDDAEEESFRKLHLKDKKRFEKANQDSGPGLSLEEFIAFEHP
EEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYD
KDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFLTSEA
TDYGRQLHDDYFYHDEL

Sequence length

317

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTRACRANIAL HEMORRHAGE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEPTIC ULCER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

RCN2 (reticulocalbin 2)