Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	59277
Gene name	Netrin 4
Gene symbol	NTN4
Synonyms (NCBI Gene)	PRO3091
Chromosome	12
Chromosome location	12q22
Summary	This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epiderm

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Show/Hide all (192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017325	hsa-miR-335-5p	Microarray	18185580
MIRT053067	hsa-miR-196a-5p	ImmunofluorescenceqRT-PCRWestern blot	24120501
MIRT756028	hsa-miR-210-3p	Luciferase reporter assayWestern blottingqRT-PCR	38175202
MIRT1196163	hsa-miR-1246	CLIP-seq
MIRT1196164	hsa-miR-3173-3p	CLIP-seq
MIRT1196165	hsa-miR-320a	CLIP-seq
MIRT1196166	hsa-miR-320b	CLIP-seq
MIRT1196167	hsa-miR-320c	CLIP-seq
MIRT1196168	hsa-miR-320d	CLIP-seq
MIRT1196169	hsa-miR-330-3p	CLIP-seq
MIRT1196170	hsa-miR-3653	CLIP-seq
MIRT1196171	hsa-miR-3658	CLIP-seq
MIRT1196172	hsa-miR-3672	CLIP-seq
MIRT1196173	hsa-miR-4279	CLIP-seq
MIRT1196174	hsa-miR-4329	CLIP-seq
MIRT1196175	hsa-miR-4429	CLIP-seq
MIRT1196176	hsa-miR-4762-3p	CLIP-seq
MIRT1196177	hsa-miR-495	CLIP-seq
MIRT1196178	hsa-miR-548a-3p	CLIP-seq
MIRT1196179	hsa-miR-548e	CLIP-seq
MIRT1196180	hsa-miR-548f	CLIP-seq
MIRT1196181	hsa-miR-938	CLIP-seq
MIRT1196177	hsa-miR-495	CLIP-seq
MIRT1196176	hsa-miR-4762-3p	CLIP-seq
MIRT1196177	hsa-miR-495	CLIP-seq
MIRT2285368	hsa-miR-196a	CLIP-seq
MIRT2285369	hsa-miR-196b	CLIP-seq
MIRT2285370	hsa-miR-3927	CLIP-seq
MIRT2285371	hsa-miR-4536	CLIP-seq
MIRT2285372	hsa-miR-4731-3p	CLIP-seq
MIRT2285373	hsa-miR-4801	CLIP-seq
MIRT2285374	hsa-miR-513b	CLIP-seq
MIRT2391790	hsa-miR-1236	CLIP-seq
MIRT2391791	hsa-miR-3182	CLIP-seq
MIRT2431664	hsa-miR-1206	CLIP-seq
MIRT2431665	hsa-miR-1283	CLIP-seq
MIRT2431666	hsa-miR-1297	CLIP-seq
MIRT2431667	hsa-miR-145	CLIP-seq
MIRT2431668	hsa-miR-2052	CLIP-seq
MIRT2431669	hsa-miR-26a	CLIP-seq
MIRT2431670	hsa-miR-26b	CLIP-seq
MIRT2431671	hsa-miR-300	CLIP-seq
MIRT2431672	hsa-miR-3074-5p	CLIP-seq
MIRT2431673	hsa-miR-3120-5p	CLIP-seq
MIRT2431674	hsa-miR-3149	CLIP-seq
MIRT2431675	hsa-miR-3152-3p	CLIP-seq
MIRT1196164	hsa-miR-3173-3p	CLIP-seq
MIRT2431676	hsa-miR-338-5p	CLIP-seq
MIRT2431677	hsa-miR-33a	CLIP-seq
MIRT2431678	hsa-miR-33b	CLIP-seq
MIRT2431679	hsa-miR-3616-5p	CLIP-seq
MIRT2431680	hsa-miR-3618	CLIP-seq
MIRT2431681	hsa-miR-3647-5p	CLIP-seq
MIRT1196170	hsa-miR-3653	CLIP-seq
MIRT1196171	hsa-miR-3658	CLIP-seq
MIRT2431682	hsa-miR-3670	CLIP-seq
MIRT2431683	hsa-miR-376c	CLIP-seq
MIRT2431684	hsa-miR-381	CLIP-seq
MIRT2431685	hsa-miR-3924	CLIP-seq
MIRT2431686	hsa-miR-410	CLIP-seq
MIRT2431687	hsa-miR-4272	CLIP-seq
MIRT2431688	hsa-miR-4282	CLIP-seq
