Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	59340
Gene name	Histamine receptor H4
Gene symbol	HRH4
Synonyms (NCBI Gene)	AXOR35BG26GPCR105GPRv53H4H4RHH4R
Chromosome	18
Chromosome location	18q11.2
Summary	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This ge

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Show/Hide all (230)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017500	hsa-miR-335-5p	Microarray	18185580
MIRT019358	hsa-miR-148b-3p	Microarray	17612493
MIRT626872	hsa-miR-4282	HITS-CLIP	19536157
MIRT724571	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT681995	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT681994	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681993	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681992	hsa-miR-1245a	HITS-CLIP	23706177
MIRT681991	hsa-miR-8079	HITS-CLIP	23706177
MIRT681990	hsa-miR-4257	HITS-CLIP	23706177
MIRT681989	hsa-miR-4459	HITS-CLIP	23706177
MIRT681988	hsa-miR-665	HITS-CLIP	23706177
MIRT681987	hsa-miR-6840-3p	HITS-CLIP	23706177
MIRT681986	hsa-miR-345-3p	HITS-CLIP	23706177
MIRT681985	hsa-miR-4732-3p	HITS-CLIP	23706177
MIRT681984	hsa-miR-125a-5p	HITS-CLIP	23706177
MIRT681983	hsa-miR-125b-5p	HITS-CLIP	23706177
MIRT681982	hsa-miR-4319	HITS-CLIP	23706177
MIRT681981	hsa-miR-1827	HITS-CLIP	23706177
MIRT681980	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681979	hsa-miR-6086	HITS-CLIP	23706177
MIRT681978	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681977	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681976	hsa-miR-3612	HITS-CLIP	23706177
MIRT681975	hsa-miR-650	HITS-CLIP	23706177
MIRT681974	hsa-miR-670-5p	HITS-CLIP	23706177
MIRT681973	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681972	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT681971	hsa-miR-1273e	HITS-CLIP	23706177
MIRT678818	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678817	hsa-miR-2392	HITS-CLIP	23824327
MIRT678816	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678815	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678814	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678813	hsa-miR-1976	HITS-CLIP	23824327
MIRT678812	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678811	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678810	hsa-miR-4454	HITS-CLIP	23824327
MIRT678809	hsa-miR-1193	HITS-CLIP	23824327
MIRT678808	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678807	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678806	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT678805	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678804	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678803	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT678802	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	23824327
MIRT626871	hsa-miR-7702	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	19536157
MIRT724571	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT681995	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT681994	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681993	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681992	hsa-miR-1245a	HITS-CLIP	23706177
MIRT681991	hsa-miR-8079	HITS-CLIP	23706177
MIRT681990	hsa-miR-4257	HITS-CLIP	23706177
MIRT681989	hsa-miR-4459	HITS-CLIP	23706177
MIRT681988	hsa-miR-665	HITS-CLIP	23706177
MIRT681987	hsa-miR-6840-3p	HITS-CLIP	23706177
MIRT681986	hsa-miR-345-3p	HITS-CLIP	23706177
MIRT681985	hsa-miR-4732-3p	HITS-CLIP	23706177
MIRT681984	hsa-miR-125a-5p	HITS-CLIP	23706177
MIRT681983	hsa-miR-125b-5p	HITS-CLIP	23706177
MIRT681982	hsa-miR-4319	HITS-CLIP	23706177
MIRT681981	hsa-miR-1827	HITS-CLIP	23706177
MIRT681980	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681979	hsa-miR-6086	HITS-CLIP	23706177
MIRT681978	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681977	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681976	hsa-miR-3612	HITS-CLIP	23706177
MIRT681975	hsa-miR-650	HITS-CLIP	23706177
MIRT681974	hsa-miR-670-5p	HITS-CLIP	23706177
MIRT681973	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681972	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT681971	hsa-miR-1273e	HITS-CLIP	23706177
MIRT678818	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678817	hsa-miR-2392	HITS-CLIP	23824327
MIRT678816	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678815	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678814	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678813	hsa-miR-1976	HITS-CLIP	23824327
MIRT678812	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678811	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678810	hsa-miR-4454	HITS-CLIP	23824327
MIRT678809	hsa-miR-1193	HITS-CLIP	23824327
