Gene Gene information from NCBI Gene database.
Entrez ID 5911
Gene name RAP2A, member of RAS oncogene family
Gene symbol RAP2A
Synonyms (NCBI Gene)
K-REVKREVRAP2RbBP-30
Chromosome 13
Chromosome location 13q32.1
miRNA miRNA information provided by mirtarbase database.
515
miRTarBase ID miRNA Experiments Reference
MIRT047381 hsa-miR-34a-5p CLASH 23622248
MIRT054331 hsa-miR-1225-3p MicroarrayqRT-PCR 23593351
MIRT054342 hsa-miR-376a-5p ImmunoblotqRT-PCRWestern blot 23093778
MIRT249192 hsa-miR-10a-5p MicroarrayqRT-PCR 22815788
MIRT385269 hsa-miR-6865-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
58
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IMP 9312017, 10591105
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IDA 1900290
GO:0003924 Function GTPase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
179540 9861 ENSG00000125249
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P10114
Protein name Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
Protein function Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts
PDB 1KAO , 2RAP , 3RAP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 5 166 Ras family Domain
Sequence
Sequence length 183
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARTHRITIS, RHEUMATOID CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 22696507
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 15986426
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 33015796, 35293963 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 38057542 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Pancreatic ductal carcinoma Pubtator 34090323 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 28747626 Associate
★☆☆☆☆
Found in Text Mining only
Cerebral Cavernous Malformations 3 Cerebral Cavernous Malformation BEFREE 24058906
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 33313944 Associate
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 28747626
★☆☆☆☆
Found in Text Mining only
Glioma Glioma BEFREE 24293123, 28405688
★☆☆☆☆
Found in Text Mining only