MIRT2431689	hsa-miR-4289	CLIP-seq
MIRT2431690	hsa-miR-4307	CLIP-seq
MIRT2431691	hsa-miR-4421	CLIP-seq
MIRT2431692	hsa-miR-4465	CLIP-seq
MIRT2431693	hsa-miR-4509	CLIP-seq
MIRT2431694	hsa-miR-452	CLIP-seq
MIRT2431695	hsa-miR-4649-3p	CLIP-seq
MIRT2431696	hsa-miR-4666-3p	CLIP-seq
MIRT2431697	hsa-miR-4676-3p	CLIP-seq
MIRT2431698	hsa-miR-4693-5p	CLIP-seq
MIRT2431699	hsa-miR-4711-3p	CLIP-seq
MIRT2285372	hsa-miR-4731-3p	CLIP-seq
MIRT2431700	hsa-miR-4744	CLIP-seq
MIRT2431701	hsa-miR-4775	CLIP-seq
MIRT2431702	hsa-miR-4778-3p	CLIP-seq
MIRT2431703	hsa-miR-4778-5p	CLIP-seq
MIRT2431704	hsa-miR-4789-5p	CLIP-seq
MIRT2431705	hsa-miR-4795-5p	CLIP-seq
MIRT2285373	hsa-miR-4801	CLIP-seq
MIRT1196177	hsa-miR-495	CLIP-seq
MIRT2431706	hsa-miR-518a-5p	CLIP-seq
MIRT2431707	hsa-miR-519a	CLIP-seq
MIRT2431708	hsa-miR-519b-3p	CLIP-seq
MIRT2431709	hsa-miR-519c-3p	CLIP-seq
MIRT2431710	hsa-miR-527	CLIP-seq
MIRT1196178	hsa-miR-548a-3p	CLIP-seq
MIRT1196179	hsa-miR-548e	CLIP-seq
MIRT1196180	hsa-miR-548f	CLIP-seq
MIRT2431711	hsa-miR-548g	CLIP-seq
MIRT2431712	hsa-miR-556-5p	CLIP-seq
MIRT2431713	hsa-miR-561	CLIP-seq
MIRT2431714	hsa-miR-568	CLIP-seq
MIRT2431715	hsa-miR-573	CLIP-seq
MIRT2431716	hsa-miR-590-3p	CLIP-seq
MIRT2431717	hsa-miR-599	CLIP-seq
MIRT2431718	hsa-miR-892a	CLIP-seq
MIRT2431719	hsa-miR-934	CLIP-seq
MIRT2439085	hsa-miR-1237	CLIP-seq
MIRT2439086	hsa-miR-1248	CLIP-seq
MIRT2439087	hsa-miR-1305	CLIP-seq
MIRT2285368	hsa-miR-196a	CLIP-seq
MIRT2285369	hsa-miR-196b	CLIP-seq
MIRT2439088	hsa-miR-329	CLIP-seq
MIRT2439089	hsa-miR-362-3p	CLIP-seq
MIRT2439090	hsa-miR-377	CLIP-seq
MIRT2285370	hsa-miR-3927	CLIP-seq
MIRT2439091	hsa-miR-421	CLIP-seq
MIRT2439092	hsa-miR-4274	CLIP-seq
MIRT2285371	hsa-miR-4536	CLIP-seq
MIRT2439093	hsa-miR-4704-3p	CLIP-seq
MIRT2439094	hsa-miR-4709-5p	CLIP-seq
MIRT2285372	hsa-miR-4731-3p	CLIP-seq
MIRT2285373	hsa-miR-4801	CLIP-seq
MIRT2285374	hsa-miR-513b	CLIP-seq
MIRT2431664	hsa-miR-1206	CLIP-seq
MIRT2583462	hsa-miR-1225-5p	CLIP-seq
MIRT2583463	hsa-miR-129-5p	CLIP-seq
MIRT2431666	hsa-miR-1297	CLIP-seq
MIRT2583464	hsa-miR-140-5p	CLIP-seq
MIRT2431668	hsa-miR-2052	CLIP-seq
MIRT2583465	hsa-miR-2355-3p	CLIP-seq
MIRT2431669	hsa-miR-26a	CLIP-seq
MIRT2431670	hsa-miR-26b	CLIP-seq
MIRT2583466	hsa-miR-3121-3p	CLIP-seq
MIRT2431674	hsa-miR-3149	CLIP-seq
MIRT2431675	hsa-miR-3152-3p	CLIP-seq
MIRT1196164	hsa-miR-3173-3p	CLIP-seq
MIRT2583467	hsa-miR-3545-5p	CLIP-seq
MIRT1196170	hsa-miR-3653	CLIP-seq
MIRT1196171	hsa-miR-3658	CLIP-seq
MIRT1196172	hsa-miR-3672	CLIP-seq
MIRT2583468	hsa-miR-3691-3p	CLIP-seq
MIRT2431685	hsa-miR-3924	CLIP-seq
MIRT2583469	hsa-miR-412	CLIP-seq