MIRT678808	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678807	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678806	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT678805	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678804	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678803	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT678802	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	23824327
MIRT626871	hsa-miR-7702	HITS-CLIP	23824327
MIRT756050	hsa-miR-3915	MicroarrayqRT-PCR	35899934
MIRT756051	hsa-miR-583	MicroarrayqRT-PCR	35899934
MIRT1054706	hsa-miR-1245	CLIP-seq
MIRT1054707	hsa-miR-125b	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT1054709	hsa-miR-1302	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT1054712	hsa-miR-3192	CLIP-seq
MIRT1054713	hsa-miR-3913-3p	CLIP-seq
MIRT1054714	hsa-miR-3925-5p	CLIP-seq
MIRT1054715	hsa-miR-3960	CLIP-seq
MIRT1054716	hsa-miR-4298	CLIP-seq
MIRT1054717	hsa-miR-4311	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054719	hsa-miR-4438	CLIP-seq
MIRT1054720	hsa-miR-451b	CLIP-seq
MIRT1054721	hsa-miR-4645-5p	CLIP-seq
MIRT1054722	hsa-miR-4673	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT1054724	hsa-miR-4773	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054726	hsa-miR-489	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054729	hsa-miR-5095	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT1054732	hsa-miR-548c-3p	CLIP-seq
MIRT1054733	hsa-miR-610	CLIP-seq
MIRT1054734	hsa-miR-626	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054736	hsa-miR-670	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT1054738	hsa-miR-944	CLIP-seq
MIRT2012441	hsa-miR-1236	CLIP-seq
MIRT2012442	hsa-miR-197	CLIP-seq
MIRT2012443	hsa-miR-3614-3p	CLIP-seq
MIRT2012444	hsa-miR-3918	CLIP-seq
MIRT2012445	hsa-miR-412	CLIP-seq
MIRT2012446	hsa-miR-4685-5p	CLIP-seq
MIRT2012441	hsa-miR-1236	CLIP-seq
MIRT2244736	hsa-miR-1237	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT1054709	hsa-miR-1302	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT2244737	hsa-miR-139-5p	CLIP-seq
MIRT2244738	hsa-miR-188-5p	CLIP-seq
MIRT2012442	hsa-miR-197	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT1054712	hsa-miR-3192	CLIP-seq
MIRT2244739	hsa-miR-33a	CLIP-seq
MIRT2244740	hsa-miR-33b	CLIP-seq
MIRT2012443	hsa-miR-3614-3p	CLIP-seq
MIRT2244741	hsa-miR-3672	CLIP-seq
MIRT1054714	hsa-miR-3925-5p	CLIP-seq
MIRT2012445	hsa-miR-412	CLIP-seq
MIRT2244742	hsa-miR-4297	CLIP-seq
MIRT1054716	hsa-miR-4298	CLIP-seq
MIRT2244743	hsa-miR-431	CLIP-seq
MIRT1054717	hsa-miR-4311	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054720	hsa-miR-451b	CLIP-seq
MIRT1054721	hsa-miR-4645-5p	CLIP-seq
MIRT1054722	hsa-miR-4673	CLIP-seq
MIRT2244744	hsa-miR-4684-5p	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT2244745	hsa-miR-4711-3p	CLIP-seq
MIRT1054724	hsa-miR-4773	CLIP-seq
MIRT2244746	hsa-miR-4780	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq
MIRT2244748	hsa-miR-581	CLIP-seq
MIRT1054733	hsa-miR-610	CLIP-seq
MIRT2244749	hsa-miR-623	CLIP-seq
MIRT1054734	hsa-miR-626	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT2389175	hsa-miR-2909	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2389177	hsa-miR-3162-5p	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2389181	hsa-miR-4445	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2389183	hsa-miR-607	CLIP-seq
MIRT1054706	hsa-miR-1245	CLIP-seq
MIRT1054707	hsa-miR-125b	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT2451387	hsa-miR-134	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT2451388	hsa-miR-3118	CLIP-seq
MIRT2451389	hsa-miR-3146	CLIP-seq
MIRT1054713	hsa-miR-3913-3p	CLIP-seq
MIRT2451390	hsa-miR-3973	CLIP-seq
MIRT2451391	hsa-miR-4276	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054726	hsa-miR-489	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT1054732	hsa-miR-548c-3p	CLIP-seq
MIRT2451392	hsa-miR-548l	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054736	hsa-miR-670	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT2451393	hsa-miR-943	CLIP-seq
MIRT1054738	hsa-miR-944	CLIP-seq
MIRT2465450	hsa-miR-1281	CLIP-seq
MIRT2465451	hsa-miR-331-3p	CLIP-seq
MIRT2465452	hsa-miR-4470	CLIP-seq
MIRT2465453	hsa-miR-4532	CLIP-seq
MIRT2465454	hsa-miR-498	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2547696	hsa-miR-3622a-5p	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2547697	hsa-miR-4423-3p	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004969	Function	Histamine receptor activity	IBA
GO:0004969	Function	Histamine receptor activity	IEA
GO:0004969	Function	Histamine receptor activity	NAS	10973974, 11118334
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0043408	Process	Regulation of MAPK cascade	IEA
GO:0045202	Component	Synapse	IBA