MIRT2431687	hsa-miR-4272	CLIP-seq
MIRT1196173	hsa-miR-4279	CLIP-seq
MIRT2431689	hsa-miR-4289	CLIP-seq
MIRT2431690	hsa-miR-4307	CLIP-seq
MIRT2583470	hsa-miR-4424	CLIP-seq
MIRT2583471	hsa-miR-4460	CLIP-seq
MIRT2431692	hsa-miR-4465	CLIP-seq
MIRT2431694	hsa-miR-452	CLIP-seq
MIRT2583472	hsa-miR-4646-3p	CLIP-seq
MIRT2431697	hsa-miR-4676-3p	CLIP-seq
MIRT2583473	hsa-miR-4679	CLIP-seq
MIRT2431698	hsa-miR-4693-5p	CLIP-seq
MIRT2583474	hsa-miR-515-5p	CLIP-seq
MIRT1196178	hsa-miR-548a-3p	CLIP-seq
MIRT2583475	hsa-miR-548ae	CLIP-seq
MIRT2583476	hsa-miR-548aj	CLIP-seq
MIRT2583477	hsa-miR-548am	CLIP-seq
MIRT1196179	hsa-miR-548e	CLIP-seq
MIRT1196180	hsa-miR-548f	CLIP-seq
MIRT2431711	hsa-miR-548g	CLIP-seq
MIRT2583478	hsa-miR-548x	CLIP-seq
MIRT2431714	hsa-miR-568	CLIP-seq
MIRT2583479	hsa-miR-759	CLIP-seq
MIRT2431718	hsa-miR-892a	CLIP-seq
MIRT2431664	hsa-miR-1206	CLIP-seq
MIRT2583462	hsa-miR-1225-5p	CLIP-seq
MIRT2439085	hsa-miR-1237	CLIP-seq
MIRT2439086	hsa-miR-1248	CLIP-seq
MIRT2431666	hsa-miR-1297	CLIP-seq
MIRT2439087	hsa-miR-1305	CLIP-seq
MIRT2583464	hsa-miR-140-5p	CLIP-seq
MIRT2431668	hsa-miR-2052	CLIP-seq
MIRT2431669	hsa-miR-26a	CLIP-seq
MIRT2431670	hsa-miR-26b	CLIP-seq
MIRT2583466	hsa-miR-3121-3p	CLIP-seq
MIRT2431674	hsa-miR-3149	CLIP-seq
MIRT2431675	hsa-miR-3152-3p	CLIP-seq
MIRT2583467	hsa-miR-3545-5p	CLIP-seq
MIRT1196172	hsa-miR-3672	CLIP-seq
MIRT2583468	hsa-miR-3691-3p	CLIP-seq
MIRT2431685	hsa-miR-3924	CLIP-seq
MIRT2583469	hsa-miR-412	CLIP-seq
MIRT2439091	hsa-miR-421	CLIP-seq
MIRT2431687	hsa-miR-4272	CLIP-seq
MIRT2439092	hsa-miR-4274	CLIP-seq
MIRT1196173	hsa-miR-4279	CLIP-seq
MIRT2431689	hsa-miR-4289	CLIP-seq
MIRT2431690	hsa-miR-4307	CLIP-seq
MIRT2583470	hsa-miR-4424	CLIP-seq
MIRT2583471	hsa-miR-4460	CLIP-seq
MIRT2431692	hsa-miR-4465	CLIP-seq
MIRT2439094	hsa-miR-4709-5p	CLIP-seq
MIRT2583474	hsa-miR-515-5p	CLIP-seq
MIRT2431714	hsa-miR-568	CLIP-seq
MIRT2583479	hsa-miR-759	CLIP-seq
MIRT2431718	hsa-miR-892a	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 32296183, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005604	Component	Basement membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007411	Process	Axon guidance	IBA
GO:0009887	Process	Animal organ morphogenesis	IBA
GO:0009888	Process	Tissue development	IBA
GO:0016322	Process	Neuron remodeling	IEA
GO:0016477	Process	Cell migration	IBA
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IBA
GO:0043237	Function	Laminin-1 binding	IEA
GO:0043256	Component	Laminin complex	IBA
GO:0060668	Process	Regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling	IEA
GO:0070831	Process	Basement membrane assembly	IBA

MIM	HGNC	e!Ensembl
610401	13658	ENSG00000074527

Q9HB63

Protein name

Netrin-4 (Beta-netrin) (Hepar-derived netrin-like protein)

Protein function

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00055	Laminin_N	34 → 260	Laminin N-terminal (Domain VI)	Family
PF00053	Laminin_EGF	262 → 329	Laminin EGF domain	Domain
PF00053	Laminin_EGF	332 → 392	Laminin EGF domain	Domain
PF00053	Laminin_EGF	395 → 451	Laminin EGF domain	Domain
PF01759	NTR	517 → 624	UNC-6/NTR/C345C module	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen. {ECO:0000269|PubMed:11038171}.

Sequence

MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATEL
YCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLD
LEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAI
CTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRND
LNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTA
GSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCD
DCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDC
PCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRP
VHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGT
HVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKL
IVNMKSFVQHWKPSLGRKVMDILKRECK

Sequence length

628

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		Netrin-1 signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CONTACT DERMATITIS DUE TO NICKEL	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (31)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	26394601	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19859801, 20730893, 27840993, 31593922		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	24325915, 25862352, 35732855, 37800632	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	20730893		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic rhinosinusitis with nasal polyps	Rhinosinusitis With Nasal Polyps	BEFREE	29754498		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23124703		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37800632	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Corneal Neovascularization	Corneal Neovascularization	BEFREE	25853509, 28253401		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	38164180	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gilles de la Tourette syndrome	Tourette Syndrome	BEFREE	25042818		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	22496621, 24265816, 30514230		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	22496621, 24265816, 30514230	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	22496621, 24265816, 30514230		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	22496621	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	BEFREE	30928649		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	GWASCAT_DG	30796134		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	37800632	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19859801, 27840993, 31593922		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20730893, 22496621, 27840993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	17545519		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	20407033		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	27172792		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19094984, 19859801, 20407033, 22496621, 23124703, 28038459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	28038459, 30160193		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	30160193, 37800632	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	32319615	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis Knee	Osteoarthritis	Pubtator	39518922	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	35394406	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	39174693	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	25909166, 37800632, 38175202	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	24325915	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NTN4 (netrin 4)