MIM	HGNC	e!Ensembl
606792	17383	ENSG00000134489

Q9H3N8

Protein name

Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144)

Protein function

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).

PDB

7YFC , 7YFD , 8HN8 , 8HOC , 8JXT , 8JXV , 8JXW , 8JXX , 8YN9 , 8YNA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	32 → 358	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of perip

Sequence

MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS

Sequence length

390

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Histamine receptors G alpha (i) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PRURITUS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (61)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	CTD_human_DG	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Basal Cell	Adenocarcinoma	CTD_human_DG	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Oxyphilic	Adenocarcinoma	CTD_human_DG	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Tubular	Adenocarcinoma	CTD_human_DG	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Allergic rhinitis (disorder)	Allergic rhinitis	BEFREE	27888642, 31583075		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	26823878		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Valve Insufficiency	Aortic Valve Insufficiency	BEFREE	27888642		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	LHGDN	17806182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	20618322		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	17978505	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	16204969, 28446753	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	22653292		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	32277847	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	28485729		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	20199554, 20618322, 21175423, 23517361		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bone Diseases	Bone disease	Pubtator	28446753	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23481304, 29988113		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21622113, 35227109, 40425926	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	35227109	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Cribriform	Carcinoma	CTD_human_DG	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Granular Cell	Carcinoma	CTD_human_DG	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	LHGDN	16203768, 18258331		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	21609450, 22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	21609450		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21609450, 22363581	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conjunctival Diseases	Conjunctival disease	Pubtator	28391980	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystitis Interstitial	Interstitial cystitis	Pubtator	31718622	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	Pubtator	32277847	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis Atopic	Atopic dermatitis	Pubtator	18239617, 36142206	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	20199554, 21104170, 23517361, 29579390		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	21104170		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	20199554, 21104170, 23517361, 29579390		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eosinophilic Esophagitis	Eosinophilia	Pubtator	25723478	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Diseases	Gastrointestinal disease	Pubtator	16299042	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	26747525	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	33328159	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leishmaniasis Visceral	Visceral leishmaniasis	Pubtator	32361248	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	20618322		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23481304, 29988113		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	31231212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	22363581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31231212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meniere Disease	Meniere Disease	BEFREE	31133025		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meniere Disease	Meniere disease	Pubtator	31133025	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	BEFREE	28460440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	25293806		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19568768, 21609450, 22363581, 29367056		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24447834, 28847511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	21614010, 27725312		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	Pubtator	21614010	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiration Disorders	Respiration Disorders	BEFREE	21741967		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	16204969, 28446753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	LHGDN	17978505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhinitis	Rhinitis	Pubtator	32277847	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	23422377		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Spondylitis Ankylosing	Ankylosing spondylitis	Pubtator	26823878	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	22363581		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach neoplasms	Pubtator	22363581	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	35227109	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

HRH4 (histamine receptor H4)